家庭经鼻高流量氧疗在慢性阻塞性肺疾病中的应用研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

张波 , 曾红美 , 李星茹 ,  程玉生

皖南医学院弋矶山医院呼吸与危重症医学科（安徽芜湖 241001）;

Corresponding author：

程玉生, Email: chengys1222@126.com

Keywords：

DOI：

10.7507/1671-6205.202401012

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Citation： 张波, 曾红美, 李星茹, 程玉生. 家庭经鼻高流量氧疗在慢性阻塞性肺疾病中的应用研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2024, 23(12): 894-899. doi: 10.7507/1671-6205.202401012 Copy

1.	GBD Chronic Respiratory Disease Collaborators. Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Respir Med, 2020, 8(6): 585-596.
2.	Wang C, Xu J, Yang L, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet, 2018, 391(10131): 1706-1717.
3.	Crimi C, Cortegiani A. High-flow nasal therapy in acute and chronic respiratory failure: past, present, and future. J Clin Med, 2023, 12(7): 2666.
4.	Storgaard LH, Hockey HU, Weinreich UM. Development in PaCO₂ over 12 months in patients with COPD with persistent hypercapnic respiratory failure treated with high-flow nasal cannula--post-hoc analysis from a randomised controlled trial. BMJ Open Respir Res, 2020, 7(1): e000712.
5.	D’Cruz R, Rossel A, Suh ES, et al. Home nasal high-flow following severe COPD exacerbation: a mixed-methods feasibility randomised controlled trial. Eur Respir J, 2021, 58(suppl 65): OA1626.
6.	Elshof J, Duiverman ML. Clinical evidence of nasal high-flow therapy in chronic obstructive pulmonary disease patients. Respiration, 2020, 99(2): 140-153.
7.	Vega Pittao ML, Schifino G, Pisani L, et al. Home high-flow therapy in patients with chronic respiratory diseases: physiological rationale and clinical results. J Clin Med, 2023, 12(7): 2663.
8.	Mall MA, Harkema JR, Trojanek JB, et al. Development of chronic bronchitis and emphysema in β-epithelial Na⁺ channel–overexpressing mice. Am J Respir Crit Care Med, 2008, 177(7): 730-742.
9.	Chidekel A, Zhu Y, Wang J, et al. The effects of gas humidification with high-flow nasal cannula on cultured human airway epithelial cells. Pulm Med, 2012, 2012: 380686.
10.	Zhao E, Zhou Y, He C, et al. Factors influencing nasal airway pressure and comfort in high-flow nasal cannula oxygen therapy: a volunteer study. BMC Pulm Med, 2023, 23(1): 449.
11.	Pinkham MI, Domanski U, Franke KJ, et al. Effect of respiratory rate and size of cannula on pressure and dead-space clearance during nasal high flow in patients with COPD and acute respiratory failure. J Appl Physiol, 2022, 132(2): 553-563.
12.	Möller W, Celik G, Feng S, et al. Nasal high flow clears anatomical dead space in upper airway models. J Appl Physiol, 2015, 118(12): 1525-1532.
13.	Delorme M, Bouchard PA, Simon M, et al. Physiologic effects of high-flow nasal cannula in healthy subjects. Respir Care, 2020, 65(9): 1346-1354.
14.	Li J, Scott JB, Fink JB, et al. Optimizing high-flow nasal cannula flow settings in adult hypoxemic patients based on peak inspiratory flow during tidal breathing. Ann Intensive Care, 2021, 11: 164.
15.	Parke RL, Eccleston ML, McGuinness SP. The effects of flow on airway pressure during nasal high-flow oxygen therapy. Respir Care, 2011, 56(8): 1151-1155.
