低氧激发试验在评估慢性肺部疾病患者飞行缺氧中的应用_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

赵然然 ,  王浩彦

首都医科大学附属北京友谊医院呼吸内科（北京 100050）;

Corresponding author：

王浩彦, Email: haoyanw@ccmu.edu.cn

Keywords：

DOI：

10.7507/1671-6205.201903089

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Citation： 赵然然, 王浩彦. 低氧激发试验在评估慢性肺部疾病患者飞行缺氧中的应用. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(5): 510-514. doi: 10.7507/1671-6205.201903089 Copy

1.	Ergan B, Akgun M, Pacilli AMG, et al. Should I stay or should I go? COPD and air travel. Eur Respir Rev, 2018, 27(148): 180030.
2.	李松林, 吴坚, 梅亮, 等. 中国民用航空卫生保障工作的现状思考与展望. 空军医学杂志, 2011, 27(1): 8-20.
3.	Aerospace Medical Association, Aviation Safety Committee, Civil Aviation subcommittee. Cabin cruising altitudes for regular transport aircraft. Aviat Space Environ Med, 2008, 79(4): 433-439.
4.	Aerospace Medical Association Medical Guidelines Task Force. Medical Guidelines for Airline Travel, 2nd ed. Aviat Space Environ Med, 2003, 74(5 Suppl): A1-A9.
5.	Shrikrishna D, Coker RK, Air Travel Working Party of the British Thoracic Society Standards of Care Committee. Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations. Thorax, 2011, 66(9): 831-833.
6.	Dine CJ, Kreider ME. Hypoxia altitude simulation test. Chest, 2008, 133(4): 1002-1005.
7.	Lee AP, Yamamoto LG, Relles NL. Commercial airline travel decreases oxygen saturation in children. Pediatr Emerg Care, 2002, 18(2): 78-80.
8.	Ahmedzai S, Balfour-Lynn IM, Bewick T, et al. Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations. Thorax, 2011, 66(Suppl 1): i1-i30.
9.	Harding RM, Mills FJ. Aviation medicine. Problems of altitude 1: hypoxia and hyperventilation. Br Med J (Clin Res Ed), 1983, 286(6375): 1408-1410.
10.	Nicholson TT, Sznajder JI. Fitness to fly in patients with lung disease. Ann Am Thorac Soc, 2014, 11(10): 1614-1622.
11.	Mohr LC. The hypoxia altitude simulation test: an increasingly performed test for the evaluation of patients prior to air travel. Chest, 2008, 133(4): 839-842.
12.	Gong H Jr, Tashkin DP, Lee EY, et al. Hypoxia-altitude simulation test. Evaluation of patients with chronic airway obstruction. Am Rev Respir Dis, 1984, 130(6): 980-986.
13.	Kelly PT, Swanney MP, Seccombe LM, et al. Air travel hypoxemia vs. the hypoxia inhalation test in passengers with COPD. Chest, 2008, 133(4): 920-926.
14.	Billings CG, Wei HL, Thomas P, et al. The prediction of in-flight hypoxaemia using non-liner equations. Respir Med, 2013, 107(6): 841-847.
15.	Balfour-Lynn IM. Hypoxic challenge test for airflight in children with respiratory disease. Paediatr Respir Rev, 2017, 21: 62-64.
16.	Bagshaw M. Telemedicine in British airways. J Telemed Telecare, 1996, (2 Suppl): 36-38.
17.	王建智, 刘立, 郭俊, 等. 商业航空飞行中的紧急医学事件. 中华航空航天医学杂志, 2006, 17(3): 237-241.
18.	Akerø A, Edvardsen A, Christensen CC, et al. COPD and air travel: oxygen equipment and preflight titration of supplemental oxygen. Chest, 2011, 140(1): 84-90.
19.	Edvardsen A, Akerø A, Hardie JA, et al. High prevalence of respiratory symptoms during air travel in patients with COPD. Respir Med, 2011, 105(1): 50-56.
20.	Coker RK, Shiner RJ, Partridge MR. Is air travel safe for those with lung disease?. Eur Respir J, 2007, 30(6): 1057-1063.
