Therapeutic Progress of Congestive Heart Failure Treated with Mesenchymal Stem Cells_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LIUSheng-chen , WANGQiang , LUZi-run ,  WANGDong-jin

Department of Cardiothoracic Surgery, Drum Tower Hospital Affiliated to Nanjing University, Nanjing 210008, P. R. China;

Corresponding author：

WANGDong-jin, Email: gldjw@163.com

Keywords：

Congestive heart failure; Mesenchymal stem cells; Myocardium regeneration; Myocyte transplantation

DOI：

10.7507/1007-4848.20160259

Video：

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Congestive heart failure is a complication of myocardial infarction threatening human health. Although the pharmacotherapy is effective, it is still a worldwide challenge to thoroughly repair the injured myocardium induced by myocardial infarction. It has been demonstrated that mesenchymal stem cells (MSCs) can repair infarcted myocardium. Much evidence shows that MSCs can generate new myocardial cells in both human and animals' hearts. This review aims at discussing the therapeutic progress of the congestive heart failure treated with MSCs.

Citation： LIUSheng-chen, WANGQiang, LUZi-run, WANGDong-jin. Therapeutic Progress of Congestive Heart Failure Treated with Mesenchymal Stem Cells. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2016, 23(11): 1108-1111. doi: 10.7507/1007-4848.20160259 Copy

