Research progress on the role of dendritic cells in immune metabolism of rheumatoid arthritis_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

HAN Guangtao , SUN Shuo , WANG Qin ,  KANG Pengde

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;

Corresponding author：

KANG Pengde, Email: kangpengde69@126.com

Keywords：

Rheumatoid arthritis; dendritic cells; metabolic characteristics; immune metabolism

DOI：

10.7507/1002-1892.202408002

Video：

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Objective To review the role of dendritic cells (DC) in immune metabolism of rheumatoid arthritis (RA). Methods Literature on the role of DC in the immune metabolism of RA was extensively reviewed in recent years, and the metabolic characteristics of RA, the role of DC in RA, the correlation between the immune metabolism of DC and pathogenesis of RA, and the treatment were summarized and analyzed. Results DC promotes the progression of RA under hypoxia, increased glycolysis, inhibition of oxidative phosphorylation, and decreased lipid metabolism. Moreover, many DCs (especially conventional DC and monocyte-derived DC) have different functions and phenotypic characteristics in RA, which are closely related to the occurrence and development of RA. Conclusion DC plays an important role in the immune metabolism of RA, and immunometabolism therapy based on DC can provide targeted therapy for the treatment of RA.

Citation： HAN Guangtao, SUN Shuo, WANG Qin, KANG Pengde. Research progress on the role of dendritic cells in immune metabolism of rheumatoid arthritis. Chinese Journal of Reparative and Reconstructive Surgery, 2024, 38(12): 1537-1541. doi: 10.7507/1002-1892.202408002 Copy

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Chinese Journal of Reparative and Reconstructive Surgery

Research progress on the role of dendritic cells in immune metabolism of rheumatoid arthritis

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