Regulation of long non-coding RNA in signal pathways related to osteogenic differentiation_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

SHI Xiangwen ¹ , NI Haonan ¹ , LI Mingjun ¹ , WU Yipeng ^1,2 ,  XU Yongqing ^1,2

1. Postgraduate Department of Kunming Medical University, Kunming Yunnan, 650000, P. R. China;
2. Department of Orthopedics, the 920th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Kunming Yunnan, 650000, P. R. China;

Corresponding author：

XU Yongqing, Email: xuyongqingkm@163.net

Keywords：

Long non-coding RNA; osteogenic differentiation; signal pathway; mechanism

DOI：

10.7507/1002-1892.202111098

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the mechanism of long non-coding RNA (lncRNA) in signal pathways related to osteogenic differentiation. Methods Relevant domestic and foreign researches in recent years were consulted. The characteristics and biological functions of lncRNA were introduced, and the specific mechanism of lncRNA regulating related signal pathways in osteogenic differentiation was elaborated. Results The exertion and maintenance of normal function of bone requires the closed coordination of transcription networks and signal pathways. However, most of these signal pathways or networks are dysregulated under pathological conditions that affect bone homeostasis. lncRNA can regulate the differentiation of various bone cells by activating or inhibiting signal pathways to achieve the balance of bone homeostasis, thereby reversing the pathological state of bones and achieving the purpose of treating bone metabolic diseases. Conclusion At present, the research on the mechanism of lncRNA regulating various osteogenic differentiation pathways is still in the early stage. Its in-depth regulator mechanism, especially the cross-talk of complex signal pathways needs to be further studied. And how to apply these molecular targets to clinical treatment is also a big challenge.

Citation： SHI Xiangwen, NI Haonan, LI Mingjun, WU Yipeng, XU Yongqing. Regulation of long non-coding RNA in signal pathways related to osteogenic differentiation. Chinese Journal of Reparative and Reconstructive Surgery, 2022, 36(4): 479-486. doi: 10.7507/1002-1892.202111098 Copy