16.	Vieira F, Bezerra FS, Coudroy R, et al. High flow nasal cannula compared to continuous positive airway pressure: a bench and physiological study. J Appl Physiol, 2022, 132(6): 1580-1590.
17.	Pisani L, Fasano L, Corcione N, et al. Change in pulmonary mechanics and the effect on breathing pattern of high flow oxygen therapy in stable hypercapnic COPD. Thorax, 2017, 72(4): 373-375.
18.	Li J, Albuainain FA, Tan W, et al. The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review. Crit Care, 2023, 27: 78.
19.	Lacasse Y, Casaburi R, Sliwinski P, et al. Home oxygen for moderate hypoxaemia in chronic obstructive pulmonary disease: a systematic review and meta-analysis. Lancet Respir Med, 2022, 10(11): 1029-1037.
20.	Jacobs SS, Krishnan JA, Lederer DJ, et al. Home oxygen therapy for adults with chronic lung disease. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med, 2020, 202(10): e121-e141.
21.	Ringbaek TJ, Lange P. Trends in long-term oxygen therapy for COPD in Denmark from 2001 to 2010. Respir Med, 2014, 108(3): 511-516.
22.	Chen YH, Huang CC, Lin HL, et al. Effects of high flow nasal cannula on exercise endurance in patients with chronic obstructive pulmonary disease. J Formos Med Assoc, 2022, 121(1, Part 2): 381-387.
23.	Storgaard LH, Hockey HU, Laursen BS, et al. Long-term effects of oxygen-enriched high-flow nasal cannula treatment in COPD patients with chronic hypoxemic respiratory failure. Int J Chron Obstruct Pulmon Dis, 2018, 13: 1195-1205.
24.	Criner GJ, Criner L YH, George SA, et al. Feasibility of using daily home high-flow nasal therapy in COPD patients following a recent COPD hospitalization. Chronic Obstr Pulm Dis, 2022, 9(1): 4-14.
25.	Nagata K, Kikuchi T, Horie T, et al. Domiciliary high-flow nasal cannula oxygen therapy for patients with stable hypercapnic chronic obstructive pulmonary disease. A multicenter randomized crossover trial. Ann Am Thorac Soc, 2018, 15(4): 432-439.
26.	Yang H, Huang D, Luo J, et al. The use of high-flow nasal cannula in patients with chronic obstructive pulmonary disease under exacerbation and stable phases: a systematic review and meta-analysis. Heart Lung, 2023, 60: 116-126.
27.	Ergan B, Oczkowski S, Rochwerg B, et al. European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD. Eur Respir J, 2019, 54(3): 1901003.
28.	韩姗姗, 王瑾, 贠秀俐. 无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭失败危险因素的Meta分析. 中国呼吸与危重监护杂志, 2021, 20(10): 694-702.
29.	Holm CP, Gantzhorn EK, Weinreich UM, et al. LT-NIV. 2020. [(accessed on 15 November 2023)]. Available online: https://lungemedicin.dk/wp-content/uploads/2021/05/KOL-LT-NIV-DLS-2020.pdf.
30.	Spoletini G, Mega C, Pisani L, et al. High-flow nasal therapy vs standard oxygen during breaks off noninvasive ventilation for acute respiratory failure: a pilot randomized controlled trial. J Crit Care, 2018, 48: 418-425.
31.	Weinreich UM, Storgaard LH. A real-life study of combined treatment with long-term non-invasive ventilation and high flow nasal cannula in patients with end-stage chronic obstructive lung disease. J Clin Med, 2023, 12(13): 4485.
32.	慢性阻塞性肺疾病急性加重诊治专家组. 慢性阻塞性肺疾病急性加重诊治中国专家共识(2023年修订版). 国际呼吸杂志, 2023, 43(2): 132-149.
