CHEN Hao 1,2,3 , ZHU Jianwei 1,2,3 , SHI Hongcan 1,2,3
  • 1. Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225009, Jiangsu, P. R. China;
  • 2. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225009, Jiangsu, P. R. China;
  • 3. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou, Jiangsu, 225009, P. R. China;
SHI Hongcan, Email: shihongcan@yzu.edu.cn
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[Abstract]Extracellular matrix (ECM) provides a unique tissue-specific microenvironment for resident cells with the structure and biochemical signaling required for their functioning. Decellularized extracellular matrix (dECM) is designed to remove cells that mediate immune rejection and retain the original tissue structure and matrix function. dECM has attracted extensive attention in tissue engineering and has become a new full-fledged tissue engineering material. This article summarizes representative methods for decellularization, and discusses the emerging frontiers of decellularized tissue-derived materials and bioinks in the field of thoracic and cardiovascular surgery. Finally, we analyze the current problems and challenges faced by decellularized matrices, and anticipate future development trends.