1.	Li Y, Li J, Chen L, et al. The roles of long non-coding RNA in osteoporosis. Curr Stem Cell Res Ther, 2020, 15(7): 639-645.
2.	Charles JF, Aliprantis AO. Osteoclasts: more than ‘bone eaters’. Trends Mol Med, 2014, 20(8): 449-459.
3.	Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol, 2011, 6: 121-145.
4.	Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future. Lancet, 2011, 377(9773): 1276-1287.
5.	Sun H, Peng G, Wu H, et al. Long non-coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (review). Biomed Rep, 2020, 13(1): 15-21.
6.	Huang Y, Zheng Y, Jia L, et al. Long noncoding RNA H19 promotes osteoblast differentiation via TGF-β₁/Smad3/HDAC signaling pathway by deriving miR-675. Stem Cells, 2015, 33(12): 3481-3492.
7.	Jathar S, Kumar V, Srivastava J, et al. Technological developments in lncRNA biology. Adv Exp Med Biol, 2017, 1008: 283-323.
8.	Wu H, Yang L, Chen LL. The diversity of long noncoding RNAs and their generation. Trends Genet, 2017, 33(8): 540-552.
9.	Du Toit A. Non-coding RNA: RNA stability control by Pol Ⅱ. Nat Rev Mol Cell Biol, 2013, 14(3): 128. doi: 10.1038/nrm3521.
10.	Goodrich JA, Kugel JF. Dampening DNA binding: a common mechanism of transcriptional repression for both ncRNAs and protein domains. RNA Biol, 2010, 7(3): 305-309.
11.	Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell, 2009, 136(4): 629-641.
12.	Kapranov P, Cheng J, Dike S, et al. RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science, 2007, 316(5830): 1484-1488.
13.	Schmitz SU, Grote P, Herrmann BG. Mechanisms of long noncoding RNA function in development and disease. Cell Mol Life Sci, 2016, 73(13): 2491-2509.
14.	Krol J, Krol I, Alvarez CP, et al. A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture. Nat Commun, 2015, 6: 7305. doi: 10.1038/ncomms8305.
15.	Kopp F, Mendell JT. Functional classification and experimental dissection of long noncoding RNAs. Cell, 2018, 172(3): 393-407.
16.	St Laurent G, Wahlestedt C, Kapranov P. The landscape of long noncoding RNA classification. Trends Genet, 2015, 31(5): 239-251.
17.	Feng J, Bi C, Clark BS, et al. The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. Genes Dev, 2006, 20(11): 1470-1484.
18.	Ohno M, Fukagawa T, Lee JS, et al. Triplex-forming DNAs in the human interphase nucleus visualized in situ by polypurine/polypyrimidine DNA probes and antitriplex antibodies. Chromosoma, 2002, 111(3): 201-213.
19.	Smart F, Aschrafi A, Atkins A, et al. Two isoforms of the cold-inducible mRNA-binding protein RBM3 localize to dendrites and promote translation. J Neurochem, 2007, 101(5): 1367-1379.
20.	Chen K, Zhu H, Zheng MQ, et al. LncRNA MEG3 inhibits the degradation of the extracellular matrix of chondrocytes in osteoarthritis via targeting miR-93/TGFBR2 axis. Cartilage, 2021, 13(2 suppl): 1274S-1284S.
21.	Zhu J, Wang Y, Yu W, et al. Long noncoding RNA: function and mechanism on differentiation of mesenchymal stem cells and embryonic stem cells. Curr Stem Cell Res Ther, 2019, 14(3): 259-267.
22.	de Andrés MC, Kingham E, Imagawa K, et al. Epigenetic regulation during fetal femur development: DNA methylation matters. PLoS One, 2013, 8(1): e54957. doi: 10.1371/journal.pone.0054957.
23.	Grixti JM, Ayers D. Long noncoding RNAs and their link to cancer. Noncoding RNA Res, 2020, 5(2): 77-82.
24.	Yao RW, Wang Y, Chen LL. Cellular functions of long noncoding RNAs. Nat Cell Biol, 2019, 21(5): 542-551.
25.	Fatica A, Bozzoni I. Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet, 2014, 15(1): 7-21.
26.	Wu J, Qian D, Sun X. Long noncoding RNAs as potential biomarkers in retinoblastoma: a systematic review and meta-analysis. Cancer Cell Int, 2020, 20: 201. doi: 10.1186/s12935-020-01281-0.