33.	Zhang L, Wang Y, Ye Y, et al. Comparison of high-flow nasal cannula with conventional oxygen therapy in patients with hypercapnic chronic obstructive pulmonary disease: a systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis, 2023, 18: 895-906.
34.	Nagata K, Horie T, Chohnabayashi N, et al. Home high-flow nasal cannula oxygen therapy for stable hypercapnic copd: a randomized clinical trial. Am J Respir Crit Care Med, 2022, 206(11): 1326-1335.
35.	Pitre T, Abbasi S, Su J, et al. Home high flow nasal cannula for chronic hypercapnic respiratory failure in COPD: a systematic review and meta-analysis. Respir Med, 2023, 219: 107420.
36.	Cortegiani A, Longhini F, Madotto F, et al. High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non-inferiority randomized trial. Crit Care, 2020, 24: 692.
37.	Pisani L, Betti S, Biglia C, et al. Effects of high-flow nasal cannula in patients with persistent hypercapnia after an acute COPD exacerbation: a prospective pilot study. BMC Pulm Med, 2020, 20(1): 12.
38.	Bräunlich J, Dellweg D, Bastian A, et al. Nasal high-flow versus noninvasive ventilation in patients with chronic hypercapnic COPD. Int J Chron Obstruct Pulmon Dis, 2019, 14: 1411-1421.
39.	Pennec S, Gaymu J, Riou F, et al. A majority of people would prefer to die at home, but few actually do so. Population Societies, 2015, 524(7): 1-4.
40.	Bode S, Grove G. Use of humidified high flow nasal oxygen in community palliative care: a case report. Palliat Med Rep, 2020, 1(1): 179-182.
41.	Huang JY, Steele P, Dabscheck E, et al. Nasal high flow therapy for symptom management in people receiving palliative care. J Pain Symptom Manage, 2022, 63(2): e237-e245.
42.	Dolidon S, Dupuis J, Molano Valencia LC, et al. Characteristics and outcome of patients set up on high-flow oxygen therapy at home. Ther Adv Respir, 2019, 13: 1753466619879794.
43.	Sørensen SS, Storgaard LH, Weinreich UM. Cost-effectiveness of domiciliary high flow nasal cannula treatment in COPD patients with chronic respiratory failure. Clinicoecon Outcomes Res, 2021, 13: 553-564.
44.	Milne RJ, Hockey HU, Garrett J. Hospital cost savings for sequential COPD Patients receiving domiciliary nasal high flow therapy. Int J Chron Obstruct Pulmon Dis, 2022, 17: 1311-1322.
45.	Groessl EJ, Tally SR, Hillery N. Cost-effectiveness of humidified high-flow therapy (HHFT) for COPD patients on long-term oxygen therapy. Clinicoecon Outcomes Res, 2023, 15: 239-250.
46.	Crimi C, Nolasco S, Campisi R, et al. Long-term domiciliary high-flow nasal therapy in patients with bronchiectasis: a preliminary retrospective observational case-control study. J Clin Med, 2022, 11(24): 7323.
47.	Simioli F, Fiorentino G, Cauteruccio R, et al. Long-term high flow nasal cannula therapy in primary and secondary bronchiectasis. Healthcare (Basel), 2023, 11(9): 1250.
48.	Weinreich UM, Burchardt C, Huremovic J. The effect of domiciliary high flow nasal cannula treatment on dyspnea and walking distance in patients with interstitial lung disease --A pilot study. Chron Respir Dis, 2022, 19: 14799731221137085.
49.	Annunziata A, Coppola A, Carannante N, et al. Home management of patients with moderate or severe respiratory failure secondary to COVID-19, using remote monitoring and oxygen with or without HFNC. Pathogens, 2021, 10(4): 413.

