Dorzolamide/Timolol Combination Versus Latanoprost in the Treatment of Open-angle Glaucoma: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

MEI LI KE MU Ai shan ,  Ju er ti Ha di er

Department of Ophthalmology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;

Corresponding author：

Ju er ti Ha di er, Email: juret.foreye@yahoo.com.cn

Keywords：

Dorzolamide plus timolol; Latanoprost; Open-angle glaucoma; Systematic review

DOI：

10.7507/1672-2531.20090066

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To assess the efficacy and safety of a dorzolamide/timolol combination versus latanoprost in the treatment of open-angle glaucoma.
Method 　We searched for randomized control trials concerning a dorzolamide/timolol combination versus latanoprost in the treatment of open-angle glaucoma,in electronic databases , and handsearched some related journals. The quality was evaluated and meta-analysis was conducted using the software RevMan 5.0.
Results 　Six randomized control trials involving 361 patients and 361 eyes were identified. The Meta-analysis showed that at the end of study, there was a statistically significant difference between the two study groups with WMD – 0.49, and 95%CI – 1.06 to 0.07 ( P=0.09) in lowering intraocular pressure; there was no statistically significant difference between the two groups with WMD 1.43 and 95%CI 0.49 to 4.21 (P=0.53); and there was no statistically significant differences between the two groupswith WMD 0.40 and 95%CI 0.13 to 1.26 (P=0.12) in incidence of headache.
Conclusion 　Compared with latanoprost, dorzolamide-timolol combination have increased efficacu in lowering intraocular pressure (IOP).If we want a more reliable result ,we need a large number of multi-centre,double-blinded randomized control trials.

Citation： MEI LI KE MU Ai shan,Ju er ti Ha di er. Dorzolamide/Timolol Combination Versus Latanoprost in the Treatment of Open-angle Glaucoma: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2009, 09(3): 350-354. doi: 10.7507/1672-2531.20090066 Copy

1.	hypertension and glaucoma: a six-month masked, multicenter trial in the United States. Ophthalmology, 1996, 103(1): 138-147.
2.	He MG, Foster PJ, Ge J, et al. Prevalence and clinical characteristics of glaucoma in adult Chinese: a population 2 based study in liwan district, guang zhou. Invest Ophthalmol Vis Sci, 2006, 47(7): 2782-2788.
3.	Zou YH, Chiou CY. New ideas for medical therapy of glaucoma in the future. International Journal of Ophthalmology, 2005, 5(3): 411.
4.	Alm A, Stjernschantz J. Effects on intraocular pressure and side effects of 0.005% latanoprost applied once daily, evening or morning. A comparison with timolol. Scandinavian Latanoprost Study Group. Ophthalmology, 1995, 102(12): 1743-1752.
5.	Camras CB and United States Latanoprost Study Group. Comparison of latanoprost and timolol in patients with ocular.
6.	Watson P, Stjernschantz J and Latanoprost Study Group. A sixmonth, randomized, double-masked study comparing latanoprost with timolol in open-angle glaucoma and ocular hypertension. Ophthalmology, 1996, 103(1): 126-137.
7.	Smith SL, Pruitt CA, Sine CS. The use of latanoprost 0.005% once daily to simplify medical therapy in patients with primary openangle glaucoma or ocular hypertension. Acta Ophthalmol Scand, 1999, 77(2): 189-192.
8.	Clineschmidt CM, Williams RD, Snyder E, et al. A randomized trial in patients inadequately controlled on timolol alone comparing the dorzolamide-timolol combination to monotherapy with timolol or dorzolamide. Ophthalmology, 1999, 106(12 Suppl): 17-24.
9.	Hutzelmann J, Owens S, Shedden A, et al. Comparison of the safety and efficacy of the fixed combination of dorzolamide/timolol and the concomitant administration of dorzolamide and timolol: a clinical equivalence study. Br J Ophthalmol, 1998, 82(11): 1249-1253.
10.	Boyle JE, Ghosh K, Gieser DK, et al. A randomized trial comparing the dorzolamide-timolol combination given twice daily to monotherapy with timolol or dorzolamide. Ophthalmology, 1999, 106(12 Suppl): 10-16.
11.	Polo V, Larrosa JM, Gomez ML, et al. Latanoprost versus combined therapy with timolol plus dorzolamide: IOP-lowering effect in openangle glaucoma. Acta Ophthalmol Scand, 2001, 79(1): 6-9.
12.	Honrubia FM, Larsson LI, Spiegel D. European latanoprost studygroup. A comparison of the effects on intraocular pressure of latanoprost 0.005% and the fixed combination of dorzolamide 2% and timolol 0.5% in patients with open-angle glaucoma. Acta Ophthalmol Scand, 2002, 80(6): 635-641.
13.	Martínez A, Sánchez M. A comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patients. Curr Med Res Opin, 2006, 22(1): 67-73.
14.	Mulaney J, Sonty S, Ahmad A, et al. Comparison of daytime efficacy and safety of dorzolamide/timolol maleate fixed combination versus latanoprost. Eur J Ophthalmol, 2008, 18(4): 556-562.
15.	Quaranta L, Miglior S, Floriani I, et al. Effects of the timololdorzolamide fixed combination and latanoprost on circadian diastolic ocular perfusion pressure in glaucoma. Invest Ophthalmol Vis Sci, 2008, 49(10): 4226-4231.
16.	Janulevicien? I, Harris A, Kagemann L, et al. A comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open-angle glaucoma patients. Acta Ophthalmol Scand, 2004, 82(6): 730-737.