1.	Loprinzi PD. Physical activity and peripheral arterial disease among patients with coronary artery disease or congestive heart failure. Int J Cardiol, 2016, 207(1): 110-111.
2.	Michel A, Martin-Perez M, Ruigomez A, et al. Incidence and risk factors for severe renal impairment after first diagnosis of heart failure: A cohort and nested case-control study in UK general practice. Int J Cardiol, 2016, 207(1): 252-257.
3.	Correa AD, Makdisse M, Katz M, et al. Analysis treatment guide-line versus clinical practice protocol in patients hospitalized due to heart failure. Arq Bras Cardiol, 2016, 106(3): 210-217.
4.	Shen H, Wang Y, Zhang Z, et al. Mesenchymal stem cells for cardiac regenerative therapy: optimization of cell differentiation strategy. Stem Cells Int, 2015, 2015: 524756.
5.	Perin EC, Borow KM, Silva GV, et al. A Phase II dose-escalation study of allogeneic mesenchymal precursor cells in patients with ischemic or nonischemic heart failure. Circ Res, 2015, 117(6): 576-584.
6.	Suresh SC, Selvaraju V, Thirunavukkarasu M, et al. Thioredoxin-1 (Trx1) engineered mesenchymal stem cell therapy increased pro-angiogenic factors, reduced fibrosis and improved heart function in the infarcted rat myocardium. Int J Cardiol, 2015, 201(10): 517-528.
7.	Hou L, Kim JJ, Woo YJ, et al. Stem cell-based therapies to promote angiogenesis in ischemic cardiovascular disease. Am J Physiol Heart Circ Physiol, 2016, 310(4): H455-H465.
8.	Teng X, Chen L, Chen W, et al. Mesenchymal stem cell-derived exosomes improve the microenvironment of infarcted myocardium contributing to angiogenesis and anti-inflammation. Cell Physiol Biochem, 2015, 37(6): 2415-2424.
9.	Kim SW, Jin HL, Kang SM, et al. Therapeutic effects of late outgrowth endothelial progenitor cells or mesenchymal stem cells derived from human umbilical cord blood on infarct repair. Int J Cardiol, 2016, 203: 498-507.
10.	Kim HJ, Kwon YR, Bae YJ, et al. Enhancement of human mesench-ymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A. Biotechnol Lett, 2016, 38(1): 167-174.
11.	Deng F, Lei H, Hu Y, et al. Combination of retinoic acid, dimethyl sulfoxide and 5-azacytidine promotes cardiac differentiation of human fetal liver-derived mesenchymal stem cells. Cell Tissue Bank, 2016, 17(1): 147-159.
12.	Venugopal JR, Prabhakaran MP, Mukherjee S, et al. Biomaterial strategies for alleviation of myocardial infarction. J R Soc Interface, 2012, 9(66): 1-19.
13.	Musialek P, Mazurek A, Jarocha D, et al. Myocardial regeneration strategy using Wharton's jelly mesenchymal stem cells as an off-the-shelf 'unlimited' therapeutic agent: results from the Acute Myocar-dial Infarction First-in-Man Study. Postepy Kardiol Interwencyjnej, 2015, 11(2): 100-107.
14.	Seeger FH, Tonn T, Krzossok N, et al. Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myoc-ardial infarction. Eur Heart J, 2007, 28(6): 766-772.
15.	Heeschen C, Lehmann R, Honold J, et al. Profoundly reduced neov-ascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation, 2004, 109(13): 1615-1622.
16.	Lu W, Xiu X, Zhao Y, et al. Improved proliferation and differentia-tion of bone marrow mesenchymal stem cells into vascular endothe-lial cells with sphingosine 1-phosphate. Transplant Proc, 2015, 47 (6): 2035-2040.
17.	Zafir A, Bradley JA, Long BW, et al. O-GlcNAcylation negatively regulates cardiomyogenic fate in adult mouse cardiac mesenchymal stromal cells. PLoS One, 2015, 10(11): e0142939.
18.	Fukuda K. Use of adult marrow mesenchymal stem cells for regener-ation of cardiomyocytes. Bone Marrow Transplant, 2003, 32 (Suppl 1): S25-S27.
19.	Supokawej A, Kheolamai P, Nartprayut K, et al. Cardiogenic and myogenic gene expression in mesenchymal stem cells after 5-azacy-tidine treatment. Turk J Haematol, 2013, 30(2): 115-121.
20.	Madonna R, Petrov L, Teberino MA, et al. Transplantation of adipose tissue mesenchymal cells conjugated with VEGF-releasing microcarriers promotes repair in murine myocardial infarction. Cardiovasc Res, 2015, 108(1): 39-49.
21.	Schmuck EG, Koch JM, Hacker TA, et al. Intravenous followed by x-ray fused with MRI-guided transendocardial mesenchymal stem cell injection improves contractility reserve in a swine model of myocardial infarction. J Cardiovasc Transl Res, 2015, 8(7): 438-448.
22.	Hua P, Tao J, Liu JY, et al. Cell transplantation into ischemic myoc-ardium using mesenchymal stem cells transfected by vascular endo-thelial growth factor. Int J Clin Exp Pathol, 2014, 7(11): 7782-7788.
