Objective To explore factors that affect the assessment of sexual self-defense capacity and to evaluate the effect of social functions on sexual self-defense capacity in patients with mental retardation. Methods A 1∶1 matched case-control study was carried out, which included 174 sexual assault cases, 87 with mental retardation and 87 without mental retardation. A record of forensic psychiatry assessment designed by ourselves was used to collect the general characteristics. Wechsler Adult Intelligence-Rerisedin China (WAIS-RC) was used to determine the intelligence quotient. Rating Scale of Intellectual Disability (RSID) and Global Assessment Function (GAF) were used to assess social functions. Results Besides factors such as culture, occupation, knowledge about sex and payment claim, the scores of GAF and RSID were also related to the assessment of sexual self-defense capacity. Moreover, the correct ratio of discrimination was 73.1% (yes), 66.9% (impaired) and 87.2% (no), respectively, and the general correct ratio of discrimination was 78.1%. Conclusion Not only social and legal factors but also the level of social functions should be considered in the assessment of sexual self-defense capacity. Therefore, it might be concluded that multiple discriminant analysis can be useful when assessing the sexual self-defense capacity of patients with mental retardation.
ObjectiveTo investigate the effect of early different nutritional diet on the expression of IGFs and its receptor in retarded intrauterine growth rat pups. MethodsThe IUGR rat model was established by food restriction of pregnant rats.Newborn IUGR rats were randomly divided into four groups:IUGR model (S/N) group,IUGR high sugar diet (A) group,IUGR high protein diet (B) group,IUGR high fat (C) group.Only the mother rats were given those different diets individually,and all IUGR newborn pups were lactated for three weeks.All IUGR pups were fed with those different diets individually till the end of the month.Normal birth weight newborn rats were used as the control group fed with normal diet.Liver and lung tissues were detected by immunohistochemical staining and pancreatic tissues were stained with HE detection for all groups of rats. ResultsPolypeptide glycoprotein metalloprotease 12(ADAM12) test results each month showed no statistical difference (P>0.05).The determination results of plasma protein A (PAPP-A) in rat pups was statistically different among the groups in the first month (P<0.05),but no statistical difference was found in the second month,third month,and fourth month (P>0.05).TLR-4 test results had no statistical difference (P>0.05).Rat pancreatic tissue test results were statistically different in the first month (P<0.05),but the difference was not significant in the second month,third month,and fourth month (P>0.05). ConclusionADAM-12 and pregnancy associated PAPP-A expression results suggest that ADAM12 and PAPP-A may be closely related with rat catch-up growth,while the TLR-4 test results are not statistically different,but the chances of high glucose group and high fat group pancreatic inflammation are relatively large.
ObjectiveTo recognize and carry out early diagnosis for Cockayne syndrome (CS) as it is an extremely rare auto-recessive genetic syndrome characterized by multiple symptoms including growth failure and impaired development of the nervous system. MethodsHere we reported a case of typical CS with an unusual appearance. The 19-year-old young male patient was referred to West China Hospital on December 24th 2012. We analyzed the clinical characteristics of the patient and followed the literature review to help improve the knowledge on CS for clinicians. ResultsThe patient's parents were cousins. Laboratory data showed that lipoprotein profile, blood glucose and electrolytes, liver and renal function, as well as hormones (thyroxin, para-thyroxin, growth hormones, adrenocorticotropic hormone, corticosteroid) were all within normal limit. Electronic hearing examination showed moderate neural hearing loss. CT scan indicated multiple intracranial calcifications. The patient was definitely diagnosed with CS. He received nutritional support and symptomatic treatment but discharged due to lack of effective treatment. ConclusionCS is a progressive multisystem disorder characterized by a specific cellular defect in transcription-coupled repair. Typical features include developmental delay and impaired development of the nervous system. Typical clinical manifestations and imaging changes are helpful for clinical diagnosis of CS. Genotyping is necessary for patients with CS. Unfortunately, there is no ideal treatment for CS. Most of the patients with CS have poor prognosis.
It is the main method for amplifying the specific gene to use the nucleic acid amplification system to accomplish polymerase chain reaction (PCR). The temperature retard between heat source and sample exists in the heating and cooling progresses of most nucleic acid amplification system. The retard would result in the problem that the sample would take a long time to reach the set temperature and the problem would reduce the speed of integrate reaction. Non-specific products would be created in the process of amplification when the sample cannot reach the set temperature within a certainly time and the amplified efficiency would be reduced. A miniaturization nucleic acid amplification system heated by air was designed in this study according to the principle of air-heated nucleic acid amplification system and the characteristics of the PCR instrument Smart-cycler. The heat transfer process was analyzed and the heat transfer time was calculated. The actual temperature was measured in real time, and the temperature curves were fitted. The heating time was chosen by analysis results and data fitting and the air temperature was changed, while the sample temperature was recorded. The retard between sample and air was optimized by choosing the best curve of sample temperature. The temperature retard between sample and air was reduced sharply and the required time of integrate progress is shortened to 50%. We confirmed from the amplification experiment of Listeria monocytogenes that the improved system could complete 3 cycles within 4 minutes, and the amplification effect was good. The amplification speed and effect could be improved effectively by optimizing the delay between sample and air.