Research Progress of Black Cohosh Root Extract in The Treatment of Menopausal Symptoms for Patients with Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CHAIYu-lin ¹ , SONGYi-ning ¹ , SUJun-qiang ² ,  JIHong-liang ¹

1. Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China;
2. Department of Surgical Oncology, The First Affiliated Hospital of Jiamusi University, Jiamusi 154007, Heilongjiang Province, China;

Corresponding author：

JIHong-liang, Email: jihongliang2012@163.com

Keywords：

Black cohosh root extract; Menopausal symptoms; Breast cancer

DOI：

10.7507/1007-9424.20140380

Video：

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Objective To summarize the research progress of black cohosh root extract in the treatment of menopausal symptoms for patients with breast cancer. Methods Domestic and foreign literatures about the effect of black cohosh root extract in the treatment of menopausal symptoms for patients with breast cancer were collected to make a review. Results Black cohosh root extract was a kind of herbal preparations. In the treatment of menopausal symptoms in breast cancer patients, it not only had significantly curative effect but also had less adverse reactions. Conclusions In the treatment of menopausal symptoms in breast cancer patients, black cohosh root extract gives people a new treatment idea. It has significant side effect and can be widely promoted and applied in clinical.

Citation： CHAIYu-lin, SONGYi-ning, SUJun-qiang, JIHong-liang. Research Progress of Black Cohosh Root Extract in The Treatment of Menopausal Symptoms for Patients with Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(12): 1598-1601. doi: 10.7507/1007-9424.20140380 Copy

