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find Keyword "布比卡因" 6 results
  • PERIPHERAL ANTI-HYPERALGESIC EFFECT AND NEUROTOXICOLOGIC SCREENING OF AMITRIPTYLINE AND BUPIVACAINE ON SCIATIC NERVE BLOCKADE CHRONICALLY ON NEUROPATHIC PAIN IN RATS

    Objective To investigate whether the peri pheral administration of amitri ptyl ine and bupivacaine produces anti-hyperalgesic effect and to screen the neurotoxicological effect on sciatic nerve blockade in a rat model of neuropathic pain. Methods Twenty-four adult male SD rats [weighing (200 ± 20) g] were made the models of chronic constriction injury (CCI) and randomly divided into 3 groups (n=8) 5 days after operation: group A (amitriptyl ine), group B (bupivacaine) and group C (normal sal ine). 0.5 mL 0.5% amitriptyl ine, 0.5% bupivacaine or normal sal ine were given in group A, group B, and group C, respectively through implanted cannulas after 5, 7 and 9 days of CCI once a day for successive 3 days. The motor function was measured before administration and 1, 2, 4, 8, 12 and 24 hours after every administration. Mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured before administration and 1, 3, 5 and 7 days after the third administration. The operated sciatic nerve samples were obtained for neuropathological examination under l ight microscope. Results Twenty-four CCI rats were all survival without infection, palsy and catheter fall ing off. Compared with group C, the rats of group A and group B both produced significant ambulation deficits after every administration (P lt; 0.05). The ambulation deficits lasted 2 hours (group B) and 8 hours (group A) respectively. But the ambulation deficits of CCI rats were all reversible. The MWT and TWL of group A 1 and 3 days after the third administration increased when compared with those before administration and 5 and 7 days after the third administration, and when compared with group B and group C (P lt; 0.05). There was no significant difference (P gt; 0.05) in l ight microscopic neuropathological examination among three groups. Epineurial tissue and endoneurium tissue integrity, tidy arrangement of fibers, less inflammatory cell and no marked degeneration of myel inated fibers were observed. Conclusion Repeated sciatic nerve blockade with 0.5% amitriptyl ine has peripheral anti-hyperalgesic effects on neuropathic pain of rats. No morphological evidence of neurotoxicity in the sciatic nerve of rats is observed in 0.5% amitriptyl ine.

    Release date:2016-09-01 09:07 Export PDF Favorites Scan
  • Effectiveness and Safety of Ropivacaine and Bupivacaine in Spinal Anesthesia: A Meta-analysis

    Objective To evaluate the effectiveness and safety of ropivacaine in spinal anesthesia. Methods We searched PubMed (1999 to 2008), OVID (1999 to 2008), EBSCO (1999 to 2008), The Cochrane Library (2000 to 2008), and CNKI (1999 to 2008) databases to identify randomized controlled trials (RCTs) that compared ropivacaine and bupivacaine for spinal anesthesia. The quality of the included RCTs was evaluated by two reviewers independently, and meta-analysis was performed by RevMan 5.0 software. Results Six RCTs were included. The methodological quality of them were all poor. Among the six RCTs, 215 patients received ropivacaine and 215 received bupivacaine. The results of meta-analyses showed that the motor-block time to complete block of ropivacaine was significantly shorter than that of bupivacaine (WMD=2.18 min, 95%CI 0.32 to 4.03, P=0.02). The motor-block time to complete recovery of ropivacaine was significantly shorter than that of bupivacaine for cesarean delivery in spinal anesthesia (SMD= – 1.82, 95%CI – 3.05 to – 0.59, P=0.004). The incidence rate of hypotension and bradycardia in spinal anestheisa with ropivacaine was lower than that with bupivacaine (OR=0.49, 95%CI 0.31 to 0.80, P=0.004; OR=0.40, 95%CI 0.03 to 4.99, P=0.47). Conclusion Equivalent doses of ropivacaine and bupivacaine provide similar analgesia in spinal anesthesia for cesarean delivery. However, haemodynamics in spinal anesthesia with ropivacaine fluctuate lightlier than with bupivacaine. Ropivacaine is suitable for spinal anesthesia in low-abdominal operations.

