Improving the recognition of vitreoretinal interface in children_Chinese Journal of Ocular Fundus Diseases

Authors：

 Huang Houbin ^1,2,3

1. Department of Ophthalmology, Hainan Hospital of PLA General Hospital, Sanya 572013, China;
2. Senior Department of Ophthalmology, PLA General Hospital, Beijing 100853, China;
3. The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510280, China;

Corresponding author：

Huang Houbin, Email: 536273642@qq.com

Keywords：

Posterior vitreous cortex; Internal limiting membrane; Vitreretinal interface; Child; Editorial

DOI：

10.3760/cma.j.cn511434-20230106-00012

Video：

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Vitreoretinal interface is consisted of posterior vitreous cortex, retina internal limiting membrane, and extracellular matrix between them. Basement membrane-like complex is formed in the interface. The interface in children is of much difference with that in adult. The adhesion of it is much tight in children. The posterior edge of vitreous base is closed to ora serrata. The retina internal limiting membrane is thin. But with age, the posterior margin of vitreous base extends posteriorly, internal limiting membrane thickens and its elasticity decreases, the adhesion in vitreoretinal interface weakens, and posterior vitreous detachment develops. To recognize fully the interface in children is of much importance for understanding the pathophysiology and treatment strategy of pediatric vitreoretinal diseases.

Citation： Huang Houbin. Improving the recognition of vitreoretinal interface in children. Chinese Journal of Ocular Fundus Diseases, 2023, 39(1): 1-4. doi: 10.3760/cma.j.cn511434-20230106-00012 Copy

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1. Kishi S. Vitreous anatomy and the vitreomacular correlation[J]. Jpn J Ophthalmol, 2016, 60(4): 239-273. DOI: 10.1007/s10384-016-0447-z.
2. Kishi S, Demaria C, Shimizu K. Vitreous cortex remnants at the fovea after spontaneous vitreous detachment[J]. Int Ophthalmol, 1986, 9(4): 253-260. DOI: 10.1007/bf00137539.
3. Gupta P, Yee KM, Garcia P, et al. Vitreoschisis in macular diseases[J]. Br J Ophthalmol, 2011, 95(3): 376-380. DOI: 10.1136/bjo.2009.175109.
4. Sebag J, Balazs EA. Human vitreous fibres and vitreoretinal disease[J]. Trans Ophthalmol Soc U K(1962), 1985, 104 (Pt 2): 123-128.
5. Sebag J. Anomalous posterior vitreous detachment: a unifying concept in vitreo-retinal disease[J]. Graefe's Arch Clin Exp Ophthalmol, 2004, 242(8): 690-698. DOI: 10.1007/s00417-004-0980-1.
6. Mitry D, Fleck BW, Wright AF, et al. Pathogenesis of rhegmatogenous retinal detachment: predisposing anatomy and cell biology[J]. Retina, 2010, 30(10): 1561-1572. DOI: 10.1097/IAE.0b013e3181f669e6.
7. Sebag J. Anatomy and pathology of the vitreo-retinal interface[J]. Eye (Lond), 1992, 6(Pt 6): 541-552. DOI: 10.1038/eye.1992.119.
8. Sebag J. Vitreous and Vitreoretinal Interface[M]//Schachat AP. Ryan's retina. 6th ed. Amsterdam: Elsevier Inc, 2018: 544-581.
9. Phillips JD, Hwang ES, Morgan DJ, et al. Structure and mechanics of the vitreoretinal interface[J/OL]. J Mech Behav Biomed Mater, 2022, 134: 105399[2022-08-05]. https://pubmed.ncbi.nlm.nih.gov/35963021/. DOI: 10.1016/j.jmbbm.2022.105399.
10. Sebag J. Diabetic vitreopathy[J]. Ophthalmology, 1996, 103(2): 205-206. DOI: 10.1016/s0161-6420(96)30716-1.
11. Creveling CJ, Colter J, Coats B. Changes in vitreoretinal adhesion with age and region in human and sheep eyes[J]. Front Bioeng Biotechnol, 2018, 6: 153. DOI: 10.3389/fbioe.2018.00153.
12. Luo RH, Tram NK, Parekh AM, et al. The roles of vitreous biomechanics in ocular disease, biomolecule transport, and pharmacokinetics[J]. Curr Eye Res, 2022, 5: 1-13. DOI: 10.1080/02713683.2022.2033271.
13. Sebag J. Age-related differences in the human vitreoretinal interface[J]. Arch Ophthalmol, 1991, 109(7): 966-971. DOI: 10.1001/archopht.1991.01080070078039.
14. Tsukahara M, Mori K, Gehlbach PL, Mori K. Posterior vitreous detachment as observed by wide-angle OCT imaging[J]. Ophthalmology, 2018, 125(9): 1372-1383. DOI: 10.1016/j.ophtha.2018.02.039.
15. Wang J, McLeod D, Henson DB, et al. Age-dependent changes in the basal retinovitreous adhesion[J]. Invest Ophthalmol Vis Sci, 2003, 44(5): 1793-800. DOI: 10.1167/iovs.02-0802.
16. Richards AJ, McNinch A, Martin H, et al. Stickler syndrome and the vitreous phenotype: mutations in COL2A1 and COL11A1[J/OL]. Hum Mutat, 2010, 31(6): E1461-1471[2010-06-01]. https://pubmed.ncbi.nlm.nih.gov/20513134/. DOI: 10.1002/humu.21257.
17. Kohno T, Sorgente N, Ishibashi T, et al. Immunofluorescent studies of fibronectin and laminin in the human eye[J]. Invest Ophthalmol Vis Sci, 1987, 28(3): 506-514.

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