Research status of lung transplantation and standardized management during transplantation period_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

XU Longming ¹ , ZUO Yunxia ¹ ,  LIN Yidan ²

1. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, P.R. China;
2. Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P.R. China;

Corresponding author：

LIN Yidan, Email: zuoyxhxa@163.com

Keywords：

Lung transplantation; extracorporeal membraneoxygenation (ECMO); donor lungs; anesthetic management; bridge of ECMO

DOI：

10.7507/1007-4848.201907022

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Lung transplantation is the only treatment for patients with end-stage lung diseases. And this field is also a research hotspot in the international field at presen. Relevant researches not only promote the progress and development of lung transplantation, but also improve the life quality of patients after transplantation. With the development of lung transplantation technology, the guidelines for identifying candidates are constantly being revised, and the source of donor lungs has always been an urgent problem for all transplantation centers. The standardized management during transplantation period involves anesthesia induction, intraoperative fluid management, airway management, management of important operative steps and postoperative pain management. Extracorporeal life support (ECLS) includes cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO). With the progress and development of ECLS technology, the advantages of ECMO as a bridge for lung transplantation, intraoperative and postoperative circulatory support are becoming more and more prominent, enabling recipient patients to successfully pass the period of lung transplantation. Although lung transplantation in basic science and clinical researches has got a lot of progress, to improve the survival rate after transplantation, we must overcome many challenges including how to successfully perform lung transplantation, expand lung donor library, induce tolerance, and prevent complications after transplantation, primary graft dysfunction (PGD), cell and antibody mediated rejection and infection.

Citation： XU Longming, ZUO Yunxia, LIN Yidan. Research status of lung transplantation and standardized management during transplantation period. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2020, 27(2): 209-213. doi: 10.7507/1007-4848.201907022 Copy

