The study of the risk factors and pathogenesis of idiopathic epimacular membrane_Chinese Journal of Ocular Fundus Diseases

Authors：

Zhang Hongmei ¹ ,  Liu Hongtao ²

1. The First Clinical Institute, Zunyi Medical University, Zunyi 563000, China;
2. Department of Ophthalmology, The Second Affiliated Hospital Zunyi Medical University, Zunyi 563000, China;

Corresponding author：

Liu Hongtao, Email: 616193653@qq.com

Keywords：

Macula lutea; Membrane; Risk factors; Review

DOI：

10.3760/cma.j.cn511434-20200612-00279

Video：

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Abstract Full text Figures/Tables Video References Cited by

Idiopathic macular membrane (iERM) is a fibrocellular membrane that forms on the inner surface of the retina. In its early stages, symptoms of iERM are usually not apparent. However, advanced iERM can cause different degrees of visual impairment and effect the quality of life of patients. Current studies suggest that iERM may be associated with posterior vitreous detachment (PVD), age, sex, race and/or ethnicity, poor lifestyle, refractive error, diabetes, hypercholesterolemia, and cardiovascular disease. The most well-established risk factors for iERM are age and PVD. The pathogenesis of iERM is extremely complex. Various cell types, such as Müller cells, Hyalocytes and myofibroblasts, nerve growth factor, interleukin-6, transforming growth factor β, vascular endothelial growth factor and other cytokines and growth factors, as well as a variety of genes and proteins are directly or indirectly involved in the formation of iERM, however, their exact role remains a mystery. In the future, further studies at the molecular level and gene level are needed to provide greater help for the clinical diagnosis and treatment of iERM.

Citation： Zhang Hongmei, Liu Hongtao. The study of the risk factors and pathogenesis of idiopathic epimacular membrane. Chinese Journal of Ocular Fundus Diseases, 2021, 37(8): 651-655. doi: 10.3760/cma.j.cn511434-20200612-00279 Copy

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15. 曾苗, 陈晓, 洪玲, 等. 特发性黄斑前膜患眼玻璃体切割联合内界膜剥除手术前后视力和视物变形度与黄斑形态结构的相关性[J]. 中华眼底病杂志, 2017, 33(4): 378-382. DOI: 10.3760/cma.j.issn.1005-1015.2017.04.012.Zeng M, Chen X, Hong L, Xia Q, et al. Correlation of visual acuity and metamorphopsia with foveal morphology before and after vitrectomy with internal limiting membrane peeling in idiopathic macular epiretinal membrane eyes[J]. Chin J Ocul Fundus Dis, 2017, 33(4): 378-382. DOI: 10.3760/cma.j.issn.1005-1015.2017.04.012.
16. 曾苗, 陈晓, 洪玲, 等. 特发性黄斑前膜患者中心凹无血管区面积与中心凹形态相关性研究[J]. 中华眼底病杂志, 2019, 35(1): 15-19. DOI: 10.3760/cma.j.issn.1005-1015.2019.01.004.Zeng M, Chen X, Hong L, et al. Correlation between foveal avascular zone size and foveal morphology in patients with idiopathic macular epiretinal membrane[J]. Chin J Ocul Fundus Dis, 2019, 35(1): 15-19. DOI: 10.3760/cma.j.issn.1005-1015.2019.01.004.
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18. Semeraro F, Morescalchi F, Duse S, et al. Current trends about inner limiting membrane peeling in surgery for epiretinal membranes[J/OL]. J Ophthalmol, 2015, 2015: 671905[2015-09-03]. https://pubmed.ncbi.nlm.nih.gov/26425352/. DOI: 10.1155/2015/671905.
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23. Sato T, Morishita S, Horie T, et al. Involvement of premacular mast cells in the pathogenesis of macular diseases[J/OL]. PLoS One, 2019, 14(2): e0211438[2019-02-22]. https://pubmed.ncbi.nlm.nih.gov/30794552/. DOI: 10.1371/journal.pone.0211438.
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Chinese Journal of Ocular Fundus Diseases

The study of the risk factors and pathogenesis of idiopathic epimacular membrane

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