经气管插管机械通气对呼吸道菌群影响的研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

邓石坤 , 植丽佳 ,  高培阳

成都中医药大学附属医院（四川成都 610072）;

Corresponding author：

高培阳, Email: gaopy930@126.com

Keywords：

DOI：

10.7507/1671-6205.202107064

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Citation： 邓石坤, 植丽佳, 高培阳. 经气管插管机械通气对呼吸道菌群影响的研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2022, 21(3): 221-224. doi: 10.7507/1671-6205.202107064 Copy

1.	Sommer F, Backhed F. The gut microbiota-masters of host development and physiology. Nat Rev Microbiol, 2013, 11(4): 227-238.
2.	Levy M, Blacher E, Elinav E. Microbiome, metabolites and host immunity. Curr Opin Microbiol, 2017, 35: 8-15.
3.	Camberlein E, Cohen JM, Jose R, et al. Importance of bacterial replication and alveolar macrophage-independent clearance mechanisms during early lung infection with Streptococcus pneumoniae. Infect Immun, 2015, 83(3): 1181-1189.
4.	Siegel SJ, Weiser JN. Mechanisms of bacterial colonization of the respiratory tract. Annu Rev Microbiol, 2015, 69: 425-444.
5.	Woo S, Park SY, Kim Y, et al. The dynamics of respiratory microbiota during mechanical ventilation in patients with pneumonia. J Clin Med, 2020, 9(3): 638-654.
6.	Roux D, van Oort PM, Ricard JD, et al. Airway microbiome research: a modern perspective on surveillance cultures?. Ann Transl Med, 2017, 5(22): 445.
7.	Baek MG, Woo SJ, Kim NE, et al. Respiratory microbiome profiles differ by recent hospitalization and nursing home residence in patients on mechanical ventilation. J Transl Med, 2020, 18(1): 464-474.
8.	Charlson ES, Bittinger K, Haas AR, et al. Topographical continuity of bacterial populations in the healthy human respiratory tract. Am J Respir Crit Care Med, 2011, 184(8): 957-963.
9.	Man WH, de Steenhuijsen Piters WA, Bogaert D. The microbiota of the respiratory tract: gatekeeper to respiratory health. Nat Rev Microbiol, 2017, 15(5): 259-270.
10.	Wypych TP, Wickramasinghe LC, Marsland BJ. The influence of the microbiome on respiratory health. Nat Immunol, 2019, 20(10): 1279-1290.
11.	Bousbia S, Papazian L, Saux P, et al. Repertoire of intensive care unit pneumonia microbiota. PLoS One, 2012, 7(2): e32486.
12.	Dickson RP, Erb-Downward JR, Freeman CM, et al. Bacterial topography of the healthy human lower respiratory tract. mBio, 2017, 8(1): e02287-16.
13.	Morris A, Beck JM, Schloss PD, et al. Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med, 2013, 187(10): 1067-1075.
14.	Kitsios GD, Morowitz MJ, Dickson RP, et al. Dysbiosis in the intensive care unit: Microbiome science coming to the bedside. J Crit Care, 2017, 38: 84-91.
15.	Hjelmsø MH, Shah SA, Thorsen J, et al. Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial. Nat Commun, 2020, 11(1): 426-436.
16.	Gollwitzer ES, Marsland BJ. Impact of early-life exposures on immune maturation and susceptibility to disease. Trends Immunol, 2015, 36(11): 684-696.
17.	Pattaroni C, Watzenboeck ML, Schneidegger S, et al. Early-life formation of the microbial and immunological environment of the human airways. Cell Host Microbe, 2018, 24(6): 857-865.e4.