1.	张海燕, 任钧, 张高东, 等.产后妇女骨密度变化及影响因素研究[J].重庆医学, 2011, 40(25):2539-2540.
2.	Freeman EW, Guthrie KA, Caan B, et al.Efficacy of escitalopram for hot flashes in healthy menopausal women:a randomized controlled trial[J].JAMA, 2011, 305(3):267-274.
3.	Parkin DM, Pisani P, Ferlay J.Global cancer statistics[J].CA Cancer J Clin, 1999, 49(1):33-64.
4.	Cancer Genome Atlas Network.Comprehensive molecular portr-aits of human breast tumours[J].Nature, 2012, 490(7418):61-70.
5.	Henneicke-Von Zepelin HH, Meden H, Kostev K, et al.Isopro-panolic black cohosh extract and recurrence-free survival after breast cancer[J].Int J Clin Pharmacol Ther, 2007, 45(3):143-154.
6.	Park IH, Han HS, Lee H, et al.Resumption or persistence of menstruation after cytotoxic chemotherapy is a prognostic factor for poor disease-free survival in premenopausal patients with early breast cancer[J].Ann Oncol, 2012, 23(9):2283-2289.
7.	黄秀霞, 陈丽珍.性激素替代治疗妇女更年期综合征100例临床分析[J].中外医学研究, 2011, 9(15):51-52.
8.	Fillmore CM, Gupta PB, Rudnick JA, et al.Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling[J].Proc Natl Acad Sci U S A, 2010, 107(50):21737-21742.
9.	林莉芬.小剂量雌激素治疗围绝经期综合征疗效分析[J].中国当代医药, 2012, 19(6):65-67.
10.	Kloosterboer HJ.Historical milestones in the development of tibolone (Livial^®)[J].Climacteric, 2011, 14(6):609-621.
11.	Saxe EL.Chemopreventive potential and action of the herb black cohosh on Sprague-Dawley rats[J].Anticancer Res, 2012, 3(1):455-457.
12.	张莉.围绝经期抑郁症状与血清性激素水平的关联性研究[J].安徽卫生职业技术学院学报, 2010, 9((2):29-30.
13.	方芳, 张绍芬.绝经后激素治疗应用时机及期限[J].中国实用妇科与产科杂志, 2011, 27(5):330-333.
14.	Lobo RA.Potential options for preservation of fertility in women[J].N Engl J Med, 2005, 353(1):64-73.
15.	Posada MN, Kolp L, Garcia JE.Fertility options for female cancer patients:facts and fiction[J].Fertil Steril, 2001, 75(4):647-653.
16.	Fiaher B, Dignam J, Bryant J, et al.Five versus more than five years of tamoxifen for lymph node-negative breast cancer:updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial[J].J Natl Cancer Inst, 2001, 93(9):684-690.
17.	孙宁霞, 金志军, 贾晓峰, 等.黑升麻制剂改善绝经后妇女阴道萎缩症状的探讨[J].第二军医大学学报, 2012, 33(3):339-342.
18.	李文, 孙宁霞, 陈旭, 等.早期子宫内膜癌患者术后应用黑升麻制剂治疗绝经相关症状[J].第二军医大学学报, 2012, 33(5):562-564.
19.	Hostanska K, Nisslein T, Freudenstein J, et al.Evaluation of cell death caused by triterpene glycosides and phenolic substances from Cimicifuga racemosa extract in human MCF-7 breast cancer cells[J].Biol Pharm Bull, 2004, 27(12):1970-1975.
20.	Liske E, Hänggi W, Henneicke-Von Zepelin HH, et al.Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizoma):a 6-month clinical study demonstrates no systemic estrogenic effect[J].J Womens Health Gend Based Med, 2002, 11(2):163-174.
21.	Bodinet C, Freudenstein J.Influence of marketed herbal menopause preparations on MCF-7 cell proliferation[J].Menopause, 2004, 11(3):281-289.
22.	Gurley BJ, Swain A, Hubbard MA, et al.Clinical assessment of CYP2D6-mediated herb-drug interactions in humans:effects of milk thistle, black cohosh, goldenseal, kava kava, St.John's wort, and Echinacea[J].Mol Nutr Food Res, 2008, 52(7):755-763.
23.	Powell SL, Gödecke T, Nikolic D, et al.In vitro serotonergic activity of black cohosh and identification of N (omega)-methylserotonin as a potential active constituent[J].J Agric Food Chem, 2008, 56(24):11718-11726.
24.	马晓艳, 张慧, 王珂, 等.莉芙敏对去卵巢大鼠下丘脑视前区5-HT1AR和5-HT2AR表达的影响[J].国际妇产科学杂志, 2011, 38(2):148-154.
25.	Cicek SS, Khom S, Taferner B, et al.Bioactivity-guided isolation of GABA (A) receptor modulating constituents from the rhizo-mes of Actaea racemosa[J].J Nat Prod, 2010, 73(12):2024-2028.
26.	Reame NE, Lukacs JL, Padmanabhan V, et al.Black cohosh has central opioid activity in postmenopausal women:evidence from naloxone blockade and positron emission tomography neuroimaging[J].Menopause, 2008, 15(5):832-840.
27.	Teschke R, Schwarzenboeck A.Suspected hepatotoxicity by Cimicifugae racemosae rhizoma (black cohosh, root):critical analysis and structured causality assessment[J].Phytomedicine, 2009, 16(1):72-84.
28.	潘雪飞, 杜斌, 范群, 等.综合分析药物性肝损伤4076例[J].东南国防医药, 2009, 11(6):505-507.
29.	Kass-Annese B.Altemative therapies for menopause[J].Clin Obstet Gynecol, 2000, 43(1):162-183.
30.	曹泽毅.中华妇产科学[M].北京:人民卫生出版社, 1999:518-519.
31.	Burdette JE, Liu J, Chen SN, et al.Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor[J].J Agric Food Chem, 2003, 51(19):5661-5670.
32.	Hickey M, Davis SR, Sturdee DW.Treatment of menopausal zymptoms:what shall we do now?[J].Lancet, 2005, 366(9483):409-421.
33.	Rebbeck TR, Troxel AB, Norman S, et al.A retrospective case-control study of the use of hormone-related supplements and association with breast cancer[J].Int J Cancer, 2007, 120(7):1523-1528.
34.	庞雪, 孟莉英, 张欣, 等.治疗围绝经期综合征的传统植物药——莉芙敏[J].中国药学杂志, 2010, 45(16):1279-1280.
35.	Rossouw JE, Anderson GL, Prentice RL, et al.Risks and benefits of estrogen plus progestin in healthy postmenopausal women:principal results from the Women's Health Initiative randomized controlled trial[J].JAMA, 2002, 288(3):321-333.
36.	Bai W, Henneicke-Von Zepelin HH, Wang S, et al.Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms:a randomized, double blind, parallel-controlled study versus tibolone[J].Maturitas, 2007, 58(1):31-41.
37.	Borrelli F, Ernst E.Cimicifuga racemosa:a systematic review of its clinical efficacy[J].Eur J Clin Pharmacol, 2002, 58(4):235-241.
38.	Qsmers R, Friede M, Liske E, et al.Efficacy and safety of isopro-panolic black cohosh extract for climacteric symptoms[J].Obstet Gynecol, 2005, 105(5 Pt 1):1074-1083.
39.	徐融.莉芙敏片与利维爱改善围绝经期症状的效果和安全性比较[J].中国全科医学, 2011, 14(35):4060-4063.
40.	李轶琳, 崔满华, 高双.黑升麻类药物莉芙敏治疗更年期症状临床疗效观察[J].现代妇产科进展, 2011, 20(6):462-465.
41.	Jacobsen DE, Melis RJ, Verhaar HJ, et al.Raloxifene and tibo-lone in elderly women:a randomized, double-blind, double-dummy, placebo-controlled trial[J].J Am Med Dir Assoc, 2012, 13(2):189.e1-189.e7.
42.	Ahn BS, Yang M, Jang H, et al.Evaluation of the antiosteopo-rotic potential of Cimicifuga heracleifolia in female mice[J].Phytother Res, 2012, 26(5):663-668.
43.	Li-Yu J, Perez EC, Cañete A, et al.Consensus statements on osteoporosis diagnosis, prevention, and management in the Philippines[J].Int J Rheum Dis, 2011, 14(3):223-238.

