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find Author "吴星伟" 5 results
  • 视网膜静脉阻塞继发黄斑水肿的治疗进展

    视网膜静脉阻塞(RVO)继发黄斑水肿(ME)传统的治疗方法主要为激光光凝和以曲安奈德、地塞米松为主的糖皮质激素治疗。近年来,雷珠单抗(商品名Lucentis)、贝伐单抗(商品名Avastin)等抗血管内皮生长因子药物玻璃体腔注射以及玻璃体视网膜手术治疗是RVO继发ME治疗探索的主要方向。虽然许多非随机、缺乏对照的临床试验结果表明这些新的治疗方法能明显改善ME并提高视力,但仍需进行大规模、多中心、随机对照临床试验研究,以更加客观地评价这些疗法的治疗效果和安全性。

    Release date:2016-09-02 05:22 Export PDF Favorites Scan
  • 息肉样脉络膜血管病变的治疗研究进展

    息肉样脉络膜血管病变(PCV)的治疗方法主要为激光光凝治疗、光动力疗法(PDT)治疗、抗血管内皮生长因子(VEGF)药物治疗、糖皮质激素治疗、联合治疗以及针对并发症的手术治疗等。其中,PDT联合抗VEGF药物治疗已有较多非随机、缺乏对照的临床试验结果,显示出较佳效果,是目前PCV治疗方法的主要研究方向。但最佳治疗效果仍需大规模、多中心、随机对照临床试验进一步探索。

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  • Effects of lutein supplementation on macular pigment optic density in patients with early age-related macular degeneration

    Objective To measure the macular pigment optical density (MPOD) and investigate the effects of lutein supplementation on MPOD in patients with early age-related macular degeneration (AMD).Methods Forty-two early AMD eyes, which have been diagnosed by visual acuity, fundus photography and indirect ophthalmoscopy, and 42 fellow eyes were enrolled in this study. Lutein was administered in dose of 15.1 mg daily for one month. The MPOD value before and after lutein supplementation were measured by heterochromatic flicker photometry. The relationship between the MPOD value and lutein supplementation was analyzed.Results The MPOD value of AMD eyes and fellow eyes before lutein supplementation was 0.347plusmn;0.182 and 0.426plusmn;0.173 respectively, the difference was statistically significant (t=-2.042,P=0.044). The MPOD value of AMD eyes and fellow eyes after lutein supplementation was 0.406plusmn;0.155 and 0.446plusmn;0.128 respectively, the difference was not statistically significant (t=-1.283,P=0.203). For AMD eyes, there was an increasing trend of MPOD values after lutein supplementation, but no statistically significant differences (t=-1.594,P=0.115). Furthermore, there was a negative correlation between the changes of MPOD and initial MPOD in both AMD eyes (r=-0.552,P=0.000) and the fellow eyes (r=-0.731,P=0.000).Conclusions Early AMD eyes have less MPOD. Lutein supplementation may play a role in enhancing the MPOD in these eyes.

    Release date:2016-09-02 05:26 Export PDF Favorites Scan
  • 青年国人黄斑色素密度与眼轴长度的相关性研究

    Release date:2016-09-02 05:37 Export PDF Favorites Scan
  • Protective effects of recombinant erythropoietin on photoreceptor cells in rat with retinal detachment

      Objective To investigate the protective effect of recombinant erythropoietin (EPO) on the photoreceptor cells in rat with retinal detachment (RD).Methods One hundred and sixtytwo normal male rats were randomly divided into normal control (NC) group, RD model group, RD+phosphate buffer solution (RD+PBS) group, RD+EPO 100 ng group, RD+EPO 200 ng group and RD+EPO 400 ng group. Three days after RD, activated caspase3 and bclXL were detected by Western blot and/or immunofluorescence, and apoptosis were measured by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate digoxigenin nick-end labeling(TUNEL). Fourteen and 28 days and two months after RD, the outer nuclear layer (ONL)thickness was measured by histopathologic method.Results Western bolt indicated that the protein level of activated caspase-3 and bcl-XL between six groups were statistically significant(F=35.96, 30.75;P<0.01). The number of TUNEL positive cells and activated caspase-3 positive cells are consistent with each other in different groups. Fourteen days and two months after RD,the differences of ONL thickness between six groups were statistically significant(F=21.52,96.25;P<0.01).Conclusion Supplement of EPO after RD can alleviate apoptosis by inhibiting of the caspase-3 activity and increasing the expression of bcl-XL,thus exerts protective effect on photoreceptor cells.

    Release date:2016-09-02 05:41 Export PDF Favorites Scan
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