Changes of serum cTnI level in patients after lung transplantation: A retrospective study in a single center_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

JIANG Wenyang , WANG Wei , JIANG Wanli , WANG Bo , SU Yunshu , DING Xiangchao , ZHANG Xinghua , KANG Ganjun ,  LIN Huiqing ,  GENG Qing

Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, P. R. China;

Corresponding author：

LIN Huiqing, Email: huiqing.lin@whu.edu.cn; GENG Qing, Email: szgqing@126.com

Keywords：

Lung transplantation; troponin; restrictive pulmonary disease; obstructive pulmonary disease

DOI：

10.7507/1007-4848.202304011

Video：

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Objective To investigate the changes of serum cardiac-specific troponin I (cTnI) level in patients after lung transplantation. Methods Clinical data of patients undergoing lung transplantation in our hospital from December 2016 to December 2022 were retrospectively analyzed. The relationship between postoperative serum cTnI level and clinical characteristics were explored. Results Finally 20 patients were collected, including 15 males and 5 females with an average age of (51.65±12.79) years. The serum cTnI level was significantly increased after lung transplantation. The serum cTnI reached the highest level on the first day after transplantation, and significantly decreased from the third day after transplantation. The serum cTnI levels in patients with obstructive pulmonary disease and bilateral lung transplantation were significantly higher than those in patients with restrictive pulmonary disease and unilateral lung transplantation on the day after surgery and on the first day after transplantation. Conclusion Transient myocardial injury can occur after lung transplantation, which is characterized by an abnormal increase in serum cTnI level.

Citation： JIANG Wenyang, WANG Wei, JIANG Wanli, WANG Bo, SU Yunshu, DING Xiangchao, ZHANG Xinghua, KANG Ganjun, LIN Huiqing, GENG Qing. Changes of serum cTnI level in patients after lung transplantation: A retrospective study in a single center. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2024, 31(11): 1621-1624. doi: 10.7507/1007-4848.202304011 Copy

1.	Jaffe AS, Ravkilde J, Roberts R, et al. It's time for a change to a troponin standard. Circulation, 2000, 102(11): 1216-1220.
2.	Wong PSC, Lip GYH. The diagnostic role of cardiac troponin I beyond acute myocardial infarction. Ann Transl Med, 2023, 11(3): 142.
3.	Puelacher C, Lurati Buse G, Seeberger D, et al. Perioperative myocardial injury after noncardiac surgery: Incidence, mortality, and characterization. Circulation, 2018, 137(12): 1221-1232.
4.	江文洋, 耿庆, 王博, 等. 单中心肺移植围手术期治疗经验总结. 临床外科杂志, 2020, 28(3): 247-249.Jiang WY, Geng Q, Wang B, et al. Experience of perioperative treatment of lung transplantation in a single institute. J Clin Surg, 2020, 28(3): 247-249.
5.	Maisel AS, Bhalla V, Braunwald E. Cardiac biomarkers: A contemporary status report. Nat Clin Pract Cardiovasc Med, 2006, 3(1): 24-34.
6.	中国医师协会检验医师分会心血管专家委员会. 心肌肌钙蛋白实验室检测与临床应用中国专家共识. 中华医学杂志, 2021, 101(37): 2947-2961.Cardiovascular Expert Committee of the Laboratory Physicians Branch of the Chinese Medical Association. Chinese experts consensus on laboratory testing and clinical application of cardiac troponin. Natl Med J China, 2021, 101(37): 2947-2961.
7.	Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J, 2019, 40(3): 237-269.
8.	De Santo LS, Torella M, Romano G, et al. Perioperative myocardial injury after adult heart transplant: Determinants and prognostic value. PLoS One, 2015, 10(5): e0120813.
9.	Ambrosi P, Kreitmann B, Fromonot J, et al. Plasma ultrasensitive cardiac troponin during long-term follow-up of heart transplant recipients. J Card Fail, 2015, 21(2): 103-107.
10.	Canbolat IP, Adali G, Akdeniz CS, et al. Postoperative myocardial injury does not predict early and 1-year mortality after living donor liver transplantation. Transplant Proc, 2019, 51(7): 2478-2481.
11.	Park J, Lee SH, Han S, et al. Elevated high-sensitivity troponin I during living donor liver transplantation is associated with postoperative adverse outcomes. Transplantation, 2018, 102(5): e236-e244.
12.	Jankowski K, Trzebicki J, Bielecki M, et al. Prognostic value of perioperative assessment of plasma cardiac troponin I in patients undergoing liver transplantation. Acta Biochim Pol, 2017, 64(2): 331-337.
13.	Shroff GR, Akkina SK, Miedema MD, et al. Troponin I levels and postoperative myocardial infarction following renal transplantation. Am J Nephrol, 2012, 35(2): 175-180.
14.	Bozbas H, Korkmaz ME, Atar I, et al. Serum levels of cardiac enzymes before and after renal transplantation. Clin Cardiol, 2004, 27(10): 559-562.
15.	芦树军, 张雅静, 喻文立. 乌司他丁对胰-肾联合移植患者围术期心肌损伤的影响. 临床麻醉学杂志, 2022, 38(5): 453-457.Lu SJ, Zhang YJ, Yu WL. Influence of uinastatin on perioperative myocardial injury in patients undergoing simultaneous pan-creas-kidney transplantation. J Clin Anesthesiol, 2022, 38(5): 453-457.
16.	Rotz SJ, Ryan TD, Jodele S, et al. The injured heart: Early cardiac effects of hematopoietic stem cell transplantation in children and young adults. Bone Marrow Transplant, 2017, 52(8): 1171-1179.