21.	Akerø A, Christensen CC, Edvardsen A, et al. Pulse oximetry in the preflight evaluation of patients with chronic obstructive pulmonary disease. Aviat Space Environ Med, 2008, 79(5): 518-524.
22.	Edvardsen A, Akerø A, Christensen CC, et al. Air travel and chronic obstructive pulmonary disease: a new algorithm for pre-flight evaluation. Thorax, 2012, 67(11): 964-969.
23.	Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Arch Bronconeumol, 2017, 53(3): 128-149.
24.	Dillard TA, Moores LK, Bilello KL, et al. The preflight evaluation. A comparison of the hypoxia inhalation test with hypobaric exposure. Chest, 1995, 107(2): 352-357.
25.	Akerø A, Christensen CC, Edvardsen A, et al. Hypoxaemia in chronic obstructive pulmonary disease patients during a commercial flight. Eur Respir J, 2005, 25(4): 725-730.
26.	Christensen CC, Ryg M, Refvem OK, et al. Development of severe hypoxaemia in chronic obstructive pulmonary disease patients at 2, 438 m (8, 000 ft) altitude. Eur Respir J, 2000, 15(4): 635-639.
27.	Bradi AC, Faughnan ME, Stanbrook MB, et al. Predicting the need for supplemental oxygen during airline flight in patients with chronic obstructive pulmonary disease: a comparison of predictive equations and altitude simulation. Can Respir J, 2009, 16(4): 119-124.
28.	Chetta A, Castagnetti C, Aiello M, et al. Walking capacity and fitness to fly in patients with chronic respiratory disease. Aviat Space Environ Med, 2007, 78(8): 789-792.
29.	Elborn JS. Cystic fibrosis. Lancet, 2016, 388(10059): 2519-2531.
30.	Rose DM, Fleck B, Thews O, et al. Blood gas-analyses in patients with cystic fibrosis to estimate hypoxemia during exposure to high altitudes in a hypobaric-chamber. Eur J Med Res, 2000, 5(1): 9-12.
31.	Fischer R, Lang SM, Brückner, et al. Lung function in adults with cystic fibrosis at altitude: impact on air travel. Eur Respir J, 2005, 25(4): 718-724.
32.	Peckham D, Watson A, Pollard K, et al. Predictors of desaturation during formal hypoxic challenge in adult patients with cystic fibrosis. J Cyst Fibros, 2002, 1(4): 281-286.
33.	Edvardsen E, Akerø A, Skjønsberg OH, et al. Pre-flight evaluation of adult patients with cystic fibrosis: a cross-sectional study. BMC Res Notes, 2017, 10(1): 84.
34.	Kamin W, Fleck B, Rose DM, et al. Predicting hypoxia in cystic fibrosis patients during exposure to high altitudes. J Cyst Fibros, 2006, 5(4): 223-228.
35.	Ali M, Smith IE, Gulati A, et al. Hypoxic challenge assessment in individuals with obstructive sleep apnea. Sleep Med, 2011, 12(2): 158-162.
36.	李静, 王菡侨, 徐茂人, 等. 肥胖低通气综合征. 临床荟萃, 2016, 31(12): 1295-1297.
37.	Ali M, Smith IE, Gulati A, et al. Pre-flight assessment in patients with obesity hypoventilation syndrome. Respirology, 2014, 19(8): 1229-1232.
38.	蔡柏蔷, 李龙云, 主编. 协和呼吸病学. 第2版. 北京: 中国协和医科大学出版社, 2011, 1409.
39.	Seccombe LM, Kelly PT, Wong CK, et al. Effect of simulated commercial flight on oxygenation in patients with interstitial lung disease and chronic obstructive pulmonary disease. Thorax, 2004, 59(11): 966-970.
40.	Barratt SL, Shaw J, Jones R, et al. Physiological predictors of hypoxic challenge testing (HCT) outcomes in interstitial lung disease (ILD). Respir Med, 2018, 135: 51-56.

