【摘要】 目的 探讨乳腺恶性淋巴瘤的临床病理特征、治疗方式及其与预后关系。 方法 1980年1月-2007年12月对收治的21例乳腺恶性淋巴瘤患者的临床病理特点、诊断和治疗方法进行回顾性分析。 结果 21例乳腺恶性淋巴瘤患者均为女性，中位年龄47岁；其中原发性乳腺恶性淋巴瘤18例，继发性恶性淋巴瘤3例。原发性乳腺恶性淋巴瘤均为非霍奇金淋巴瘤，B细胞来源为主，大多为术后诊断，治疗均采用手术+化学疗法。 结论 乳腺恶性淋巴瘤治疗应强调手术，化学疗法和放射治疗的综合治疗。【Abstract】 Objective To study the clinico-pathological features and treatment modality of malignant breast lymphoma, and their relationships with the prognosis of the disease. Methods The clinico-pathological features, diagnosis and treatment methods of 21 cases of malignant breast lymphoma diagnosed between January 1980 and December 2007 were analyzed retrospectively and related domestic and overseas literature was reviewed. Results Among the 21 female patients, 18 had primary breast lymphoma (PBL), 3 had secondary breast lymphoma. All cases of PBL were non-Hodgkin’s lymphoma with mainly B cells as the origin. The median age of the patients was 46.5 years old. Most of the cases were diagnosed postoperatively and all patients were treated by operation combined with chemotherapy. Related literature reviewing showed that clinical staging and treatment modality were important factors of prognosis. Conclusion In treating malignant breast lymphoma, operation and chemoradiotherapy should be combined together to get a better result.
目的 通过检测浸润性乳腺癌中白细胞介素18（IL-18）和血管内皮生长因子（VEGF）的表达情况，探讨其表达相关性及与临床病理学参数的关系。 方法 应用免疫组织化学法检测IL-18和VEGF在42例浸润性乳腺癌组织和12例正常乳腺组织中的表达情况。 结果 IL-18和VEGF在42例浸润性乳腺癌中的表达阳性率均显著高于12例正常乳腺组织（P＜0.05）。且在42例浸润性乳腺癌组织中，IL-18阳性组中VEGF阳性率（87.1%）显著高于IL-18阴性组中VEGF阳性率（12.9%），差异有统计学意义（P＜0.05）。在亚组分析中，IL-18的表达只与有无腋窝淋巴结转移有相关性（P＜0.05），而VEGF的表达与有无腋窝淋巴结转移和TNM分期有相关性（P＜0.05）。 结论 在浸润性乳腺癌中，IL-18的表达上调与VEGF的表达上调显著相关，IL-18可能具有促进肿瘤新生血管形成的作用。
ObjectiveTo summarize the complications after supraclavicular lymph node dissection for invasive breast cancer patients with ipsilateral supraclavicular lymph node metastasis but without distant metastasis, and to analyze its safty. MethodsA retrospectively clinical analysis of the complications of 98 invasive breast cancer patients with ipsilateral supraclavicular lymph node metastasis but without distant metastasis, who underwent supraclavicular lymph node dissection in our hospital from Jan. 2014 to Dec. 2015 was performed. ResultsThere were 20 cases of lymphedema (20.4%, 20/98), 4 cases of hypaesthesia (4.1%, 4/98), and 4 cases of abduction restriction of shoulder joint (4.1%, 4/98). No other serious complications occurred. There was no shape change of shoulder and upper arm abduction, facial edema, head and neck disorders, pleural effusion or chylothorax happened. The extubation time of drainage tube at axillary and chest wall in 78 cases was in 1 month after the operation, 18 cases was in 1-2 months, and 2 cases was in 2-3 months. There were 14 cases (14.3%) suffered from the ipsilateral axillary or pleural effusion after extubation. The extubation time of supraclavicular drainage tube in 98 cases was 3-7 days after the surgery, with the median of 4.5 days, including 3 cases (3.1%) of chyle leakage. ConclusionThe supraclavicular lymph node dissection has no serious postoperative complications, and is safe to patients with ipsilateral supraclavicular lymph node metastasis but without distant metastasis.
【摘要】 目的 比较酸性成纤维细胞生长因子(acid fibroblast growth factor,aFGF或FGF1)在正常乳腺组织、乳腺良性肿瘤及乳腺癌中的表达差异,探讨FGF1与乳腺癌血管生成的关系。方法 应用免疫组织化学(immunohistochemistry,IHC)SP法检测FGF1在40例乳腺癌组织、12例良性乳腺肿瘤组织及12例正常乳腺组织中的表达情况；以CD34抗体标记血管内皮细胞CD34抗原行乳腺癌组织微血管密度(micro vessel density,MVD)计数。〖HTH〗结果〖HTSS〗 FGF1在40例乳腺癌中的阳性表达率（57.5%，23/40)显著高于12例乳腺良性肿瘤组织中阳性表达率(16.7%,2/12)以及正常乳腺组织阳性表达率(0,0/12),差异有统计学意义(Plt;0.05)；良性肿瘤组FGF1表达率和正常乳腺组织比较无统计学意义(Pgt;0.05)。40例乳腺癌组织MVD计数为(70.17±29.33)个/HP,在23例FGF1阳性组中MVD计数为(89.48±23.23)个/HP,显著高于17例阴性组(44.06±12.53)个/HP,差异有统计学意义(Plt;0.05)。〖HTH〗结论 〖HTSS〗FGF1可能参与乳腺癌微血管生成。
目的探讨甲状腺功能亢进（简称甲亢）手术后出现骨饥饿综合征的发病机理。方法回顾性分析四川大学华西医院2009年收治的2例甲亢手术后严重低钙患者的临床资料。结果本组2例病例在甲亢手术后均出现了严重低钙血症，1例低镁血症; 2例病例手术前、后骨代谢碱性磷酸酶均有不同程度升高。结论甲亢手术后骨饥饿综合征是多因素造成的临床症状，所以对手术后低钙症状应给予正确分析和判断，并尽可能在问题出现前给予预测和处理。对于甲亢患者和绝经期女性在围手术期给予钙的补充，手术中注意保存甲状旁腺血供是减少骨饥饿综合征的最佳手段，甲亢手术后及时补钙是必要的。