Pay attention to the correct diagnosis and rational treatment of ciliary body tumors_Chinese Journal of Ocular Fundus Diseases

Authors：

 Wei Wenbin , Wang Qian

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;

Corresponding author：

Wei Wenbin, Email: weiwenbintr@163.com

Keywords：

Eye neoplasms; Ciliary body; Diagnosis; Antineoplastic protocols; Editorial

DOI：

10.3760/cma.j.cn511434-20220221-00099

Video：

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Ciliary body tumor is a rare intraocular tumor. Due to its unique anatomical location, its correct diagnosis and reasonable treatment are very difficult problems. In terms of diagnosis and differential diagnosis, ophthalmologists need to fully utilize the role of slit lamp microscope and transillumination experiment to capture secondary changes in the anterior segment caused by hidden ciliary body tumors, such as monocular localized cataract, lens indentation, and pigment dissemination, etc. Ophthalmological imaging methods, especially ultrasound biomicroscopy, can achieve the purpose of early detection and early diagnosis. According to the size, location and morphological characteristics of the tumor, a reasonable treatment plan is formulated. Since ciliary body tumors are mostly benign, the recurrence rate of local resection is low, which can satisfy the pathological diagnosis and preserve part of the patient's vision. Therefore, eye-preserving treatment should be advocated. However, enucleation remains the treatment of choice for tumors that are too large to be treated with local excision or radiation, eyes with refractory glaucoma, and tumors that do not respond to radiation therapy.

Citation： Wei Wenbin, Wang Qian. Pay attention to the correct diagnosis and rational treatment of ciliary body tumors. Chinese Journal of Ocular Fundus Diseases, 2022, 38(3): 178-181. doi: 10.3760/cma.j.cn511434-20220221-00099 Copy