1. Ergan B, Akgun M, Pacilli AMG, et al. Should I stay or should I go? COPD and air travel. Eur Respir Rev, 2018, 27(148): 180030.
2. 李松林, 吴坚, 梅亮, 等. 中国民用航空卫生保障工作的现状思考与展望. 空军医学杂志, 2011, 27(1): 8-20.
3. Aerospace Medical Association, Aviation Safety Committee, Civil Aviation subcommittee. Cabin cruising altitudes for regular transport aircraft. Aviat Space Environ Med, 2008, 79(4): 433-439.
4. Aerospace Medical Association Medical Guidelines Task Force. Medical Guidelines for Airline Travel, 2nd ed. Aviat Space Environ Med, 2003, 74(5 Suppl): A1-A9.
5. Shrikrishna D, Coker RK, Air Travel Working Party of the British Thoracic Society Standards of Care Committee. Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations. Thorax, 2011, 66(9): 831-833.
6. Dine CJ, Kreider ME. Hypoxia altitude simulation test. Chest, 2008, 133(4): 1002-1005.
7. Lee AP, Yamamoto LG, Relles NL. Commercial airline travel decreases oxygen saturation in children. Pediatr Emerg Care, 2002, 18(2): 78-80.
8. Ahmedzai S, Balfour-Lynn IM, Bewick T, et al. Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations. Thorax, 2011, 66(Suppl 1): i1-i30.
9. Harding RM, Mills FJ. Aviation medicine. Problems of altitude 1: hypoxia and hyperventilation. Br Med J (Clin Res Ed), 1983, 286(6375): 1408-1410.
10. Nicholson TT, Sznajder JI. Fitness to fly in patients with lung disease. Ann Am Thorac Soc, 2014, 11(10): 1614-1622.
11. Mohr LC. The hypoxia altitude simulation test: an increasingly performed test for the evaluation of patients prior to air travel. Chest, 2008, 133(4): 839-842.
12. Gong H Jr, Tashkin DP, Lee EY, et al. Hypoxia-altitude simulation test. Evaluation of patients with chronic airway obstruction. Am Rev Respir Dis, 1984, 130(6): 980-986.
13. Kelly PT, Swanney MP, Seccombe LM, et al. Air travel hypoxemia vs. the hypoxia inhalation test in passengers with COPD. Chest, 2008, 133(4): 920-926.
14. Billings CG, Wei HL, Thomas P, et al. The prediction of in-flight hypoxaemia using non-liner equations. Respir Med, 2013, 107(6): 841-847.
15. Balfour-Lynn IM. Hypoxic challenge test for airflight in children with respiratory disease. Paediatr Respir Rev, 2017, 21: 62-64.
16. Bagshaw M. Telemedicine in British airways. J Telemed Telecare, 1996, (2 Suppl): 36-38.
17. 王建智, 刘立, 郭俊, 等. 商业航空飞行中的紧急医学事件. 中华航空航天医学杂志, 2006, 17(3): 237-241.
18. Akerø A, Edvardsen A, Christensen CC, et al. COPD and air travel: oxygen equipment and preflight titration of supplemental oxygen. Chest, 2011, 140(1): 84-90.
19. Edvardsen A, Akerø A, Hardie JA, et al. High prevalence of respiratory symptoms during air travel in patients with COPD. Respir Med, 2011, 105(1): 50-56.
20. Coker RK, Shiner RJ, Partridge MR. Is air travel safe for those with lung disease?. Eur Respir J, 2007, 30(6): 1057-1063.
21. Akerø A, Christensen CC, Edvardsen A, et al. Pulse oximetry in the preflight evaluation of patients with chronic obstructive pulmonary disease. Aviat Space Environ Med, 2008, 79(5): 518-524.