27.	Hassan MQ, Tye CE, Stein GS, et al. Non-coding RNAs: Epigenetic regulators of bone development and homeostasis. Bone, 2015, 81: 746-756.
28.	Yang Q, Jia L, Li X, et al. Long noncoding RNAs: New players in the osteogenic differentiation of bone marrow- and adipose-derived mesenchymal stem cells. Stem Cell Rev Rep, 2018, 14(3): 297-308.
29.	Steinhart Z, Angers S. Wnt signaling in development and tissue homeostasis. Development, 2018, 145(11): dev146589. doi: 10.1242/dev.146589.
30.	Shen JJ, Zhang CH, Chen ZW, et al. LncRNA HOTAIR inhibited osteogenic differentiation of BMSCs by regulating Wnt/β-catenin pathway. Eur Rev Med Pharmacol Sci, 2019, 23(17): 7232-7246.
31.	Chen L, Song Z, Huang S, et al. lncRNA DANCR suppresses odontoblast-like differentiation of human dental pulp cells by inhibiting wnt/β-catenin pathway. Cell Tissue Res, 2016, 364(2): 309-318.
32.	Jiang SY, Miao YX, Hirokazu T, et al. Effects of lncRNA DANCR on proliferation and differentiation of osteoblasts by regulating the Wnt/β-catenin pathway. Eur Rev Med Pharmacol Sci, 2019, 23(13): 5558-5566.
33.	Deng L, Hong H, Zhang X, et al. Down-regulated lncRNA MEG3 promotes osteogenic differentiation of human dental follicle stem cells by epigenetically regulating Wnt pathway. Biochem Biophys Res Commun, 2018, 503(3): 2061-2067.
34.	Liu YB, Lin LP, Zou R, et al. Silencing long non-coding RNA MEG3 accelerates tibia fraction healing by regulating the Wnt/β-catenin signalling pathway. J Cell Mol Med, 2019, 23(6): 3855-3866.
35.	Yin C, Tian Y, Yu Y, et al. Long noncoding RNA AK039312 and AK079370 inhibits bone formation via miR-199b-5p. Pharmacol Res, 2021, 163: 105230. doi: 10.1016/j.phrs.2020.105230.
36.	Li D, Tian Y, Yin C, et al. Silencing of lncRNA AK045490 promotes osteoblast differentiation and bone formation via β-Catenin/TCF1/Runx2 signaling axis. Int J Mol Sci, 2019, 20(24): 6229. doi: 10.3390/ijms20246229.
37.	Lin Y, Fu F, Chen Y, et al. Genetic variants in long noncoding RNA H19 contribute to the risk of breast cancer in a southeast China Han population. Onco Targets Ther, 2017, 10: 4369-4378.
38.	Liang WC, Fu WM, Wang YB, et al. H19 activates Wnt signaling and promotes osteoblast differentiation by functioning as a competing endogenous RNA. Sci Rep, 2016, 6: 20121. doi: 10.1038/srep20121.
39.	Liu SC, Sun QZ, Qiao XF, et al. LncRNA TUG1 influences osteoblast proliferation and differentiation through the Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci, 2019, 23(11): 4584-4590.
40.	Mulati M, Kobayashi Y, Takahashi A, et al. The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in mice. Bone, 2020, 130: 115076. doi: 10.1016/j.bone.2019.115076.
41.	Xiang J, Fu HQ, Xu Z, et al. lncRNA SNHG1 attenuates osteogenic differentiation via the miR-101/DKK1 axis in bone marrow mesenchymal stem cells. Mol Med Rep, 2020, 22(5): 3715-3722.
42.	Gao X, Ge J, Li W, et al. LncRNA KCNQ1OT1 promotes osteogenic differentiation to relieve osteolysis via Wnt/β-catenin activation. Cell Biosci, 2018, 8: 19. doi: 10.1186/s13578-018-0216-4.
43.	Yang K, Tian N, Liu H, et al. LncRNAp21 promotes osteogenic differentiation of mesenchymal stem cells in the rat model of osteoporosis by the Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci, 2019, 23(10): 4303-4309.
44.	Wang L, Wu F, Song Y, et al. Long noncoding RNA related to periodontitis interacts with miR-182 to upregulate osteogenic differentiation in periodontal mesenchymal stem cells of periodontitis patients. Cell Death Dis, 2016, 7(8): e2327. doi: 10.1038/cddis.2016.125.
