Therapeutic Effect of Low Dose of Digitalis in Lung Cancer Patients After Pneumonectomy_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

CHENJia-kuan ¹ ,  YANGBo ² , WANGJian ¹ , LIJian-zhong ³ , ZHOULin ¹ , ZHANGHong ¹ , XIAYan-min ¹ , WANGWen-chen ¹ ,  JIANGTao ¹

1. Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, P. R. China;
2. Department of Thoracic Surgery, Tianjin First Central Hospital, Tianjin 300192, P. R. China;
Department of Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, P. R. China;

Corresponding author：

YANGBo, Email: yangbochest@126.com; JIANGTao, Email: jiangtaochest@163.com

Keywords：

Digitalis; Pneumonectomy; Cardiac function

DOI：

10.7507/1007-4848.20160109

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the clinical significance of applying digitalis preparations after pneumonec-tomy. Methods We retrospectively analyzed the clinical data of 78 patients who underwent pneumonectomy in the Tangdu Hospital of The Fourth Military Medical University from August 2010 to August 2013. The patients were divided into a control group (39 patients with 27 males and 12 females at a mean age of 56.8±14.8 years) and a trial group (39 patients with 24 males and 15 females at a mean age of 57.4±10.1 years). After pneumonectomy, the trial group received low dose of digitalis treatment. On 3, 5, and 7 days, the arterial partial pressure of oxygen (PaO₂), systolic pulmonary artery pressure (SPAP), mean arterial pressure (MAP), diastolic pulmonary artery pressure (DPAP), and the rate of complications were examined. Results After treatment with the low dose of digitalis, the SPAP, MAP, DPAP of the trial group were statistically lower than those of the control group (P < 0.05). Incidence of arrhythmia in the trial group was statistically lower than that of the control group (P < 0.05). There was no statistical difference between the two groups in the PaO₂, the incidence of pulmonary infection, and circulation disorder (P > 0.05). Conclusion Low dose of digitalis preparations can improve cardiac function after pneumonectomy.

Citation： CHENJia-kuan, YANGBo, WANGJian, LIJian-zhong, ZHOULin, ZHANGHong, XIAYan-min, WANGWen-chen, JIANGTao. Therapeutic Effect of Low Dose of Digitalis in Lung Cancer Patients After Pneumonectomy. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2016, 23(5): 463-466. doi: 10.7507/1007-4848.20160109 Copy

