Progress in research on urinary stem cells_West China Medical Journal

Authors：

GUAN Qing ^1,2 , CHEN Long ¹ ,  XIANG Zhou ¹

1. Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Orthopaedics, the First People’s Hospital of Yibin City, Yibin, Sichuan 644000, P. R. China;

Corresponding author：

XIANG Zhou, Email: xiangzhou15@hotmail.com

Keywords：

Urine-derived stem cells; Stem cells; Tissue engineering

DOI：

10.7507/1002-0179.201609046

Video：

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Urine-derived stem cells are a kind of cells with strong proliferative ability and multi-directional differentiation characteristics of mesenchymal stem cells isolated from urine. Urine-derived stem cells are derived from the kidney and express mesenchymal stem cell-specific antigens; experimental studies have shown that they can differentiate into a variety of cells such as adipocytes, chondrocytes, bone cells, nerve cells, etc., and have the function of promoting tissue repair. A review of the research progress of urinary stem cells is now available.

Citation： GUAN Qing, CHEN Long, XIANG Zhou. Progress in research on urinary stem cells. West China Medical Journal, 2018, 33(8): 1033-1036. doi: 10.7507/1002-0179.201609046 Copy

1.	Kopp JL, Grompe M, Sander M. Stem cells versus plasticity in liver and pancreas regeneration. Nat Cell Biol, 2016, 18(3): 238-245.
2.	Damdimopoulou P, Rodin S, Stenfelt S, et al. Human embryonic stem cells. Best Pract Res Clin Obstet Gynaecol, 2016, 31: 2-12.
3.	Martins M, Ribeiro D, Martins A, et al. Extracellular vesicles derived from osteogenically induced human bone marrow mesenchymal stem cells can modulate lineage commitment. Stem Cell Reports, 2016, 6(3): 284-291.
4.	Chen JY, Miyanishi M, Wang SK, et al. Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche. Nature, 2016, 530(7589): 223-227.
5.	Kosaraju R, Rennert RC, Maan ZN, et al. Adipose-derived stem cell-seeded hydrogels increase endogenous progenitor cell recruitment and neovascularization in wounds. Tissue Eng Part A, 2016, 22(3/4): 295-305.
6.	Wang L, Siegenthaler JA, Dowell RD, et al. Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. Science, 2016, 351(6273): 613-617.
7.	Kloskowski T, Nowacki M, Pokrywczyńska M, et al. Urine--a waste or the future of regenerative medicine?. Med Hypotheses, 2015, 84(4): 344-349.
8.	Qin D, Long T, Deng J, et al. Urine-derived stem cells for potential use in bladder repair. Stem Cell Res Ther, 2014, 5(3): 69.
9.	Oliveira Arcolino F, Tort Piella A, Papadimitriou E, et al. Human urine as a noninvasive source of kidney cells. Stem Cells Int, 2015: 362562.
10.	Yang H, Chen B, Deng J, et al. Characterization of rabbit urine-derived stem cells for potential application in lower urinary tract tissue regeneration. Cell Tissue Res, 2018.
11.	Chen L, Li L, Xing F, et al. Human urine-derived stem cells: potential for cell-based therapy of cartilage defects. Stem Cells Int, 2018: 4686259.
12.	Li J, Luo H, Dong X, et al. Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model. Stem Cell Res Ther, 2017, 8(1): 107.
