Research Progress of Mucinous Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Mucinous breast cancer; Pure mucinous breast cancer; Mixed mucinous breast cancer; Molecular markers; Lymph node metastasis

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10.7507/1007-9424.20150198

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Objective To summarize the research progress of mucinous breast cancer (MBC). Methods Literatures about the recent studies of MBC were reviewed. Results MBC was one of special subtype of infiltrating breast cancer. According to the mucus ingredient in the ratio of the mass, MBC was divided into pure mucinous breast cancer (PMBC) and mixed mucinous breast cancer (MMBC). Compared to infiltrating ductal cancer-not otherwise specified (IDC-NOS), MBC showed higher positive expression rates of estrogen receptor (ER) and progestrogen receptor (PR), with reduced lymph node metastasis rate and better prognosis. PMBC had lower lymph node metastasis rate and better outcome than MMBC. Conclusions There is significant difference about clinical and pathological characteristics between MBC and IDC-NOS. Researches are generally believed that MBC is an uncommon breast neoplasm which is associated with a good prognosis.

Citation： . Research Progress of Mucinous Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(6): 763-766. doi: 10.7507/1007-9424.20150198 Copy

1.	Ha KY, Deleon P, Deleon W. Invasive mucinous carcinoma of the breast. Proc (Bayl Univ Med Cent), 2013, 26(3):295-297.
2.	Bae SY, Choi MY, Cho DH, et al. Mucinous carcinoma of the breast in comparison with invasive ductal carcinoma:clinicopathologic characteristics and prognosis. J Breast Cancer, 2011, 14(4):308-313.
3.	Cardenosa G, Doudna C, Eklund GW. Mucinous (colloid) breast cancer:clinical and mammographic findings in 10 patients. AJR Am J Roentgenol, 1994, 162(5):1077-1079.
4.	Lam WW, Chu WC, Tse GM, et al. Sonographic appearance of mucinous carcinoma of the breast. AJR Am J Roentgenol, 2004, 182(4):1069-1074.
5.	Cyrta J, Andreiuolo F, Azoulay S, et al. Pure and mixed mucinous carcinoma of the breast:fine needle aspiration cytology findings and review of the literature. Cytopathology, 2013, 24(6):377-384.
6.	Kashiwagi S, Onoda N, Asano Y, et al. Clinical significance of the sub-classification of 71 cases mucinous breast carcinoma. Springerplus, 2013, 2:481.
7.	Ranade A, Batra R, Sandhu G, et al. Clinicopathological evaluation of 100 cases of mucinous carcinoma of breast with emphasis on axillary staging and special reference to a micropapillary pattern. J Clin Pathol, 2010, 63(12):1043-1047.
8.	蔺会云, 皋岚湘, 金木兰, 等.以微乳头状结构为特点的乳腺单纯型黏液癌临床病理观察.中华病理学杂志, 2012, 41(9):613-617.
9.	Ishida M, Umeda T, Abe H, et al. Neuroendocrine carcinoma of the breast with a mucinous carcinoma component:a case report with review of the literature. Oncol Lett, 2012, 4(1):29-32.
10.	Park S, Koo J, Kim JH, et al. Clinicopathological characteristics of mucinous carcinoma of the breast in Korea:comparison with invasive ductal carcinoma-not otherwise specified. J Korean Med Sci, 2010, 25(3):361-368.
11.	Leung KM, Yeoh GP, Chan JK, et al. Ductal type signet ring cell carcinoma of breast with growth pattern of pure mucinous carcinoma. Pathology, 2011, 43(3):282-284.
12.	Tseng HS, Lin C, Chan SE, et al. Pure mucinous carcinoma of the breast:clinicopathologic characteristics and long-term outcome among Taiwanese women. World J Surg Oncol, 2013, 11:139.
