Application of automatic injection device based on automatic hemostasis in injection of radiopharmaceutical bolus injection_Journal of Biomedical Engineering

Authors：

 LI Jin ^1,2 , FAN Wenhong ³ , MA Jianxiong ¹ , ZHOU Wei ² , PANG Xinxin ² , TIAN Cungui ² , YANG Guohui ² , WANG Yan ¹ , ZHAO Na ²

1. Tianjin Hospital, Tianjin University, Tianjin 300211, P. R. China;
2. CNNC High Energy Equipment (Tianjin) Co., Ltd., Tianjin 300300, P. R. China;
3. Tianjin Medical University General Hospital, Tianjin 300052, P. R. China;

Corresponding author：

LI Jin, Email: mjx969@163.com

Keywords：

Radiopharmaceutical dynamic imaging; Bolus injection; Automatic injection device

DOI：

10.7507/1001-5515.202301013

Video：

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In clinical practice, radiopharmaceutical dynamic imaging technology requires the bolus injection method to complete injection. Due to the failure rate and radiation damage of manual injection, even experienced technicians still bear a lot of psychological burden. This study combined the advantages and disadvantages of various manual injection modes to develop the radiopharmaceutical bolus injector, and explored the application of automatic injection in the field of bolus injection from four aspects: radiation protection, occlusion response, sterility of injection process and effect of bolus injection. Compared with the current mainstream manual injection method, the bolus manufactured by the radiopharmaceutical bolus injector based on the automatic hemostasis method had a narrower full width at half maximum and better repeatability. At the same time, radiopharmaceutical bolus injector had reduced the radiation dose of the technician’s palm by 98.8%, and ensured more efficient vein occlusion recognition performance and sterility of the entire injection process. The radiopharmaceutical bolus injector based on automatic hemostasis has application potential in improving the effect and repeatability of bolus injection.

Citation： LI Jin, FAN Wenhong, MA Jianxiong, ZHOU Wei, PANG Xinxin, TIAN Cungui, YANG Guohui, WANG Yan, ZHAO Na. Application of automatic injection device based on automatic hemostasis in injection of radiopharmaceutical bolus injection. Journal of Biomedical Engineering, 2023, 40(2): 320-326. doi: 10.7507/1001-5515.202301013 Copy