1.	Hartert M, Senbaklavacin O, Gohrbandt B, et al. Lung transplantation: a treatment option in end-stage lung disease. Dtsch Arztebl Int, 2014, 111(7): 107-116.
2.	Yusen RD, Edwards LB, Dipchand AI, et al. The Registry of the International Society for Heart and Lung Transplantation: Thirty-third adult lung and heart-lung transplant report-2016; Focus theme: primary diagnostic indications for transplant. J Heart Lung Transplant, 2016, 35(10): 1170-1184.
3.	Singer JP, Katz PP, Soong A, et al. Effect of lung transplantation on health-related quality of life in the era of the lung allocation score: A U.S. prospective cohort study. Am J Transplant, 2017, 17(5): 1334-1345.
4.	Vock DM, Durheim MT, Tsuang WM, et al. Survival benefit of lung transplantation in the modern era of lung allocation. Ann Am Thorac Soc, 2017, 14(2): 172-181.
5.	Oude Lansink-Hartgring A, Hessels L, de Vries AJ, et al. Donor hypernatremia is not related with the duration of postoperative mechanical ventilation, primary graft dysfunction, or long-term outcome following lung transplantation. Ann Transplant, 2018, 23: 500-506.
6.	Weill D, Benden C, Corris PA, et al. A consensus document for the selection of lung transplant candidates: 2014--an update from the Pulmonary Transplantation Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant, 2015, 34(1): 1-15.
7.	Verleden GM, Dupont L, Yserbyt J, et al. Recipient selection process and listing for lung transplantation. J Thorac Dis, 2017, 9(9): 3372-3384.
8.	Ceulemans LJ, Strypstein S, Neyrinck A, et al. Combined liver-thoracic transplantation: single-center experience with introduction of the ‘liver-first’ principle. Transpl Int, 2016, 29(6): 715-726.
9.	Fong TL, Cho YW, Hou L, et al. Outcomes after lung transplantation and practices of lung transplant programs in the United States regarding hepatitis C seropositive recipients. Transplantation, 2011, 91(11): 1293-1296.
10.	Bendorf A, Kelly PJ, Kerridge IH, et al. An international comparison of the effect of policy shifts to organ donation following cardiocirculatory death (DCD) on donation rates after brain death (DBD) and transplantation rates. PLoS One, 2013, 8(5): e62010.
11.	Costa J, Shah L, Robbins H, et al. Use of lung allografts from donation after cardiac death donors: A single-center experience. Ann Thorac Surg, 2018, 105(1): 271-278.
12.	Ruttens D, Martens A, Ordies S, et al. Short- and long-term outcomes after lung transplantation from circulatory-dead donors: A single-center experience. transplantation, 2017, 101(11): 2691-2694.
13.	Starnes VA, Bowdish ME, Woo MS, et al. A decade of living lobar lung transplantation: recipient outcomes. J Thorac Cardiovasc Surg, 2004, 127(1): 114-122.
14.	Date H. Current status and problems of lung transplantation in Japan. J Thorac Dis, 2016, 8(Suppl 8): S631-S636.
15.	McIlroy DR, Pilcher DV, Snell GI. Does anaesthetic management affect early outcomes after lung transplant? An exploratory analysis. Br J Anaesth, 2009, 102(4): 506-514.
16.	Sfakianaki AK, Copel JA. Congenital cystic lesions of the lung: congenital cystic adenomatoid malformation and broncho-pulmonary sequestration. Rev Obstet Gynecol, 2012, 5(2): 85-93.
17.	Lynch JP 3rd, Sayah DM, Belperio JA, et al. Lung transplantation for cystic fibrosis: results, indications, complications, and controversies. Semin Respir Crit Care Med, 2015, 36(2): 299-320.
18.	Yeung JC, Keshavjee S. Overview of clinical lung transplantation. Cold Spring Harb Perspect Med, 2014, 4(1): a015628.
19.	Weinstein EJ, Levene JL, Cohen MS, et al. Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent postoperative pain in adults and children. Cochrane Database Syst Rev, 2018, 4: CD007105.
20.	Sen A, Callisen HE, Alwardt CM, et al. Adult venovenous extracorporeal membrane oxygenation for severe respiratory failure: Current status and future perspectives. Ann Card Anaesth, 2016, 19(1): 97-111.
21.	Zangrillo A, Garozzo FA, Biondi-Zoccai G, et al. Miniaturized cardiopulmonary bypass improves short-term outcome in cardiac surgery: a meta-analysis of randomized controlled studies. J Thorac Cardiovasc Surg, 2010, 139(5): 1162-1169.
22.	Lafarge M, Mordant P, Thabut G, et al. Experience of extracorporeal membrane oxygenation as a bridge to lung transplantation in France. J Heart Lung Transplant, 2013, 32(9): 905-913.
23.	Oto T, Rosenfeldt F, Rowland M, et al. Extracorporeal membrane oxygenation after lung transplantation: evolving technique improves outcomes. Ann Thorac Surg, 2004, 78(4): 1230-1235.
24.	Ratnani I, Tuazon D, Zainab A, et al. The role and impact of extracorporeal membrane oxygenation in critical Care. Methodist Debakey Cardiovasc J, 2018, 14(2): 110-119.
25.	Delnoij TS, Driessen R, Sharma AS, et al. Venovenous extracorporeal membrane oxygenation in intractable pulmonary insufficiency: practical issues and future directions. Biomed Res Int, 2016, 2016: 9367464.
26.	Hayanga AJ, Aboagye J, Esper S, et al. Extracorporeal membrane oxygenation as a bridge to lung transplantation in the United States: an evolving strategy in the management of rapidly advancing pulmonary disease. J Thorac Cardiovasc Surg, 2015, 149(1): 291-296.
27.	Sharma NS, Hartwig MG, Hayes D Jr. Extracorporeal membrane oxygenation in the pre and post lung transplant period. Ann Transl Med, 2017, 5(4): 74.
28.	Hayanga JW, Lira A, Aboagye JK, et al. Extracorporeal membrane oxygenation as a bridge to lung transplantation: what lessons might we learn from volume and expertise? Interact Cardiovasc Thorac Surg, 2016, 22(4): 406-410.
29.	Nosotti M, Rosso L, Tosi D, et al. Extracorporeal membrane oxygenation with spontaneous breathing as a bridge to lung transplantation. Interact Cardiovasc Thorac Surg, 2013, 16(1): 55-59.
30.	Opelz G, DöHler B, Ruhenstroth A, et al. The collaborative transplant study registry. Transplant Rev, 2013, 27(2): 43-45.
31.	Meyer KC. Recent advances in lung transplantation. F1000 Res, 2018, 7: 1684.

