Objective To compare chordal transposition and chordal shortening in repairing anterior leaflet prolapse (ALP)， and explore the surgical indications as well as merits and demerits of these two techniques. 〖WTHZ〗Methods We retrospectively reviewed the data of 90 ALP patients recruited into Anzhen Hospital between March 1986 and March 2008, and classified them into chordal shortening group (n=23) and chordal transposition group (n=67). KaplanMeier survival curve and freedom from reoperation curve were established to compare the two groups. Univariate analysis and multivariate logistic analysis regression were used to identify independent risk factors for early death and late cardiac events. 〖WTHZ〗Results There were three perioperative deaths in chordal shortening group（13.0%）, and three deaths in chordal transposition group (4.4%), and the difference was not significant (χ2=2.019，P=0.155). The follow-up time ranged from 1 month to 18 yrs（7.70±5.41 yrs）. There were 5 late deaths, of which 3 were in chordal shortening group and 2 in chordal transposition group. The KaplanMeier survival curve showed that 5-year survival rate of chordal shortening group was significantly lower than chordal transposition group (70.00%±18.24% vs.98.00%±1.98%,χ2=12.50, P=0.000); And the KaplanMeier freedom from reoperation curve showed [CM(159mm]that 5-year reoperation rate of chordal shortening group was also significantly lower than chordal transposition group (83.30%±15.20% vs.96.10%±2.71%,χ2=10.27，P≤0.001). By the univariate analysis, we found that age＞55 yrs old, concomitant CABG procedure, New York Heart Association (NYHA) function class Ⅲ-Ⅳ, preoperative heart failure history, aortic clamping time＞90 min, and preoperative lefe ventricular ejection fraction (LVEF)＜45% were the risk factors for perioperative death and risk factors for late cardiac events included postoperative mitral regurgitation＞2+, chordal shortening technique, preoperative heart failure history, and aortic clamping time＞90 min. The multivariate logistic analysis regression showed that aortic clamping time＞90 min, concomitant CABG procedure, preoperative LVEF＜45% were the independent predictors for perioperative death, and NYHA class ⅢⅣ, chordalshortening technique and residual mitral regurgitation＞2+ were the independent predictors for the late cardiac events. Conclusion （1） There is no statistically difference between chordal transposition and chordal shortening in the perioperative survival rate. (2) Chordal transposition has a relative superiority to chordal shortening in terms of 5-year survival rate. (3) Chordal transposition has a higher mid and longterm rate of freedom from reoperation than chordal shortening. （4） Although chordal transposition has a lower incidence of reoperation and ahigher mid and longterm survival rate, the indication for it is restricted to less extensive ALP and patients with transferrable chord in the posterior leaflet. Chordal shortening is an independent risk factor for late events.

Citation： CHEN Wei,ZHANG Jianqun,GAN Huili,et al .. Comparison Analysis Between Chordal Transposition and Chordal Shortening in Repairing Anterior Leaflet Prolapse. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2010, 17(1): 26-31. doi: Copy