1.	Wei WB, Yang WL, Hu SM, et al. Local exision of ciliary body tumors: a long-term prospective cohort study in China[J]. Chin Med J (Engl), 2008, 121(21): 2152-2156. DOI: 10.1097/00029330-200811010-00009.
2.	Goto H, Yamakawa N, Tsubota K, et al. Clinicopathologic analysis of 32 ciliary body tumors[J]. Jpn J Ophthalmol, 2021, 65(2): 237-249. DOI: 10.1007/s10384-021-00814-y.
3.	魏文斌, 杨文利, 胡士敏, 等. 睫状体肿瘤的临床与病理分析[J]. 眼科, 2003, 12(4): 216-218. DOI: 10.3969/j.issn.1004-4469.2003.04.008.Wei WB, Yang WL, Hu SM, et al. Clinical and pathogenic study of ciliary tumor[J]. Ophthalmol CHN, 2003, 12(4): 216-218. DOI: 10.3969/j.issn.1004-4469.2003.04.008.
4.	魏文斌. 熟练掌握双目间接检眼镜检查法是眼科医师的基本功[J]. 眼科, 2002, 11(3): 133-135. DOI: 10.3969/j.issn.1004-4469.2002.03.002.Wei WB. Proficiency in binocular indirect ophthalmoscopy is the basic skill of ophthalmologists[J]. Ophthalmol CHN, 2002, 11(3): 133-135. DOI: 10.3969/j.issn.1004-4469.2002.03.002.
5.	Shields CL, Shields JA, Shields MB, et al. Prevalence and mechanisms of secondary intraocular pressure elevation in eyes with intraocular tumors[J]. Ophthalmology, 1987, 94: 839-846. DOI: 10.1016/s0161-6420(87)33537-7.
6.	刘桂琴, 吴中耀, 冯官光, 等. 虹膜睫状体肿瘤37例的临床分析[J]. 中华眼科杂志, 2003, 39(2): 77-80. DOI: 10.3760/j:issn:0412-4081.2003.02.004.Liu GQ, Wu ZY, Feng GG, et al. Clinical analysis of tumors of the iris and ciliary bod[J]. Chin J Ocul Fundus Dis, 2003, 39(2): 77-80. DOI: 10.3760/j:issn:0412-4081.2003.02.004.
7.	魏文斌, 李彬, 杨文利, 等. 儿童睫状体髓上皮瘤四例[J]. 中华眼底病杂志, 2011, 27(2): 186-187. DOI: 10.3760/cma.j.issn.1005-1015.2011.02.025.Wei WB, Li B, Yang WL, et al. Four cases of ciliary body medulloepithelioma in children[J]. Chin J Ocul Fundus Dis, 2011, 27(2): 186-187. DOI: 10.3760/cma.j.issn.1005-1015.2011.02.025.
8.	Marigo FA, Finger PT. Anterior segment tumors: current concepts and innovations[J]. Surv Ophthalmol, 2003, 48: 569-593. DOI: 10.1016/j.survophthal.2003.08.001.
9.	Conway RM, Chew T, Golchet P, et al. Ultrasound biomicroscopy: role in diagnosis and management in 130 consecutive patients evaluated for anterior segment tumours[J]. Br J Ophthalmol, 2005, 89(8): 950-955. DOI: 10.1136/bjo.2004.059535.
10.	吴中耀, 杨华胜, 颜建华, 等. 虹膜睫状体肿物的超声生物显微镜检查[J]. 中华眼底病杂志, 2002, 18(2): 128-130. DOI: 10.3760/j.issn:1005-1015.2002.02.014.Wu ZY, Yang HS, Yang JH, et al. Ultrasound biomicroscopy in 34 cases of iris and ciliary tumor[J]. Chin J Ocul Fundus Dis, 2002, 18(2): 128-130. DOI: 10.3760/j.issn:1005-1015.2002.02.014.
11.	Adam G, Brab M, Bohndorf K, et al. Gadolinium-DTPA-enhanced MRI of intraocular tumors[J]. Magn Reson Imaging, 1990, 8(6): 683-689. DOI: 10.1016/0730-725x(90)90002-j.
12.	Nakazawa T, Abe T, Sato Y, et al. Magnetic resonance imaging of a non-pigmented adenoma of the ciliary epithelium[J]. Acta Ophthalmol Scand, 2000, 78(4): 470-473. DOI: 10.1034/j.1600-0420.2000.078004470.x.
13.	Johnson SM, Cheng HM, Pineda R, et al. Magnetic resonance imaging of cyclodialysis clefts[J]. Graefe's Arch Clin Exp Ophthalmol, 1997, 235(7): 468-471. DOI: 10.1007/BF00947068.
14.	Finger PT. Plaque radiation therapy for malignant melanoma of the iris and ciliary body[J]. Am J Ophthalmol, 2001, 132(3): 328-335. DOI: 10.1016/s0002-9394(01)01007-8.
15.	魏文斌, 胡士敏, 朱晓青, 等. 睫状体肿瘤局部切除联合玻璃体视网膜手术的疗效分析[J]. 中华眼科杂志, 2002, 38(5): 301-306. DOI: 10.3760/j:issn:0412-4081.2002.05.010.Wei WB, Hu SM, Zhu XQ, et al. Local resection of ciliary body tumors with vitreoretinal surgery[J]. Chin J Ophthalmol, 2002, 38(5): 301-306. DOI: 10.3760/j:issn:0412-4081.2002.05.010.
16.	赵芳, 魏文斌. 睫状体脉络膜神经鞘瘤二例[J]. 中华眼底病杂志, 2005, 21(3): 193-194. DOI: 10.3760/j.issn:1005-1015.2005.03.023.Zhao F, Wei WB. Two cases of ciliary body choroidal schwannoma[J]. Chin J Ocul Fundus Dis, 2005, 21(3): 193-194. DOI: 10.3760/j.issn:1005-1015.2005.03.023.
17.	李彬, 孙宪丽, 郑邦和, 等. 52例睫状体占位性病变的组织来源、临床特征及组织病理分析[J]. 中华眼科杂志, 2000, 36(4): 250-254. DOI: 10.3760/j:issn:0412-4081.2000.04.003.Li B, Sun XL, Zheng BH, et al. Histological origin, clinical features and histopathological analysis of 52 cases of ciliary body space-occupying lesions[J]. Chin J Ophthalmol, 2000, 36(4): 250-254. DOI: 10.3760/j:issn:0412-4081.2000.04.003.