18.	Ramírez-Labrada AG, Isla D, Artal A, et al. The influence of lung microbiota on lung carcinogenesis, immunity, and immunotherapy. Trends Cancer, 2020, 6(2): 86-97.
19.	Bevivino A, Bacci G, Drevinek P, et al. Deciphering the ecology of cystic fibrosis bacterial communities: towards systems-level integration. Trends Mol Med, 2019, 25(12): 1110-1122.
20.	贺文芳, 马越云, 周磊, 等. 微生物菌群在呼吸道疾病中的作用. 中华检验医学杂志, 2016, 39(4): 322-325.
21.	王洪济, 赵红红, 范同平, 等. 气管插管病人下呼吸道菌群分布及其细菌耐药性. 解放军预防医学杂志, 1993, 4(5): 390-391.
22.	Latorre FD, Pont T, Ferrer A, et al. Pattern of tracheal colonization during mechanical ventilation. Am J Respir Crit Care Med, 1995, 152(3): 1028-1033.
23.	Smith AD, Zhang Y, Barber RC, et al. Common lung microbiome identified among mechanically ventilated surgical patients. PLoS One, 2016, 11(11): e0166313.
24.	Lozupone CA, Stombaugh JI, Gordon JI, et al. Diversity, stability and resilience of the human gut microbiota. Nature, 2012, 489(7415): 220-230.
25.	Lamarche D, Johnstone J, Zytaruk N, et al. Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study. Respir Res, 2018, 19(1): 245-257.
26.	Zakharkina T, Martin-Loeches I, Matamoros S, et al. The dynamics of the pulmonary microbiome during mechanical ventilation in the intensive care unit and the association with occurrence of pneumonia. Thorax, 2017, 72(9): 803-810.
27.	Yeh A, Rogers MB, Firek B, et al. Dysbiosis across multiple body sites in critically ill adult surgical patients. Shock, 2016, 46(6): 649-654.
28.	Kelly BJ, Imai I, Bittinger K, et al. Composition and dynamics of the respiratory tract microbiome in intubated patients. Microbiome, 2016, 4: 7-20.
29.	Dickson RP, Erb-Downward JR, Huffnagle GB. Towards an ecology of the lung: new conceptual models of pulmonary microbiology and pneumonia pathogenesis. Lancet Respir Med, 2014, 2(3): 238-246.
30.	Chastre J, Fagon JY. Ventilator-associated pneumonia. Am J Respir Crit Care Med, 2002, 165(7): 867-903.
31.	尤荣开, 邵朝朝, 薛丽珠, 等. 声门下分泌物引流对呼吸机相关性肺炎发病的影响. 中国呼吸与危重监护杂志, 2010, 9(3): 318-319.
32.	Nakagawa NK, Franchini ML, Driusso P, et al. Mucociliary clearance is impaired in acutely ill patients. Chest, 2005, 128(4): 2772-2777.
33.	于洪涛, 贾金广, 王敏, 等. 呼吸重症监护病房呼吸机相关性肺炎的危险因素分析. 中国呼吸与危重监护杂志, 2011, 10(1): 69-71.
34.	Human Microbiome Project C. Structure, function and diversity of the healthy human microbiome. Nature, 2012, 486(7402): 207-214.
35.	Mariano E. Nosocomial pneumonia in the intensive care unit acquired by mechanically ventilated versus nonventilated patients. Am J Respir Crit Care Med, 2010, 182(12): 1533-1539.
36.	Schmitt FCF, Lipinski A, Hofer S, et al. Pulmonary microbiome patterns correlate with the course of the disease in patients with sepsis-induced ARDS following major abdominal surgery. J Hosp Infect, 2020, 6701(20): 30203-30206.
37.	Albrich WC, Madhi SA, Adrian PV, et al. Use of a rapid test of pneumococcal colonization density to diagnose pneumococcal pneumonia. Clin Infect Dis, 2012, 54(5): 601-609.

