目的 总结胰腺实性假乳头状瘤（solid-pseudopapillary tumor of pancreas, SPTP）的诊治经验。方法 回顾性分析我院1999年11月至2007年10月期间收治的6例SPTP患者的临床资料。结果 6例均为女性，其中4例为年轻女性； 术前均未确诊； 行胰腺体尾部切除2例，肿瘤局部切除4例，其中2例加脾切除，术后病理报告确诊为SPTP。 术后无严重并发症，随访1～95个月，无复发和转移。结论 SPTP多发于年轻女性，术中冰冻切片对术中处理提供参考，手术切除为首选治疗方法，预后良好。
Objective To summarize the current diagnostic and therapeutic advancement of solid pseudopapillary tumor of the pancreas. Methods Relevant literatures about the diagnosis and treatment of solid pseudopapillary tumor of the pancreas, which were published recently domestic and abroad were collected and reviewed. Results Solid pseudopapillary tumor of the pancreas is now considered to be a low-grade malignancy with characteristic clinical, imaging and pathological features. Resection is considered to be the optimal choice with favourable prognosis. Conclusion An awareness of the features may guide us to a correct diagnosis and treatment of this rare neoplasm, but the deep understanding of the disease needs the accumulation of more cases and fundamental research.
目的 总结胰腺实性假乳头状瘤再次手术病例的诊断和治疗经验。方法 回顾性分析2002年12月至2011年12月期间笔者所在医院收治的4例胰腺实性假乳头状瘤再次手术患者的临床资料。结果 4例患者均行手术治疗，术后恢复良好，随访时间3个月～8年，平均47个月。至2012年3月，3例患者分别无瘤生存3个月、3个月以及8年；1例患者于术后8年死于营养吸收障碍，死亡时无肿瘤复发。结论 胰腺实性假乳头状瘤具有低度恶性倾向，以局部复发为主，远处转移少见。手术是复发、转移病例的最佳选择，具有较好疗效。
ObjectiveTo investigate the CT and MR imaging manifestation of solid-pseudopapillary neoplasm of pancreas (SPNP), deepen the understanding of imaging and clinical pathological characteristics of SPNP and improve the level of diagnosis. MethodsBetween Jan 2010 and Dec 2015, the CT and MR imaging data of seven patients with SPTP proved by surgery and histopathologically were analyzed retrospectively. The following imaging features were reviewed: tumor size, location, shape, margin, encapsulation, calcification, hemorrhage, solid-cystic ratio, pancreatic and bile duct dilatation, the manifestation of plain scan and dynamic pattern of enhancement. ResultsThe population comprised 7 women, the average age was 28.3 years oldwith a median tumor size of 5.7 cm. Tumors were located at body tail of pancreas in 5 cases, at the head in 1 case, and at the tail in 1 case. The tumor were exogenous in 5 cases, endogenous in 2 cases. Five tumors showed the regular margin, inregular in 2 cases. Four cases of plain and enhanced CT scan showed cystic-solid tumors, the solid and encapsulation part ofSPNP presented as hipo-, iso-density, and gradually enhancement after injecting contrast medium. Three cases were examined by MRI, 2 cases appeared hemorrhage, tumor located in the head of pancreas leaded to the secondary ducts dilatations in 1 case. Conciusions There are some characteristics in CT and MRI manifestation of SPNP. Accurate diagnosis meybe created by the imaging study combined with the clinical feature.
Objective To discuss the methods of diagnosis and treatment of cystic neoplasms of pancreas. Methods Demographic data, clinical manifestations, diagnostic exams, surgical procedures, pathological diagnosis, postoperative complications, and follow-up data of 29 patients with cystic neoplasms of pancreas were analyzed retrospectively. Results There were 8 （28%） serous cystic tumors （SCN）, 12 （41%） mucinous cystic tumors （MCN）, 3 （10%） intraductal papillary mucinous tumors （IPMN）, and 6 （21%） solid pseudopapillary tumors （SPT）. Eight cases of SCN, 7 cases of MCN, 1 case of IPMN, and 5 cases of SPT were all benign. The ages of the patients were from 15 to 78 years〔average, （49±17）years〕and all tumors were more common in female （76%, 22/29）. Twenty-three cases of 29 patients were performed operations, 22 cases were underwent surgical resection, and 1 case was performed exploration and biopsy. There was no surgery-related death. The rest 6 cases were not performed operation. Twenty-one cases followed-up for 6 months to 8 years 〔average, （2.7±2.3） years〕, 8 cases didn’t followed-up. Sixteen cases with surgical resection had no recurrence during follow-up period, 1 case performed exploration and biopsy died in 1 year after operation, and 4 cases of SCN without surgery didn’t deteriorate. Conclusions The most common cystic neoplasms of pancreas are mucinous and serous cysts. These tumors are more frequent in female. Although almost all serous cysts are benign, 42% of mucinous cysts are malignant. Misdiagnosis may delay appropriate treatment and increase mortality. The resection rate of pancreatic cystic tumor is high, and the prognosis is good after radical resection.
目的 探讨内镜下治疗胆管乳头状瘤的价值。方法 6例经病理学检查证实的胆管乳头状瘤患者在行“胆道探查+ T管引流术”后6～8周行胆道镜下高频电刀烧灼术，对术后治疗效果进行评估。结果 6例患者术后胆汁引流量逐渐增多至100～400 ml/d(平均250 ml/d)，胆汁黏稠度明显减轻，黄疸减退。术后随访1～3年，平均2年，3例患者术后黄疸、腹痛明显减轻，至今无复发； 2例在继续治疗中； 1例患者随访半年，T管引流通畅，但因严重肺部感染并发多器官功能衰竭死亡。结论 内镜下高频电刀烧灼治疗胆管乳头状瘤能有效缓解患者的临床症状，明显提高患者的生存质量。