13.	Zhang M, Teng XD, Guo XX, et al. Clinicopathological characteristics and prognosis of mucinous breast carcinoma. J Cancer Res Clin Oncol, 2014, 140(2):265-269.
14.	Cao AY, He M, Liu ZB, et al. Outcome of pure mucinous breast carcinoma compared to infiltrating ductal carcinoma:a population-based study from China. Ann Surg Oncol, 2012, 19(9):3019-3027.
15.	Zekioglu O, Erhan Y, Ciriş M, et al. Neuroendocrine differentiated carcinomas of the breast:a distinct entity. Breast, 2003, 12(4):251-257.
16.	Erhan Y, Ciris M, Zekioglu O, et al. Do clinical and immunohistochemical findings of pure mucinous breast carcinoma differ from mixed mucinous breast carcinoma?. Acta Chir Belg, 2009, 109(2):204-208.
17.	Sharma S, Bansal R, Khare A, et al. Mucinous carcinoma of breast:cytodiagnosis of a case. J Cytol, 2011, 28(1):42-44.
18.	Aggarwal R, Rajni, Khanna G, et al. Mucinous carcinoma in a male breast. J Cytol, 2011, 28(2):84-86.
19.	Ingle AP, Kulkarni AS, Patil SP, et al. Mucinous carcinoma of the male breast with axillary lymph node metastasis:report of a case based on fine needle aspiration cytology. J Cytol, 2012, 29(1):72-74.
20.	Di Saverio S, Gutierrez J, Avisar E. A retrospective review with long term follow up of 11 400 cases of pure mucinous breast carcinoma. Breast Cancer Res Treat, 2008, 111(3):541-547.
21.	Norris HJ, Taylor HB. Prognosis of mucinous (gelatinous) carcinoma of the breast. Cancer, 1965, 18:879-885.
22.	Ahmed A. The myoepithelium in human breast carcinoma. J Pathol, 1974, 114(3):135-138.
23.	Melamed MR, Robbins GF, Foote FW Jr. Prognostic significance of gelations mammary carcinoma. Cancer, 1961, 14(4):699-704.
24.	王桂兰, 耿翠芝, 吴祥德, 等.乳腺粘液腺癌的临床特性分析.实用癌症杂志, 1995, 10(2):96-98.
25.	Jambal P, Badtke MM, Harrell JC, et al. Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features. Breast Cancer Res Treat, 2013, 137(2):431-448.
26.	Liu H, Tan H, Cheng Y, et al. Imaging findings in mucinous breast carcinoma and correlating factors. Eur J Radiol, 2011, 80(3):706-712.
27.	Zhang L, Jia N, Han L, et al. Comparative analysis of imaging and pathology features of mucinous carcinoma of the breast. Clin Breast Cancer, 2015, 15(2):e147-e154.
28.	Kaoku S, Konishi E, Fujimoto Y, et al. Sonographic and pathologic image analysis of pure mucinous carcinoma of the breast. Ultrasound Med Biol, 2013, 39(7):1158-1167.
29.	Tan JZ, Waugh J, Kumar B, et al. Mucinous carcinomas of the breast:imaging features and potential for misdiagnosis. J Med Imaging Radiat Oncol, 2013, 57(1):25-31.
30.	Dhillon R, Depree P, Metcalf C, et al. Screen-detected mucinous breast carcinoma:potential for delayed diagnosis. Clin Radiol, 2006, 61(5):423-430.
31.	Baltatzis GE, Gaitanarou H, Arnogianaki N, et al.Biochemical and ultrastructural correlations of calreticulin and thioredoxin expression in breast mucinous carcinoma and infiltrating ductal carcinoma non-special type.Ultrastruct Pathol, 2011, 35(1):7-13.
32.	范林军, 姜军, 赵菲, 等.乳腺粘液癌临床病理特点分析.第三军医大学学报, 2003, 25(23):2077-2079.
33.	Dogan E, Aksoy S, Dizdar O, et al.Pure mucinous carcinoma of the breast:a single center experience.J BUON, 2011, 16(3):565-567.
34.	Nakagawa T, Sato K, Moriwaki M, et al.Successful endocrine therapy for locally advanced mucinous carcinoma of the breast.Breast J, 2012, 18(6):632-633.
35.	Hanagiri T, Ono K, Baba T, et al.Clinicopathologic characteristics of mucinous carcinoma of the breast.Int Surg, 2010, 95(2):126-129.

