Recent research progress on the role of Hippo-Yap signaling pathway in retinal diseases_Chinese Journal of Ocular Fundus Diseases

Authors：

Zhang Wei ,  Chen Song

Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University, Tianjin 300020, China;

Corresponding author：

Chen Song, Email: chensong9999@126.com

Keywords：

Diabetic retinopathy; Reperfusion injury; Proliferative vitreoretinopathy; Yap signaling pathway; Hippo signaling pathway; Review

DOI：

10.3760/cma.j.cn511434-20210406-00172

Video：

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Abstract Full text Figures/Tables Video References Cited by

The classical Hippo pathway leads to the phosphorylation of downstream effector molecules Hippo-Yes-associated protein (Yap) and transcriptional coactivator PDZ-binding motif (Taz) serine sites through a kinase response, thereby promoting cell proliferation, controlling cell polarity, changing cytoskeleton, it plays an important regulatory role in various pathophysiological processes such as epithelial-mesenchymal transition and inhibition of cell contact. Studies have shown that Yap/Taz can affect the progression of vitreoretinal diseases, opening up new prospects for the pathogenesis and clinical treatment of diabetic retinopathy, proliferative vitreoretinopathy, and retinal ischemia-reperfusion injury. Exploring the molecular mechanism of Yap/Taz provides a possible therapeutic target for future research in the treatment of retinal fibrosis diseases such as diabetic retinopathy and proliferative vitreoretinopathy. At the same time, regulating the activity of local Yap/Taz in the retina will also become an effective therapeutic target for damage-repair in retinal ischemia-reperfusion injury. However, Yap inhibitors have potential retinal toxicity and are still in the preclinical development stage. Further research on the mechanism of action and clinical safety of Yap inhibitors will provide new methods for the treatment of retinal diseases.

Citation： Zhang Wei, Chen Song. Recent research progress on the role of Hippo-Yap signaling pathway in retinal diseases. Chinese Journal of Ocular Fundus Diseases, 2022, 38(10): 867-871. doi: 10.3760/cma.j.cn511434-20210406-00172 Copy