1. Wei WB, Yang WL, Hu SM, et al. Local exision of ciliary body tumors: a long-term prospective cohort study in China[J]. Chin Med J (Engl), 2008, 121(21): 2152-2156. DOI: 10.1097/00029330-200811010-00009.
2. Goto H, Yamakawa N, Tsubota K, et al. Clinicopathologic analysis of 32 ciliary body tumors[J]. Jpn J Ophthalmol, 2021, 65(2): 237-249. DOI: 10.1007/s10384-021-00814-y.
3. 魏文斌, 杨文利, 胡士敏, 等. 睫状体肿瘤的临床与病理分析[J]. 眼科, 2003, 12(4): 216-218. DOI: 10.3969/j.issn.1004-4469.2003.04.008.Wei WB, Yang WL, Hu SM, et al. Clinical and pathogenic study of ciliary tumor[J]. Ophthalmol CHN, 2003, 12(4): 216-218. DOI: 10.3969/j.issn.1004-4469.2003.04.008.
4. 魏文斌. 熟练掌握双目间接检眼镜检查法是眼科医师的基本功[J]. 眼科, 2002, 11(3): 133-135. DOI: 10.3969/j.issn.1004-4469.2002.03.002.Wei WB. Proficiency in binocular indirect ophthalmoscopy is the basic skill of ophthalmologists[J]. Ophthalmol CHN, 2002, 11(3): 133-135. DOI: 10.3969/j.issn.1004-4469.2002.03.002.
5. Shields CL, Shields JA, Shields MB, et al. Prevalence and mechanisms of secondary intraocular pressure elevation in eyes with intraocular tumors[J]. Ophthalmology, 1987, 94: 839-846. DOI: 10.1016/s0161-6420(87)33537-7.
6. 刘桂琴, 吴中耀, 冯官光, 等. 虹膜睫状体肿瘤37例的临床分析[J]. 中华眼科杂志, 2003, 39(2): 77-80. DOI: 10.3760/j:issn:0412-4081.2003.02.004.Liu GQ, Wu ZY, Feng GG, et al. Clinical analysis of tumors of the iris and ciliary bod[J]. Chin J Ocul Fundus Dis, 2003, 39(2): 77-80. DOI: 10.3760/j:issn:0412-4081.2003.02.004.
7. 魏文斌, 李彬, 杨文利, 等. 儿童睫状体髓上皮瘤四例[J]. 中华眼底病杂志, 2011, 27(2): 186-187. DOI: 10.3760/cma.j.issn.1005-1015.2011.02.025.Wei WB, Li B, Yang WL, et al. Four cases of ciliary body medulloepithelioma in children[J]. Chin J Ocul Fundus Dis, 2011, 27(2): 186-187. DOI: 10.3760/cma.j.issn.1005-1015.2011.02.025.
8. Marigo FA, Finger PT. Anterior segment tumors: current concepts and innovations[J]. Surv Ophthalmol, 2003, 48: 569-593. DOI: 10.1016/j.survophthal.2003.08.001.
9. Conway RM, Chew T, Golchet P, et al. Ultrasound biomicroscopy: role in diagnosis and management in 130 consecutive patients evaluated for anterior segment tumours[J]. Br J Ophthalmol, 2005, 89(8): 950-955. DOI: 10.1136/bjo.2004.059535.
10. 吴中耀, 杨华胜, 颜建华, 等. 虹膜睫状体肿物的超声生物显微镜检查[J]. 中华眼底病杂志, 2002, 18(2): 128-130. DOI: 10.3760/j.issn:1005-1015.2002.02.014.Wu ZY, Yang HS, Yang JH, et al. Ultrasound biomicroscopy in 34 cases of iris and ciliary tumor[J]. Chin J Ocul Fundus Dis, 2002, 18(2): 128-130. DOI: 10.3760/j.issn:1005-1015.2002.02.014.
11. Adam G, Brab M, Bohndorf K, et al. Gadolinium-DTPA-enhanced MRI of intraocular tumors[J]. Magn Reson Imaging, 1990, 8(6): 683-689. DOI: 10.1016/0730-725x(90)90002-j.
12. Nakazawa T, Abe T, Sato Y, et al. Magnetic resonance imaging of a non-pigmented adenoma of the ciliary epithelium[J]. Acta Ophthalmol Scand, 2000, 78(4): 470-473. DOI: 10.1034/j.1600-0420.2000.078004470.x.
13. Johnson SM, Cheng HM, Pineda R, et al. Magnetic resonance imaging of cyclodialysis clefts[J]. Graefe's Arch Clin Exp Ophthalmol, 1997, 235(7): 468-471. DOI: 10.1007/BF00947068.
14. Finger PT. Plaque radiation therapy for malignant melanoma of the iris and ciliary body[J]. Am J Ophthalmol, 2001, 132(3): 328-335. DOI: 10.1016/s0002-9394(01)01007-8.
15. 魏文斌, 胡士敏, 朱晓青, 等. 睫状体肿瘤局部切除联合玻璃体视网膜手术的疗效分析[J]. 中华眼科杂志, 2002, 38(5): 301-306. DOI: 10.3760/j:issn:0412-4081.2002.05.010.Wei WB, Hu SM, Zhu XQ, et al. Local resection of ciliary body tumors with vitreoretinal surgery[J]. Chin J Ophthalmol, 2002, 38(5): 301-306. DOI: 10.3760/j:issn:0412-4081.2002.05.010.
16. 赵芳, 魏文斌. 睫状体脉络膜神经鞘瘤二例[J]. 中华眼底病杂志, 2005, 21(3): 193-194. DOI: 10.3760/j.issn:1005-1015.2005.03.023.Zhao F, Wei WB. Two cases of ciliary body choroidal schwannoma[J]. Chin J Ocul Fundus Dis, 2005, 21(3): 193-194. DOI: 10.3760/j.issn:1005-1015.2005.03.023.
17. 李彬, 孙宪丽, 郑邦和, 等. 52例睫状体占位性病变的组织来源、临床特征及组织病理分析[J]. 中华眼科杂志, 2000, 36(4): 250-254. DOI: 10.3760/j:issn:0412-4081.2000.04.003.Li B, Sun XL, Zheng BH, et al. Histological origin, clinical features and histopathological analysis of 52 cases of ciliary body space-occupying lesions[J]. Chin J Ophthalmol, 2000, 36(4): 250-254. DOI: 10.3760/j:issn:0412-4081.2000.04.003.

Chinese Journal of Ocular Fundus Diseases

Pay attention to the correct diagnosis and rational treatment of ciliary body tumors

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