Brain Injury Biomarkers Monitoring for the Patients during Extracorporeal Membrane Oxygenation: A Systematic Review_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

 YOUTao , WANGXin-kuan , LIUXing-guang , HOUXiao-dong , DINGFan , YIKang

Department of Cardiovascular Surgery of Gansu Provincial Hospital, Lanzhou 730000, P. R. China;

Corresponding author：

YOUTao, Email: syxzwk@126.com

Keywords：

Brain injury biomarkers; Extracorporeal membrane oxygenation; Systematic review

DOI：

10.7507/1007-4848.20160037

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Objective To evaluate the monitoring value of brain injury biomarkers in the patients during extracorporeal membrane oxygenation (ECMO). Methods We searched PubMed, EMbase, the Cochrane Library, CNKI, and CBM from inception of each database to May 2015 to identify randomized controlled trials, or case-control trials, or cohort trials of brain injury biomarkers predict brain injury during ECMO. Data were extracted independently by two reviewers. Meta-analysis was conducted using STATA 12.0 software. Results Four retrospective trials were included. The results showed that compared with patients without brain injury, the patients with brain injury had a higher level of S100B protein (P < 0.05). The incidence of major neurological events was higher for high neuron-specific enolase level patients than mild-to-moderate neuron-specific enolase level patients (85% vs. 29%, P=0.01). The incidence of brain injury was higher for normal glial fibrillary acidic protein level than patients with glial fibrillary acidic protein > 0.436 ng/ml (OR=11.5, 95%CI 1.3-98.3). Conclusions Brain injury biomarkers may be used as an indicator for earlier diagnosis of brain injury in patients during ECMO.

Citation： YOUTao, WANGXin-kuan, LIUXing-guang, HOUXiao-dong, DINGFan, YIKang. Brain Injury Biomarkers Monitoring for the Patients during Extracorporeal Membrane Oxygenation: A Systematic Review. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2016, 23(2): 168-172. doi: 10.7507/1007-4848.20160037 Copy

1.	Conrad SA, Rycus PT, Dalton H. Extracorporeal life support registry report 2004. ASAIO J, 2005, 51(1): 4-10.
2.	格日乐, 李志涛.体外膜肺氧合的护理.中外健康文摘, 2012, 9(22): 351-352.
3.	黑飞龙, 龙村, 于坤, 等.体外膜肺氧合并发症研究.中国体外循环杂志, 2005, 3(4): 243-245.
4.	Cilley RE, Zwischenberger JB, Andrews AF, et al. Intracranial haemorrhage during extracorporeal membrane oxygenation in neonates. Pediatrics, 1986, 78(4): 699-704.
5.	Cengiz P, Seidel K, Rycus PT, et al. Central nervous system compli-cations during pediatric extracorporeal life support: incidence and risk factors. Crit Care Med, 2005, 33(12): 2817-2824.
6.	Rollins MD, Yoder BA, Moore KR, et al. Utility of neuroradiogra-phic imaging in predicting outcomes after neonatal extracorporeal membrane oxygenation. J Pediatr Surg, 2012, 47(1): 76-80.
7.	Lidegran MK, Mosskin M, Ringertz HG, et al. Cranial CT for diagnosis of intracranial complications in adult and pediatric patients during ECMO: Clinical benefits in diagnosis and treatment. Acad Radiol, 2007, 14(1): 62-71.
8.	Bembea MM, Felling R, Anton B, et al. Neuromonitoring during extracorporeal membrane oxygenation: a systematic review of the literature. Pediatr Crit Care Med, 2015[Epub ahead of print].
9.	Zhang J, Zhang CH, Lin XL, et al. Serum glial fibrillary acidic protein as a biomarker for differentiating intracerebral hemorrhage and ischemic stroke in patients with symptoms of acute stroke: a systematic review and meta-analysis. Neurol Sci, 2013, 34(11): 1887-1892.
10.	Mercier E, Boutin A, Lauzier F, et al. Predictive value of S-100βprotein for prognosis in patients with moderate and severe traumatic brain injury: systematic review and meta-analysis. BMJ, 2013, 346: f1757.
11.	Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of non-randomized studies in meta-analyses. Eur J Epid, 2010, 25(9): 603-605.
12.	Gazzolo D, Masetti P, Meli M, et al. Elevated S100B protein as an early indicator of intracranial haemorrhage in infants subjected to extracorporeal membrane oxygenation. Acta Paediatr, 2002, 91(2): 218-221.
13.	Nguyen DN, Huyghens L, Wellens F, et al. Serum S100B Protein Could Help to Detect Cerebral Complications Associated with Extracorporeal Membrane Oxygenation (ECMO). Neurocrit Care, 2014, 20(3): 367-374.
14.	Floerchinger B, Philipp A, Foltan M, et al. Neuron-specific enolase serum levels predict severe neuronal injury after extracorporeal life support in resuscitation. Eur J Cardiothorac Surg, 2014, 45(3): 496-501.
15.	Bembea MM, Savage W, Strouse JJ, et al. Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation. Pediatr Crit Care Med, 2011, 12(5): 572-579.
16.	吴蓓, 龙村.体外膜肺氧合与脑损伤.中国体外循环杂志, 2009, 7(4): 246-249.
17.	龙村, 胡盛寿, 刘晋萍, 等.体外膜肺氧合支持治疗在成人终末期心脏病中的临床应用.中国胸心血管外科临床杂志, 2007, 14(5): 334-337.
18.	Hervey-Jumper SL, Annich GM, Yancon AR, et al. Neurological complications of extracorporeal membrane oxygenation in children. J Neurosurg Pediatr, 2011, 7: 338-7344.
19.	Mateen FJ, Muralidharam R, Shinohara RT, et al. Neurological injury in adults treated with extracorporeal membrane oxygenation. Arch Neurol, 2011, 68: 1543-1549.
20.	刘学敏.不同孕龄胎盘和脐带组织中S100b、NSE、GFAP的表达.中国医科大学硕士学位论文, 2007.
21.	Nagdyman N, Kö men W, Ko HK, et al. Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia. Pediatr Res, 2001, 49(4): 502-506.
22.	Gazzolo D, Marinoni E, Di Iorio R, et al. Measurement of urinary S100B protein concentrations for the early identification of brain damage in asphyxiated full-term infants. Arch Pediatr Adolesc Med, 2003, 157(12): 1163-1168.

