Correlation analysis between monocyte count to high-density lipoprotein ratio and early complications after coronary artery bypass grafting_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

HOU Yusheng ¹ ,  ZHOU Zhongxin ² , CAO Guodong ¹ , DU Miaomiao ^1,2 , LI Qing ^1,2

1. Graduate School of Xuzhou Medical University, Xuzhou, 221004, Jiangsu, P. R. China;
2. Department of Cardiothoracic Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221006, Jiangsu, P. R. China;

Corresponding author：

ZHOU Zhongxin, Email: zzxgqh@163.com

Keywords：

Coronary heart disease; coronary artery bypass grafting; monocyte count to high-density lipoprotein ratio; postoperative atrial fibrillation; acute kidney injury

DOI：

10.7507/1007-4848.202405057

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the effect of monocyte count to high density lipoprotein ratio (MHR) on early complications after off-pump coronary artery bypass grafting and to explore the predictive factors for early complications in patients after off-pump coronary artery bypass grafting. Methods The clinical data of patients who underwent simple off-pump coronary artery bypass grafting from October 2021 to September 2023 in our hospital were retrospectively analyzed. The patients were divided into a low value group and a high value group according to the median MHR value. The clinical data of the two groups were compared, and binary logistic regression analysis was used to explore the and predictors of atrial fibrillation (AF) and acute kidney injury (AKI) after coronary artery bypass grafting. Results A total of 220 patients were included, with a median MHR of 0.48. There were 108 patients in the low value group (MHR<0.48), including 71 males and 37 females, with an average age of 65.28±7.85 years. There were 112 patients in the high-value group (MHR≥0.48), including 84 males and 28 females, with an average age of 64.57±8.75 years. There was no statistical difference between the two groups in terms of general basic data such as gender or age (P>0.05). The incidence of postoperative AF and AKI in the high-value group was significantly higher than that in the low-value group (P<0.05), and no statistical difference in terms of other postoperative complications was observed. Binary logistic regression analysis showed that MHR was a risk factor for postoperative AKI and postoperative AF (P<0.05). Conclusion The study shows that MHR is a risk factor for new-onset AF and AKI after coronary artery bypass grafting.

1.	Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med, 2005, 352(16): 1685-1695.
2.	Unal EU, Durukan AB, Ozen A, et al. Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery. Turk Gogus Kalp Damar, 2013, 21: 588-593.
3.	Oylumlu M, Yıldız A, Oylumlu M, et al. Platelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome. Anatol J Cardiol, 2015, 15(4): 277-283.
4.	Ganjali S, Gotto AM, Ruscica M, et al. Monocyte-to-HDL-cholesterol ratio as a prognostic marker in cardiovascular diseases. J Cell Physiol, 2018, 233(12): 9237-9246.
5.	Kanbay M, Solak Y, Unal HU, et al. Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease. Int Urol Nephrol, 2014, 46(8): 1619-1625.
6.	Wu Q, Mao W. New prognostic factor for hepatitis B virus-related decompensated cirrhosis: Ratio of monocytes to HDL-cholesterol. J Clin Lab Anal, 2021, 35(11): e24007.
7.	Karahan S, Okuyan E. Monocyte-to-high density lipoprotein cholesterol ratio as a predictor of mortality in patients with transcatheter aortic valve replacement. Eur Rev Med Pharmacol Sci, 2021, 25(16): 5153-5162.
8.	Cardoso CRL, Leite NC, Salles GF. Importance of hematological parameters for micro- and macrovascular outcomes in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study. Cardiovasc Diabetol, 2021, 20(1): 133.
9.	Li Q, Lin X, Bo X, et al. Monocyte to high-density lipoprotein cholesterol ratio predicts poor outcomes in ischaemic heart failure patients combined with diabetes: a retrospective study. Eur J Med Res, 2023, 28(1): 493.
10.	Saskin H, Serhan Ozcan K, Yilmaz S. High preoperative monocyte count/high-density lipoprotein ratio is associated with postoperative atrial fibrillation and mortality in coronary artery bypass grafting. Interact Cardiovasc Thorac Surg, 2017, 24(3): 395-401.
11.	Kellum JA, Lameire N,. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care, 2013, 17(1): 204.
12.	Manfrini O, Cenko E, Ricci B, et al. Post cardiovascular surgery atrial fibrillation. biomarkers determining prognosis. Curr Med Chem, 2019, 26(5): 916-924.
13.	Chatterjee S, Chandra P, Guha G, et al. Pre-procedural elevated white blood cell count and neutrophil-lymphocyte (N/L) ratio are predictors of ventricular arrhythmias during percutaneous coronary intervention. Cardiovasc Hematol Disord Drug Targets, 2011, 11(2): 58-60.
14.	Bäck M, Yurdagul A, Tabas I, et al. Inflammation and its resolution in atherosclerosis: Mediators and therapeutic opportunities. Nat Rev Cardiol, 2019, 16(7): 389-406.
15.	Yılmaz M, Kayançiçek H. A New Inflammatory Marker: Elevated Monocyte to HDL Cholesterol Ratio Associated with Smoking. J Clin Med, 2018, 7(4): 76.
16.	Canpolat U, Aytemir K, Yorgun H, et al. The role of preprocedural monocyte-to-high-density lipoprotein ratio in prediction of atrial fibrillation recurrence after cryoballoon-based catheter ablation. Europace, 2015, 17(12): 1807-1815.
17.	Korodi S, Toganel R, Benedek T, et al. Impact of inflammation-mediated myocardial fibrosis on the risk of recurrence after successful ablation of atrial fibrillation - the FIBRO-RISK study: Protocol for a non-randomized clinical trial. Medicine (Baltimore), 2019, 98(9): e14504.
18.	Wang Y, Bellomo R. Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment. Nat Rev Nephrol, 2017, 13(11): 697-711.
19.	Wu X, Ma C, Sun D, et al. Inflammatory indicators and hematological indices in contrast-induced nephropathy among patients receiving coronary intervention: A systematic review and meta-analysis. Angiology, 2021, 72(9): 867-877.
20.	Parlar H, Arıkan AA, Önmez A. Dynamic changes in perioperative cellular inflammation and acute kidney injury after coronary artery bypass grafting. Braz J Cardiovasc Surg, 2021, 36(3): 354-364.
21.	Şaşkın H. Is pre-operative monocyte count-high-density lipoprotein ratio associated with postoperative acute kidney injury in isolated coronary artery bypass grafting? Cardiovasc J Afr, 2023, 34(5): 278-284.

1. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med, 2005, 352(16): 1685-1695.
2. Unal EU, Durukan AB, Ozen A, et al. Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery. Turk Gogus Kalp Damar, 2013, 21: 588-593.
3. Oylumlu M, Yıldız A, Oylumlu M, et al. Platelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome. Anatol J Cardiol, 2015, 15(4): 277-283.
4. Ganjali S, Gotto AM, Ruscica M, et al. Monocyte-to-HDL-cholesterol ratio as a prognostic marker in cardiovascular diseases. J Cell Physiol, 2018, 233(12): 9237-9246.
5. Kanbay M, Solak Y, Unal HU, et al. Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease. Int Urol Nephrol, 2014, 46(8): 1619-1625.
6. Wu Q, Mao W. New prognostic factor for hepatitis B virus-related decompensated cirrhosis: Ratio of monocytes to HDL-cholesterol. J Clin Lab Anal, 2021, 35(11): e24007.
7. Karahan S, Okuyan E. Monocyte-to-high density lipoprotein cholesterol ratio as a predictor of mortality in patients with transcatheter aortic valve replacement. Eur Rev Med Pharmacol Sci, 2021, 25(16): 5153-5162.
8. Cardoso CRL, Leite NC, Salles GF. Importance of hematological parameters for micro- and macrovascular outcomes in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study. Cardiovasc Diabetol, 2021, 20(1): 133.
9. Li Q, Lin X, Bo X, et al. Monocyte to high-density lipoprotein cholesterol ratio predicts poor outcomes in ischaemic heart failure patients combined with diabetes: a retrospective study. Eur J Med Res, 2023, 28(1): 493.
10. Saskin H, Serhan Ozcan K, Yilmaz S. High preoperative monocyte count/high-density lipoprotein ratio is associated with postoperative atrial fibrillation and mortality in coronary artery bypass grafting. Interact Cardiovasc Thorac Surg, 2017, 24(3): 395-401.
11. Kellum JA, Lameire N,. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care, 2013, 17(1): 204.
12. Manfrini O, Cenko E, Ricci B, et al. Post cardiovascular surgery atrial fibrillation. biomarkers determining prognosis. Curr Med Chem, 2019, 26(5): 916-924.
13. Chatterjee S, Chandra P, Guha G, et al. Pre-procedural elevated white blood cell count and neutrophil-lymphocyte (N/L) ratio are predictors of ventricular arrhythmias during percutaneous coronary intervention. Cardiovasc Hematol Disord Drug Targets, 2011, 11(2): 58-60.
14. Bäck M, Yurdagul A, Tabas I, et al. Inflammation and its resolution in atherosclerosis: Mediators and therapeutic opportunities. Nat Rev Cardiol, 2019, 16(7): 389-406.
15. Yılmaz M, Kayançiçek H. A New Inflammatory Marker: Elevated Monocyte to HDL Cholesterol Ratio Associated with Smoking. J Clin Med, 2018, 7(4): 76.
16. Canpolat U, Aytemir K, Yorgun H, et al. The role of preprocedural monocyte-to-high-density lipoprotein ratio in prediction of atrial fibrillation recurrence after cryoballoon-based catheter ablation. Europace, 2015, 17(12): 1807-1815.
17. Korodi S, Toganel R, Benedek T, et al. Impact of inflammation-mediated myocardial fibrosis on the risk of recurrence after successful ablation of atrial fibrillation - the FIBRO-RISK study: Protocol for a non-randomized clinical trial. Medicine (Baltimore), 2019, 98(9): e14504.
18. Wang Y, Bellomo R. Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment. Nat Rev Nephrol, 2017, 13(11): 697-711.
19. Wu X, Ma C, Sun D, et al. Inflammatory indicators and hematological indices in contrast-induced nephropathy among patients receiving coronary intervention: A systematic review and meta-analysis. Angiology, 2021, 72(9): 867-877.
20. Parlar H, Arıkan AA, Önmez A. Dynamic changes in perioperative cellular inflammation and acute kidney injury after coronary artery bypass grafting. Braz J Cardiovasc Surg, 2021, 36(3): 354-364.
21. Şaşkın H. Is pre-operative monocyte count-high-density lipoprotein ratio associated with postoperative acute kidney injury in isolated coronary artery bypass grafting? Cardiovasc J Afr, 2023, 34(5): 278-284.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Latest ArticlesCorrelation analysis between monocyte count to high-density lipoprotein ratio and early complications after coronary artery bypass grafting

Abstract Full text Figures/Tables Video References Cited by

Format

Content