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find Keyword "不典型" 16 results
  • 锡类散思密达治疗溃疡性结肠炎伴不典型增生研究

    摘要:目的:锡类散思密达联合治疗溃疡性结肠炎伴不典型增生临床疗效观察。方法:锡类散思密达保留灌肠每晚一次,治疗4周后复查。结果:临床完全缓解32例,有效8例,无效2例,有效率95.23%;结肠镜下治疗后较治疗前明显改善,组织病理从治疗前轻度38例、中度4例治疗后无不典型增生30例、轻度10例、中度2例改变。结论:锡类散思密达治疗溃疡性结肠炎,疗效确切,症状改善快,副作用小。

    Release date:2016-08-26 03:57 Export PDF Favorites Scan
  • CHANGES OF BASEMENT MEMBRANE DURING CARCINOGENIC CHANGE OF THE ATYPICAL HYPERPLASIA OF THE MAMMARY.

    Objective To observe the changes of basement membrane (BM) during carcinogenic change of the atypical hyperplasia of the mammary. MethodsSP immunohistochemical method and two special stain method (Foot and PAS stain method) and the electron microscope were used to observe the changes of the BM. Results BM already changed in atypical hyperplasia grade Ⅱ, and more significantly changed in atypical hyperplasia grade Ⅲ. BM was thinner or thicker somewhere distinctively under the microscope, and some little deletions were observed under the electron microscope in atypical hyperplasia grade Ⅲ, and there was no BM in breast cancer.Conclusion The change procedure of BM was correlated with the changes of the epithelial, atypical hyperplasia. The changes of BM in the atypical hyperplasia are a part of the carcinogenic procedure from the epithelial atypical hyperplasia of the mammary.

    Release date:2016-08-28 05:29 Export PDF Favorites Scan
  • TENASCIN EXPRESSION IN ATYPICAL HYPERPLASIA OF MAMMARY AND INFILTRATING DUCTAL BREAST CANCER

    To investigate the changes of tenascin (TN) expression during the course of canceration through atypical hyperplasia of breast epithelia. The SP immunohistochemical method was used to study TN expresson in 50 different breast tissues. Results: There was no TN expression in normal breast and grade Ⅰ hyperplasia; immunostaining of TN was detected in 2 cases with grade Ⅱ atypical hyperplasia; the expression of TN in grade Ⅲ atypical hyperplasia (80%) and infiltrating ductal breast cancer (90%) was significantly higher than that in grade Ⅱ atypical hyperplasia (20%); and immunostaining of TN was detected in part of the cancer cells. Conclusion: These results suggest that TN expression in the stroma of serious atypical hyperplasia may play a role in limiting the outgrowth of hyperplastic epithelia.

    Release date:2016-08-29 09:20 Export PDF Favorites Scan
  • SIGNIFICANCE OF THE CHANGES OF DNA CONTENT, ULTRASTRUCTURE AND TUMOR-RELATED ANTIGNES EXPRESSION IN ATYPICAL HYPERPLASIA OF BREAST

    The DNA content, cellular ultrastructure and the expression of blood group Y antigen and immunosuppressive acidic protein-2(IAP-2) were observed in normal breast, cystic hyperplasia of breast and breast cancer. The results showed: the results observed in the cells of cystic hyperplasia with epithelial proliferation grade Ⅰ were similar to those in normal breast cells. The DNA content increased, the hypoplasia and dedifferentiation features in some structures of cellular membrane and nucleus were observed, and the abnormal antigens expressed in part of the atypical hyperplasic cells. The DNA content and ultrastructure in a part of cells with aypical hyperplasia grade Ⅲ were similar to those in the cells of breast cancer grade Ⅰ. The results indicated that in the couse of atypical hyperplasia, the biological abnormalities and its extent of those cells were closely related to the differentiation extent, the developing tendency and the risk of canceration of the cystic hyperplasia of breast.

    Release date:2016-08-29 03:18 Export PDF Favorites Scan
  • THE RELATIONSHIP BETWEEN THE EXPRESION OF C-erb B-2 ONCOGENE PROTEIN IN ATYPICAL HYPERPLASIA OF BREAST AND BREAST CARCINOGENESIS

    The expression of C-erb B-2 oncogene protein in the tissues of normal breast, atypical cystic hyperplasia of breast and breast carcinoma were determined in order to analyse the significance of the changes of C-erb B-2 oncogene in the course from atypical hyperplasia to carcinoma of breast. Results: there were no expression of C-erb B-2 protein in the tissues of normal breast and cystic hyperplasia of breast with epithelia proliferation grade Ⅰ. The positive rates of the expressions of C-erb B-2 protein in the tissues of atypical hyperplasia grades Ⅱ, Ⅲ and carcinoma of breast were 20.0%, 40.0% and 54.2% respectively. The results indicated that the abnormal changes of C-erb B-2 nocogene might occured in the carcinomatous transformation phase along with the changes from normal breast epithelial cell through atypical hyperplasia to breast cancer, those changes could be the result or promotion factor of abnormal proliferation of atypical hyperplasia of breast and was one of the markers of malignant transformation of epithelia of breast.