1. Conrad SA, Rycus PT, Dalton H. Extracorporeal life support registry report 2004. ASAIO J, 2005, 51(1): 4-10.
2. 格日乐, 李志涛.体外膜肺氧合的护理.中外健康文摘, 2012, 9(22): 351-352.
3. 黑飞龙, 龙村, 于坤, 等.体外膜肺氧合并发症研究.中国体外循环杂志, 2005, 3(4): 243-245.
4. Cilley RE, Zwischenberger JB, Andrews AF, et al. Intracranial haemorrhage during extracorporeal membrane oxygenation in neonates. Pediatrics, 1986, 78(4): 699-704.
5. Cengiz P, Seidel K, Rycus PT, et al. Central nervous system compli-cations during pediatric extracorporeal life support: incidence and risk factors. Crit Care Med, 2005, 33(12): 2817-2824.
6. Rollins MD, Yoder BA, Moore KR, et al. Utility of neuroradiogra-phic imaging in predicting outcomes after neonatal extracorporeal membrane oxygenation. J Pediatr Surg, 2012, 47(1): 76-80.
7. Lidegran MK, Mosskin M, Ringertz HG, et al. Cranial CT for diagnosis of intracranial complications in adult and pediatric patients during ECMO: Clinical benefits in diagnosis and treatment. Acad Radiol, 2007, 14(1): 62-71.
8. Bembea MM, Felling R, Anton B, et al. Neuromonitoring during extracorporeal membrane oxygenation: a systematic review of the literature. Pediatr Crit Care Med, 2015[Epub ahead of print].
9. Zhang J, Zhang CH, Lin XL, et al. Serum glial fibrillary acidic protein as a biomarker for differentiating intracerebral hemorrhage and ischemic stroke in patients with symptoms of acute stroke: a systematic review and meta-analysis. Neurol Sci, 2013, 34(11): 1887-1892.
10. Mercier E, Boutin A, Lauzier F, et al. Predictive value of S-100βprotein for prognosis in patients with moderate and severe traumatic brain injury: systematic review and meta-analysis. BMJ, 2013, 346: f1757.
11. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of non-randomized studies in meta-analyses. Eur J Epid, 2010, 25(9): 603-605.
12. Gazzolo D, Masetti P, Meli M, et al. Elevated S100B protein as an early indicator of intracranial haemorrhage in infants subjected to extracorporeal membrane oxygenation. Acta Paediatr, 2002, 91(2): 218-221.
13. Nguyen DN, Huyghens L, Wellens F, et al. Serum S100B Protein Could Help to Detect Cerebral Complications Associated with Extracorporeal Membrane Oxygenation (ECMO). Neurocrit Care, 2014, 20(3): 367-374.
14. Floerchinger B, Philipp A, Foltan M, et al. Neuron-specific enolase serum levels predict severe neuronal injury after extracorporeal life support in resuscitation. Eur J Cardiothorac Surg, 2014, 45(3): 496-501.
15. Bembea MM, Savage W, Strouse JJ, et al. Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation. Pediatr Crit Care Med, 2011, 12(5): 572-579.
16. 吴蓓, 龙村.体外膜肺氧合与脑损伤.中国体外循环杂志, 2009, 7(4): 246-249.
17. 龙村, 胡盛寿, 刘晋萍, 等.体外膜肺氧合支持治疗在成人终末期心脏病中的临床应用.中国胸心血管外科临床杂志, 2007, 14(5): 334-337.
18. Hervey-Jumper SL, Annich GM, Yancon AR, et al. Neurological complications of extracorporeal membrane oxygenation in children. J Neurosurg Pediatr, 2011, 7: 338-7344.
19. Mateen FJ, Muralidharam R, Shinohara RT, et al. Neurological injury in adults treated with extracorporeal membrane oxygenation. Arch Neurol, 2011, 68: 1543-1549.
20. 刘学敏.不同孕龄胎盘和脐带组织中S100b、NSE、GFAP的表达.中国医科大学硕士学位论文, 2007.
21. Nagdyman N, Kö men W, Ko HK, et al. Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia. Pediatr Res, 2001, 49(4): 502-506.
22. Gazzolo D, Marinoni E, Di Iorio R, et al. Measurement of urinary S100B protein concentrations for the early identification of brain damage in asphyxiated full-term infants. Arch Pediatr Adolesc Med, 2003, 157(12): 1163-1168.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Brain Injury Biomarkers Monitoring for the Patients during Extracorporeal Membrane Oxygenation: A Systematic Review

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