23.	Tong J, Ding J, Shen X, et al. Mesenchymal stem cell transplanta-tion enhancement in myocardial infarction rat model under ultraso-und combined with nitric oxide microbubbles. PLoS One, 2013, 8(11): e80186.
24.	Murry CE, Soonpaa MH, Reinecke H, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature, 2004, 428(6983): 664-668.
25.	Rose RA, Jiang H, Wang X, et al. Bone marrow-derived mesenchy-mal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro. Stem Cells, 2008, 26(11): 2884-2892.
26.	Santos Nascimento D, Mosqueira D, Sousa LM, , et al. Human umbilical cord tissue-derived mesenchymal stromal cells attenuate remodeling after myocardial infarction by proangiogenic, antiapo-ptotic, and endogenous cell-activation mechanisms. Stem Cell Res Ther, 2014, 5(1): 5.
27.	Dayan V, Yannarelli G, Billia F, et al. Mesenchymal stromal cells mediate a switch to alternatively activated monocytes/macrophages after acute myocardial infarction. Basic Res Cardiol, 2011, 106(6): 1299-1310.
28.	Vassalli G, Moccetti T. Cardiac repair with allogeneic mesenchymal stem cells after myocardial infarction. Swiss Med Wkly, 2011, 141: w13209.
29.	Guo HD, Wang HJ, Tan YZ, et al. Transplantation of marrow-derived cardiac stem cells carried in fibrin improves cardiac function after myocardial infarction. Tissue Eng Part A, 2011, 17(1-2): 45-58.
30.	Rahbarghazi R, Nassiri SM, Khazraiinia P, et al. Juxtacrine and paracrine interactions of rat marrow-derived mesenchymal stem cells, muscle-derived satellite cells, and neonatal cardiomyocytes with endothelial cells in angiogenesis dynamics. Stem Cells Dev, 2013, 22(6): 855-865.
31.	Li Z, Guo X, Palmer AF, et al. High-efficiency matrix modulus-induced cardiac differentiation of human mesenchymal stem cells inside a thermosensitive hydrogel. Acta Biomater, 2012, 8(10): 3586-3595.
32.	Cashman TJ, Gouon-Evans V, Costa KD. Mesenchymal stem cells for cardiac therapy: practical challenges and potential mechanisms. Stem Cell Rev, 2013, 9(3): 254-265.
33.	Sheng CC, Zhou L, Hao J. Current stem cell delivery methods for myocardial repair. Biomed Res Int, 2013, 2013: 547902.
34.	Strauer BE, Brehm M, Zeus T, et al. Intrakoronare, humane autologe Stammzelltransplantation zur Myokardregeneration nach Herzin-farkt. Dtsch Med Wochenschr, 2001, 126(34-35): 932-938.
35.	Schächinger V, Erbs S, Elsässer A, et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med, 2006, 355(12): 1210-1221.
36.	Schachinger V, Erbs S, Elsasser A, et al. Improved clinical outcome after intracoronary administration of bone-marrow-derived proge-nitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial. Eur Heart J, 2006, 27(23): 2775-2783.
37.	Erbs S, Linke A, Schachinger V, et al. Restoration of microvascular function in the infarct-related artery by intracoronary transplanta-tion of bone marrow progenitor cells in patients with acute myocar-dial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) trial. Circulation, 2007, 116(4): 366-374.
38.	Abdel-Latif A, Bolli R, Tleyjeh IM, et al. Adult bone marrow-derived cells for cardiac repair. Arch Intern Med, 2007, 167(10): 989-997.
39.	Singh S, Arora R, Handa K, et al. Stem cells improve left ventricular function in acute myocardial infarction. Clin Cardiol, 2009, 32(4): 176-180.
40.	Zhou Y, Singh AK, Hoyt RF, et al. Regulatory T cells enhance mesen-chymal stem cell survival and proliferation following autologous cotransplantation in ischemic myocardium. J Thorac Cardiovasc Surg, 2014, 148(3): 1131-1137.
41.	Yao Y, Zhang F, Wang L, et al. Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells transplantation in a rat model of acute myocardial infarction. J Biomed Sci, 2009, 16(10): 74.
42.	Rodrigues M, Turner O, Stolz D, et al. Production of reactive oxygen species by multipotent stromal cells/mesenchymal stem cells upon exposure to fas ligand. Cell Transplant, 2012, 21(10): 2171-2187.
43.	Lu WB, Tang Y, Zhang ZW, et al. Inhibiting the mobilization of Ly6Chigh monocytes after acute myocardial infarction enhances the efficiency of mesenchymal stromal cell transplantation and curbs myocardial remodeling. Am J Transl Res, 2015, 7(3): 587-597.
44.	王峰, 肖明第, 廖斌, 等.小肠粘膜下层-骨髓间充质干细胞移植治疗陈旧性心肌梗死.中国胸心血管外科临床杂志, 2010, 17(4): 344-346.
45.	周骐, 周建业, 胡盛寿, 等.大网膜联合组织工程心肌移植改善心肌梗死后大鼠心功能.中国胸心血管外科临床杂志, 2008, 15(6): 432-437.