1. Ha KY, Deleon P, Deleon W. Invasive mucinous carcinoma of the breast. Proc (Bayl Univ Med Cent), 2013, 26(3):295-297.
2. Bae SY, Choi MY, Cho DH, et al. Mucinous carcinoma of the breast in comparison with invasive ductal carcinoma:clinicopathologic characteristics and prognosis. J Breast Cancer, 2011, 14(4):308-313.
3. Cardenosa G, Doudna C, Eklund GW. Mucinous (colloid) breast cancer:clinical and mammographic findings in 10 patients. AJR Am J Roentgenol, 1994, 162(5):1077-1079.
4. Lam WW, Chu WC, Tse GM, et al. Sonographic appearance of mucinous carcinoma of the breast. AJR Am J Roentgenol, 2004, 182(4):1069-1074.
5. Cyrta J, Andreiuolo F, Azoulay S, et al. Pure and mixed mucinous carcinoma of the breast:fine needle aspiration cytology findings and review of the literature. Cytopathology, 2013, 24(6):377-384.
6. Kashiwagi S, Onoda N, Asano Y, et al. Clinical significance of the sub-classification of 71 cases mucinous breast carcinoma. Springerplus, 2013, 2:481.
7. Ranade A, Batra R, Sandhu G, et al. Clinicopathological evaluation of 100 cases of mucinous carcinoma of breast with emphasis on axillary staging and special reference to a micropapillary pattern. J Clin Pathol, 2010, 63(12):1043-1047.
8. 蔺会云, 皋岚湘, 金木兰, 等.以微乳头状结构为特点的乳腺单纯型黏液癌临床病理观察.中华病理学杂志, 2012, 41(9):613-617.
9. Ishida M, Umeda T, Abe H, et al. Neuroendocrine carcinoma of the breast with a mucinous carcinoma component:a case report with review of the literature. Oncol Lett, 2012, 4(1):29-32.
10. Park S, Koo J, Kim JH, et al. Clinicopathological characteristics of mucinous carcinoma of the breast in Korea:comparison with invasive ductal carcinoma-not otherwise specified. J Korean Med Sci, 2010, 25(3):361-368.
11. Leung KM, Yeoh GP, Chan JK, et al. Ductal type signet ring cell carcinoma of breast with growth pattern of pure mucinous carcinoma. Pathology, 2011, 43(3):282-284.
12. Tseng HS, Lin C, Chan SE, et al. Pure mucinous carcinoma of the breast:clinicopathologic characteristics and long-term outcome among Taiwanese women. World J Surg Oncol, 2013, 11:139.
13. Zhang M, Teng XD, Guo XX, et al. Clinicopathological characteristics and prognosis of mucinous breast carcinoma. J Cancer Res Clin Oncol, 2014, 140(2):265-269.
14. Cao AY, He M, Liu ZB, et al. Outcome of pure mucinous breast carcinoma compared to infiltrating ductal carcinoma:a population-based study from China. Ann Surg Oncol, 2012, 19(9):3019-3027.
15. Zekioglu O, Erhan Y, Ciriş M, et al. Neuroendocrine differentiated carcinomas of the breast:a distinct entity. Breast, 2003, 12(4):251-257.
16. Erhan Y, Ciris M, Zekioglu O, et al. Do clinical and immunohistochemical findings of pure mucinous breast carcinoma differ from mixed mucinous breast carcinoma?. Acta Chir Belg, 2009, 109(2):204-208.
17. Sharma S, Bansal R, Khare A, et al. Mucinous carcinoma of breast:cytodiagnosis of a case. J Cytol, 2011, 28(1):42-44.
18. Aggarwal R, Rajni, Khanna G, et al. Mucinous carcinoma in a male breast. J Cytol, 2011, 28(2):84-86.
19. Ingle AP, Kulkarni AS, Patil SP, et al. Mucinous carcinoma of the male breast with axillary lymph node metastasis:report of a case based on fine needle aspiration cytology. J Cytol, 2012, 29(1):72-74.
20. Di Saverio S, Gutierrez J, Avisar E. A retrospective review with long term follow up of 11 400 cases of pure mucinous breast carcinoma. Breast Cancer Res Treat, 2008, 111(3):541-547.
21. Norris HJ, Taylor HB. Prognosis of mucinous (gelatinous) carcinoma of the breast. Cancer, 1965, 18:879-885.
22. Ahmed A. The myoepithelium in human breast carcinoma. J Pathol, 1974, 114(3):135-138.
23. Melamed MR, Robbins GF, Foote FW Jr. Prognostic significance of gelations mammary carcinoma. Cancer, 1961, 14(4):699-704.
24. 王桂兰, 耿翠芝, 吴祥德, 等.乳腺粘液腺癌的临床特性分析.实用癌症杂志, 1995, 10(2):96-98.
25. Jambal P, Badtke MM, Harrell JC, et al. Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features. Breast Cancer Res Treat, 2013, 137(2):431-448.
26. Liu H, Tan H, Cheng Y, et al. Imaging findings in mucinous breast carcinoma and correlating factors. Eur J Radiol, 2011, 80(3):706-712.
27. Zhang L, Jia N, Han L, et al. Comparative analysis of imaging and pathology features of mucinous carcinoma of the breast. Clin Breast Cancer, 2015, 15(2):e147-e154.
28. Kaoku S, Konishi E, Fujimoto Y, et al. Sonographic and pathologic image analysis of pure mucinous carcinoma of the breast. Ultrasound Med Biol, 2013, 39(7):1158-1167.
29. Tan JZ, Waugh J, Kumar B, et al. Mucinous carcinomas of the breast:imaging features and potential for misdiagnosis. J Med Imaging Radiat Oncol, 2013, 57(1):25-31.
30. Dhillon R, Depree P, Metcalf C, et al. Screen-detected mucinous breast carcinoma:potential for delayed diagnosis. Clin Radiol, 2006, 61(5):423-430.
31. Baltatzis GE, Gaitanarou H, Arnogianaki N, et al.Biochemical and ultrastructural correlations of calreticulin and thioredoxin expression in breast mucinous carcinoma and infiltrating ductal carcinoma non-special type.Ultrastruct Pathol, 2011, 35(1):7-13.
32. 范林军, 姜军, 赵菲, 等.乳腺粘液癌临床病理特点分析.第三军医大学学报, 2003, 25(23):2077-2079.
33. Dogan E, Aksoy S, Dizdar O, et al.Pure mucinous carcinoma of the breast:a single center experience.J BUON, 2011, 16(3):565-567.
34. Nakagawa T, Sato K, Moriwaki M, et al.Successful endocrine therapy for locally advanced mucinous carcinoma of the breast.Breast J, 2012, 18(6):632-633.
35. Hanagiri T, Ono K, Baba T, et al.Clinicopathologic characteristics of mucinous carcinoma of the breast.Int Surg, 2010, 95(2):126-129.

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