The correlation of serum 8-hydroxydeoxyguanosine and endothelin-1 levels with cognitive dysfunction in COPD patients_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHU Xiaoying ¹ , LIU Conghui ² ,  GE Yanlei ¹ , WANG Hongyang ¹ , CHEN Qiancheng ¹ , ZHANG Ci ¹ , LI Hongli ¹ , ZHANG Jiabin ¹ , WANG Yuan ¹

1. Department of Respiratory Medicine, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei 063000, P. R. China;
2. Department of Endocrinology, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei 063000, P. R. China;

Corresponding author：

GE Yanlei, Email: 495732196@qq.com

Keywords：

Chronic obstructive pulmonary disease; Cognitive function; Montreal cognitive assessment; 8-hydroxydeoxyguanosine; Endothelin-1

DOI：

10.7507/1671-6205.201805068

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Objective To investigate the correlation and clinical significance of 8-hydroxydeoxyguanosine (8-OHdG) and endothelin-1 (ET-1) levels with cognitive dysfunction in patients with chronic obstructive pulmonary disease (COPD), and provide new idea for the prevention and treatment for cognitive dysfunction in COPD patients.Methods A total of 103 COPD patients, according to the Montreal cognitive assessment scale standard for evaluation, were divided into a cognitive dysfunction group and a cognitive normal group. Serum 8-OHdG and ET-1 levels were compared between the two groups and their correlations with cognitive function were analyzed with the receiver operating characteristic (ROC) curve.Results The levels of serum 8-OHdG and ET-1 in the COPD patients with cognitive impairment were significantly higher than those in the cognitive normal group ［8-OHdG: (13.91±9.04) ng/ml vs. (7.28±3.00) ng/ml; ET-1: (95.64±57.66)pg/ml vs. (69.20±7.89)pg/ml］ (both P<0.05). The levels of 8-OHdG (OR=22.94, 95%CI 7.06-74.53) and ET-1 (OR=19.76, 95%CI 6.59-59.31) were associated with cognitive impairment in the COPD patients. The areas under ROC curve of serum 8-OHdG and ET-1 levels to predict cognitive dysfunction in the COPD patients were 0.786 (95%CI 0.691-0.881) and 0.790(95%CI 0.695-0.885).Conclusions The serum levels of 8-OHdG and ET-1 are associated with cognitive impairment in COPD patients. The levels of 8-OHdG and ET-1 in serum can predict cognitive impairment with high specificity.

Citation： ZHU Xiaoying, LIU Conghui, GE Yanlei, WANG Hongyang, CHEN Qiancheng, ZHANG Ci, LI Hongli, ZHANG Jiabin, WANG Yuan. The correlation of serum 8-hydroxydeoxyguanosine and endothelin-1 levels with cognitive dysfunction in COPD patients. Chinese Journal of Respiratory and Critical Care Medicine, 2019, 18(1): 10-14. doi: 10.7507/1671-6205.201805068 Copy

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4.	Wauters A, Dreyfuss C, Pochet S, et al. Acute exposure to diesel exhaust impairs nitric oxide-mediated endothelial vasomotor function by increasing endothelial oxidativestress. Hypertension, 2013, 62(2): 352-358.
5.	洪丽, 赵燕民, 李珂. 血清尿酸及血管内皮素-1 与轻度认知功能障碍相关性研究. 中华实用诊断与治疗杂志, 2013, 27(7): 670-672.
6.	郭炳鹏, 周露茜, 关力理, 等. 慢性阻塞性肺疾病呼吸康复与炎症反应及氧化应激的研究进展. 中华结核和呼吸杂志, 2017, 40(12): 15-17.
7.	蒋雪莲, 钟萍, 黄成亮, 等. 氧化应激反应标记物对慢性阻塞性肺疾病稳定期患者血清中的表达及意义. 中国呼吸与危重监护杂志, 2016, 15(6): 542-547.
8.	Li JH, Fei GH. The evaluation of cognitive impairment and relevant factors in patients with chronic obstructive pulmonary disease. Respiration, 2013, 85(2): 98-105.
9.	Milnerowicz H, Ściskalska M, Dul M. Molecular mechanisms of the impact of smoke-oxidants. Exp Toxicol Pathol, 2015, 67(7-8): 377-382.
10.	Dodd JW, Getov SV, Jones PW. Cognitive function in COPD. Eur Respir J, 2010, 35(4): 913-922.
11.	Valavanidis A, Vlachogianni T, Fiotakis C, et al. 8-hydroxy-2'-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 2009, 27(2): 120-139.
12.	Nakajima H, Unoda K, Ito T, et al. The relation of urinary 8-OHdG, a marker of oxidative stress to DNA, and clinical outcomes for ischemic stroke. Open Neurol J, 2012, 6: 51-57.
13.	苏恩勇, 高传玉. 内皮功能障碍与心血管疾病关系的研究进展. 中华实用诊断与治疗杂志, 2018, 32(6): 622-624.
14.	Spiropoulos K, Trakada G, Nikolaou E, et al. Endothelin-1 levels in the pathophysiology of chronic obstructive pulmonary disease and bronchial asthma. Respir Med, 2003, 97(8): 983-989.
15.	Vanhoutte PM, Shimokawa H, Feletou M, et al. Endothelial dysfunction and vascular a disease: a 30th anniversary update. Acta Physiol (Ocf), 2017, 219(1): 22-96.
16.	Briyal S, Philip T, Gulati A. Endothelin-A receptor antagonists prevent amyloid-beta-induced increase in ETA receptor expression, oxidative stress and cognitive impairment. J Alzheimers Dis, 2011, 23(3): 491-503.
17.	张魁, 田文静, 朱云亮, 等. 依那普利治疗老年脑血栓患者的疗效及其对内皮素-1 和超氧化物歧化酶水平的影响. 疑难病杂志, 2016, 15(6): 563-566.