13.	Jia B, Chen S, Zhao Z, et al. Modeling of hemophilia A using patient-specific induced pluripotent stem cells derived from urine cells. Life Sci, 2014, 108(1): 22-29.
14.	Jouni M, Si-Tayeb K, Es-Salah-Lamoureux Z, et al. Toward personalized medicine: using cardiomyocytes differentiated from urine-derived pluripotent stem cells to recapitulate electrophysiological characteristics of type 2 long QT syndrome. J Am Heart Assoc, 2015, 4(9): e002159.
15.	Lee KI, Kim HT, Hwang DY. Footprint- and xeno-free human iPSCs derived from urine cells using extracellular matrix-based culture conditions. Biomaterials, 2014, 35(29): 8330-8338.
16.	Wang C, Hei F, Ju Z, et al. Differentiation of urine-derived human induced pluripotent stem cells to alveolar type Ⅱ epithelial cells. Cell Reprogram, 2016, 18(1): 30-36.
17.	Zhang Y, Mcneill E, Tian H, et al. Urine derived cells are a potential source for urological tissue Reconstruction. J Urol, 2008, 180(5): 2226-2233.
18.	Ye Y, Wang B, Jiang X, et al. Proliferative capacity of stem/progenitor-like cells in the kidney may associate with the outcome of patients with acute tubular necrosis. Hum Pathol, 2011, 42(8): 1132-1141.
19.	Eng DG, Sunseri MW, Kaverina NV, et al. Glomerular parietal epithelial cells contribute to adult podocyte regeneration in experimental focal segmental glomerulosclerosis. Kidney Int, 2015, 88(5): 999-1012.
20.	Sallustio F, Serino G, Schena FP. Potential reparative role of resident adult renal stem/progenitor cells in acute kidney injury. Biores Open Access, 2015, 4(1): 326-333.
21.	Bussolati B, Camussi G. Therapeutic use of human renal progenitor cells for kidney regeneration. Nucleic Acids Res, 2015, 11(12): 695-706.
22.	Bharadwaj S, Liu G, Shi Y, et al. Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology. Stem Cells, 2013, 31(9): 1840-1856.
23.	Chun SY, Kim HT, Lee JS, et al. Characterization of urine-derived cells from upper urinary tract in patients with bladder cancer. Urology, 2012, 79(5): 1186.e1-1186.e7.
24.	Bharadwaj S, Liu G, Shi Y, et al. Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering. Tissue Eng Part A, 2011, 17(15/16): 2123-2132.
25.	Guan JJ, Niu X, Gong FX, et al. Biological characteristics of human-urine-derived stem cells: potential for cell-based therapy in neurology. Tissue Eng Part A, 2014, 20(13/14): 1794-1806.
26.	Lang R, Liu G, Shi Y, et al. Self-renewal and differentiation capacity of urine-derived stem cells after urine preservation for 24 hours. PLoS One, 2013, 8(1): e53980.
27.	Kang HS, Choi SH, Kim BS, et al. Advanced properties of urine derived stem cells compared to adipose tissue derived stem cells in terms of cell proliferation, immune modulation and multi differentiation. J Korean Med Sci, 2015, 30(12): 1764-1776.
28.	Wu S, Liu Y, Bharadwaj S, et al. Human urine-derived stem cells seeded in a modified 3D porous small intestinal submucosa scaffold for urethral tissue engineering. J Urol, 2011, 32(5): 1317-1326.
29.	Guan J, Zhang J, Li H, et al. Human urine derived stem cells in combination with β-TCP can be applied for bone regeneration. PLoS One, 2015, 10(5): e0125253.