1.	Pavel M, Park SJ, Frake RA, et al. α-Catenin levels determine direction of Yap/Taz response to autophagy perturbation[J/OL]. Nat Commun, 2021, 12(1): 1703[2021-03-17]. https://pubmed.ncbi.nlm.nih.gov/33731717/. DOI: 10.1038/s41467-021-21882-1.
2.	Zhao D, Yin Z, Soellner MB, et al. Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation[J]. Cell Chem Biol, 2021, 28(8): 1235-1241. DOI: 10.1016/j.chembiol.2021.02.019.
3.	Matarrese P, Vona R, Ascione B, et al. Physical interaction between HPV16E7 and the actin-binding protein gelsolin regulates epithelial-mesenchymal transition via HIPPO-Yap axis[J]. Cancers (Basel), 2021, 13(2): 353. DOI: 10.3390/cancers13020353.
4.	Lee M, Goraya N, Kim S, et al. Hippo-yap signaling in ocular development and disease[J]. Dev Dyn, 2018, 247(6): 794-806. DOI: 10.1002/dvdy.24628.
5.	Masson C, García-García D, Bitard J, et al. Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy[J]. Cell Death Dis, 2020, 11(8): 631. DOI: 10.1038/s41419-020-02860-9.
6.	Santos-de-Frutos K, Segrelles C, Lorz C. Hippo pathway and yap signaling alterations in squamous cancer of the head and neck[J/OL]. J Clin Med, 2019, 8(12): 2131[2019-12-03]. https://pubmed.ncbi.nlm.nih.gov/31817001/. DOI: 10.3390/jcm8122131.
7.	Miao J, Kyoyama H, Liu L, et al. Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells[J]. J Cell Mol Med, 2020, 24(1): 1087-1098. DOI: 10.1111/jcmm.14841.
8.	Bejoy J, Wang Z, Bijonowski B, et al. Differential effects of heparin and hyaluronic acid on neural patterning of human induced pluripotent stem cells[J]. ACS Biomater Sci Eng, 2018, 4(12): 4354-4366. DOI: 10.1021/acsbiomaterials.8b01142.
9.	Kim KH, Chung C, Kim JM, et al. Clinical significance of atypical protein kinase C (PKCι and PKCζ) and its relationship with yes-associated protein in lung adenocarcinoma[J]. BMC Cancer, 2019, 19(1): 804. DOI: 10.1186/s12885-019-5992-7.
10.	Zhang G, Dai S, Chen Y, et al. Aqueous extract of Taxus chinensis var. mairei regulates the Hippo-Yap pathway and promotes apoptosis of non-small cell lung cancer via ATF3 in vivo and in vitro[J/OL]. Biomed Pharmacother, 2021, 138: 111506[2021-06-01]. https://pubmed.ncbi.nlm.nih.gov/33740524/. DOI: 10.1016/j.biopha.2021.111506.
11.	Neal SJ, Zhou Q, Pignoni F. STRIPAK-PP2A regulates Hippo-Yorkie signaling to suppress retinal fate in the Drosophila eye disc peripodial epithelium[J/OL]. J Cell Sci, 2020, 133(10): jcs237834[2020-05-26]. https://pubmed.ncbi.nlm.nih.gov/32184260/. DOI: 10.1242/jcs.237834.
12.	Deng H, Yang L, Wen P, et al. Spectrin couples cell shape, cortical tension, and Hippo signaling in retinal epithelial morphogenesis[J/OL]. J Cell Biol, 2020, 219(4): e201907018[2020-04-06]. https://pubmed.ncbi.nlm.nih.gov/32328630/. DOI: 10.1083/jcb.201907018.
13.	Ehmer U, Sage J. Control of proliferation and cancer growth by the Hippo signaling pathway[J]. Mol Cancer Res, 2016, 14(2): 127-140. DOI: 10.1158/1541-7786.MCR-15-0305.
14.	Moon KH, Kim HT, Lee D, et al. Differential expression of NF2 in neuroepithelial compartments is necessary for mammalian eye development[J]. Dev Cell, 2018, 44(1): 13-28. DOI: 10.1016/j.devcel.2017.11.011.
15.	Miesfeld JB, Link BA. Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway[J]. Mech Dev, 2014, 133: 177-88. DOI: 10.1016/j.mod.2014.02.003.
16.	Alarcon VB, Marikawa Y. ROCK and RHO playlist for preimplantation development: streaming to HIPPO pathway and apicobasal polarity in the first cell differentiation[J]. Adv Anat Embryol Cell Biol, 2018, 229: 47-68. DOI: 10.1007/978-3-319-63187-5_5.