1.	Thomas PA, Berbis J, Baste JM, et al. Pneumonectomy for lung cancer:contemporary national early morbidity and mortality outcomes. J Thorac Cardiovasc Surg, 2015, 149(1):73-82.
2.	Xiong F, Wang S, Kai J. Video-assisted thoracic surgery right sleeve lobectomy. J Thorac Dis, 2014, 6(12):1831-1833.
3.	Safi S, Benner A, Walloschek J, et al. Development and validation of a risk score for predicting death after pneumonectomy. PLoS One, 2015, 10(4):1-12.
4.	雷艺炎, 陈振光, 罗红鹤, 等. 肺癌患者围术期并发症发生的危险因素分析. 中国胸心血管外科临床杂志, 2008, 15(4):268-271.
5.	Harpole DH, Liptay MJ, DeCamp MM Jr, et al. Prospective analysis of pneumonectomy:risk factors for major morbidity and cardiac dysrhythmias. Ann Thrac Surg, 1996, 61(3):977-982.
6.	Stolz AJ, Harustiak T, Simonek J, et al. Pneumonectomy for non-small cell lung cancer:predictors of early mortality and morbidity. Acta chirurgica Belgica, 2013, 114(1):25-30.
7.	段孝凤, 傅承丽, 高晓旭, 等. 全肺切除治疗晚期肺癌420例临床分析. 现代肿瘤医学, 2014, 22(2):363-366.
8.	崔玉尚, 张志庸, 阿布都热伊木阿伊都. 开胸术后早期肺功能的变化规律及影响因素分析. 中华外科杂志, 2003, 41(12):909-912.
9.	武艳. 肺癌术后心律失常的危险因素分析. 肿瘤学杂志, 2012, 17(12):917-919.
10.	Koh WJ, Kim YH, Kwon OJ, et al. Surgical treatment of pulmonary diseases due to nontuberculous mycobacteria. J Korean Med Sci, 2008, 23(3):397-401.
11.	Pop D, Nadeemy AS, Venissac N, et al. Bronchopleural fistula:the Damocles sword of all pneumonectomies. Interact Cardiovasc Thrac Surg, 2011, 13(1):107-108.
12.	Ishikawa K, Kato T, Aragaki M, et al. Endobronchial closure of a bronchopleural fitula using a firin glue-coated collagen patch and firin glue. Ann Thrac Cardiovasc Surg, 2013, 19(6):423-427.
13.	杨波, 张志培, 姜鹏, 等. N-myc下游调节基因-2在大鼠肠缺血再灌注肺损伤中的表达及其与NF-kBp65的相关研究. 创伤外科杂志, 2012, 14(6):543-546.
14.	Yang B, Ni YF, Wang WC, et al. Melatonin attenuates intestinal ischemia-reperfusion-induced lung injury in rats by upregulating N-myc downstream-regulated gene 2. J Surg Res, 2015, 194(1):273-280.
15.	Yang B, Li XP, Ni YF, et al. Protective effect of isorhamnetin on lipopolysac charide-induced acute lung injury in mice. Inflammation, 2016, 39(1):129-137.
16.	Lloyd MS, Wallis C, Muthialu N, et al. Treatment of postpneumone-ctomy syndrome with tissue expanders:the Great Ormond Street Hospital experience. J Plast Reconstr Aesthet Surg, 2014, 67(5):725-728.
17.	Sharifpour M, Bittner EA. Postpneumonectomy syndrome:a case of shiftng priorities. Anesthesiol, 2014, 121(6):1334.
18.	支修益. 胸外科围手术期气道管理专家共识(2012年版). 中国胸心血管外科临床杂志, 2013, 20(3):251-255.
19.	Pricopi C, Mordant P, Rivera C, et al. Postoperative morbidity and mortality after pneumonectomy:a 30-year experience of 2064 consecutive patients. Interact Cardiovasc Thorac Surg, 2015, 20(3):316-321.
20.	Chandrashekhara SH, Bhalla AS, Sharma R, et al. Imaging in postpneumonectomy complications:a pictorial review. J Cancer Res Ther, 2011, 7(1):3-10.
21.	汪志海, 孙晓雁, 郭明. 全肺切除术后并发症的防治进展.中国胸心血管外科临床杂志, 2015, 22(4):380-384.
22.	Fan Y, Zhang AM, Xiao YB. Glucose-insulin-potassium therapy in adult patients undergoing cardiac surgery a meta-analysis. Eur J Cardiothorac Surg, 2011, 40(1):192-199.
23.	翁毅敏, 廖洪映, 李昀, 等. 肺癌全肺切除术后心肺并发症的防治. 中山大学学报(医学科学版), 2007, 28(B06):89-91.
24.	李学昌, 王伟, 尚立群, 等. 高龄患者全肺切除术后心律失常发生. 山东医药, 2013, 53(6):83-85.
25.	甄福喜, 赵欣, 张伟, 等. 肺癌全肺切除术后早期右心功能不全的危险因素分析. 临床肿瘤学杂志, 2013, 17(11):1006-1008.
26.	吕卓人, 薛小临, 姜馨, 等. 洋地黄在治疗慢性心力衰竭中地位的再评价. 中华心血管病杂志, 2002, 30(3):185-186.

