高原人群肺动脉高压与血红蛋白浓度的相关研究进展_Chinese Journal of Respiratory and Critical Care Medicine

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廖霞 ¹ ,  LUO Fengming ²

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LUO Fengming, Email: luofengming@hotmail.com

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10.7507/1671-6205.202201028

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Citation： LUO Fengming. 高原人群肺动脉高压与血红蛋白浓度的相关研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2022, 21(3): 225-228. doi: 10.7507/1671-6205.202201028 Copy

1.	Zubieta-Calleja G, Zubieta-DeUrioste N. The oxygen transport triad in high-altitude pulmonary edema: a perspective from the high Andes. Int J Environ Res Public Health, 2021, 18(14): 7619.
2.	Sydykov A, Mamazhakypov A, Maripov A, et al. Pulmonary hypertension in acute and chronic high altitude maladaptation disorders. Int J Environ Res Public Health, 2021, 18(4): 1692.
3.	边巴琼达, 徐钰, 黄丽萍, 等. 高原地区藏族居民脉氧饱和度和血红蛋白含量分析. 中国呼吸与危重监护杂志, 2018, 17(3): 271-274.
4.	Storz JF, Scott GR. Phenotypic plasticity, genetic assimilation, and genetic compensation in hypoxia adaptation of high-altitude vertebrates. Comp Biochem Physiol A Mol Integr Physiol, 2021, 253: 110865.
5.	Sydykov A, Maripov A, Kushubakova N, et al. an Exaggerated rise in pulmonary artery pressure in a high-altitude dweller during the cold season. Int J Environ Res Public Health, 2021, 18(8): 3984.
6.	吴天一. 高原红细胞增多症 82 例分析. 中华血液学杂志, 1979, 3(3): 27-30.
7.	Garrido E, Botella de Maglia J, Castillo O. Acute, subacute and chronic mountain sickness. Rev Clin Esp (Barc), 2021, 221(8): 481-490.
8.	吴天一. 高原医学 40 年——中国高原医学获得的大成果. 高原医学杂志, 2019, 29(1): 30-35.
9.	国际高原医学会慢性高原病专家小组. 第六届国际高原医学和低氧生理学术大会颁布慢性高原病青海诊断标准. 青海医学院学报, 2005, 26(1): 3-5.
10.	中华医学会呼吸病学分会肺栓塞与肺血管病学组, 中国医师协会呼吸医师分会肺栓塞与肺血管病工作委员会, 全国肺栓塞与肺血管病防治协作组, 等. 中国肺动脉高压诊断与治疗指南(2021 版). 中华医学杂志, 2021, 101(1): 11-51.
11.	Tang H, Vanderpool RR, Wang J, et al. Targeting L-arginine-nitric oxide-cGMP pathway in pulmonary arterial hypertension. Pulm Circ, 2017, 7(3): 569-571.
12.	Mizuno S, Ishizaki T, Toga H, et al. Endogenous Asymmetric dimethylarginine pathway in high altitude adapted yaks. Biomed Res Int, 2015, 2015: 196904.
13.	久太, 冯喜英, 关巍, 等. 急性高原肺水肿患者 ODC1 蛋白表达差异与肺动脉高压的相关性研究. 临床肺科杂志, 2017, 22(12): 2160-2163.
14.	崔建华, 张西洲, 何富文, 等. 不同海拔高度居住高原不同时间健康青年血浆内皮素和一氧化氮的测定. 西藏医药杂志, 1999, 20(4): 1-2,73.
15.	Lai YC, Potoka KC, Champion HC, et al. Pulmonary arterial hypertension: the clinical syndrome. Circ Res, 2014, 115(1): 115-130.
16.	刘鑫源, 陈兴书, 罗勇军. 波生坦防治高原肺动脉高压相关疾病研究进展. 人民军医, 2020, 63(1): 79-83.
17.	Sharma K, Mishra A, Singh HN, et al. High-altitude pulmonary edema is aggravated by risk loci and associated transcription factors in HIF-prolyl hydroxylases. Hum Mol Genet, 2021, 30(18): 1734-1749.
18.	Qin S, Predescu D, Carman B, et al. Up-regulation of the long noncoding RNA x-inactive-specific transcript and the sex bias in pulmonary arterial hypertension. Am J Pathol, 2021, 191(6): 1135-1150.
19.	Lichtblau M, Saxer S, Furian M, et al. Cardiac function and pulmonary hypertension in Central Asian highlanders at 3250 m. Eur Respir J, 2020, 56(2): 1902474.
20.	Soria R, Egger M, Scherrer U, et al. Pulmonary artery pressure and arterial oxygen saturation in people living at high or low altitude: systematic review and meta-analysis. J Appl Physiol (1985), 2016, 121(5): 1151-1159.