45.	Morikawa M, Derynck R, Miyazono K. TGF-β and the TGF-β family: Context-dependent roles in cell and tissue physiology. Cold Spring Harb Perspect Biol, 2016, 8(5): a021873. doi: 10.1101/cshperspect.a021873.
46.	Qu Q, Fang F, Wu B, et al. Potential role of long non-coding RNA in osteogenic differentiation of human periodontal ligament stem cells. J Periodontol, 2016, 87(7): e127-e137.
47.	Li M, Xie Z, Wang P, et al. The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA. Cell Death Dis, 2018, 9(5): 554. doi: 10.1038/s41419-018-0627-5.
48.	Li M, Xie Z, Li J, et al. GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation. Elife, 2020, 9: e59079. doi: 10.7554/eLife.59079.
49.	Wei B, Wei W, Zhao B, et al. Long non-coding RNA HOTAIR inhibits miR-17-5p to regulate osteogenic differentiation and proliferation in non-traumatic osteonecrosis of femoral head. PLoS One, 2017, 12(2): e0169097. doi: 10.1371/journal.pone.0169097.
50.	Miyazawa K, Miyazono K. Regulation of TGF-β family signaling by inhibitory Smads. Cold Spring Harb Perspect Biol, 2017, 9(3): a022095. doi: 10.1101/cshperspect.a022095.
51.	Zhang RF, Liu JW, Yu SP, et al. LncRNA UCA1 affects osteoblast proliferation and differentiation by regulating BMP-2 expression. Eur Rev Med Pharmacol Sci, 2019, 23(16): 6774-6782.
52.	Chen Z, Liu Z, Shen L, et al. Long non-coding RNA SNHG7 promotes the fracture repair through negative modulation of miR-9. Am J Transl Res, 2019, 11(2): 974-982.
53.	Wang Q, Chen B, Cao M, et al. Response of MAPK pathway to iron oxide nanoparticles in vitro treatment promotes osteogenic differentiation of hBMSCs. Biomaterials, 2016, 86: 11-20.
54.	Yang Q, Han Y, Liu P, et al. Long Noncoding RNA GAS5 promotes osteogenic differentiation of human periodontal ligament stem cells by regulating GDF5 and p38/JNK Ssignaling pathway. Front Pharmacol, 2020, 11: 701. doi: 10.3389/fphar.2020.00701.
55.	Zhang J, Tao Z, Wang Y. Long non-coding RNA DANCR regulates the proliferation and osteogenic differentiation of human bone-derived marrow mesenchymal stem cells via the p38 MAPK pathway. Int J Mol Med, 2018, 41(1): 213-219.
56.	Zhou QP, Zhang F, Zhang J, et al. H19 promotes the proliferation of osteocytes by inhibiting p53 during fracture healing. Eur Rev Med Pharmacol Sci, 2018, 22(8): 2226-2232.
57.	Lu Q, Xu W, Liu L, et al. Traumatic compressive stress inhibits osteoblast differentiation through long chain non-coding RNA Dancr. J Periodontol, 2020, 91(11): 1532-1540.
58.	Wang Q, Li Y, Zhang Y, et al. LncRNA MEG3 inhibited osteogenic differentiation of bone marrow mesenchymal stem cells from postmenopausal osteoporosis by targeting miR-133a-3p. Biomed Pharmacother, 2017, 89: 1178-1186.
59.	Chen S, Jia L, Zhang S, et al. DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis. Stem Cell Res Ther, 2018, 9(1): 185. doi: 10.1186/s13287-018-0935-9.
60.	Che M, Gong W, Zhao Y, et al. Long noncoding RNA HCG18 inhibits the differentiation of human bone marrow-derived mesenchymal stem cells in osteoporosis by targeting miR-30a-5p/NOTCH1 axis. Mol Med, 2020, 26(1): 106. doi: 10.1186/s10020-020-00219-6.
61.	Liu Y, Liu C, Zhang A, et al. Down-regulation of long non-coding RNA MEG3 suppresses osteogenic differentiation of periodontal ligament stem cells (PDLSCs) through miR-27a-3p/IGF1 axis in periodontitis. Aging (Albany NY), 2019, 11(15): 5334-5350.
62.	Wang J, Liu S, Shi J, et al. The role of lncRNAs in osteogenic differentiation of bone marrow mesenchymal stem cells. Curr Stem Cell Res Ther, 2020, 15(3): 243-249.
63.	Ferrè F, Colantoni A, Helmer-Citterich M. Revealing protein-lncRNA interaction. Brief Bioinform, 2016, 17(1): 106-116.