1. Jaffe AS, Ravkilde J, Roberts R, et al. It's time for a change to a troponin standard. Circulation, 2000, 102(11): 1216-1220.
2. Wong PSC, Lip GYH. The diagnostic role of cardiac troponin I beyond acute myocardial infarction. Ann Transl Med, 2023, 11(3): 142.
3. Puelacher C, Lurati Buse G, Seeberger D, et al. Perioperative myocardial injury after noncardiac surgery: Incidence, mortality, and characterization. Circulation, 2018, 137(12): 1221-1232.
4. 江文洋, 耿庆, 王博, 等. 单中心肺移植围手术期治疗经验总结. 临床外科杂志, 2020, 28(3): 247-249.Jiang WY, Geng Q, Wang B, et al. Experience of perioperative treatment of lung transplantation in a single institute. J Clin Surg, 2020, 28(3): 247-249.
5. Maisel AS, Bhalla V, Braunwald E. Cardiac biomarkers: A contemporary status report. Nat Clin Pract Cardiovasc Med, 2006, 3(1): 24-34.
6. 中国医师协会检验医师分会心血管专家委员会. 心肌肌钙蛋白实验室检测与临床应用中国专家共识. 中华医学杂志, 2021, 101(37): 2947-2961.Cardiovascular Expert Committee of the Laboratory Physicians Branch of the Chinese Medical Association. Chinese experts consensus on laboratory testing and clinical application of cardiac troponin. Natl Med J China, 2021, 101(37): 2947-2961.
7. Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J, 2019, 40(3): 237-269.
8. De Santo LS, Torella M, Romano G, et al. Perioperative myocardial injury after adult heart transplant: Determinants and prognostic value. PLoS One, 2015, 10(5): e0120813.
9. Ambrosi P, Kreitmann B, Fromonot J, et al. Plasma ultrasensitive cardiac troponin during long-term follow-up of heart transplant recipients. J Card Fail, 2015, 21(2): 103-107.
10. Canbolat IP, Adali G, Akdeniz CS, et al. Postoperative myocardial injury does not predict early and 1-year mortality after living donor liver transplantation. Transplant Proc, 2019, 51(7): 2478-2481.
11. Park J, Lee SH, Han S, et al. Elevated high-sensitivity troponin I during living donor liver transplantation is associated with postoperative adverse outcomes. Transplantation, 2018, 102(5): e236-e244.
12. Jankowski K, Trzebicki J, Bielecki M, et al. Prognostic value of perioperative assessment of plasma cardiac troponin I in patients undergoing liver transplantation. Acta Biochim Pol, 2017, 64(2): 331-337.
13. Shroff GR, Akkina SK, Miedema MD, et al. Troponin I levels and postoperative myocardial infarction following renal transplantation. Am J Nephrol, 2012, 35(2): 175-180.
14. Bozbas H, Korkmaz ME, Atar I, et al. Serum levels of cardiac enzymes before and after renal transplantation. Clin Cardiol, 2004, 27(10): 559-562.
15. 芦树军, 张雅静, 喻文立. 乌司他丁对胰-肾联合移植患者围术期心肌损伤的影响. 临床麻醉学杂志, 2022, 38(5): 453-457.Lu SJ, Zhang YJ, Yu WL. Influence of uinastatin on perioperative myocardial injury in patients undergoing simultaneous pan-creas-kidney transplantation. J Clin Anesthesiol, 2022, 38(5): 453-457.
16. Rotz SJ, Ryan TD, Jodele S, et al. The injured heart: Early cardiac effects of hematopoietic stem cell transplantation in children and young adults. Bone Marrow Transplant, 2017, 52(8): 1171-1179.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Changes of serum cTnI level in patients after lung transplantation: A retrospective study in a single center

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