17.	Keller M, Reis K, Hjerpe A, et al. Cytoskeletal organization correlates to motility and invasiveness of malignant mesothelioma cells[J]. Cancers (Basel), 2021, 13(4): 685. DOI: 10.3390/cancers13040685.
18.	Zhang T, Guo S, Zhou H, et al. Endometrial extracellular matrix rigidity and IFNτ ensure the establishment of early pregnancy through activation of Yap[J/OL]. Cell Prolif, 2021, 54(2): e12976[2021-02-04]. https://pubmed.ncbi.nlm.nih.gov/33393124/. DOI: 10.1111/cpr.12976.
19.	Aharonov A, Shakked A, Umansky KB, et al. ERBB2 drives Yap activation and EMT-like processes during cardiac regeneration[J]. Nat Cell Biol, 2020, 22(11): 1346-1356. DOI: 10.1038/s41556-020-00588-4.
20.	Rani PK, Peguda HK, Chandrashekher M, et al. Capacity building for diabetic retinopathy screening by optometrists in India: model description and pilot results[J]. Indian J Ophthalmol, 2021, 69(3): 655-659. DOI: 10.4103/ijo.IJO_1944_20.
21.	Zhang W, Jiang H, Kong Y. Exosomes derived from platelet-rich plasma activate Yap and promote the fibrogenic activity of Müller cells via the PI3K/Akt pathway[J/OL]. Exp Eye Res, 2020, 193: 107973[2020-02-12]. https://pubmed.ncbi.nlm.nih.gov/32059976/. DOI: 10.1016/j.exer.2020.107973.
22.	Zhang W, Kong Y. Yap is essential for TGF-β-induced retinal fibrosis in diabetic rats via promoting the fibrogenic activity of Müller cells[J]. J Cell Mol Med, 2020, 24(21): 12390-12400. DOI: 10.1111/jcmm.15739.
23.	Pan Q, Gao Z, Zhu C, et al. Overexpression of histone deacetylase SIRT1 exerts an antiangiogenic role in diabetic retinopathy via miR-20a elevation and Yap/HIF1α/VEGFA depletion[J/OL]. Am J Physiol Endocrinol Metab, 2020, 319(5): E932-943[2020-11-01]. https://pubmed.ncbi.nlm.nih.gov/32776826/. DOI: 10.1152/ajpendo.00051.2020.
24.	Xing W, Song Y, Li H, et al. Fufang Xueshuantong protects retinal vascular endothelial cells from high glucose by targeting Yap[J/OL]. Biomed Pharmacother, 2019, 120: 109470[2019-10-04]. https://pubmed.ncbi.nlm.nih.gov/31590124/. DOI: 10.1016/j.biopha.2019.109470.
25.	Hao GM, Lyv TT, Wu Y, et al. The Hippo signaling pathway: a potential therapeutic target is reversed by a Chinese patent drug in rats with diabetic retinopathy[J]. BMC Complement Altern Med, 2017, 17(1): 187. DOI: 10.1186/s12906-017-1678-3.
26.	Wu D, Kanda A, Liu Y, et al. Involvement of Müller glial autoinduction of TGF-β in diabetic fibrovascular proliferation via glial-mesenchymal transition[J]. Invest Ophthalmol Vis Sci, 2020, 61(14): 29. DOI: 10.1167/iovs.61.14.29.
27.	Hamon A, García-García D, Ail D, et al. Linking Yap to Müller glia quiescence exit in the degenerative retina[J]. Cell Rep, 2019, 27(6): 1712-1725. DOI: 10.1016/j.celrep.2019.04.045.
28.	Rueda EM, Hall BM, Hill MC, et al. The Hippo pathway blocks mammalian retinal müller glial cell reprogramming[J]. Cell Rep, 2019, 27(6): 1637-1649. DOI: 10.1016/j.celrep.2019.04.047.
29.	Xue Y, Shen SQ, Jui J, et al. CRALBP supports the mammalian retinal visual cycle and cone vision[J]. J Clin Invest, 2015, 125(2): 727-738. DOI: 10.1172/JCI79651.
30.	Sindal MD, Gondhale HP, Srivastav K. Clinical profile and outcomes of rhegmatogenous retinal detachment related to trauma in pediatric population[J]. Can J Ophthalmol, 2020, 56(4): 231-236. DOI: 10.1016/j.jcjo.2020.12.001.
31.	Qi T, Jing R, Wen C, et al. Interleukin-6 promotes migration and extracellular matrix synthesis in retinal pigment epithelial cells[J]. Histochem Cell Biol, 2020, 154(6): 629-638. DOI: 10.1007/s00418-020-01923-4.