22. Edvardsen A, Akerø A, Christensen CC, et al. Air travel and chronic obstructive pulmonary disease: a new algorithm for pre-flight evaluation. Thorax, 2012, 67(11): 964-969.
23. Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Arch Bronconeumol, 2017, 53(3): 128-149.
24. Dillard TA, Moores LK, Bilello KL, et al. The preflight evaluation. A comparison of the hypoxia inhalation test with hypobaric exposure. Chest, 1995, 107(2): 352-357.
25. Akerø A, Christensen CC, Edvardsen A, et al. Hypoxaemia in chronic obstructive pulmonary disease patients during a commercial flight. Eur Respir J, 2005, 25(4): 725-730.
26. Christensen CC, Ryg M, Refvem OK, et al. Development of severe hypoxaemia in chronic obstructive pulmonary disease patients at 2, 438 m (8, 000 ft) altitude. Eur Respir J, 2000, 15(4): 635-639.
27. Bradi AC, Faughnan ME, Stanbrook MB, et al. Predicting the need for supplemental oxygen during airline flight in patients with chronic obstructive pulmonary disease: a comparison of predictive equations and altitude simulation. Can Respir J, 2009, 16(4): 119-124.
28. Chetta A, Castagnetti C, Aiello M, et al. Walking capacity and fitness to fly in patients with chronic respiratory disease. Aviat Space Environ Med, 2007, 78(8): 789-792.
29. Elborn JS. Cystic fibrosis. Lancet, 2016, 388(10059): 2519-2531.
30. Rose DM, Fleck B, Thews O, et al. Blood gas-analyses in patients with cystic fibrosis to estimate hypoxemia during exposure to high altitudes in a hypobaric-chamber. Eur J Med Res, 2000, 5(1): 9-12.
31. Fischer R, Lang SM, Brückner, et al. Lung function in adults with cystic fibrosis at altitude: impact on air travel. Eur Respir J, 2005, 25(4): 718-724.
32. Peckham D, Watson A, Pollard K, et al. Predictors of desaturation during formal hypoxic challenge in adult patients with cystic fibrosis. J Cyst Fibros, 2002, 1(4): 281-286.
33. Edvardsen E, Akerø A, Skjønsberg OH, et al. Pre-flight evaluation of adult patients with cystic fibrosis: a cross-sectional study. BMC Res Notes, 2017, 10(1): 84.
34. Kamin W, Fleck B, Rose DM, et al. Predicting hypoxia in cystic fibrosis patients during exposure to high altitudes. J Cyst Fibros, 2006, 5(4): 223-228.
35. Ali M, Smith IE, Gulati A, et al. Hypoxic challenge assessment in individuals with obstructive sleep apnea. Sleep Med, 2011, 12(2): 158-162.
36. 李静, 王菡侨, 徐茂人, 等. 肥胖低通气综合征. 临床荟萃, 2016, 31(12): 1295-1297.
37. Ali M, Smith IE, Gulati A, et al. Pre-flight assessment in patients with obesity hypoventilation syndrome. Respirology, 2014, 19(8): 1229-1232.
38. 蔡柏蔷, 李龙云, 主编. 协和呼吸病学. 第2版. 北京: 中国协和医科大学出版社, 2011, 1409.
39. Seccombe LM, Kelly PT, Wong CK, et al. Effect of simulated commercial flight on oxygenation in patients with interstitial lung disease and chronic obstructive pulmonary disease. Thorax, 2004, 59(11): 966-970.
40. Barratt SL, Shaw J, Jones R, et al. Physiological predictors of hypoxic challenge testing (HCT) outcomes in interstitial lung disease (ILD). Respir Med, 2018, 135: 51-56.

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低氧激发试验在评估慢性肺部疾病患者飞行缺氧中的应用

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