1.	Jeong S, Park S B, Chang I H, et al. Estimation of renal function using kidney dynamic contrast material-enhanced CT perfusion: accuracy and feasibility. Abdom Radiol (NY), 2021, 46(5): 2045-2051.
2.	Marripudi K, Tulasi R K. Bone scan and MRI findings in a case of paediatric multifocal osteomyelitis. Clin Radiol Extra, 2021, 1(65): 99-200.
3.	Launey Y, Fryer T D, Hong Y T, et al. Spatial and temporal pattern of ischemia and abnormal vascular function following traumatic brain injury. JAMA Neurol, 2020, 77(3): 339-349.
4.	Schröder J, Heinze M, Günther M, et al. Dynamics of brain perfusion and cognitive performance in revascularization of carotid artery stenosis. Neuroimage Clin, 2019, 22: 101779.
5.	黎秀娟, 王梅珍, 陈茹芬. 弹丸式注射与核素肾动态显像的关系分析. 当代护士(学术版), 2011(10): 98-100.
6.	杨宝军, 李险峰, 赵德善. 弹丸注射质量与Gates法肾动态显像结果的关系. 山西医药杂志, 2009, 38(9): 426-427.
7.	李沛, 高永举, 施婧琦, 等. 采用静脉留置针“弹丸”注射法行⁹⁹Tc^m-DTPA肾动态显像. 中国医学影像技术, 2021, 37(11): 1752-1754.
8.	吕延娟. 护理干预在放射性核素肾动态显像检查患者中的应用效果分析. 世界最新医学信息文摘, 2018(39): 28-29.
9.	石瑾, 温庆祥, 崔璨, 等. 三通法弹丸注射残留药物对肾小球滤过率的影响. 标记免疫分析与临床, 2017, 24(6): 642-643.
10.	严春雷, 孔令华, 李冬娟, 等. 不同弹丸式注射对肾动态显像结果的影响. 交通医学, 2014, 28(5): 513-514.
11.	段艳梅, 张少丽, 王英, 等. 改良留置针注射法在肾动态显像检查中的应用. 中国临床研究, 2020, 33(5): 661-664.
12.	Zhu Lei, Liu Haibo, Wang Rui, et al. Mechanism of pulsatile flushing technique for saline injection via a peripheral intravenous catheter. Clin Biomech, 2020, 80: 105103.
13.	Zhao Peng, Chong Yinbao, Zhao An, et al. A rapid infusion pump driven by micro electromagnetic linear actuation for pre-hospital intravenous fluid administration. Proc Inst Mech Eng H, 2015, 229(2): 101-109.
14.	王岐, 薛建军, 杨路路, 等. 弹丸注射质量对Gates法测定活体肾移植供者GFR的影响. 标记免疫分析与临床, 2021, 28(7): 1141-1145.
15.	Wesolowski C A, Hogendoorn P, Vandierendonck R, et al. Bolus injections of measured amounts of radioactivity. J Nucl Med Tech, 1988, 16(1): 1-4.
16.	熊小兵, 杜飞平, 何玲. 2015-2018年四川省介入与核医学放射工作人员职业外照射个人剂量分析. 职业卫生与病伤, 2019, 34(6): 336-339.
17.	Fathy M, Khalil M M, Elshemey W M, et al. Occupational radiation dose to nuclear medicine staff due to Tc99m, F18-FDG PET and therapeutic I-131 based examinations. Radiat Prot Dosim, 2019, 186(4): 443-451.
18.	Covens P, Berus D, Vanhavere F, et al. The introduction of automated dispensing and injection during PET procedures: a step in the optimisation of extremity doses and whole-body doses of nuclear medicine staff. Radiat Prot Dosim, 2010, 140(3): 250-258.
19.	Merce M S, Ruiz N, Barth I, et al. Extremity exposure in nuclear medicine: preliminary results of a European study. Radiat Prot Dosim, 2011, 144(1-4): 515-520.
20.	Lecchi M, Lucignani G, Maioli C. Validation of a new protocol for 18F-FDG infusion using an automatic combined dispenser and injector system. Eur J Nucl Med Mol Imaging, 2012, 39(11): 1720-1729.
21.	Sánchez R M, Vano E, Fernández J M, et al. Evaluation of an automated FDG dose infuser to PET-CT patients. Radiat Prot Dosim, 2015, 165(1-4): 457-460.
22.	王瞳, 赵海燕, 任超, 等. PET自动给药系统注射与传统注射对比的研究. 中国医学装备, 2021, 18(6): 35-38.
23.	郭宁, 王瞳, 霍力, 等. 正电子放射性药物自动分装注射系统的设计与测试. 中国医学科学院学报, 2021, 43(3): 429-434.
24.	Sakat M S, Sade R, Kilic K, et al. The use of dynamic contrast-enhanced perfusion MRI in differentiating benign and malignant thyroid nodules. Indian J Otolaryngol Head Neck Surg, 2019, 71(Suppl 1): 706-711.
25.	Malla S R, Bhalla A S, Manchanda S, et al. Dynamic contrast-enhanced magnetic resonance imaging for differentiating head and neck paraganglioma and schwannoma. Head Neck, 2021, 43(9): 2611-2622.
26.	Feichtinger M, Eder H, Holl A, et al. Automatic and remote controlled ictal SPECT injection for seizure focus localization by use of a commercial contrast agent application pump. Epilepsia, 2010, 48(7): 1409-1413.
27.	陆素青, 卢彦祺, 付巍. 血管评估监测表在核素肾动态显像中的应用研究. 标记免疫分析与临床, 2019, 26(9): 1528-1531.
28.	陆素青, 卢彦祺, 付巍. 放射性核素肾动态显像弹丸注射方法的应用研究进展. 国际放射医学核医学杂志, 2020, 44(10): 667-671.