32.	Du Y, Chen Q, Huang L, et al. VEGFR2 and VEGF-C suppresses the epithelial-mesenchymal transition via yap in retinal pigment epithelial cells[J]. Curr Mol Med, 2018, 18(5): 273-286. DOI: 10.2174/1566524018666181004115304.
33.	Davis JT, Wen Q, Janmey PA, et al. Müller cell expression of genes implicated in proliferative vitreoretinopathy is influenced by substrate elastic modulus[J]. Invest Ophthalmol Vis Sci, 2012, 53(6): 3014-3019. DOI: 10.1167/iovs.11-8450.
34.	Chen HC, Zhu YT, Chen SY, et al. Wnt signaling induces epithelial-mesenchymal transition with proliferation in ARPE-19 cells upon loss of contact inhibition[J]. Lab Invest, 2012, 92(5): 676-687. DOI: 10.1038/labinvest.2011.201.
35.	van Soldt BJ, Cardoso WV. Hippo-Yap/Taz signaling: complex network interactions and impact in epithelial cell behavior[J/OL]. Wiley Interdiscip Rev Dev Biol, 2020, 9(3): e371[2020-05-01]. https://pubmed.ncbi.nlm.nih.gov/31828974/. DOI: 10.1002/wdev.371.
36.	Yuan H, Li H, Yu P, et al. Involvement of HDAC6 in ischaemia and reperfusion-induced rat retinal injury[J]. BMC Ophthalmol, 2018, 18(1): 300. DOI: 10.1186/s12886-018-0951-7.
37.	Konishi T, Schuster RM, Lentsch AB. Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and regeneration after liver ischemia-reperfusion injury[J]. Am J Physiol Gastrointest Liver Physiol, 2018, 314(4): 471-482. DOI: 10.1152/ajpgi.00153.2017.
38.	Zhang Q, Cao Y, Liu Y, et al. Shear stress inhibits cardiac microvascular endothelial cells apoptosis to protect against myocardial ischemia reperfusion injury via Yap/miR-206/PDCD4 signaling pathway[J/OL]. Biochem Pharmacol, 2021, 186: 114466[2021-02-18]. https://pubmed.ncbi.nlm.nih.gov/33610591/. DOI: 10.1016/j.bcp.2021.114466.
39.	Li L, Xu L, Chen W, et al. Reduced annexin A1 secretion by ABCA1 causes retinal inflammation and ganglion cell apoptosis in a murine glaucoma model[J]. Front Cell Neurosci, 2018, 12: 347. DOI: 10.3389/fncel.2018.00347.
40.	González Fleitas MF, Aranda ML, Dieguez HH, et al. Pre-ischemic enriched environment increases retinal resilience to acute ischemic damage in adult rats[J]. Exp Eye Res, 2019, 178: 198-211. DOI: 10.1016/j.exer.2018.10.007.
41.	Ha Y, Liu W, Liu H, et al. AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and tau oligomer formation[J]. Invest Ophthalmol Vis Sci, 2018, 59(11): 4670-4682. DOI: 10.1167/iovs.18-24427.
42.	Moon S, Lee S, Caesar JA, et al. A CTGF-Yap regulatory pathway is essential for angiogenesis and barriergenesis in the retina[J/OL]. iScience, 2020, 23(6): 101184[2020-06-26]. https://pubmed.ncbi.nlm.nih.gov/32502964/. DOI: 10.1016/j.isci.2020.101184.
43.	Brodowska K, Al-Moujahed A, Marmalidou A, et al. The clinically used photosensitizer Verteporfin (VP) inhibits Yap-TEAD and human retinoblastoma cell growth in vitro without light activation[J]. Exp Eye Res, 2014, 124: 67-73. DOI: 10.1016/j.exer.2014.04.011.
44.	Al-Moujahed A, Brodowska K, Stryjewski TP, et al. Verteporfin inhibits growth of human glioma in vitro without light activation[J/OL]. Sci Rep, 2017, 7(1): 7602[2017-08-08]. https://pubmed.ncbi.nlm.nih.gov/28790340/. DOI: 10.1038/s41598-017-07632-8.
45.	Lyubasyuk V, Ouyang H, Yu FX, et al. YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations[J/OL]. Mol Cell Oncol, 2014, 2(1): e970957[2014-12-01]. https://pubmed.ncbi.nlm.nih.gov/27308390/. DOI: 10.4161/23723548.2014.970957.
46.	Tamiya S, Kaplan HJ. Role of epithelial-mesenchymal transition in proliferative vitreoretinopathy[J]. Exp Eye Res, 2016, 142: 26-31. DOI: 10.1016/j.exer.2015.02.008.