1. 蔡柏蔷. 慢性阻塞性肺疾病诊断、处理和预防全球策略 (2017 GOLD 报告) 解读. 国际呼吸杂志, 2017, 37(1): 6-17.
2. 中华医学会呼吸学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南 (2007 修订版). 中华结核和呼吸杂志, 2007, 30(1): 8-17.
3. 李美珠. 血清 8-羟基脱氧鸟苷酸在急性脑梗死诊断中的应用. 广东医学, 2015, 36(20): 3191-3193.
4. Wauters A, Dreyfuss C, Pochet S, et al. Acute exposure to diesel exhaust impairs nitric oxide-mediated endothelial vasomotor function by increasing endothelial oxidativestress. Hypertension, 2013, 62(2): 352-358.
5. 洪丽, 赵燕民, 李珂. 血清尿酸及血管内皮素-1 与轻度认知功能障碍相关性研究. 中华实用诊断与治疗杂志, 2013, 27(7): 670-672.
6. 郭炳鹏, 周露茜, 关力理, 等. 慢性阻塞性肺疾病呼吸康复与炎症反应及氧化应激的研究进展. 中华结核和呼吸杂志, 2017, 40(12): 15-17.
7. 蒋雪莲, 钟萍, 黄成亮, 等. 氧化应激反应标记物对慢性阻塞性肺疾病稳定期患者血清中的表达及意义. 中国呼吸与危重监护杂志, 2016, 15(6): 542-547.
8. Li JH, Fei GH. The evaluation of cognitive impairment and relevant factors in patients with chronic obstructive pulmonary disease. Respiration, 2013, 85(2): 98-105.
9. Milnerowicz H, Ściskalska M, Dul M. Molecular mechanisms of the impact of smoke-oxidants. Exp Toxicol Pathol, 2015, 67(7-8): 377-382.
10. Dodd JW, Getov SV, Jones PW. Cognitive function in COPD. Eur Respir J, 2010, 35(4): 913-922.
11. Valavanidis A, Vlachogianni T, Fiotakis C, et al. 8-hydroxy-2'-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 2009, 27(2): 120-139.
12. Nakajima H, Unoda K, Ito T, et al. The relation of urinary 8-OHdG, a marker of oxidative stress to DNA, and clinical outcomes for ischemic stroke. Open Neurol J, 2012, 6: 51-57.
13. 苏恩勇, 高传玉. 内皮功能障碍与心血管疾病关系的研究进展. 中华实用诊断与治疗杂志, 2018, 32(6): 622-624.
14. Spiropoulos K, Trakada G, Nikolaou E, et al. Endothelin-1 levels in the pathophysiology of chronic obstructive pulmonary disease and bronchial asthma. Respir Med, 2003, 97(8): 983-989.
15. Vanhoutte PM, Shimokawa H, Feletou M, et al. Endothelial dysfunction and vascular a disease: a 30th anniversary update. Acta Physiol (Ocf), 2017, 219(1): 22-96.
16. Briyal S, Philip T, Gulati A. Endothelin-A receptor antagonists prevent amyloid-beta-induced increase in ETA receptor expression, oxidative stress and cognitive impairment. J Alzheimers Dis, 2011, 23(3): 491-503.
17. 张魁, 田文静, 朱云亮, 等. 依那普利治疗老年脑血栓患者的疗效及其对内皮素-1 和超氧化物歧化酶水平的影响. 疑难病杂志, 2016, 15(6): 563-566.

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The correlation of serum 8-hydroxydeoxyguanosine and endothelin-1 levels with cognitive dysfunction in COPD patients

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