• 1. Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, P. R. China;
  • 2. Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing 100029, P. R. China;
  • 3. Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, P. R. China;
  • 4. Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, P. R. China;
Export PDF Favorites Scan Get Citation

Objective To analyze the relationship between maximum standardized uptake value (SUVmax) of primary tumor detected by 18F-FDG positron emission tomography/computed tomography (PET/CT) and clinicopathologic factors in stageⅠnon-small cell lung cancer (NSCLC), and investigate the prognostic value of PET/CT on pathological feature. Methods We retrospectively analyzed clinical data of 182 patients with stageⅠNSCLC who underwent 18F-FDG PET/CT scan before lobectomy or segmentectomy in China-Japan Friendship Hospital from April 2013 to June 2014. There were 121 male and 61 female patients with their ages of 34-85 (68.1±9.8) years. Clinicopathologic factors including sex, age, smoking history, histology, TNM stage, T stage, tumor size, lymphatic vessel invasion, blood vessel invasion (BVI) and visceral pleural invasion were evaluated to identify the independent factors affecting SUVmax by univariate and multivariate regression analysis. The diagnostic efficiency and best cut-off point of SUVmax were calculated by the receiver operating characteristic curve. Results The univariate analysis identified that sex (P=0.015), smoking history (P=0.001), histology (P < 0.001), TNM stage (P=0.004), T stage (P=0.001), tumor size (P < 0.001), BVI (P=0.001) were factors affecting SUVmax. Only histology (P=0.001), tumor size (P=0.006), BVI (P=0.009) were found to be significant independent factors according to multivariate regression analysis. The SUVmax of primary tumor was a predictor for BVI with the highest diagnostic accuracy at a cut-off value of 4.85, the sensitivity and specificity were 65.5% and 71.7%. Conclusion The SUVmax is correlated with histology, tumor size and BVI in stageⅠNSCLC, higher in patients with non-adenocarcinoma, lager tumor and positive BVI. Furthermore, the probability of BVI could be predicted by SUVmax of the primary tumor.

Citation: QIANGGuang-liang, XURui, LiuJie, XUYan-yan, DIJin-xi, DAJi-ping, LIANGChao-yang, SONGZhi-yi, TIANYan-chu, SHIBin, GUOYong-qing, LIUDe-ruo. Correlation between 18F-FDG Uptake and Clinicopathological Characteristics of StageⅠNon-small Cell Lung Cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2015, 22(4): 317-322. doi: 10.7507/1007-4848.20150088 Copy

  • Previous Article

    原发性恶性心脏肿瘤一例
  • Next Article

    Preoperative NRS2002 Assessment of Nutritional Risk of Patients with Esophagus Cancer and Postoperative Results