Research on the Prognostic Value of Procalcitonin Level and Its Change for Patients with Severe Trauma Combined with Sepsis_West China Medical Journal

Authors：

 WangJiandong ,  ZhouPing , ChenYoudai , DengLei , SongMenglong

Emergency Intensive Care Unit, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

ZhouPing, Email: zp_319@163.com

Keywords：

Procalcitonin; Trauma; Sepsis; Prognosis

DOI：

10.7507/1002-0179.201600136

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the prognostic value of serum procalcitonin (PCT) level and its change for patients with severe trauma and sepsis. Methods Eighty-two patients with severe trauma and sepsis treated between June 2013 and June 2014 were chosen to be our study subjects. According to the clinical outcome at day 28, they were divided into survival group (n=54) and death group (n=28). Serum procalcitonin levels at hour 0, 24, 48, 72, 96, and 120 after admitted to the emergency intensive care unit were detected in all the patients. Then we calculated the rate of procalcitonin change in each time points, injury severity score (ISS) score, acute physiology and chronic health evaluation (APACHE)Ⅱ score and white blood cells (WBC) count. Results Procalciton level at hour 24, 48, 72, 96 and 120 of the survival group was significantly lower than the death group (P<0.05); the rate of procalcitonin change at hour 24, 48, 72, 96 and 120 was significantly lower than the death group (P<0.05), and the APACHE Ⅱ score was significantly lower than the death group (P<0.01). There was no significant difference in the ISS score and WBC count between the two groups (P>0.05). Conclusion Early procalcitonin level and its dynamic change are good indicators in judging the prognosis of patients with severe trauma and sepsis, especially the early dynamic change in the rate of procalcitonin.

Citation： WangJiandong, ZhouPing, ChenYoudai, DengLei, SongMenglong. Research on the Prognostic Value of Procalcitonin Level and Its Change for Patients with Severe Trauma Combined with Sepsis. West China Medical Journal, 2016, 31(3): 516-518. doi: 10.7507/1002-0179.201600136 Copy

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14.	刘少锋, 杨健, 刘敏. 降钙素原与创伤的研究进展[J]. 华西医学, 2012, 27(5):789-793.
15.	降钙素原急诊临床应用专家共识组. 降钙素原(PCT)急诊临床应用的专家共识[J]. 中华急诊医学杂志, 2012, 21(9):944-951.

1. Zwi A. The public health burden of injury in developing countries[J]. Trop Dis Bull, 1993, 90(1):R5-R45.
2. Mock C. Improving prehospital trauma care in rural areas of low-income countries[J]. J Trauma, 2003, 54(6):1197-1198.
3. Kocabaş E, Sarikçioğlu A, Aksaray N, et al. Role of procalcitonin, C-reactive protein, interleukin-6, interleukin-8 and tumor necrosis factor-alpha in the diagnosis of neonatal sepsis[J]. Turk J Pediatr, 2007, 49(1):7-20.
4. Long W, Deng X, Zhang Y, et al. Procalcitonin guidance for reduction of antibiotic use in low-risk outpatients with community-acquired pneumonia[J]. Respirology, 2011, 16(5):819-824.
5. Tang J, Long W, Yan L, et al. Procalcitonin guided antibiotic therapy of acute exacerbations of asthma:a randomized controlled trial[J]. BMC Infect Dis, 2013, 13(13):596.
6. Jacobs W, Lund PK, Potts JJ, et al. Procalcitonin is glycoprotein[J]. J Biol Chem, 1981, 256(6):2803-2807.
7. Brunkhorst FM, Wegscheider K, Forycki ZF, et al. Procalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis, and septic shock[J]. Intensive Care Med, 2000, 26(Suppl 2):S148-S152.
8. Nakamura A, Wada H, Ikejiri M, et al. Efficacy of procalcitonin in the early diagnosis of bacterial infections in a critical care unit[J]. Shock, 2009, 31(6):586-591.
9. Uzzan B, Cohen R, Nicolas P, et al. Procalcitonin as a diagnostic for sepsis in critically ill adults and after surgery or trauma:a systematic review and meta-analysis[J]. Crit Care Med, 2006, 34(7):1996-2003.
10. Dandona P, Nix D, Wilson MF, et al. Procalcitonin increase after endotoxin injection in normal subjects[J]. J Clin Endocrinol Metab, 1994, 79(6):1605-1608.
11. Billeter A, Turina M, Seifert B, et al. Early serum procalcitonin, interleukin-6, and 24-hour lactate clearance:useful indicators of septic infections in severely traumatized patients[J]. World J Surg, 2009, 33(3):558-566.
12. Cleć h C, Ferriere F, Karoubi P, et al. Diagnostic and prognostic value of procalcitonin in patients with seotic shork[J]. Crit Care Med, 2004, 32(5):1166-1169.
13. Jensen JU, Heslet L, Jensen TH, et al. Procalcitonin increase in early identification of critically ill patients at high risk of mortality[J]. Crit Care Med, 2006, 34(10):2596-2602.
14. 刘少锋, 杨健, 刘敏. 降钙素原与创伤的研究进展[J]. 华西医学, 2012, 27(5):789-793.
15. 降钙素原急诊临床应用专家共识组. 降钙素原(PCT)急诊临床应用的专家共识[J]. 中华急诊医学杂志, 2012, 21(9):944-951.

West China Medical Journal

Research on the Prognostic Value of Procalcitonin Level and Its Change for Patients with Severe Trauma Combined with Sepsis

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