1. Sommer F, Backhed F. The gut microbiota-masters of host development and physiology. Nat Rev Microbiol, 2013, 11(4): 227-238.
2. Levy M, Blacher E, Elinav E. Microbiome, metabolites and host immunity. Curr Opin Microbiol, 2017, 35: 8-15.
3. Camberlein E, Cohen JM, Jose R, et al. Importance of bacterial replication and alveolar macrophage-independent clearance mechanisms during early lung infection with Streptococcus pneumoniae. Infect Immun, 2015, 83(3): 1181-1189.
4. Siegel SJ, Weiser JN. Mechanisms of bacterial colonization of the respiratory tract. Annu Rev Microbiol, 2015, 69: 425-444.
5. Woo S, Park SY, Kim Y, et al. The dynamics of respiratory microbiota during mechanical ventilation in patients with pneumonia. J Clin Med, 2020, 9(3): 638-654.
6. Roux D, van Oort PM, Ricard JD, et al. Airway microbiome research: a modern perspective on surveillance cultures?. Ann Transl Med, 2017, 5(22): 445.
7. Baek MG, Woo SJ, Kim NE, et al. Respiratory microbiome profiles differ by recent hospitalization and nursing home residence in patients on mechanical ventilation. J Transl Med, 2020, 18(1): 464-474.
8. Charlson ES, Bittinger K, Haas AR, et al. Topographical continuity of bacterial populations in the healthy human respiratory tract. Am J Respir Crit Care Med, 2011, 184(8): 957-963.
9. Man WH, de Steenhuijsen Piters WA, Bogaert D. The microbiota of the respiratory tract: gatekeeper to respiratory health. Nat Rev Microbiol, 2017, 15(5): 259-270.
10. Wypych TP, Wickramasinghe LC, Marsland BJ. The influence of the microbiome on respiratory health. Nat Immunol, 2019, 20(10): 1279-1290.
11. Bousbia S, Papazian L, Saux P, et al. Repertoire of intensive care unit pneumonia microbiota. PLoS One, 2012, 7(2): e32486.
12. Dickson RP, Erb-Downward JR, Freeman CM, et al. Bacterial topography of the healthy human lower respiratory tract. mBio, 2017, 8(1): e02287-16.
13. Morris A, Beck JM, Schloss PD, et al. Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med, 2013, 187(10): 1067-1075.
14. Kitsios GD, Morowitz MJ, Dickson RP, et al. Dysbiosis in the intensive care unit: Microbiome science coming to the bedside. J Crit Care, 2017, 38: 84-91.
15. Hjelmsø MH, Shah SA, Thorsen J, et al. Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial. Nat Commun, 2020, 11(1): 426-436.
16. Gollwitzer ES, Marsland BJ. Impact of early-life exposures on immune maturation and susceptibility to disease. Trends Immunol, 2015, 36(11): 684-696.
17. Pattaroni C, Watzenboeck ML, Schneidegger S, et al. Early-life formation of the microbial and immunological environment of the human airways. Cell Host Microbe, 2018, 24(6): 857-865.e4.
18. Ramírez-Labrada AG, Isla D, Artal A, et al. The influence of lung microbiota on lung carcinogenesis, immunity, and immunotherapy. Trends Cancer, 2020, 6(2): 86-97.
19. Bevivino A, Bacci G, Drevinek P, et al. Deciphering the ecology of cystic fibrosis bacterial communities: towards systems-level integration. Trends Mol Med, 2019, 25(12): 1110-1122.
20. 贺文芳, 马越云, 周磊, 等. 微生物菌群在呼吸道疾病中的作用. 中华检验医学杂志, 2016, 39(4): 322-325.
21. 王洪济, 赵红红, 范同平, 等. 气管插管病人下呼吸道菌群分布及其细菌耐药性. 解放军预防医学杂志, 1993, 4(5): 390-391.
22. Latorre FD, Pont T, Ferrer A, et al. Pattern of tracheal colonization during mechanical ventilation. Am J Respir Crit Care Med, 1995, 152(3): 1028-1033.
23. Smith AD, Zhang Y, Barber RC, et al. Common lung microbiome identified among mechanically ventilated surgical patients. PLoS One, 2016, 11(11): e0166313.
24. Lozupone CA, Stombaugh JI, Gordon JI, et al. Diversity, stability and resilience of the human gut microbiota. Nature, 2012, 489(7415): 220-230.
25. Lamarche D, Johnstone J, Zytaruk N, et al. Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study. Respir Res, 2018, 19(1): 245-257.
26. Zakharkina T, Martin-Loeches I, Matamoros S, et al. The dynamics of the pulmonary microbiome during mechanical ventilation in the intensive care unit and the association with occurrence of pneumonia. Thorax, 2017, 72(9): 803-810.
27. Yeh A, Rogers MB, Firek B, et al. Dysbiosis across multiple body sites in critically ill adult surgical patients. Shock, 2016, 46(6): 649-654.
28. Kelly BJ, Imai I, Bittinger K, et al. Composition and dynamics of the respiratory tract microbiome in intubated patients. Microbiome, 2016, 4: 7-20.
29. Dickson RP, Erb-Downward JR, Huffnagle GB. Towards an ecology of the lung: new conceptual models of pulmonary microbiology and pneumonia pathogenesis. Lancet Respir Med, 2014, 2(3): 238-246.
30. Chastre J, Fagon JY. Ventilator-associated pneumonia. Am J Respir Crit Care Med, 2002, 165(7): 867-903.
31. 尤荣开, 邵朝朝, 薛丽珠, 等. 声门下分泌物引流对呼吸机相关性肺炎发病的影响. 中国呼吸与危重监护杂志, 2010, 9(3): 318-319.
32. Nakagawa NK, Franchini ML, Driusso P, et al. Mucociliary clearance is impaired in acutely ill patients. Chest, 2005, 128(4): 2772-2777.
33. 于洪涛, 贾金广, 王敏, 等. 呼吸重症监护病房呼吸机相关性肺炎的危险因素分析. 中国呼吸与危重监护杂志, 2011, 10(1): 69-71.
34. Human Microbiome Project C. Structure, function and diversity of the healthy human microbiome. Nature, 2012, 486(7402): 207-214.
35. Mariano E. Nosocomial pneumonia in the intensive care unit acquired by mechanically ventilated versus nonventilated patients. Am J Respir Crit Care Med, 2010, 182(12): 1533-1539.
36. Schmitt FCF, Lipinski A, Hofer S, et al. Pulmonary microbiome patterns correlate with the course of the disease in patients with sepsis-induced ARDS following major abdominal surgery. J Hosp Infect, 2020, 6701(20): 30203-30206.
37. Albrich WC, Madhi SA, Adrian PV, et al. Use of a rapid test of pneumococcal colonization density to diagnose pneumococcal pneumonia. Clin Infect Dis, 2012, 54(5): 601-609.

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经气管插管机械通气对呼吸道菌群影响的研究进展

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