21.	Gou Q, Shi R, Zhang X, et al. The prevalence and risk factors of high-altitude pulmonary hypertension among native Tibetans in Sichuan province, China. High Alt Med Biol, 2020, 21(4): 327-335.
22.	Negi PC, Marwaha R, Asotra S, et al. Prevalence of high altitude pulmonary hypertension among the natives of Spiti Valley—a high altitude region in Himachal Pradesh, India. High Alt Med Biol, 2014, 15(4): 504-510.
23.	Maggiorini M, Léon-Velarde F. High-altitude pulmonary hypertension: a pathophysiological entity to different diseases. Eur Respir J, 2003, 22(6): 1019-1025.
24.	Naeije R. Altitude and the right heart. Rev Mal Respir, 2018, 35(4): 441-451.
25.	Pethő D, Hendrik Z, Nagy A, et al. Heme cytotoxicity is the consequence of endoplasmic reticulum stress in atherosclerotic plaque progression. Sci Rep, 2021, 11(1): 10435.
26.	Gutiérrez-Muñoz C, Méndez-Barbero N, Svendsen P, et al. CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice. FASEB J, 2020, 34(11): 14960-14976.
27.	James J, Srivastava A, Varghese MV, et al. Heme induces rapid endothelial barrier dysfunction via the MKK3/p38MAPK axis. Blood, 2020, 136(6): 749-754.
28.	Ashouri R, Fangman M, Burris A, et al. Critical role of hemopexin mediated cytoprotection in the pathophysiology of sickle cell disease. Int J Mol Sci, 2021, 22(12): 6408.
29.	Zhang P, Nguyen J, Abdulla F, et al. Soluble MD-2 and heme in sickle cell disease plasma promote pro-inflammatory signaling in endothelial cells. Front Immunol, 2021, 12: 632709.
30.	Buehler PW, D’Agnillo F, Schaer DJ. Hemoglobin based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design. Trends Mol Med, 2010, 16: 447-457.
31.	Pan YK, Ern R, Morrison PR. Acclimation to prolonged hypoxia alters hemoglobin isoform expression and increases hemoglobin oxygen affinity and aerobic performance in a marine fish. Sci Rep, 2017, 7(1): 7834.
32.	Parikh J, Kapela A, Tsoukias NM. Can endothelial hemoglobin-α regulate nitric oxide vasodilatory signaling?. Am J Physiol Heart Circ Physiol, 2017, 312(4): H854-H866.
33.	Wan BN, Zhou SG, Wang M, et al. Progress on haptoglobin and metabolic diseases. World J Diabetes, 2021, 12(3): 206-214.
34.	Oh MK, Kim IS. Involvement of placental growth factor upregulated via TGF-β1-ALK1-Smad1/5 signaling in prohaptoglobin-induced angiogenesis. PLoS One, 2019, 14(4): e0216289.
35.	Yang Y, Gao C, Yang T, et al. Vascular characteristics and expression of hypoxia genes in Tibetan pigs' hearts. Vet Med Sci, 2022, 8(1): 177-186.
36.	Alvarez RA, Miller MP, Hahn SA, et al. Targeting pulmonary endothelial hemoglobin α improves nitric oxide signaling and reverses pulmonary artery endothelial dysfunction. Am J Respir Cell Mol Biol, 2017, 57(6): 733-744.
37.	Sánchez K, Ballaz SJ. Might a high hemoglobin mass be involved in non-cardiogenic pulmonary edema? The case of the chronic maladaptation to high-altitude in the Andes. Med Hypotheses, 2021, 146: 110418.
38.	何宗钊, 邓莉, 马四清, 等. 不同海拔汉族健康人大循环及微循环特征的对比. 中国应用生理学杂志, 2021, 37(4): 371-376.
39.	Rochon ER, Corti P, Gladwin MT. Hemoglobin α in pulmonary endothelium: ironing out nitric oxide signaling. Am J Respir Cell Mol Biol, 2017, 57(6): 639-641.
40.	Stembridge M, Hoiland RL, Williams AM, et al. The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia. Am J Physiol Heart Circ Physiol, 2021, 321(4): H738-H747.