    Release date:2016-08-29 03:18 Export PDF Favorites Scan
  • 胰头癌与胰头局限性不典型胰腺炎的鉴别诊断体会

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  • 不典型胸部结节病影像诊断研究

    结节病是一种原因未明的多系统肉芽肿性疾病,其特征是发生广泛的非干酪性上皮肉芽肿,可累及全身各个器官,90%可累及肺部[1]。其诊断依赖于组织学活检证实有非干酪性坏死性肉芽肿,且抗酸染色阴性,临床表现,以及影像学表现。由于组织学活检不易获得,且临床表现无特异性,故影像诊断则成为诊断该病的关键。影像学表现典型者,结节病的诊断较易,但也不乏误诊者;影像学表现不典型者,极易误诊。现回顾分析28例胸部结节病患者的相关资料,探讨结节病的影像诊断,尤其是不典型者的影像诊断,以提高结节病的诊断准确率。

    Release date:2016-08-30 11:35 Export PDF Favorites Scan
  • Esophagectomy for the Treatment of Barrett’s Esophagus

    Barrett’s esophagus is considered an important risk factor for the pathogenesis of esophageal adenocarcinoma. Treatment strategies for diseases from high-grade dysplasia (HGD) to adenocarcinoma are different. The recurrence rates of endoscopic treatment and anti-reflux surgery are comparatively higher. Abnormal lesions of the esophagus can be completely resected by esophagectomy for the treatment of HGD to adenocarcinoma, and treatment outcomes are confirmed.But appropriate surgical strategies and lymph node dissection scopes should be chosen according to different cancer staging.Lymph node metastasis is a major factor in determining prognosis.

    Release date:2016-08-30 05:45 Export PDF Favorites Scan
  • Analysis of Atypical Placental Abruption

    目的 探讨不典型胎盘早剥的临床特点。 方法 对2008年5月-2009年5月收治的55例胎盘早剥患者的临床资料进行回顾性分析。其中产前漏诊30例,疑诊15例,确诊10例。胎盘早剥的产前确诊率为18.2%,漏诊率为54.5%。所有患者均经产后证实。 结果 重度子痫前期(25.5%)、胎膜早破(12.7%)是胎盘早剥的主要发病诱因;阴道流血(52.7%)、腰腹痛(47.3%)及胎心异常(36.4%)是其常见的临床表现。胎盘早剥者,剖宫产率、胎儿窘迫及早产率均增加。 结论 不典型胎盘早剥病情隐匿。后壁胎盘、早剥面积小及B型超声检查阴性是漏诊的主要原因。对此患者应提高认识,动态监测,及时处理,以改善母婴结局。

    Release date:2016-09-07 02:34 Export PDF Favorites Scan
  • Value of Mammotome for Excision and Biopsy in Breast Cysts

    Objective To discuss the surgical indication of mammotome (MMT) operation and its auxiliary diagnosis value on breast cysts. Methods Seventy-eight patients with breast cysts from May 2010 to November 2011 in this hospital were enrolled. Excision and biopsy were performed according to the following guidelines:Single cyst with inhomogeneous interna echoes and diameter at least 1 cm;Multiple cysts associated with irregular megalgia, localized thickening of breast or ineffective drug treatment after three months;High risk of breast cancer;Hypoechoic nodules and laticifers exaggerated cysts;Ultrasonography showed disorderly echo and abundant blood supply in glandular tissues around the lesions. The result of preoperative ultrasound was compared with that of postoperative pathology diagnosis. Results In these 78 breast cysts patients with preoperative ultrasound diagnosis, 40 cases were breast multiple cysts, 38 cases were multiple cysts plus untouchable hypoecho nodules;42 cases were high risk lesions, and the other 36 cases were low risk lesions. Postoperative pathology diagnosis revealed 27 cases of cystic hyperplasia, 2 cases of atypical hyperplasia, and 1 case of breast cancer in the ultrasonic high risk lesions, and 19 cases of cystic hyperplasia in the ultrasonic low risk lesions. Ultrasound diagnostic accuracy rate was 60.26%(47/78), sensitivity was 61.22%(30/49), and specificity was 58.62%(17/29). The number of resection lesions was 13.00±8.16, the time of operation was (74.25±22.68) min. The average hospital stay was 1 d after surgery. The local hematoma occurred in 2 cases and no other complications occurred during one month of follow-up. Conclusions The guidelines of MMT protocoled according to clinical manifestation of breast cyst patients and imaging of high-frequency ultrasound in author’s department are simple and utility. Minimal excision and biopsy via MMT can confirm the histological type and help for early diagnosis of breast cancer and precancerous lesion. It is important and necessary to standardize the surgical indications of MMT in the clinical work.

    Release date:2016-09-08 10:34 Export PDF Favorites Scan
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