1. Li Y, Li J, Chen L, et al. The roles of long non-coding RNA in osteoporosis. Curr Stem Cell Res Ther, 2020, 15(7): 639-645.
2. Charles JF, Aliprantis AO. Osteoclasts: more than ‘bone eaters’. Trends Mol Med, 2014, 20(8): 449-459.
3. Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol, 2011, 6: 121-145.
4. Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future. Lancet, 2011, 377(9773): 1276-1287.
5. Sun H, Peng G, Wu H, et al. Long non-coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (review). Biomed Rep, 2020, 13(1): 15-21.
6. Huang Y, Zheng Y, Jia L, et al. Long noncoding RNA H19 promotes osteoblast differentiation via TGF-β₁/Smad3/HDAC signaling pathway by deriving miR-675. Stem Cells, 2015, 33(12): 3481-3492.
7. Jathar S, Kumar V, Srivastava J, et al. Technological developments in lncRNA biology. Adv Exp Med Biol, 2017, 1008: 283-323.
8. Wu H, Yang L, Chen LL. The diversity of long noncoding RNAs and their generation. Trends Genet, 2017, 33(8): 540-552.
9. Du Toit A. Non-coding RNA: RNA stability control by Pol Ⅱ. Nat Rev Mol Cell Biol, 2013, 14(3): 128. doi: 10.1038/nrm3521.
10. Goodrich JA, Kugel JF. Dampening DNA binding: a common mechanism of transcriptional repression for both ncRNAs and protein domains. RNA Biol, 2010, 7(3): 305-309.
11. Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell, 2009, 136(4): 629-641.
12. Kapranov P, Cheng J, Dike S, et al. RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science, 2007, 316(5830): 1484-1488.
13. Schmitz SU, Grote P, Herrmann BG. Mechanisms of long noncoding RNA function in development and disease. Cell Mol Life Sci, 2016, 73(13): 2491-2509.
14. Krol J, Krol I, Alvarez CP, et al. A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture. Nat Commun, 2015, 6: 7305. doi: 10.1038/ncomms8305.
15. Kopp F, Mendell JT. Functional classification and experimental dissection of long noncoding RNAs. Cell, 2018, 172(3): 393-407.
16. St Laurent G, Wahlestedt C, Kapranov P. The landscape of long noncoding RNA classification. Trends Genet, 2015, 31(5): 239-251.
17. Feng J, Bi C, Clark BS, et al. The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. Genes Dev, 2006, 20(11): 1470-1484.
18. Ohno M, Fukagawa T, Lee JS, et al. Triplex-forming DNAs in the human interphase nucleus visualized in situ by polypurine/polypyrimidine DNA probes and antitriplex antibodies. Chromosoma, 2002, 111(3): 201-213.
19. Smart F, Aschrafi A, Atkins A, et al. Two isoforms of the cold-inducible mRNA-binding protein RBM3 localize to dendrites and promote translation. J Neurochem, 2007, 101(5): 1367-1379.
20. Chen K, Zhu H, Zheng MQ, et al. LncRNA MEG3 inhibits the degradation of the extracellular matrix of chondrocytes in osteoarthritis via targeting miR-93/TGFBR2 axis. Cartilage, 2021, 13(2 suppl): 1274S-1284S.
21. Zhu J, Wang Y, Yu W, et al. Long noncoding RNA: function and mechanism on differentiation of mesenchymal stem cells and embryonic stem cells. Curr Stem Cell Res Ther, 2019, 14(3): 259-267.
22. de Andrés MC, Kingham E, Imagawa K, et al. Epigenetic regulation during fetal femur development: DNA methylation matters. PLoS One, 2013, 8(1): e54957. doi: 10.1371/journal.pone.0054957.
23. Grixti JM, Ayers D. Long noncoding RNAs and their link to cancer. Noncoding RNA Res, 2020, 5(2): 77-82.
24. Yao RW, Wang Y, Chen LL. Cellular functions of long noncoding RNAs. Nat Cell Biol, 2019, 21(5): 542-551.
25. Fatica A, Bozzoni I. Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet, 2014, 15(1): 7-21.
26. Wu J, Qian D, Sun X. Long noncoding RNAs as potential biomarkers in retinoblastoma: a systematic review and meta-analysis. Cancer Cell Int, 2020, 20: 201. doi: 10.1186/s12935-020-01281-0.
