• 1. The First Clinical Medical College of Lanzhou University, Lanzhou 730000, P. R. China;
  • 2. Department of Gastrointestinal Surgery, Hernia and Abdominal Wall Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, P. R. China;
YU Yongjiang, Email: ylongy@163.com
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Objective To summarise the influencing factors of gut microbiota in the perioperative period and its regulatory mechanism in postoperative pain, with the aim of providing clinical reference for postoperative pain management. Method Relevant literatures on gut microbiota and postoperative pain in recent years were systematically reviewed and synthesised. Results Anaesthesia, preoperative mechanical bowel preparation, surgical stress, etc. could cause gut microbiota dysbiosis. Gut microbiota directly or indirectly modulated the excitability of primary sensory neurons through their derived metabolites and pathogen-associated molecular patterns and influenced the pain signalling process by activating immune cells to release cytokines. Conclusions Gut microbiota play an important role in the development and progression of postoperative pain. Future studies should further clarify its role in different types of postoperative pain and develop innovative therapeutic strategies based on the regulation of gut microbiota to improve the management of postoperative pain.

Citation: LIU Xusheng, LIU Jianxiao, PENG Bo, YU Yongjiang. Advances in the study of gut microbiota and postoperative pain:mechanisms and prospects for clinical application. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2024, 31(12): 1534-1539. doi: 10.7507/1007-9424.202408032 Copy

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