1. Zubieta-Calleja G, Zubieta-DeUrioste N. The oxygen transport triad in high-altitude pulmonary edema: a perspective from the high Andes. Int J Environ Res Public Health, 2021, 18(14): 7619.
2. Sydykov A, Mamazhakypov A, Maripov A, et al. Pulmonary hypertension in acute and chronic high altitude maladaptation disorders. Int J Environ Res Public Health, 2021, 18(4): 1692.
3. 边巴琼达, 徐钰, 黄丽萍, 等. 高原地区藏族居民脉氧饱和度和血红蛋白含量分析. 中国呼吸与危重监护杂志, 2018, 17(3): 271-274.
4. Storz JF, Scott GR. Phenotypic plasticity, genetic assimilation, and genetic compensation in hypoxia adaptation of high-altitude vertebrates. Comp Biochem Physiol A Mol Integr Physiol, 2021, 253: 110865.
5. Sydykov A, Maripov A, Kushubakova N, et al. an Exaggerated rise in pulmonary artery pressure in a high-altitude dweller during the cold season. Int J Environ Res Public Health, 2021, 18(8): 3984.
6. 吴天一. 高原红细胞增多症 82 例分析. 中华血液学杂志, 1979, 3(3): 27-30.
7. Garrido E, Botella de Maglia J, Castillo O. Acute, subacute and chronic mountain sickness. Rev Clin Esp (Barc), 2021, 221(8): 481-490.
8. 吴天一. 高原医学 40 年——中国高原医学获得的大成果. 高原医学杂志, 2019, 29(1): 30-35.
9. 国际高原医学会慢性高原病专家小组. 第六届国际高原医学和低氧生理学术大会颁布慢性高原病青海诊断标准. 青海医学院学报, 2005, 26(1): 3-5.
10. 中华医学会呼吸病学分会肺栓塞与肺血管病学组, 中国医师协会呼吸医师分会肺栓塞与肺血管病工作委员会, 全国肺栓塞与肺血管病防治协作组, 等. 中国肺动脉高压诊断与治疗指南(2021 版). 中华医学杂志, 2021, 101(1): 11-51.
11. Tang H, Vanderpool RR, Wang J, et al. Targeting L-arginine-nitric oxide-cGMP pathway in pulmonary arterial hypertension. Pulm Circ, 2017, 7(3): 569-571.
12. Mizuno S, Ishizaki T, Toga H, et al. Endogenous Asymmetric dimethylarginine pathway in high altitude adapted yaks. Biomed Res Int, 2015, 2015: 196904.
13. 久太, 冯喜英, 关巍, 等. 急性高原肺水肿患者 ODC1 蛋白表达差异与肺动脉高压的相关性研究. 临床肺科杂志, 2017, 22(12): 2160-2163.
14. 崔建华, 张西洲, 何富文, 等. 不同海拔高度居住高原不同时间健康青年血浆内皮素和一氧化氮的测定. 西藏医药杂志, 1999, 20(4): 1-2,73.
15. Lai YC, Potoka KC, Champion HC, et al. Pulmonary arterial hypertension: the clinical syndrome. Circ Res, 2014, 115(1): 115-130.
16. 刘鑫源, 陈兴书, 罗勇军. 波生坦防治高原肺动脉高压相关疾病研究进展. 人民军医, 2020, 63(1): 79-83.
17. Sharma K, Mishra A, Singh HN, et al. High-altitude pulmonary edema is aggravated by risk loci and associated transcription factors in HIF-prolyl hydroxylases. Hum Mol Genet, 2021, 30(18): 1734-1749.
18. Qin S, Predescu D, Carman B, et al. Up-regulation of the long noncoding RNA x-inactive-specific transcript and the sex bias in pulmonary arterial hypertension. Am J Pathol, 2021, 191(6): 1135-1150.
19. Lichtblau M, Saxer S, Furian M, et al. Cardiac function and pulmonary hypertension in Central Asian highlanders at 3250 m. Eur Respir J, 2020, 56(2): 1902474.
20. Soria R, Egger M, Scherrer U, et al. Pulmonary artery pressure and arterial oxygen saturation in people living at high or low altitude: systematic review and meta-analysis. J Appl Physiol (1985), 2016, 121(5): 1151-1159.
21. Gou Q, Shi R, Zhang X, et al. The prevalence and risk factors of high-altitude pulmonary hypertension among native Tibetans in Sichuan province, China. High Alt Med Biol, 2020, 21(4): 327-335.