27. Hassan MQ, Tye CE, Stein GS, et al. Non-coding RNAs: Epigenetic regulators of bone development and homeostasis. Bone, 2015, 81: 746-756.
28. Yang Q, Jia L, Li X, et al. Long noncoding RNAs: New players in the osteogenic differentiation of bone marrow- and adipose-derived mesenchymal stem cells. Stem Cell Rev Rep, 2018, 14(3): 297-308.
29. Steinhart Z, Angers S. Wnt signaling in development and tissue homeostasis. Development, 2018, 145(11): dev146589. doi: 10.1242/dev.146589.
30. Shen JJ, Zhang CH, Chen ZW, et al. LncRNA HOTAIR inhibited osteogenic differentiation of BMSCs by regulating Wnt/β-catenin pathway. Eur Rev Med Pharmacol Sci, 2019, 23(17): 7232-7246.
31. Chen L, Song Z, Huang S, et al. lncRNA DANCR suppresses odontoblast-like differentiation of human dental pulp cells by inhibiting wnt/β-catenin pathway. Cell Tissue Res, 2016, 364(2): 309-318.
32. Jiang SY, Miao YX, Hirokazu T, et al. Effects of lncRNA DANCR on proliferation and differentiation of osteoblasts by regulating the Wnt/β-catenin pathway. Eur Rev Med Pharmacol Sci, 2019, 23(13): 5558-5566.
33. Deng L, Hong H, Zhang X, et al. Down-regulated lncRNA MEG3 promotes osteogenic differentiation of human dental follicle stem cells by epigenetically regulating Wnt pathway. Biochem Biophys Res Commun, 2018, 503(3): 2061-2067.
34. Liu YB, Lin LP, Zou R, et al. Silencing long non-coding RNA MEG3 accelerates tibia fraction healing by regulating the Wnt/β-catenin signalling pathway. J Cell Mol Med, 2019, 23(6): 3855-3866.
35. Yin C, Tian Y, Yu Y, et al. Long noncoding RNA AK039312 and AK079370 inhibits bone formation via miR-199b-5p. Pharmacol Res, 2021, 163: 105230. doi: 10.1016/j.phrs.2020.105230.
36. Li D, Tian Y, Yin C, et al. Silencing of lncRNA AK045490 promotes osteoblast differentiation and bone formation via β-Catenin/TCF1/Runx2 signaling axis. Int J Mol Sci, 2019, 20(24): 6229. doi: 10.3390/ijms20246229.
37. Lin Y, Fu F, Chen Y, et al. Genetic variants in long noncoding RNA H19 contribute to the risk of breast cancer in a southeast China Han population. Onco Targets Ther, 2017, 10: 4369-4378.
38. Liang WC, Fu WM, Wang YB, et al. H19 activates Wnt signaling and promotes osteoblast differentiation by functioning as a competing endogenous RNA. Sci Rep, 2016, 6: 20121. doi: 10.1038/srep20121.
39. Liu SC, Sun QZ, Qiao XF, et al. LncRNA TUG1 influences osteoblast proliferation and differentiation through the Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci, 2019, 23(11): 4584-4590.
40. Mulati M, Kobayashi Y, Takahashi A, et al. The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in mice. Bone, 2020, 130: 115076. doi: 10.1016/j.bone.2019.115076.
41. Xiang J, Fu HQ, Xu Z, et al. lncRNA SNHG1 attenuates osteogenic differentiation via the miR-101/DKK1 axis in bone marrow mesenchymal stem cells. Mol Med Rep, 2020, 22(5): 3715-3722.
42. Gao X, Ge J, Li W, et al. LncRNA KCNQ1OT1 promotes osteogenic differentiation to relieve osteolysis via Wnt/β-catenin activation. Cell Biosci, 2018, 8: 19. doi: 10.1186/s13578-018-0216-4.
43. Yang K, Tian N, Liu H, et al. LncRNAp21 promotes osteogenic differentiation of mesenchymal stem cells in the rat model of osteoporosis by the Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci, 2019, 23(10): 4303-4309.
44. Wang L, Wu F, Song Y, et al. Long noncoding RNA related to periodontitis interacts with miR-182 to upregulate osteogenic differentiation in periodontal mesenchymal stem cells of periodontitis patients. Cell Death Dis, 2016, 7(8): e2327. doi: 10.1038/cddis.2016.125.
45. Morikawa M, Derynck R, Miyazono K. TGF-β and the TGF-β family: Context-dependent roles in cell and tissue physiology. Cold Spring Harb Perspect Biol, 2016, 8(5): a021873. doi: 10.1101/cshperspect.a021873.