1. Jeong S, Park S B, Chang I H, et al. Estimation of renal function using kidney dynamic contrast material-enhanced CT perfusion: accuracy and feasibility. Abdom Radiol (NY), 2021, 46(5): 2045-2051.
2. Marripudi K, Tulasi R K. Bone scan and MRI findings in a case of paediatric multifocal osteomyelitis. Clin Radiol Extra, 2021, 1(65): 99-200.
3. Launey Y, Fryer T D, Hong Y T, et al. Spatial and temporal pattern of ischemia and abnormal vascular function following traumatic brain injury. JAMA Neurol, 2020, 77(3): 339-349.
4. Schröder J, Heinze M, Günther M, et al. Dynamics of brain perfusion and cognitive performance in revascularization of carotid artery stenosis. Neuroimage Clin, 2019, 22: 101779.
5. 黎秀娟, 王梅珍, 陈茹芬. 弹丸式注射与核素肾动态显像的关系分析. 当代护士(学术版), 2011(10): 98-100.
6. 杨宝军, 李险峰, 赵德善. 弹丸注射质量与Gates法肾动态显像结果的关系. 山西医药杂志, 2009, 38(9): 426-427.
7. 李沛, 高永举, 施婧琦, 等. 采用静脉留置针“弹丸”注射法行⁹⁹Tc^m-DTPA肾动态显像. 中国医学影像技术, 2021, 37(11): 1752-1754.
8. 吕延娟. 护理干预在放射性核素肾动态显像检查患者中的应用效果分析. 世界最新医学信息文摘, 2018(39): 28-29.
9. 石瑾, 温庆祥, 崔璨, 等. 三通法弹丸注射残留药物对肾小球滤过率的影响. 标记免疫分析与临床, 2017, 24(6): 642-643.
10. 严春雷, 孔令华, 李冬娟, 等. 不同弹丸式注射对肾动态显像结果的影响. 交通医学, 2014, 28(5): 513-514.
11. 段艳梅, 张少丽, 王英, 等. 改良留置针注射法在肾动态显像检查中的应用. 中国临床研究, 2020, 33(5): 661-664.
12. Zhu Lei, Liu Haibo, Wang Rui, et al. Mechanism of pulsatile flushing technique for saline injection via a peripheral intravenous catheter. Clin Biomech, 2020, 80: 105103.
13. Zhao Peng, Chong Yinbao, Zhao An, et al. A rapid infusion pump driven by micro electromagnetic linear actuation for pre-hospital intravenous fluid administration. Proc Inst Mech Eng H, 2015, 229(2): 101-109.
14. 王岐, 薛建军, 杨路路, 等. 弹丸注射质量对Gates法测定活体肾移植供者GFR的影响. 标记免疫分析与临床, 2021, 28(7): 1141-1145.
15. Wesolowski C A, Hogendoorn P, Vandierendonck R, et al. Bolus injections of measured amounts of radioactivity. J Nucl Med Tech, 1988, 16(1): 1-4.
16. 熊小兵, 杜飞平, 何玲. 2015-2018年四川省介入与核医学放射工作人员职业外照射个人剂量分析. 职业卫生与病伤, 2019, 34(6): 336-339.
17. Fathy M, Khalil M M, Elshemey W M, et al. Occupational radiation dose to nuclear medicine staff due to Tc99m, F18-FDG PET and therapeutic I-131 based examinations. Radiat Prot Dosim, 2019, 186(4): 443-451.
18. Covens P, Berus D, Vanhavere F, et al. The introduction of automated dispensing and injection during PET procedures: a step in the optimisation of extremity doses and whole-body doses of nuclear medicine staff. Radiat Prot Dosim, 2010, 140(3): 250-258.
19. Merce M S, Ruiz N, Barth I, et al. Extremity exposure in nuclear medicine: preliminary results of a European study. Radiat Prot Dosim, 2011, 144(1-4): 515-520.
20. Lecchi M, Lucignani G, Maioli C. Validation of a new protocol for 18F-FDG infusion using an automatic combined dispenser and injector system. Eur J Nucl Med Mol Imaging, 2012, 39(11): 1720-1729.
21. Sánchez R M, Vano E, Fernández J M, et al. Evaluation of an automated FDG dose infuser to PET-CT patients. Radiat Prot Dosim, 2015, 165(1-4): 457-460.
22. 王瞳, 赵海燕, 任超, 等. PET自动给药系统注射与传统注射对比的研究. 中国医学装备, 2021, 18(6): 35-38.
23. 郭宁, 王瞳, 霍力, 等. 正电子放射性药物自动分装注射系统的设计与测试. 中国医学科学院学报, 2021, 43(3): 429-434.
24. Sakat M S, Sade R, Kilic K, et al. The use of dynamic contrast-enhanced perfusion MRI in differentiating benign and malignant thyroid nodules. Indian J Otolaryngol Head Neck Surg, 2019, 71(Suppl 1): 706-711.
25. Malla S R, Bhalla A S, Manchanda S, et al. Dynamic contrast-enhanced magnetic resonance imaging for differentiating head and neck paraganglioma and schwannoma. Head Neck, 2021, 43(9): 2611-2622.
26. Feichtinger M, Eder H, Holl A, et al. Automatic and remote controlled ictal SPECT injection for seizure focus localization by use of a commercial contrast agent application pump. Epilepsia, 2010, 48(7): 1409-1413.
27. 陆素青, 卢彦祺, 付巍. 血管评估监测表在核素肾动态显像中的应用研究. 标记免疫分析与临床, 2019, 26(9): 1528-1531.
28. 陆素青, 卢彦祺, 付巍. 放射性核素肾动态显像弹丸注射方法的应用研究进展. 国际放射医学核医学杂志, 2020, 44(10): 667-671.

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