1. Pavel M, Park SJ, Frake RA, et al. α-Catenin levels determine direction of Yap/Taz response to autophagy perturbation[J/OL]. Nat Commun, 2021, 12(1): 1703[2021-03-17]. https://pubmed.ncbi.nlm.nih.gov/33731717/. DOI: 10.1038/s41467-021-21882-1.
2. Zhao D, Yin Z, Soellner MB, et al. Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation[J]. Cell Chem Biol, 2021, 28(8): 1235-1241. DOI: 10.1016/j.chembiol.2021.02.019.
3. Matarrese P, Vona R, Ascione B, et al. Physical interaction between HPV16E7 and the actin-binding protein gelsolin regulates epithelial-mesenchymal transition via HIPPO-Yap axis[J]. Cancers (Basel), 2021, 13(2): 353. DOI: 10.3390/cancers13020353.
4. Lee M, Goraya N, Kim S, et al. Hippo-yap signaling in ocular development and disease[J]. Dev Dyn, 2018, 247(6): 794-806. DOI: 10.1002/dvdy.24628.
5. Masson C, García-García D, Bitard J, et al. Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy[J]. Cell Death Dis, 2020, 11(8): 631. DOI: 10.1038/s41419-020-02860-9.
6. Santos-de-Frutos K, Segrelles C, Lorz C. Hippo pathway and yap signaling alterations in squamous cancer of the head and neck[J/OL]. J Clin Med, 2019, 8(12): 2131[2019-12-03]. https://pubmed.ncbi.nlm.nih.gov/31817001/. DOI: 10.3390/jcm8122131.
7. Miao J, Kyoyama H, Liu L, et al. Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells[J]. J Cell Mol Med, 2020, 24(1): 1087-1098. DOI: 10.1111/jcmm.14841.
8. Bejoy J, Wang Z, Bijonowski B, et al. Differential effects of heparin and hyaluronic acid on neural patterning of human induced pluripotent stem cells[J]. ACS Biomater Sci Eng, 2018, 4(12): 4354-4366. DOI: 10.1021/acsbiomaterials.8b01142.
9. Kim KH, Chung C, Kim JM, et al. Clinical significance of atypical protein kinase C (PKCι and PKCζ) and its relationship with yes-associated protein in lung adenocarcinoma[J]. BMC Cancer, 2019, 19(1): 804. DOI: 10.1186/s12885-019-5992-7.
10. Zhang G, Dai S, Chen Y, et al. Aqueous extract of Taxus chinensis var. mairei regulates the Hippo-Yap pathway and promotes apoptosis of non-small cell lung cancer via ATF3 in vivo and in vitro[J/OL]. Biomed Pharmacother, 2021, 138: 111506[2021-06-01]. https://pubmed.ncbi.nlm.nih.gov/33740524/. DOI: 10.1016/j.biopha.2021.111506.
11. Neal SJ, Zhou Q, Pignoni F. STRIPAK-PP2A regulates Hippo-Yorkie signaling to suppress retinal fate in the Drosophila eye disc peripodial epithelium[J/OL]. J Cell Sci, 2020, 133(10): jcs237834[2020-05-26]. https://pubmed.ncbi.nlm.nih.gov/32184260/. DOI: 10.1242/jcs.237834.
12. Deng H, Yang L, Wen P, et al. Spectrin couples cell shape, cortical tension, and Hippo signaling in retinal epithelial morphogenesis[J/OL]. J Cell Biol, 2020, 219(4): e201907018[2020-04-06]. https://pubmed.ncbi.nlm.nih.gov/32328630/. DOI: 10.1083/jcb.201907018.
13. Ehmer U, Sage J. Control of proliferation and cancer growth by the Hippo signaling pathway[J]. Mol Cancer Res, 2016, 14(2): 127-140. DOI: 10.1158/1541-7786.MCR-15-0305.
14. Moon KH, Kim HT, Lee D, et al. Differential expression of NF2 in neuroepithelial compartments is necessary for mammalian eye development[J]. Dev Cell, 2018, 44(1): 13-28. DOI: 10.1016/j.devcel.2017.11.011.
15. Miesfeld JB, Link BA. Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway[J]. Mech Dev, 2014, 133: 177-88. DOI: 10.1016/j.mod.2014.02.003.
16. Alarcon VB, Marikawa Y. ROCK and RHO playlist for preimplantation development: streaming to HIPPO pathway and apicobasal polarity in the first cell differentiation[J]. Adv Anat Embryol Cell Biol, 2018, 229: 47-68. DOI: 10.1007/978-3-319-63187-5_5.