30.	Qin H, Zhu C, An Z, et al. Silver nanoparticles promote osteogenic differentiation of human urine-derived stem cells at noncytotoxic concentrations. Int J Nanomedicine, 2014, 20(9): 2469-2478.
31.	Guan J, Zhang J, Zhu Z, et al. Bone morphogenetic protein 2 gene transduction enhances the osteogenic potential of human urine-derived stem cells. Stem Cell Res Ther, 2015, 7(6): 5.
32.	Bodin A, Bharadwaj S, Wu S, et al. Tissue-engineered conduit using urine-derived stem cells seeded bacterial cellulose polymer in urinary reconstruction and diversion. Biomaterials, 2010, 31(34): 8889-8901.
33.	Fu Y, Guan J, Guo S, et al. Human urine-derived stem cells in combination with polycaprolactone/gelatin nanofibrous membranes enhance wound healing by promoting angiogenesis. J Transl Med, 2014, 12: 274.
34.	Guan J, Zhang J, Guo S, et al. Human urine-derived stem cells can be induced into osteogenic lineage by silicate bioceramics via activation of the Wnt/β-catenin signaling pathway. Biomaterials, 2015, 55: 1-11.
35.	Liu G, Pareta RA, Wu R, et al. Skeletal myogenic differentiation of urine-derived stem cells and angiogenesis using microbeads loaded with growth factors. Biomaterials, 2013, 34(4): 1311-1326.
36.	Chen W, Xie M, Yang B, et al. Skeletal myogenic differentiation of human urine-derived cells as a potential source for skeletal muscle regeneration. J Tissue Eng Regen Med, 2017, 11(2): 334-341.
37.	Lee JN, Chun SY, Lee HJ, et al. Human urine-derived stem cells seeded surface modified composite scaffold grafts for bladder Reconstruction in a rat model. J Korean Med Sci, 2015, 30(12): 1754-1763.
38.	Wu S, Wang Z, Bharadwaj S, et al. Implantation of autologous urine derived stem cells expressing vascular endothelial growth factor for potential use in genitourinary reconstruction. J Urol, 2011, 186(2): 640-647.
39.	Zhang D, Wei G, Li P, et al. Urine-derived stem cells: a novel and versatile progenitor source for cell-based therapy and regenerative medicine. J Urol, 2014, 1(1): 8-17.
40.	Wu S, Wang Z, Bharadwaj S, et al. Implantation of autologous urine derived stem cells expressing vascular endothelial growth factor for potential use in genitourinary reconstruction. J Urol, 2011, 185(4): e304-e305.
41.	Liu GH, Wu SF, Bharadwaj S, et al. Promoting muscle and nerve regeneration after human urine-derived stem cells expression of vascular endothelial growth factor for potential use in treatment of stress urinary incontinency. J Urol, 2011, 185(4, S): e462.
42.	Kim YS, Kwon OR, Choi YJ, et al. Comparative matched-pair analysis of the injection versus implantation of mesenchymal stem cells for knee osteoarthritis. Am J Sports Med, 2015, 43(11): 2738-2746.
43.	Kim YS, Choi YJ, Koh YG. Mesenchymal stem cell implantation in knee osteoarthritis: an assessment of the factors influencing clinical outcomes. Am J Sports Med, 2015, 43(9): 2293-2301.
44.	Ozeki N, Muneta T, Koga H, et al. Not single but periodic injections of synovial mesenchymal stem cells maintain viable cells in knees and inhibit osteoarthritis progression in rats. Osteoarthritis Cartilage, 2016, 24(6): 1061-1070.