1. GBD Chronic Respiratory Disease Collaborators. Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Respir Med, 2020, 8(6): 585-596.
2. Wang C, Xu J, Yang L, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet, 2018, 391(10131): 1706-1717.
3. Crimi C, Cortegiani A. High-flow nasal therapy in acute and chronic respiratory failure: past, present, and future. J Clin Med, 2023, 12(7): 2666.
4. Storgaard LH, Hockey HU, Weinreich UM. Development in PaCO₂ over 12 months in patients with COPD with persistent hypercapnic respiratory failure treated with high-flow nasal cannula--post-hoc analysis from a randomised controlled trial. BMJ Open Respir Res, 2020, 7(1): e000712.
5. D’Cruz R, Rossel A, Suh ES, et al. Home nasal high-flow following severe COPD exacerbation: a mixed-methods feasibility randomised controlled trial. Eur Respir J, 2021, 58(suppl 65): OA1626.
6. Elshof J, Duiverman ML. Clinical evidence of nasal high-flow therapy in chronic obstructive pulmonary disease patients. Respiration, 2020, 99(2): 140-153.
7. Vega Pittao ML, Schifino G, Pisani L, et al. Home high-flow therapy in patients with chronic respiratory diseases: physiological rationale and clinical results. J Clin Med, 2023, 12(7): 2663.
8. Mall MA, Harkema JR, Trojanek JB, et al. Development of chronic bronchitis and emphysema in β-epithelial Na⁺ channel–overexpressing mice. Am J Respir Crit Care Med, 2008, 177(7): 730-742.
9. Chidekel A, Zhu Y, Wang J, et al. The effects of gas humidification with high-flow nasal cannula on cultured human airway epithelial cells. Pulm Med, 2012, 2012: 380686.
10. Zhao E, Zhou Y, He C, et al. Factors influencing nasal airway pressure and comfort in high-flow nasal cannula oxygen therapy: a volunteer study. BMC Pulm Med, 2023, 23(1): 449.
11. Pinkham MI, Domanski U, Franke KJ, et al. Effect of respiratory rate and size of cannula on pressure and dead-space clearance during nasal high flow in patients with COPD and acute respiratory failure. J Appl Physiol, 2022, 132(2): 553-563.
12. Möller W, Celik G, Feng S, et al. Nasal high flow clears anatomical dead space in upper airway models. J Appl Physiol, 2015, 118(12): 1525-1532.
13. Delorme M, Bouchard PA, Simon M, et al. Physiologic effects of high-flow nasal cannula in healthy subjects. Respir Care, 2020, 65(9): 1346-1354.
14. Li J, Scott JB, Fink JB, et al. Optimizing high-flow nasal cannula flow settings in adult hypoxemic patients based on peak inspiratory flow during tidal breathing. Ann Intensive Care, 2021, 11: 164.
15. Parke RL, Eccleston ML, McGuinness SP. The effects of flow on airway pressure during nasal high-flow oxygen therapy. Respir Care, 2011, 56(8): 1151-1155.
16. Vieira F, Bezerra FS, Coudroy R, et al. High flow nasal cannula compared to continuous positive airway pressure: a bench and physiological study. J Appl Physiol, 2022, 132(6): 1580-1590.
17. Pisani L, Fasano L, Corcione N, et al. Change in pulmonary mechanics and the effect on breathing pattern of high flow oxygen therapy in stable hypercapnic COPD. Thorax, 2017, 72(4): 373-375.
18. Li J, Albuainain FA, Tan W, et al. The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review. Crit Care, 2023, 27: 78.
19. Lacasse Y, Casaburi R, Sliwinski P, et al. Home oxygen for moderate hypoxaemia in chronic obstructive pulmonary disease: a systematic review and meta-analysis. Lancet Respir Med, 2022, 10(11): 1029-1037.
20. Jacobs SS, Krishnan JA, Lederer DJ, et al. Home oxygen therapy for adults with chronic lung disease. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med, 2020, 202(10): e121-e141.
21. Ringbaek TJ, Lange P. Trends in long-term oxygen therapy for COPD in Denmark from 2001 to 2010. Respir Med, 2014, 108(3): 511-516.
22. Chen YH, Huang CC, Lin HL, et al. Effects of high flow nasal cannula on exercise endurance in patients with chronic obstructive pulmonary disease. J Formos Med Assoc, 2022, 121(1, Part 2): 381-387.
23. Storgaard LH, Hockey HU, Laursen BS, et al. Long-term effects of oxygen-enriched high-flow nasal cannula treatment in COPD patients with chronic hypoxemic respiratory failure. Int J Chron Obstruct Pulmon Dis, 2018, 13: 1195-1205.
24. Criner GJ, Criner L YH, George SA, et al. Feasibility of using daily home high-flow nasal therapy in COPD patients following a recent COPD hospitalization. Chronic Obstr Pulm Dis, 2022, 9(1): 4-14.
25. Nagata K, Kikuchi T, Horie T, et al. Domiciliary high-flow nasal cannula oxygen therapy for patients with stable hypercapnic chronic obstructive pulmonary disease. A multicenter randomized crossover trial. Ann Am Thorac Soc, 2018, 15(4): 432-439.