17. Keller M, Reis K, Hjerpe A, et al. Cytoskeletal organization correlates to motility and invasiveness of malignant mesothelioma cells[J]. Cancers (Basel), 2021, 13(4): 685. DOI: 10.3390/cancers13040685.
18. Zhang T, Guo S, Zhou H, et al. Endometrial extracellular matrix rigidity and IFNτ ensure the establishment of early pregnancy through activation of Yap[J/OL]. Cell Prolif, 2021, 54(2): e12976[2021-02-04]. https://pubmed.ncbi.nlm.nih.gov/33393124/. DOI: 10.1111/cpr.12976.
19. Aharonov A, Shakked A, Umansky KB, et al. ERBB2 drives Yap activation and EMT-like processes during cardiac regeneration[J]. Nat Cell Biol, 2020, 22(11): 1346-1356. DOI: 10.1038/s41556-020-00588-4.
20. Rani PK, Peguda HK, Chandrashekher M, et al. Capacity building for diabetic retinopathy screening by optometrists in India: model description and pilot results[J]. Indian J Ophthalmol, 2021, 69(3): 655-659. DOI: 10.4103/ijo.IJO_1944_20.
21. Zhang W, Jiang H, Kong Y. Exosomes derived from platelet-rich plasma activate Yap and promote the fibrogenic activity of Müller cells via the PI3K/Akt pathway[J/OL]. Exp Eye Res, 2020, 193: 107973[2020-02-12]. https://pubmed.ncbi.nlm.nih.gov/32059976/. DOI: 10.1016/j.exer.2020.107973.
22. Zhang W, Kong Y. Yap is essential for TGF-β-induced retinal fibrosis in diabetic rats via promoting the fibrogenic activity of Müller cells[J]. J Cell Mol Med, 2020, 24(21): 12390-12400. DOI: 10.1111/jcmm.15739.
23. Pan Q, Gao Z, Zhu C, et al. Overexpression of histone deacetylase SIRT1 exerts an antiangiogenic role in diabetic retinopathy via miR-20a elevation and Yap/HIF1α/VEGFA depletion[J/OL]. Am J Physiol Endocrinol Metab, 2020, 319(5): E932-943[2020-11-01]. https://pubmed.ncbi.nlm.nih.gov/32776826/. DOI: 10.1152/ajpendo.00051.2020.
24. Xing W, Song Y, Li H, et al. Fufang Xueshuantong protects retinal vascular endothelial cells from high glucose by targeting Yap[J/OL]. Biomed Pharmacother, 2019, 120: 109470[2019-10-04]. https://pubmed.ncbi.nlm.nih.gov/31590124/. DOI: 10.1016/j.biopha.2019.109470.
25. Hao GM, Lyv TT, Wu Y, et al. The Hippo signaling pathway: a potential therapeutic target is reversed by a Chinese patent drug in rats with diabetic retinopathy[J]. BMC Complement Altern Med, 2017, 17(1): 187. DOI: 10.1186/s12906-017-1678-3.
26. Wu D, Kanda A, Liu Y, et al. Involvement of Müller glial autoinduction of TGF-β in diabetic fibrovascular proliferation via glial-mesenchymal transition[J]. Invest Ophthalmol Vis Sci, 2020, 61(14): 29. DOI: 10.1167/iovs.61.14.29.
27. Hamon A, García-García D, Ail D, et al. Linking Yap to Müller glia quiescence exit in the degenerative retina[J]. Cell Rep, 2019, 27(6): 1712-1725. DOI: 10.1016/j.celrep.2019.04.045.
28. Rueda EM, Hall BM, Hill MC, et al. The Hippo pathway blocks mammalian retinal müller glial cell reprogramming[J]. Cell Rep, 2019, 27(6): 1637-1649. DOI: 10.1016/j.celrep.2019.04.047.
29. Xue Y, Shen SQ, Jui J, et al. CRALBP supports the mammalian retinal visual cycle and cone vision[J]. J Clin Invest, 2015, 125(2): 727-738. DOI: 10.1172/JCI79651.
30. Sindal MD, Gondhale HP, Srivastav K. Clinical profile and outcomes of rhegmatogenous retinal detachment related to trauma in pediatric population[J]. Can J Ophthalmol, 2020, 56(4): 231-236. DOI: 10.1016/j.jcjo.2020.12.001.
31. Qi T, Jing R, Wen C, et al. Interleukin-6 promotes migration and extracellular matrix synthesis in retinal pigment epithelial cells[J]. Histochem Cell Biol, 2020, 154(6): 629-638. DOI: 10.1007/s00418-020-01923-4.