22. Negi PC, Marwaha R, Asotra S, et al. Prevalence of high altitude pulmonary hypertension among the natives of Spiti Valley—a high altitude region in Himachal Pradesh, India. High Alt Med Biol, 2014, 15(4): 504-510.
23. Maggiorini M, Léon-Velarde F. High-altitude pulmonary hypertension: a pathophysiological entity to different diseases. Eur Respir J, 2003, 22(6): 1019-1025.
24. Naeije R. Altitude and the right heart. Rev Mal Respir, 2018, 35(4): 441-451.
25. Pethő D, Hendrik Z, Nagy A, et al. Heme cytotoxicity is the consequence of endoplasmic reticulum stress in atherosclerotic plaque progression. Sci Rep, 2021, 11(1): 10435.
26. Gutiérrez-Muñoz C, Méndez-Barbero N, Svendsen P, et al. CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice. FASEB J, 2020, 34(11): 14960-14976.
27. James J, Srivastava A, Varghese MV, et al. Heme induces rapid endothelial barrier dysfunction via the MKK3/p38MAPK axis. Blood, 2020, 136(6): 749-754.
28. Ashouri R, Fangman M, Burris A, et al. Critical role of hemopexin mediated cytoprotection in the pathophysiology of sickle cell disease. Int J Mol Sci, 2021, 22(12): 6408.
29. Zhang P, Nguyen J, Abdulla F, et al. Soluble MD-2 and heme in sickle cell disease plasma promote pro-inflammatory signaling in endothelial cells. Front Immunol, 2021, 12: 632709.
30. Buehler PW, D’Agnillo F, Schaer DJ. Hemoglobin based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design. Trends Mol Med, 2010, 16: 447-457.
31. Pan YK, Ern R, Morrison PR. Acclimation to prolonged hypoxia alters hemoglobin isoform expression and increases hemoglobin oxygen affinity and aerobic performance in a marine fish. Sci Rep, 2017, 7(1): 7834.
32. Parikh J, Kapela A, Tsoukias NM. Can endothelial hemoglobin-α regulate nitric oxide vasodilatory signaling?. Am J Physiol Heart Circ Physiol, 2017, 312(4): H854-H866.
33. Wan BN, Zhou SG, Wang M, et al. Progress on haptoglobin and metabolic diseases. World J Diabetes, 2021, 12(3): 206-214.
34. Oh MK, Kim IS. Involvement of placental growth factor upregulated via TGF-β1-ALK1-Smad1/5 signaling in prohaptoglobin-induced angiogenesis. PLoS One, 2019, 14(4): e0216289.
35. Yang Y, Gao C, Yang T, et al. Vascular characteristics and expression of hypoxia genes in Tibetan pigs' hearts. Vet Med Sci, 2022, 8(1): 177-186.
36. Alvarez RA, Miller MP, Hahn SA, et al. Targeting pulmonary endothelial hemoglobin α improves nitric oxide signaling and reverses pulmonary artery endothelial dysfunction. Am J Respir Cell Mol Biol, 2017, 57(6): 733-744.
37. Sánchez K, Ballaz SJ. Might a high hemoglobin mass be involved in non-cardiogenic pulmonary edema? The case of the chronic maladaptation to high-altitude in the Andes. Med Hypotheses, 2021, 146: 110418.
38. 何宗钊, 邓莉, 马四清, 等. 不同海拔汉族健康人大循环及微循环特征的对比. 中国应用生理学杂志, 2021, 37(4): 371-376.
39. Rochon ER, Corti P, Gladwin MT. Hemoglobin α in pulmonary endothelium: ironing out nitric oxide signaling. Am J Respir Cell Mol Biol, 2017, 57(6): 639-641.
40. Stembridge M, Hoiland RL, Williams AM, et al. The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia. Am J Physiol Heart Circ Physiol, 2021, 321(4): H738-H747.

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