1. Loprinzi PD. Physical activity and peripheral arterial disease among patients with coronary artery disease or congestive heart failure. Int J Cardiol, 2016, 207(1): 110-111.
2. Michel A, Martin-Perez M, Ruigomez A, et al. Incidence and risk factors for severe renal impairment after first diagnosis of heart failure: A cohort and nested case-control study in UK general practice. Int J Cardiol, 2016, 207(1): 252-257.
3. Correa AD, Makdisse M, Katz M, et al. Analysis treatment guide-line versus clinical practice protocol in patients hospitalized due to heart failure. Arq Bras Cardiol, 2016, 106(3): 210-217.
4. Shen H, Wang Y, Zhang Z, et al. Mesenchymal stem cells for cardiac regenerative therapy: optimization of cell differentiation strategy. Stem Cells Int, 2015, 2015: 524756.
5. Perin EC, Borow KM, Silva GV, et al. A Phase II dose-escalation study of allogeneic mesenchymal precursor cells in patients with ischemic or nonischemic heart failure. Circ Res, 2015, 117(6): 576-584.
6. Suresh SC, Selvaraju V, Thirunavukkarasu M, et al. Thioredoxin-1 (Trx1) engineered mesenchymal stem cell therapy increased pro-angiogenic factors, reduced fibrosis and improved heart function in the infarcted rat myocardium. Int J Cardiol, 2015, 201(10): 517-528.
7. Hou L, Kim JJ, Woo YJ, et al. Stem cell-based therapies to promote angiogenesis in ischemic cardiovascular disease. Am J Physiol Heart Circ Physiol, 2016, 310(4): H455-H465.
8. Teng X, Chen L, Chen W, et al. Mesenchymal stem cell-derived exosomes improve the microenvironment of infarcted myocardium contributing to angiogenesis and anti-inflammation. Cell Physiol Biochem, 2015, 37(6): 2415-2424.
9. Kim SW, Jin HL, Kang SM, et al. Therapeutic effects of late outgrowth endothelial progenitor cells or mesenchymal stem cells derived from human umbilical cord blood on infarct repair. Int J Cardiol, 2016, 203: 498-507.
10. Kim HJ, Kwon YR, Bae YJ, et al. Enhancement of human mesench-ymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A. Biotechnol Lett, 2016, 38(1): 167-174.
11. Deng F, Lei H, Hu Y, et al. Combination of retinoic acid, dimethyl sulfoxide and 5-azacytidine promotes cardiac differentiation of human fetal liver-derived mesenchymal stem cells. Cell Tissue Bank, 2016, 17(1): 147-159.
12. Venugopal JR, Prabhakaran MP, Mukherjee S, et al. Biomaterial strategies for alleviation of myocardial infarction. J R Soc Interface, 2012, 9(66): 1-19.
13. Musialek P, Mazurek A, Jarocha D, et al. Myocardial regeneration strategy using Wharton's jelly mesenchymal stem cells as an off-the-shelf 'unlimited' therapeutic agent: results from the Acute Myocar-dial Infarction First-in-Man Study. Postepy Kardiol Interwencyjnej, 2015, 11(2): 100-107.
14. Seeger FH, Tonn T, Krzossok N, et al. Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myoc-ardial infarction. Eur Heart J, 2007, 28(6): 766-772.
15. Heeschen C, Lehmann R, Honold J, et al. Profoundly reduced neov-ascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation, 2004, 109(13): 1615-1622.
16. Lu W, Xiu X, Zhao Y, et al. Improved proliferation and differentia-tion of bone marrow mesenchymal stem cells into vascular endothe-lial cells with sphingosine 1-phosphate. Transplant Proc, 2015, 47 (6): 2035-2040.
17. Zafir A, Bradley JA, Long BW, et al. O-GlcNAcylation negatively regulates cardiomyogenic fate in adult mouse cardiac mesenchymal stromal cells. PLoS One, 2015, 10(11): e0142939.
18. Fukuda K. Use of adult marrow mesenchymal stem cells for regener-ation of cardiomyocytes. Bone Marrow Transplant, 2003, 32 (Suppl 1): S25-S27.
19. Supokawej A, Kheolamai P, Nartprayut K, et al. Cardiogenic and myogenic gene expression in mesenchymal stem cells after 5-azacy-tidine treatment. Turk J Haematol, 2013, 30(2): 115-121.
20. Madonna R, Petrov L, Teberino MA, et al. Transplantation of adipose tissue mesenchymal cells conjugated with VEGF-releasing microcarriers promotes repair in murine myocardial infarction. Cardiovasc Res, 2015, 108(1): 39-49.
21. Schmuck EG, Koch JM, Hacker TA, et al. Intravenous followed by x-ray fused with MRI-guided transendocardial mesenchymal stem cell injection improves contractility reserve in a swine model of myocardial infarction. J Cardiovasc Transl Res, 2015, 8(7): 438-448.
22. Hua P, Tao J, Liu JY, et al. Cell transplantation into ischemic myoc-ardium using mesenchymal stem cells transfected by vascular endo-thelial growth factor. Int J Clin Exp Pathol, 2014, 7(11): 7782-7788.