1. 张海燕, 任钧, 张高东, 等.产后妇女骨密度变化及影响因素研究[J].重庆医学, 2011, 40(25):2539-2540.
2. Freeman EW, Guthrie KA, Caan B, et al.Efficacy of escitalopram for hot flashes in healthy menopausal women:a randomized controlled trial[J].JAMA, 2011, 305(3):267-274.
3. Parkin DM, Pisani P, Ferlay J.Global cancer statistics[J].CA Cancer J Clin, 1999, 49(1):33-64.
4. Cancer Genome Atlas Network.Comprehensive molecular portr-aits of human breast tumours[J].Nature, 2012, 490(7418):61-70.
5. Henneicke-Von Zepelin HH, Meden H, Kostev K, et al.Isopro-panolic black cohosh extract and recurrence-free survival after breast cancer[J].Int J Clin Pharmacol Ther, 2007, 45(3):143-154.
6. Park IH, Han HS, Lee H, et al.Resumption or persistence of menstruation after cytotoxic chemotherapy is a prognostic factor for poor disease-free survival in premenopausal patients with early breast cancer[J].Ann Oncol, 2012, 23(9):2283-2289.
7. 黄秀霞, 陈丽珍.性激素替代治疗妇女更年期综合征100例临床分析[J].中外医学研究, 2011, 9(15):51-52.
8. Fillmore CM, Gupta PB, Rudnick JA, et al.Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling[J].Proc Natl Acad Sci U S A, 2010, 107(50):21737-21742.
9. 林莉芬.小剂量雌激素治疗围绝经期综合征疗效分析[J].中国当代医药, 2012, 19(6):65-67.
10. Kloosterboer HJ.Historical milestones in the development of tibolone (Livial^®)[J].Climacteric, 2011, 14(6):609-621.
11. Saxe EL.Chemopreventive potential and action of the herb black cohosh on Sprague-Dawley rats[J].Anticancer Res, 2012, 3(1):455-457.
12. 张莉.围绝经期抑郁症状与血清性激素水平的关联性研究[J].安徽卫生职业技术学院学报, 2010, 9((2):29-30.
13. 方芳, 张绍芬.绝经后激素治疗应用时机及期限[J].中国实用妇科与产科杂志, 2011, 27(5):330-333.
14. Lobo RA.Potential options for preservation of fertility in women[J].N Engl J Med, 2005, 353(1):64-73.
15. Posada MN, Kolp L, Garcia JE.Fertility options for female cancer patients:facts and fiction[J].Fertil Steril, 2001, 75(4):647-653.
16. Fiaher B, Dignam J, Bryant J, et al.Five versus more than five years of tamoxifen for lymph node-negative breast cancer:updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial[J].J Natl Cancer Inst, 2001, 93(9):684-690.
17. 孙宁霞, 金志军, 贾晓峰, 等.黑升麻制剂改善绝经后妇女阴道萎缩症状的探讨[J].第二军医大学学报, 2012, 33(3):339-342.
18. 李文, 孙宁霞, 陈旭, 等.早期子宫内膜癌患者术后应用黑升麻制剂治疗绝经相关症状[J].第二军医大学学报, 2012, 33(5):562-564.
19. Hostanska K, Nisslein T, Freudenstein J, et al.Evaluation of cell death caused by triterpene glycosides and phenolic substances from Cimicifuga racemosa extract in human MCF-7 breast cancer cells[J].Biol Pharm Bull, 2004, 27(12):1970-1975.
20. Liske E, Hänggi W, Henneicke-Von Zepelin HH, et al.Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizoma):a 6-month clinical study demonstrates no systemic estrogenic effect[J].J Womens Health Gend Based Med, 2002, 11(2):163-174.
21. Bodinet C, Freudenstein J.Influence of marketed herbal menopause preparations on MCF-7 cell proliferation[J].Menopause, 2004, 11(3):281-289.
22. Gurley BJ, Swain A, Hubbard MA, et al.Clinical assessment of CYP2D6-mediated herb-drug interactions in humans:effects of milk thistle, black cohosh, goldenseal, kava kava, St.John's wort, and Echinacea[J].Mol Nutr Food Res, 2008, 52(7):755-763.
23. Powell SL, Gödecke T, Nikolic D, et al.In vitro serotonergic activity of black cohosh and identification of N (omega)-methylserotonin as a potential active constituent[J].J Agric Food Chem, 2008, 56(24):11718-11726.