32. Du Y, Chen Q, Huang L, et al. VEGFR2 and VEGF-C suppresses the epithelial-mesenchymal transition via yap in retinal pigment epithelial cells[J]. Curr Mol Med, 2018, 18(5): 273-286. DOI: 10.2174/1566524018666181004115304.
33. Davis JT, Wen Q, Janmey PA, et al. Müller cell expression of genes implicated in proliferative vitreoretinopathy is influenced by substrate elastic modulus[J]. Invest Ophthalmol Vis Sci, 2012, 53(6): 3014-3019. DOI: 10.1167/iovs.11-8450.
34. Chen HC, Zhu YT, Chen SY, et al. Wnt signaling induces epithelial-mesenchymal transition with proliferation in ARPE-19 cells upon loss of contact inhibition[J]. Lab Invest, 2012, 92(5): 676-687. DOI: 10.1038/labinvest.2011.201.
35. van Soldt BJ, Cardoso WV. Hippo-Yap/Taz signaling: complex network interactions and impact in epithelial cell behavior[J/OL]. Wiley Interdiscip Rev Dev Biol, 2020, 9(3): e371[2020-05-01]. https://pubmed.ncbi.nlm.nih.gov/31828974/. DOI: 10.1002/wdev.371.
36. Yuan H, Li H, Yu P, et al. Involvement of HDAC6 in ischaemia and reperfusion-induced rat retinal injury[J]. BMC Ophthalmol, 2018, 18(1): 300. DOI: 10.1186/s12886-018-0951-7.
37. Konishi T, Schuster RM, Lentsch AB. Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and regeneration after liver ischemia-reperfusion injury[J]. Am J Physiol Gastrointest Liver Physiol, 2018, 314(4): 471-482. DOI: 10.1152/ajpgi.00153.2017.
38. Zhang Q, Cao Y, Liu Y, et al. Shear stress inhibits cardiac microvascular endothelial cells apoptosis to protect against myocardial ischemia reperfusion injury via Yap/miR-206/PDCD4 signaling pathway[J/OL]. Biochem Pharmacol, 2021, 186: 114466[2021-02-18]. https://pubmed.ncbi.nlm.nih.gov/33610591/. DOI: 10.1016/j.bcp.2021.114466.
39. Li L, Xu L, Chen W, et al. Reduced annexin A1 secretion by ABCA1 causes retinal inflammation and ganglion cell apoptosis in a murine glaucoma model[J]. Front Cell Neurosci, 2018, 12: 347. DOI: 10.3389/fncel.2018.00347.
40. González Fleitas MF, Aranda ML, Dieguez HH, et al. Pre-ischemic enriched environment increases retinal resilience to acute ischemic damage in adult rats[J]. Exp Eye Res, 2019, 178: 198-211. DOI: 10.1016/j.exer.2018.10.007.
41. Ha Y, Liu W, Liu H, et al. AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and tau oligomer formation[J]. Invest Ophthalmol Vis Sci, 2018, 59(11): 4670-4682. DOI: 10.1167/iovs.18-24427.
42. Moon S, Lee S, Caesar JA, et al. A CTGF-Yap regulatory pathway is essential for angiogenesis and barriergenesis in the retina[J/OL]. iScience, 2020, 23(6): 101184[2020-06-26]. https://pubmed.ncbi.nlm.nih.gov/32502964/. DOI: 10.1016/j.isci.2020.101184.
43. Brodowska K, Al-Moujahed A, Marmalidou A, et al. The clinically used photosensitizer Verteporfin (VP) inhibits Yap-TEAD and human retinoblastoma cell growth in vitro without light activation[J]. Exp Eye Res, 2014, 124: 67-73. DOI: 10.1016/j.exer.2014.04.011.
44. Al-Moujahed A, Brodowska K, Stryjewski TP, et al. Verteporfin inhibits growth of human glioma in vitro without light activation[J/OL]. Sci Rep, 2017, 7(1): 7602[2017-08-08]. https://pubmed.ncbi.nlm.nih.gov/28790340/. DOI: 10.1038/s41598-017-07632-8.
45. Lyubasyuk V, Ouyang H, Yu FX, et al. YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations[J/OL]. Mol Cell Oncol, 2014, 2(1): e970957[2014-12-01]. https://pubmed.ncbi.nlm.nih.gov/27308390/. DOI: 10.4161/23723548.2014.970957.
46. Tamiya S, Kaplan HJ. Role of epithelial-mesenchymal transition in proliferative vitreoretinopathy[J]. Exp Eye Res, 2016, 142: 26-31. DOI: 10.1016/j.exer.2015.02.008.

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