1. Hartert M, Senbaklavacin O, Gohrbandt B, et al. Lung transplantation: a treatment option in end-stage lung disease. Dtsch Arztebl Int, 2014, 111(7): 107-116.
2. Yusen RD, Edwards LB, Dipchand AI, et al. The Registry of the International Society for Heart and Lung Transplantation: Thirty-third adult lung and heart-lung transplant report-2016; Focus theme: primary diagnostic indications for transplant. J Heart Lung Transplant, 2016, 35(10): 1170-1184.
3. Singer JP, Katz PP, Soong A, et al. Effect of lung transplantation on health-related quality of life in the era of the lung allocation score: A U.S. prospective cohort study. Am J Transplant, 2017, 17(5): 1334-1345.
4. Vock DM, Durheim MT, Tsuang WM, et al. Survival benefit of lung transplantation in the modern era of lung allocation. Ann Am Thorac Soc, 2017, 14(2): 172-181.
5. Oude Lansink-Hartgring A, Hessels L, de Vries AJ, et al. Donor hypernatremia is not related with the duration of postoperative mechanical ventilation, primary graft dysfunction, or long-term outcome following lung transplantation. Ann Transplant, 2018, 23: 500-506.
6. Weill D, Benden C, Corris PA, et al. A consensus document for the selection of lung transplant candidates: 2014--an update from the Pulmonary Transplantation Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant, 2015, 34(1): 1-15.
7. Verleden GM, Dupont L, Yserbyt J, et al. Recipient selection process and listing for lung transplantation. J Thorac Dis, 2017, 9(9): 3372-3384.
8. Ceulemans LJ, Strypstein S, Neyrinck A, et al. Combined liver-thoracic transplantation: single-center experience with introduction of the ‘liver-first’ principle. Transpl Int, 2016, 29(6): 715-726.
9. Fong TL, Cho YW, Hou L, et al. Outcomes after lung transplantation and practices of lung transplant programs in the United States regarding hepatitis C seropositive recipients. Transplantation, 2011, 91(11): 1293-1296.
10. Bendorf A, Kelly PJ, Kerridge IH, et al. An international comparison of the effect of policy shifts to organ donation following cardiocirculatory death (DCD) on donation rates after brain death (DBD) and transplantation rates. PLoS One, 2013, 8(5): e62010.
11. Costa J, Shah L, Robbins H, et al. Use of lung allografts from donation after cardiac death donors: A single-center experience. Ann Thorac Surg, 2018, 105(1): 271-278.
12. Ruttens D, Martens A, Ordies S, et al. Short- and long-term outcomes after lung transplantation from circulatory-dead donors: A single-center experience. transplantation, 2017, 101(11): 2691-2694.
13. Starnes VA, Bowdish ME, Woo MS, et al. A decade of living lobar lung transplantation: recipient outcomes. J Thorac Cardiovasc Surg, 2004, 127(1): 114-122.
14. Date H. Current status and problems of lung transplantation in Japan. J Thorac Dis, 2016, 8(Suppl 8): S631-S636.
15. McIlroy DR, Pilcher DV, Snell GI. Does anaesthetic management affect early outcomes after lung transplant? An exploratory analysis. Br J Anaesth, 2009, 102(4): 506-514.
16. Sfakianaki AK, Copel JA. Congenital cystic lesions of the lung: congenital cystic adenomatoid malformation and broncho-pulmonary sequestration. Rev Obstet Gynecol, 2012, 5(2): 85-93.
17. Lynch JP 3rd, Sayah DM, Belperio JA, et al. Lung transplantation for cystic fibrosis: results, indications, complications, and controversies. Semin Respir Crit Care Med, 2015, 36(2): 299-320.
18. Yeung JC, Keshavjee S. Overview of clinical lung transplantation. Cold Spring Harb Perspect Med, 2014, 4(1): a015628.
19. Weinstein EJ, Levene JL, Cohen MS, et al. Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent postoperative pain in adults and children. Cochrane Database Syst Rev, 2018, 4: CD007105.
20. Sen A, Callisen HE, Alwardt CM, et al. Adult venovenous extracorporeal membrane oxygenation for severe respiratory failure: Current status and future perspectives. Ann Card Anaesth, 2016, 19(1): 97-111.
21. Zangrillo A, Garozzo FA, Biondi-Zoccai G, et al. Miniaturized cardiopulmonary bypass improves short-term outcome in cardiac surgery: a meta-analysis of randomized controlled studies. J Thorac Cardiovasc Surg, 2010, 139(5): 1162-1169.
22. Lafarge M, Mordant P, Thabut G, et al. Experience of extracorporeal membrane oxygenation as a bridge to lung transplantation in France. J Heart Lung Transplant, 2013, 32(9): 905-913.
23. Oto T, Rosenfeldt F, Rowland M, et al. Extracorporeal membrane oxygenation after lung transplantation: evolving technique improves outcomes. Ann Thorac Surg, 2004, 78(4): 1230-1235.
24. Ratnani I, Tuazon D, Zainab A, et al. The role and impact of extracorporeal membrane oxygenation in critical Care. Methodist Debakey Cardiovasc J, 2018, 14(2): 110-119.
25. Delnoij TS, Driessen R, Sharma AS, et al. Venovenous extracorporeal membrane oxygenation in intractable pulmonary insufficiency: practical issues and future directions. Biomed Res Int, 2016, 2016: 9367464.
26. Hayanga AJ, Aboagye J, Esper S, et al. Extracorporeal membrane oxygenation as a bridge to lung transplantation in the United States: an evolving strategy in the management of rapidly advancing pulmonary disease. J Thorac Cardiovasc Surg, 2015, 149(1): 291-296.
27. Sharma NS, Hartwig MG, Hayes D Jr. Extracorporeal membrane oxygenation in the pre and post lung transplant period. Ann Transl Med, 2017, 5(4): 74.
28. Hayanga JW, Lira A, Aboagye JK, et al. Extracorporeal membrane oxygenation as a bridge to lung transplantation: what lessons might we learn from volume and expertise? Interact Cardiovasc Thorac Surg, 2016, 22(4): 406-410.
29. Nosotti M, Rosso L, Tosi D, et al. Extracorporeal membrane oxygenation with spontaneous breathing as a bridge to lung transplantation. Interact Cardiovasc Thorac Surg, 2013, 16(1): 55-59.
30. Opelz G, DöHler B, Ruhenstroth A, et al. The collaborative transplant study registry. Transplant Rev, 2013, 27(2): 43-45.
31. Meyer KC. Recent advances in lung transplantation. F1000 Res, 2018, 7: 1684.

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Research status of lung transplantation and standardized management during transplantation period

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