24. 马晓艳, 张慧, 王珂, 等.莉芙敏对去卵巢大鼠下丘脑视前区5-HT1AR和5-HT2AR表达的影响[J].国际妇产科学杂志, 2011, 38(2):148-154.
25. Cicek SS, Khom S, Taferner B, et al.Bioactivity-guided isolation of GABA (A) receptor modulating constituents from the rhizo-mes of Actaea racemosa[J].J Nat Prod, 2010, 73(12):2024-2028.
26. Reame NE, Lukacs JL, Padmanabhan V, et al.Black cohosh has central opioid activity in postmenopausal women:evidence from naloxone blockade and positron emission tomography neuroimaging[J].Menopause, 2008, 15(5):832-840.
27. Teschke R, Schwarzenboeck A.Suspected hepatotoxicity by Cimicifugae racemosae rhizoma (black cohosh, root):critical analysis and structured causality assessment[J].Phytomedicine, 2009, 16(1):72-84.
28. 潘雪飞, 杜斌, 范群, 等.综合分析药物性肝损伤4076例[J].东南国防医药, 2009, 11(6):505-507.
29. Kass-Annese B.Altemative therapies for menopause[J].Clin Obstet Gynecol, 2000, 43(1):162-183.
30. 曹泽毅.中华妇产科学[M].北京:人民卫生出版社, 1999:518-519.
31. Burdette JE, Liu J, Chen SN, et al.Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor[J].J Agric Food Chem, 2003, 51(19):5661-5670.
32. Hickey M, Davis SR, Sturdee DW.Treatment of menopausal zymptoms:what shall we do now?[J].Lancet, 2005, 366(9483):409-421.
33. Rebbeck TR, Troxel AB, Norman S, et al.A retrospective case-control study of the use of hormone-related supplements and association with breast cancer[J].Int J Cancer, 2007, 120(7):1523-1528.
34. 庞雪, 孟莉英, 张欣, 等.治疗围绝经期综合征的传统植物药——莉芙敏[J].中国药学杂志, 2010, 45(16):1279-1280.
35. Rossouw JE, Anderson GL, Prentice RL, et al.Risks and benefits of estrogen plus progestin in healthy postmenopausal women:principal results from the Women's Health Initiative randomized controlled trial[J].JAMA, 2002, 288(3):321-333.
36. Bai W, Henneicke-Von Zepelin HH, Wang S, et al.Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms:a randomized, double blind, parallel-controlled study versus tibolone[J].Maturitas, 2007, 58(1):31-41.
37. Borrelli F, Ernst E.Cimicifuga racemosa:a systematic review of its clinical efficacy[J].Eur J Clin Pharmacol, 2002, 58(4):235-241.
38. Qsmers R, Friede M, Liske E, et al.Efficacy and safety of isopro-panolic black cohosh extract for climacteric symptoms[J].Obstet Gynecol, 2005, 105(5 Pt 1):1074-1083.
39. 徐融.莉芙敏片与利维爱改善围绝经期症状的效果和安全性比较[J].中国全科医学, 2011, 14(35):4060-4063.
40. 李轶琳, 崔满华, 高双.黑升麻类药物莉芙敏治疗更年期症状临床疗效观察[J].现代妇产科进展, 2011, 20(6):462-465.
41. Jacobsen DE, Melis RJ, Verhaar HJ, et al.Raloxifene and tibo-lone in elderly women:a randomized, double-blind, double-dummy, placebo-controlled trial[J].J Am Med Dir Assoc, 2012, 13(2):189.e1-189.e7.
42. Ahn BS, Yang M, Jang H, et al.Evaluation of the antiosteopo-rotic potential of Cimicifuga heracleifolia in female mice[J].Phytother Res, 2012, 26(5):663-668.
43. Li-Yu J, Perez EC, Cañete A, et al.Consensus statements on osteoporosis diagnosis, prevention, and management in the Philippines[J].Int J Rheum Dis, 2011, 14(3):223-238.

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Research Progress of Black Cohosh Root Extract in The Treatment of Menopausal Symptoms for Patients with Breast Cancer

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