Deng Xinyi 1 , Liu Hui 2 , Mao Jianbo 1 , Sun Mingzhai 2 , Zhang Zhengxi 1 , Tao Jiwei 1 , She Xiangjun 1 , Chen Yiqi 1 , Shen Lijun 1,3
  • 1. Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, China;
  • 2. Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230022, China;
  • 3. Department of Ophthalmology, Zhejiang Provincial People’s Hospital, Hangzhou 310000, China;
Shen Lijun, Email: slj@mail.eye.ac.cn
Retinal vein occlusion; Oxygen saturation; Vascular morphology; Deep learning; Dual-model fundus camera
10.3760/cma.j.cn511434-20220104-00010
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Objective To study a deep learning-based dual-modality fundus camera which was used to study retinal blood oxygen saturation and vascular morphology changes in eyes with branch retinal vein occlusion (BRVO). Methods A prospective study. From May to October 2020, 31 patients (31 eyes) of BRVO (BRVO group) and 20 healthy volunteers (20 eyes) with matched gender and age (control group) were included in the study. Among 31 patients (31 eyes) in BRVO group, 20 patients (20 eyes) received one intravitreal injection of anti-vascular endothelial growth factor drugs before, and 11 patients (11 eyes) did not receive any treatment. They were divided into treatment group and untreated group accordingly. Retinal images were collected with a dual-modality fundus camera; arterial and vein segments were segmented in the macular region of interest (MROI) using deep learning; the optical density ratio was used to calculate retinal blood oxygen saturation (SO2) on the affected and non-involved sides of the eyes in the control group and patients in the BRVO group, and calculated the diameter, curvature, fractal dimension and density of arteriovenous in MROI. Quantitative data were compared between groups using one-way analysis of variance. Results There was a statistically significant difference in arterial SO2 (SO2-A) in the MROI between the affected eyes, the fellow eyes in the BRVO group and the control group (F=4.925, P<0.001), but there was no difference in the venous SO2 (SO2-V) (F=0.607, P=0.178). Compared with the control group, the SO2-A in the MROI of the affected side and the non-involved side of the untreated group was increased, and the difference was statistically significant (F=4.925, P=0.012); there was no significant difference in SO2-V (F=0.607, P=0.550). There was no significant difference in SO2-A and SO2-V in the MROI between the affected side, the non-involved side in the treatment group and the control group (F=0.159, 1.701; P=0.854, 0.197). There was no significant difference in SO2-A and SO2-V in MROI between the affected side of the treatment group, the untreated group and the control group (F=2.553, 0.265; P=0.088, 0.546). The ophthalmic artery diameter, arterial curvature, arterial fractal dimension, vein fractal dimension, arterial density, and vein density were compared in the untreated group, the treatment group, and the control group, and the differences were statistically significant (F=3.527, 3.322, 7.251, 26.128, 4.782, 5.612; P=0.047, 0.044, 0.002, <0.001, 0.013, 0.006); there was no significant difference in vein diameter and vein curvature (F=2.132, 1.199; P=0.143, 0.321). Conclusion Arterial SO2 in BRVO patients is higher than that in healthy eyes, it decreases after anti-anti-vascular endothelial growth factor drugs treatment, SO2-V is unchanged.

Citation： Deng Xinyi, Liu Hui, Mao Jianbo, Sun Mingzhai, Zhang Zhengxi, Tao Jiwei, She Xiangjun, Chen Yiqi, Shen Lijun. The oxygen saturation and vascular morphology of branch retinal vein occlusion by a dual-model fundus camera based on deep learning. Chinese Journal of Ocular Fundus Diseases, 2022, 38(2): 108-113. doi: 10.3760/cma.j.cn511434-20220104-00010 Copy

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