微小RNA-21与结直肠癌_West China Medical Journal

Authors：

 德吉 ,  王一平

四川大学华西医院消化内科（成都，610041）;

Corresponding author：

王一平, Email: wyplm2012@163.com

Keywords：

微小RNA-21; 微小RNA; 结直肠癌

DOI：

10.7507/1002-0179.20140174

Video：

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Abstract Full text Figures/Tables Video References Cited by

结直肠癌是最常见的恶性肿瘤之一，全球发病率呈逐年上升趋势。微小RNA-21（miR-21）作为微小RNA家族中一员，在许多肿瘤中过度表达。近年来越来越多的研究表明，miR-21表达异常与结直肠癌的发生、发展及预后密切相关。现就近年来miR-21在结直肠癌的诊断、预后及治疗等方面的最新研究进行系统综述。

Citation： 德吉, 王一平. 微小RNA-21与结直肠癌. West China Medical Journal, 2014, 29(3): 578-581. doi: 10.7507/1002-0179.20140174 Copy

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36.	马一杰, 赵卫杰, 陈贝贝, 等. miR-21与结直肠癌细胞5-氟尿嘧啶化疗敏感性关系[J]. 中国保健营养, 2013(2):180-181.
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1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009[J]. CA Cancer J Clin, 2009, 59(4):225-249.
2. Jema1 A, Bray F, Center MM, et a1. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2):69-90.
3. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J]. Cell, 1993, 75(5):843-854.
4. Lee Y, Kim M, Han J, et al. MicroRNA genes are transcribed by RNA polymerase Ⅱ[J]. EMBO J, 2004, 23(20):4051-4060.
5. Borchert GM, Lanier W, Davidson BL. RNA polymerase Ⅲ transcribes human microRNAs[J]. Nat Struct Mol Biol, 2006, 13(12):1097-1101.
6. Lee Y, Han J, Yeom KH, et al. Drosha in primary microRNA processing[J]. Cold Spring Harb Symp Quant Biol, 2006, 71(8):51-57.
7. Várallyay É, Burgyán J, Havelda Z. Detection of microRNAs by northern blot analyses using LNA probes[J]. Methods, 2007, 43(2):140-145.
8. Castoldi M, Schmidt S, Benes V, et al. miChip:an array-based method for microRNA expression profiling using locked nucleic acid capture probes[J]. Nat Protoc, 2008, 3(2):321-329.
9. Yao Y, Guo G, Ni Z, et al. Cloning and characterization of microRNAs from wheat (Triticum aestivum L.)[J]. Genome Biol, 2007, 8(6):R96.
10. Raymond CK, Roberts BS, Garrett-Engele P, et al. Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs[J]. RNA, 2005, 11(11):1737-1744.
11. Ji R, Cheng Y, Yue J, et al. MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation[J]. Circ Res, 2007, 100(11):1579-1588.
12. Zhu S, Si ML, Wu H, et al. MicroRNA-21 targets the tumor suppressor gene tropomyosin 1(TPM1)[J]. J Biol Chem, 2007, 282(19):14328-14336.
13. Asangani IA, Rasheed SA, Nikolova DA, et al. MicroRNA-21(miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer[J]. Oncogene, 2008, 27(15):2128-2136.
14. Chen Y, Liu W, Chao T, et al. MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G[J]. Cancer Lett, 2008, 272(2):197-205.
15. Gabriely G, Wurdinger T, Kesari S, et al. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators[J]. Mol Cell Biol, 2008, 28(17):5369-5380.
16. Fujita S, Ito T, Mizutani T, et al. miR-21 gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism[J]. J Mol Biol, 2008, 378(3):492-504.
17. Qin W, Zhao B, Shi Y, et al. BMPRⅡ is a direct target of miR-21[J]. Acta Biochim Biophys Sin (Shanghai), 2009, 41(7):618-623.
18. Lieberman D. Progress and challenges in colorectal cancer screening and surveitlance[J]. Gastroenterology, 2010, 138(6):2115-2126.
19. Graser A, Stieber P, Nagel D, et al. Comparison of CT colonography, colonoscopy, sigmoidoscopy and faecal occult blood tests for the detection of advanced adenoma in an average risk population[J]. Gut, 2009, 58(2):241-248.
20. Bandrés E, Cubedo E, Agirre X, et al. Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues[J]. Mol Cancer, 2006, 5(1):29-38.
21. Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets[J]. Proc Natl Acad Sci USA, 2006, 103(7):2257-2261.
22. Rossi L, Bonmassar E, Faraoni I. Modification of miR gene expression pattern in human colon cancer cells following exposure to 5-fluorouracil in vitro[J]. Pharmacol Res, 2007, 56(3):248-253.
23. Yantiss RK, Goodarzi M, Zhou XK, et al. Clinical, pathologic, and molecular features of early-onset colorectal carcinoma[J]. Am J Surg Pathol, 2009, 33(4):572-582.
24. Ng EK, Chong WW, Jin H, et al. Differential expression of microRNAs in plasma of patients with colorectal cancer:a potential marker for colorectal cancer screening[J]. Gut, 2009, 58(10):1375-1381.
25. Kulda V, Pesta M, Topolcan O, et al. Relevance of miR-21 and miR-143 expression in tissue samples of colorectal carcinoma and its liver metastases[J]. Cancer Genet Cytogenet, 2010, 200(2):154-160.
26. Kanaan Z, Rai SN, Eichenberger MR, et al. Plasma miR-21:a potential diagnostic marker of colorectal cancer[J]. Ann Surg, 2012, 256(3):544-551.
27. Schetter AJ, Leung SY, Sohn JJ, et al. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma[J]. JAMA, 2008, 299(4):425-436.
28. Shibuya H, Iinuma H, Shimada R, et al. Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer[J]. Oncology, 2010, 79(3/4):313-320.
29. Wu CW, Ng SS, Dong YJ, et al. Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps[J]. Gut, 2012, 61(5):739-745.
30. Link A, Balaguer F, Shen Y, et al. Fecal mieroRNAs as novel biomarkers for colon cancer screening[J]. Cancer Epidemiol Biomarkers Prey, 2010, 19(7):1766-1774.
31. Lawrie CH, Gal S, Dunlop HM, et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma[J]. Br J Haematol, 2008, 141(5):672-675.
32. Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum:a novel class of biomarkers for diagnosis of cancer and other diseases[J]. Cell Res, 2008, 18(10):997-1006.
33. Slaby O, Svoboda M, Fabian P, et al. Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer[J]. Oncology, 2007, 72(5/6):397-402.
34. Yamamichi N, Shimomura R, Inada K, et al. Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development[J]. Clin Cancer Res, 2009, 15(12):4009-4016.
35. 李先承, 李秀男, 宋希双. MicroRNA-21与实体肿瘤关系的研究进展[J]. 大连医科大学学报, 2012, 34(2):182-188.
36. 马一杰, 赵卫杰, 陈贝贝, 等. miR-21与结直肠癌细胞5-氟尿嘧啶化疗敏感性关系[J]. 中国保健营养, 2013(2):180-181.
37. Liu K, Li G, Fan C, et al. Increased expression of microRNA-21and its association with chemotherapeutic response in human colorectal cancer[J]. J Int Med Res, 2011, 39(6):2288-2295.

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