1. Kopp JL, Grompe M, Sander M. Stem cells versus plasticity in liver and pancreas regeneration. Nat Cell Biol, 2016, 18(3): 238-245.
2. Damdimopoulou P, Rodin S, Stenfelt S, et al. Human embryonic stem cells. Best Pract Res Clin Obstet Gynaecol, 2016, 31: 2-12.
3. Martins M, Ribeiro D, Martins A, et al. Extracellular vesicles derived from osteogenically induced human bone marrow mesenchymal stem cells can modulate lineage commitment. Stem Cell Reports, 2016, 6(3): 284-291.
4. Chen JY, Miyanishi M, Wang SK, et al. Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche. Nature, 2016, 530(7589): 223-227.
5. Kosaraju R, Rennert RC, Maan ZN, et al. Adipose-derived stem cell-seeded hydrogels increase endogenous progenitor cell recruitment and neovascularization in wounds. Tissue Eng Part A, 2016, 22(3/4): 295-305.
6. Wang L, Siegenthaler JA, Dowell RD, et al. Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. Science, 2016, 351(6273): 613-617.
7. Kloskowski T, Nowacki M, Pokrywczyńska M, et al. Urine--a waste or the future of regenerative medicine?. Med Hypotheses, 2015, 84(4): 344-349.
8. Qin D, Long T, Deng J, et al. Urine-derived stem cells for potential use in bladder repair. Stem Cell Res Ther, 2014, 5(3): 69.
9. Oliveira Arcolino F, Tort Piella A, Papadimitriou E, et al. Human urine as a noninvasive source of kidney cells. Stem Cells Int, 2015: 362562.
10. Yang H, Chen B, Deng J, et al. Characterization of rabbit urine-derived stem cells for potential application in lower urinary tract tissue regeneration. Cell Tissue Res, 2018.
11. Chen L, Li L, Xing F, et al. Human urine-derived stem cells: potential for cell-based therapy of cartilage defects. Stem Cells Int, 2018: 4686259.
12. Li J, Luo H, Dong X, et al. Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model. Stem Cell Res Ther, 2017, 8(1): 107.
13. Jia B, Chen S, Zhao Z, et al. Modeling of hemophilia A using patient-specific induced pluripotent stem cells derived from urine cells. Life Sci, 2014, 108(1): 22-29.
14. Jouni M, Si-Tayeb K, Es-Salah-Lamoureux Z, et al. Toward personalized medicine: using cardiomyocytes differentiated from urine-derived pluripotent stem cells to recapitulate electrophysiological characteristics of type 2 long QT syndrome. J Am Heart Assoc, 2015, 4(9): e002159.
15. Lee KI, Kim HT, Hwang DY. Footprint- and xeno-free human iPSCs derived from urine cells using extracellular matrix-based culture conditions. Biomaterials, 2014, 35(29): 8330-8338.
16. Wang C, Hei F, Ju Z, et al. Differentiation of urine-derived human induced pluripotent stem cells to alveolar type Ⅱ epithelial cells. Cell Reprogram, 2016, 18(1): 30-36.
17. Zhang Y, Mcneill E, Tian H, et al. Urine derived cells are a potential source for urological tissue Reconstruction. J Urol, 2008, 180(5): 2226-2233.
18. Ye Y, Wang B, Jiang X, et al. Proliferative capacity of stem/progenitor-like cells in the kidney may associate with the outcome of patients with acute tubular necrosis. Hum Pathol, 2011, 42(8): 1132-1141.
19. Eng DG, Sunseri MW, Kaverina NV, et al. Glomerular parietal epithelial cells contribute to adult podocyte regeneration in experimental focal segmental glomerulosclerosis. Kidney Int, 2015, 88(5): 999-1012.
20. Sallustio F, Serino G, Schena FP. Potential reparative role of resident adult renal stem/progenitor cells in acute kidney injury. Biores Open Access, 2015, 4(1): 326-333.
21. Bussolati B, Camussi G. Therapeutic use of human renal progenitor cells for kidney regeneration. Nucleic Acids Res, 2015, 11(12): 695-706.
22. Bharadwaj S, Liu G, Shi Y, et al. Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology. Stem Cells, 2013, 31(9): 1840-1856.
23. Chun SY, Kim HT, Lee JS, et al. Characterization of urine-derived cells from upper urinary tract in patients with bladder cancer. Urology, 2012, 79(5): 1186.e1-1186.e7.
24. Bharadwaj S, Liu G, Shi Y, et al. Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering. Tissue Eng Part A, 2011, 17(15/16): 2123-2132.