26. Yang H, Huang D, Luo J, et al. The use of high-flow nasal cannula in patients with chronic obstructive pulmonary disease under exacerbation and stable phases: a systematic review and meta-analysis. Heart Lung, 2023, 60: 116-126.
27. Ergan B, Oczkowski S, Rochwerg B, et al. European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD. Eur Respir J, 2019, 54(3): 1901003.
28. 韩姗姗, 王瑾, 贠秀俐. 无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭失败危险因素的Meta分析. 中国呼吸与危重监护杂志, 2021, 20(10): 694-702.
29. Holm CP, Gantzhorn EK, Weinreich UM, et al. LT-NIV. 2020. [(accessed on 15 November 2023)]. Available online: https://lungemedicin.dk/wp-content/uploads/2021/05/KOL-LT-NIV-DLS-2020.pdf.
30. Spoletini G, Mega C, Pisani L, et al. High-flow nasal therapy vs standard oxygen during breaks off noninvasive ventilation for acute respiratory failure: a pilot randomized controlled trial. J Crit Care, 2018, 48: 418-425.
31. Weinreich UM, Storgaard LH. A real-life study of combined treatment with long-term non-invasive ventilation and high flow nasal cannula in patients with end-stage chronic obstructive lung disease. J Clin Med, 2023, 12(13): 4485.
32. 慢性阻塞性肺疾病急性加重诊治专家组. 慢性阻塞性肺疾病急性加重诊治中国专家共识(2023年修订版). 国际呼吸杂志, 2023, 43(2): 132-149.
33. Zhang L, Wang Y, Ye Y, et al. Comparison of high-flow nasal cannula with conventional oxygen therapy in patients with hypercapnic chronic obstructive pulmonary disease: a systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis, 2023, 18: 895-906.
34. Nagata K, Horie T, Chohnabayashi N, et al. Home high-flow nasal cannula oxygen therapy for stable hypercapnic copd: a randomized clinical trial. Am J Respir Crit Care Med, 2022, 206(11): 1326-1335.
35. Pitre T, Abbasi S, Su J, et al. Home high flow nasal cannula for chronic hypercapnic respiratory failure in COPD: a systematic review and meta-analysis. Respir Med, 2023, 219: 107420.
36. Cortegiani A, Longhini F, Madotto F, et al. High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non-inferiority randomized trial. Crit Care, 2020, 24: 692.
37. Pisani L, Betti S, Biglia C, et al. Effects of high-flow nasal cannula in patients with persistent hypercapnia after an acute COPD exacerbation: a prospective pilot study. BMC Pulm Med, 2020, 20(1): 12.
38. Bräunlich J, Dellweg D, Bastian A, et al. Nasal high-flow versus noninvasive ventilation in patients with chronic hypercapnic COPD. Int J Chron Obstruct Pulmon Dis, 2019, 14: 1411-1421.
39. Pennec S, Gaymu J, Riou F, et al. A majority of people would prefer to die at home, but few actually do so. Population Societies, 2015, 524(7): 1-4.
40. Bode S, Grove G. Use of humidified high flow nasal oxygen in community palliative care: a case report. Palliat Med Rep, 2020, 1(1): 179-182.
41. Huang JY, Steele P, Dabscheck E, et al. Nasal high flow therapy for symptom management in people receiving palliative care. J Pain Symptom Manage, 2022, 63(2): e237-e245.
42. Dolidon S, Dupuis J, Molano Valencia LC, et al. Characteristics and outcome of patients set up on high-flow oxygen therapy at home. Ther Adv Respir, 2019, 13: 1753466619879794.
43. Sørensen SS, Storgaard LH, Weinreich UM. Cost-effectiveness of domiciliary high flow nasal cannula treatment in COPD patients with chronic respiratory failure. Clinicoecon Outcomes Res, 2021, 13: 553-564.
44. Milne RJ, Hockey HU, Garrett J. Hospital cost savings for sequential COPD Patients receiving domiciliary nasal high flow therapy. Int J Chron Obstruct Pulmon Dis, 2022, 17: 1311-1322.
45. Groessl EJ, Tally SR, Hillery N. Cost-effectiveness of humidified high-flow therapy (HHFT) for COPD patients on long-term oxygen therapy. Clinicoecon Outcomes Res, 2023, 15: 239-250.
46. Crimi C, Nolasco S, Campisi R, et al. Long-term domiciliary high-flow nasal therapy in patients with bronchiectasis: a preliminary retrospective observational case-control study. J Clin Med, 2022, 11(24): 7323.
47. Simioli F, Fiorentino G, Cauteruccio R, et al. Long-term high flow nasal cannula therapy in primary and secondary bronchiectasis. Healthcare (Basel), 2023, 11(9): 1250.
48. Weinreich UM, Burchardt C, Huremovic J. The effect of domiciliary high flow nasal cannula treatment on dyspnea and walking distance in patients with interstitial lung disease --A pilot study. Chron Respir Dis, 2022, 19: 14799731221137085.
49. Annunziata A, Coppola A, Carannante N, et al. Home management of patients with moderate or severe respiratory failure secondary to COVID-19, using remote monitoring and oxygen with or without HFNC. Pathogens, 2021, 10(4): 413.

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家庭经鼻高流量氧疗在慢性阻塞性肺疾病中的应用研究进展

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