46. Qu Q, Fang F, Wu B, et al. Potential role of long non-coding RNA in osteogenic differentiation of human periodontal ligament stem cells. J Periodontol, 2016, 87(7): e127-e137.
47. Li M, Xie Z, Wang P, et al. The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA. Cell Death Dis, 2018, 9(5): 554. doi: 10.1038/s41419-018-0627-5.
48. Li M, Xie Z, Li J, et al. GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation. Elife, 2020, 9: e59079. doi: 10.7554/eLife.59079.
49. Wei B, Wei W, Zhao B, et al. Long non-coding RNA HOTAIR inhibits miR-17-5p to regulate osteogenic differentiation and proliferation in non-traumatic osteonecrosis of femoral head. PLoS One, 2017, 12(2): e0169097. doi: 10.1371/journal.pone.0169097.
50. Miyazawa K, Miyazono K. Regulation of TGF-β family signaling by inhibitory Smads. Cold Spring Harb Perspect Biol, 2017, 9(3): a022095. doi: 10.1101/cshperspect.a022095.
51. Zhang RF, Liu JW, Yu SP, et al. LncRNA UCA1 affects osteoblast proliferation and differentiation by regulating BMP-2 expression. Eur Rev Med Pharmacol Sci, 2019, 23(16): 6774-6782.
52. Chen Z, Liu Z, Shen L, et al. Long non-coding RNA SNHG7 promotes the fracture repair through negative modulation of miR-9. Am J Transl Res, 2019, 11(2): 974-982.
53. Wang Q, Chen B, Cao M, et al. Response of MAPK pathway to iron oxide nanoparticles in vitro treatment promotes osteogenic differentiation of hBMSCs. Biomaterials, 2016, 86: 11-20.
54. Yang Q, Han Y, Liu P, et al. Long Noncoding RNA GAS5 promotes osteogenic differentiation of human periodontal ligament stem cells by regulating GDF5 and p38/JNK Ssignaling pathway. Front Pharmacol, 2020, 11: 701. doi: 10.3389/fphar.2020.00701.
55. Zhang J, Tao Z, Wang Y. Long non-coding RNA DANCR regulates the proliferation and osteogenic differentiation of human bone-derived marrow mesenchymal stem cells via the p38 MAPK pathway. Int J Mol Med, 2018, 41(1): 213-219.
56. Zhou QP, Zhang F, Zhang J, et al. H19 promotes the proliferation of osteocytes by inhibiting p53 during fracture healing. Eur Rev Med Pharmacol Sci, 2018, 22(8): 2226-2232.
57. Lu Q, Xu W, Liu L, et al. Traumatic compressive stress inhibits osteoblast differentiation through long chain non-coding RNA Dancr. J Periodontol, 2020, 91(11): 1532-1540.
58. Wang Q, Li Y, Zhang Y, et al. LncRNA MEG3 inhibited osteogenic differentiation of bone marrow mesenchymal stem cells from postmenopausal osteoporosis by targeting miR-133a-3p. Biomed Pharmacother, 2017, 89: 1178-1186.
59. Chen S, Jia L, Zhang S, et al. DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis. Stem Cell Res Ther, 2018, 9(1): 185. doi: 10.1186/s13287-018-0935-9.
60. Che M, Gong W, Zhao Y, et al. Long noncoding RNA HCG18 inhibits the differentiation of human bone marrow-derived mesenchymal stem cells in osteoporosis by targeting miR-30a-5p/NOTCH1 axis. Mol Med, 2020, 26(1): 106. doi: 10.1186/s10020-020-00219-6.
61. Liu Y, Liu C, Zhang A, et al. Down-regulation of long non-coding RNA MEG3 suppresses osteogenic differentiation of periodontal ligament stem cells (PDLSCs) through miR-27a-3p/IGF1 axis in periodontitis. Aging (Albany NY), 2019, 11(15): 5334-5350.
62. Wang J, Liu S, Shi J, et al. The role of lncRNAs in osteogenic differentiation of bone marrow mesenchymal stem cells. Curr Stem Cell Res Ther, 2020, 15(3): 243-249.
63. Ferrè F, Colantoni A, Helmer-Citterich M. Revealing protein-lncRNA interaction. Brief Bioinform, 2016, 17(1): 106-116.

Chinese Journal of Reparative and Reconstructive Surgery

Regulation of long non-coding RNA in signal pathways related to osteogenic differentiation

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