25. Guan JJ, Niu X, Gong FX, et al. Biological characteristics of human-urine-derived stem cells: potential for cell-based therapy in neurology. Tissue Eng Part A, 2014, 20(13/14): 1794-1806.
26. Lang R, Liu G, Shi Y, et al. Self-renewal and differentiation capacity of urine-derived stem cells after urine preservation for 24 hours. PLoS One, 2013, 8(1): e53980.
27. Kang HS, Choi SH, Kim BS, et al. Advanced properties of urine derived stem cells compared to adipose tissue derived stem cells in terms of cell proliferation, immune modulation and multi differentiation. J Korean Med Sci, 2015, 30(12): 1764-1776.
28. Wu S, Liu Y, Bharadwaj S, et al. Human urine-derived stem cells seeded in a modified 3D porous small intestinal submucosa scaffold for urethral tissue engineering. J Urol, 2011, 32(5): 1317-1326.
29. Guan J, Zhang J, Li H, et al. Human urine derived stem cells in combination with β-TCP can be applied for bone regeneration. PLoS One, 2015, 10(5): e0125253.
30. Qin H, Zhu C, An Z, et al. Silver nanoparticles promote osteogenic differentiation of human urine-derived stem cells at noncytotoxic concentrations. Int J Nanomedicine, 2014, 20(9): 2469-2478.
31. Guan J, Zhang J, Zhu Z, et al. Bone morphogenetic protein 2 gene transduction enhances the osteogenic potential of human urine-derived stem cells. Stem Cell Res Ther, 2015, 7(6): 5.
32. Bodin A, Bharadwaj S, Wu S, et al. Tissue-engineered conduit using urine-derived stem cells seeded bacterial cellulose polymer in urinary reconstruction and diversion. Biomaterials, 2010, 31(34): 8889-8901.
33. Fu Y, Guan J, Guo S, et al. Human urine-derived stem cells in combination with polycaprolactone/gelatin nanofibrous membranes enhance wound healing by promoting angiogenesis. J Transl Med, 2014, 12: 274.
34. Guan J, Zhang J, Guo S, et al. Human urine-derived stem cells can be induced into osteogenic lineage by silicate bioceramics via activation of the Wnt/β-catenin signaling pathway. Biomaterials, 2015, 55: 1-11.
35. Liu G, Pareta RA, Wu R, et al. Skeletal myogenic differentiation of urine-derived stem cells and angiogenesis using microbeads loaded with growth factors. Biomaterials, 2013, 34(4): 1311-1326.
36. Chen W, Xie M, Yang B, et al. Skeletal myogenic differentiation of human urine-derived cells as a potential source for skeletal muscle regeneration. J Tissue Eng Regen Med, 2017, 11(2): 334-341.
37. Lee JN, Chun SY, Lee HJ, et al. Human urine-derived stem cells seeded surface modified composite scaffold grafts for bladder Reconstruction in a rat model. J Korean Med Sci, 2015, 30(12): 1754-1763.
38. Wu S, Wang Z, Bharadwaj S, et al. Implantation of autologous urine derived stem cells expressing vascular endothelial growth factor for potential use in genitourinary reconstruction. J Urol, 2011, 186(2): 640-647.
39. Zhang D, Wei G, Li P, et al. Urine-derived stem cells: a novel and versatile progenitor source for cell-based therapy and regenerative medicine. J Urol, 2014, 1(1): 8-17.
40. Wu S, Wang Z, Bharadwaj S, et al. Implantation of autologous urine derived stem cells expressing vascular endothelial growth factor for potential use in genitourinary reconstruction. J Urol, 2011, 185(4): e304-e305.
41. Liu GH, Wu SF, Bharadwaj S, et al. Promoting muscle and nerve regeneration after human urine-derived stem cells expression of vascular endothelial growth factor for potential use in treatment of stress urinary incontinency. J Urol, 2011, 185(4, S): e462.
42. Kim YS, Kwon OR, Choi YJ, et al. Comparative matched-pair analysis of the injection versus implantation of mesenchymal stem cells for knee osteoarthritis. Am J Sports Med, 2015, 43(11): 2738-2746.
43. Kim YS, Choi YJ, Koh YG. Mesenchymal stem cell implantation in knee osteoarthritis: an assessment of the factors influencing clinical outcomes. Am J Sports Med, 2015, 43(9): 2293-2301.
44. Ozeki N, Muneta T, Koga H, et al. Not single but periodic injections of synovial mesenchymal stem cells maintain viable cells in knees and inhibit osteoarthritis progression in rats. Osteoarthritis Cartilage, 2016, 24(6): 1061-1070.

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