1. hypertension and glaucoma: a six-month masked, multicenter trial in the United States. Ophthalmology, 1996, 103(1): 138-147.
2. He MG, Foster PJ, Ge J, et al. Prevalence and clinical characteristics of glaucoma in adult Chinese: a population 2 based study in liwan district, guang zhou. Invest Ophthalmol Vis Sci, 2006, 47(7): 2782-2788.
3. Zou YH, Chiou CY. New ideas for medical therapy of glaucoma in the future. International Journal of Ophthalmology, 2005, 5(3): 411.
4. Alm A, Stjernschantz J. Effects on intraocular pressure and side effects of 0.005% latanoprost applied once daily, evening or morning. A comparison with timolol. Scandinavian Latanoprost Study Group. Ophthalmology, 1995, 102(12): 1743-1752.
5. Camras CB and United States Latanoprost Study Group. Comparison of latanoprost and timolol in patients with ocular.
6. Watson P, Stjernschantz J and Latanoprost Study Group. A sixmonth, randomized, double-masked study comparing latanoprost with timolol in open-angle glaucoma and ocular hypertension. Ophthalmology, 1996, 103(1): 126-137.
7. Smith SL, Pruitt CA, Sine CS. The use of latanoprost 0.005% once daily to simplify medical therapy in patients with primary openangle glaucoma or ocular hypertension. Acta Ophthalmol Scand, 1999, 77(2): 189-192.
8. Clineschmidt CM, Williams RD, Snyder E, et al. A randomized trial in patients inadequately controlled on timolol alone comparing the dorzolamide-timolol combination to monotherapy with timolol or dorzolamide. Ophthalmology, 1999, 106(12 Suppl): 17-24.
9. Hutzelmann J, Owens S, Shedden A, et al. Comparison of the safety and efficacy of the fixed combination of dorzolamide/timolol and the concomitant administration of dorzolamide and timolol: a clinical equivalence study. Br J Ophthalmol, 1998, 82(11): 1249-1253.
10. Boyle JE, Ghosh K, Gieser DK, et al. A randomized trial comparing the dorzolamide-timolol combination given twice daily to monotherapy with timolol or dorzolamide. Ophthalmology, 1999, 106(12 Suppl): 10-16.
11. Polo V, Larrosa JM, Gomez ML, et al. Latanoprost versus combined therapy with timolol plus dorzolamide: IOP-lowering effect in openangle glaucoma. Acta Ophthalmol Scand, 2001, 79(1): 6-9.
12. Honrubia FM, Larsson LI, Spiegel D. European latanoprost studygroup. A comparison of the effects on intraocular pressure of latanoprost 0.005% and the fixed combination of dorzolamide 2% and timolol 0.5% in patients with open-angle glaucoma. Acta Ophthalmol Scand, 2002, 80(6): 635-641.
13. Martínez A, Sánchez M. A comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patients. Curr Med Res Opin, 2006, 22(1): 67-73.
14. Mulaney J, Sonty S, Ahmad A, et al. Comparison of daytime efficacy and safety of dorzolamide/timolol maleate fixed combination versus latanoprost. Eur J Ophthalmol, 2008, 18(4): 556-562.
15. Quaranta L, Miglior S, Floriani I, et al. Effects of the timololdorzolamide fixed combination and latanoprost on circadian diastolic ocular perfusion pressure in glaucoma. Invest Ophthalmol Vis Sci, 2008, 49(10): 4226-4231.
16. Janulevicien? I, Harris A, Kagemann L, et al. A comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open-angle glaucoma patients. Acta Ophthalmol Scand, 2004, 82(6): 730-737.

Chinese Journal of Evidence-Based Medicine

Dorzolamide/Timolol Combination Versus Latanoprost in the Treatment of Open-angle Glaucoma: A Systematic Review

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