1. Thomas PA, Berbis J, Baste JM, et al. Pneumonectomy for lung cancer:contemporary national early morbidity and mortality outcomes. J Thorac Cardiovasc Surg, 2015, 149(1):73-82.
2. Xiong F, Wang S, Kai J. Video-assisted thoracic surgery right sleeve lobectomy. J Thorac Dis, 2014, 6(12):1831-1833.
3. Safi S, Benner A, Walloschek J, et al. Development and validation of a risk score for predicting death after pneumonectomy. PLoS One, 2015, 10(4):1-12.
4. 雷艺炎, 陈振光, 罗红鹤, 等. 肺癌患者围术期并发症发生的危险因素分析. 中国胸心血管外科临床杂志, 2008, 15(4):268-271.
5. Harpole DH, Liptay MJ, DeCamp MM Jr, et al. Prospective analysis of pneumonectomy:risk factors for major morbidity and cardiac dysrhythmias. Ann Thrac Surg, 1996, 61(3):977-982.
6. Stolz AJ, Harustiak T, Simonek J, et al. Pneumonectomy for non-small cell lung cancer:predictors of early mortality and morbidity. Acta chirurgica Belgica, 2013, 114(1):25-30.
7. 段孝凤, 傅承丽, 高晓旭, 等. 全肺切除治疗晚期肺癌420例临床分析. 现代肿瘤医学, 2014, 22(2):363-366.
8. 崔玉尚, 张志庸, 阿布都热伊木阿伊都. 开胸术后早期肺功能的变化规律及影响因素分析. 中华外科杂志, 2003, 41(12):909-912.
9. 武艳. 肺癌术后心律失常的危险因素分析. 肿瘤学杂志, 2012, 17(12):917-919.
10. Koh WJ, Kim YH, Kwon OJ, et al. Surgical treatment of pulmonary diseases due to nontuberculous mycobacteria. J Korean Med Sci, 2008, 23(3):397-401.
11. Pop D, Nadeemy AS, Venissac N, et al. Bronchopleural fistula:the Damocles sword of all pneumonectomies. Interact Cardiovasc Thrac Surg, 2011, 13(1):107-108.
12. Ishikawa K, Kato T, Aragaki M, et al. Endobronchial closure of a bronchopleural fitula using a firin glue-coated collagen patch and firin glue. Ann Thrac Cardiovasc Surg, 2013, 19(6):423-427.
13. 杨波, 张志培, 姜鹏, 等. N-myc下游调节基因-2在大鼠肠缺血再灌注肺损伤中的表达及其与NF-kBp65的相关研究. 创伤外科杂志, 2012, 14(6):543-546.
14. Yang B, Ni YF, Wang WC, et al. Melatonin attenuates intestinal ischemia-reperfusion-induced lung injury in rats by upregulating N-myc downstream-regulated gene 2. J Surg Res, 2015, 194(1):273-280.
15. Yang B, Li XP, Ni YF, et al. Protective effect of isorhamnetin on lipopolysac charide-induced acute lung injury in mice. Inflammation, 2016, 39(1):129-137.
16. Lloyd MS, Wallis C, Muthialu N, et al. Treatment of postpneumone-ctomy syndrome with tissue expanders:the Great Ormond Street Hospital experience. J Plast Reconstr Aesthet Surg, 2014, 67(5):725-728.
17. Sharifpour M, Bittner EA. Postpneumonectomy syndrome:a case of shiftng priorities. Anesthesiol, 2014, 121(6):1334.
18. 支修益. 胸外科围手术期气道管理专家共识(2012年版). 中国胸心血管外科临床杂志, 2013, 20(3):251-255.
19. Pricopi C, Mordant P, Rivera C, et al. Postoperative morbidity and mortality after pneumonectomy:a 30-year experience of 2064 consecutive patients. Interact Cardiovasc Thorac Surg, 2015, 20(3):316-321.
20. Chandrashekhara SH, Bhalla AS, Sharma R, et al. Imaging in postpneumonectomy complications:a pictorial review. J Cancer Res Ther, 2011, 7(1):3-10.
21. 汪志海, 孙晓雁, 郭明. 全肺切除术后并发症的防治进展.中国胸心血管外科临床杂志, 2015, 22(4):380-384.
22. Fan Y, Zhang AM, Xiao YB. Glucose-insulin-potassium therapy in adult patients undergoing cardiac surgery a meta-analysis. Eur J Cardiothorac Surg, 2011, 40(1):192-199.
23. 翁毅敏, 廖洪映, 李昀, 等. 肺癌全肺切除术后心肺并发症的防治. 中山大学学报(医学科学版), 2007, 28(B06):89-91.
24. 李学昌, 王伟, 尚立群, 等. 高龄患者全肺切除术后心律失常发生. 山东医药, 2013, 53(6):83-85.
25. 甄福喜, 赵欣, 张伟, 等. 肺癌全肺切除术后早期右心功能不全的危险因素分析. 临床肿瘤学杂志, 2013, 17(11):1006-1008.
26. 吕卓人, 薛小临, 姜馨, 等. 洋地黄在治疗慢性心力衰竭中地位的再评价. 中华心血管病杂志, 2002, 30(3):185-186.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Therapeutic Effect of Low Dose of Digitalis in Lung Cancer Patients After Pneumonectomy

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content