23. Tong J, Ding J, Shen X, et al. Mesenchymal stem cell transplanta-tion enhancement in myocardial infarction rat model under ultraso-und combined with nitric oxide microbubbles. PLoS One, 2013, 8(11): e80186.
24. Murry CE, Soonpaa MH, Reinecke H, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature, 2004, 428(6983): 664-668.
25. Rose RA, Jiang H, Wang X, et al. Bone marrow-derived mesenchy-mal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro. Stem Cells, 2008, 26(11): 2884-2892.
26. Santos Nascimento D, Mosqueira D, Sousa LM, , et al. Human umbilical cord tissue-derived mesenchymal stromal cells attenuate remodeling after myocardial infarction by proangiogenic, antiapo-ptotic, and endogenous cell-activation mechanisms. Stem Cell Res Ther, 2014, 5(1): 5.
27. Dayan V, Yannarelli G, Billia F, et al. Mesenchymal stromal cells mediate a switch to alternatively activated monocytes/macrophages after acute myocardial infarction. Basic Res Cardiol, 2011, 106(6): 1299-1310.
28. Vassalli G, Moccetti T. Cardiac repair with allogeneic mesenchymal stem cells after myocardial infarction. Swiss Med Wkly, 2011, 141: w13209.
29. Guo HD, Wang HJ, Tan YZ, et al. Transplantation of marrow-derived cardiac stem cells carried in fibrin improves cardiac function after myocardial infarction. Tissue Eng Part A, 2011, 17(1-2): 45-58.
30. Rahbarghazi R, Nassiri SM, Khazraiinia P, et al. Juxtacrine and paracrine interactions of rat marrow-derived mesenchymal stem cells, muscle-derived satellite cells, and neonatal cardiomyocytes with endothelial cells in angiogenesis dynamics. Stem Cells Dev, 2013, 22(6): 855-865.
31. Li Z, Guo X, Palmer AF, et al. High-efficiency matrix modulus-induced cardiac differentiation of human mesenchymal stem cells inside a thermosensitive hydrogel. Acta Biomater, 2012, 8(10): 3586-3595.
32. Cashman TJ, Gouon-Evans V, Costa KD. Mesenchymal stem cells for cardiac therapy: practical challenges and potential mechanisms. Stem Cell Rev, 2013, 9(3): 254-265.
33. Sheng CC, Zhou L, Hao J. Current stem cell delivery methods for myocardial repair. Biomed Res Int, 2013, 2013: 547902.
34. Strauer BE, Brehm M, Zeus T, et al. Intrakoronare, humane autologe Stammzelltransplantation zur Myokardregeneration nach Herzin-farkt. Dtsch Med Wochenschr, 2001, 126(34-35): 932-938.
35. Schächinger V, Erbs S, Elsässer A, et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med, 2006, 355(12): 1210-1221.
36. Schachinger V, Erbs S, Elsasser A, et al. Improved clinical outcome after intracoronary administration of bone-marrow-derived proge-nitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial. Eur Heart J, 2006, 27(23): 2775-2783.
37. Erbs S, Linke A, Schachinger V, et al. Restoration of microvascular function in the infarct-related artery by intracoronary transplanta-tion of bone marrow progenitor cells in patients with acute myocar-dial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) trial. Circulation, 2007, 116(4): 366-374.
38. Abdel-Latif A, Bolli R, Tleyjeh IM, et al. Adult bone marrow-derived cells for cardiac repair. Arch Intern Med, 2007, 167(10): 989-997.
39. Singh S, Arora R, Handa K, et al. Stem cells improve left ventricular function in acute myocardial infarction. Clin Cardiol, 2009, 32(4): 176-180.
40. Zhou Y, Singh AK, Hoyt RF, et al. Regulatory T cells enhance mesen-chymal stem cell survival and proliferation following autologous cotransplantation in ischemic myocardium. J Thorac Cardiovasc Surg, 2014, 148(3): 1131-1137.
41. Yao Y, Zhang F, Wang L, et al. Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells transplantation in a rat model of acute myocardial infarction. J Biomed Sci, 2009, 16(10): 74.
42. Rodrigues M, Turner O, Stolz D, et al. Production of reactive oxygen species by multipotent stromal cells/mesenchymal stem cells upon exposure to fas ligand. Cell Transplant, 2012, 21(10): 2171-2187.
43. Lu WB, Tang Y, Zhang ZW, et al. Inhibiting the mobilization of Ly6Chigh monocytes after acute myocardial infarction enhances the efficiency of mesenchymal stromal cell transplantation and curbs myocardial remodeling. Am J Transl Res, 2015, 7(3): 587-597.
44. 王峰, 肖明第, 廖斌, 等.小肠粘膜下层-骨髓间充质干细胞移植治疗陈旧性心肌梗死.中国胸心血管外科临床杂志, 2010, 17(4): 344-346.
45. 周骐, 周建业, 胡盛寿, 等.大网膜联合组织工程心肌移植改善心肌梗死后大鼠心功能.中国胸心血管外科临床杂志, 2008, 15(6): 432-437.

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