    Release date:2016-09-07 11:23 Export PDF Favorites Scan
  • Effectiveness of Caudal Bupivacaine with Neostigmine for Postoperative Pain Management after Hypospadias Surgery in Children: A Systematic Review

    Objective To assess the analgesic effect of caudal bupivacaine with neostigmine for hypospadias surgery in children. Methods We searched The Cochrane Library (Issue 2, 2008), MEDLINE (1966-2008), EMbase (1980-2008), CBMdisc (1978-2008), CNKI (1989-2008) and Wanfang Database using the keywords “bupivacaine”, “neostigmine” and “hypospadias” to identify randomized control trials (RCTs) of caudal bupivacaine with neostigmine versus bupivacaine alone for hypospadias surgery in children. The methodological quality of included RCTs was evaluated by two reviewers independently, and Meta-analysis was conducted using RevMan 5.0.13 software. Results We identified 3 RCTs including 160 patients which had an uncertain risk of bias. The results of meta-analysis showed no significant difference found between bupivacine alone and bupivacine plus 1 µg/kg neostigmine (WMD= 0.05, 95%CI – 6.76 to 6.86, P= 0.99), but a difference was found between bupivacine alone and bupivacine plus 1 µg/ kg, 2 µg/kg, or 3 µg/ kg neostigmine (WMD= 12.79, 95%CI 10.96 to 14.62, Plt; 0.000 01; WMD= 12.10, 95%CI – 6.76 to 6.86, Plt; 0.000 01; WMD= 11.90, 95%CI 9.17 to 14.63, Plt;0.000 01). The duration of postoperative analgesia of the bupivacaine with neostigmine group was longer than that of bupivacine alone. Conclusions Because of the small sample size and the unclear risk of bias in the included RCTs, the effectiveness of caudal bupivacaine with neostigmine for postoperative pain management after hypospadias surgery in children is not completely confirmed. So more large sample size, double-blind RCTs are needed.

    Release date:2016-09-07 02:09 Export PDF Favorites Scan
  • 布比卡因复合舒芬太尼蛛网膜下隙阻滞剖宫产术的临床观察

    目的观察布比卡因复合不同剂量舒芬太尼蛛网膜下隙阻滞对剖宫产术血流动力学的影响及安全性。 方法将2012年3月-12月收治的美国麻醉医师协会分级Ⅰ级行剖宫产术的75例产妇随机分成A、B、C、D、E 5组,每组各15例,蛛网膜下隙注射药物配制为重比重混合液。A组:布比卡因5 mg+0.2 mL生理盐水,B组:布比卡因5 mg+舒芬太尼5 μg,C组:布比卡因5 mg+舒芬太尼7.5 μg,D组:布比卡因5 mg+舒芬太尼10 μg,E组:布比卡因10 mg。记录麻醉后每分钟收缩压、舒张压、平均动脉压(MAP)、心率、心电监测、动脉血氧浓度情况,同时记录低血压例数(包括麻黄素使用例数)、寒战、恶心、呕吐和牵拉痛等不良反应的发生情况。 结果手术期间最低收缩压、舒张压、MAP值D、E组比A组低(P<0.05);D、E组低血压发生率和麻黄素使用率比A、B、C组高(P<0.05);B、C、D组镇痛效果好于A、E组(P<0.05),D组皮肤瘙痒发生率比A、B、C、E组高(P<0.05)。 结论小剂量布比卡因5 mg复合舒芬太尼5.0~7.5 μg蛛网膜下隙阻滞剖宫产术麻醉效果好,对血流动力学影响小,不良反应发生率低。

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  • 局部麻醉药心脏毒性不良反应的研究进展

    自局部麻醉药应用于临床以来,临床上出现了许多局部麻醉药心脏毒性不良反应的案例,但目前对这方面的认识仍然存在争议。该文对局部麻醉药心脏毒性不良反应的构效关系、量效关系、诊断、预防及治疗方面的研究进展进行了综述。

    Release date:2017-10-27 11:09 Export PDF Favorites Scan
  • Effectiveness of intercostal nerve block and analgesia with bupivacaine liposomes in single-port thoracoscopic lung surgery: A prospective study

    Objective To compare the analgesic effect, duration and incidence of adverse reactions of liposome bupivacaine (LB) and bupivacaine hydrochloride after intercostal nerve block in single-port thoracoscopic lung surgery. Methods In Department of Thoracic Surgery of the First Affiliated Hospital of Xinxiang Medical University between September 2023 and March 2024, 228 patients who needed to undergo thoracoscopic lung surgery were selected and divided into two groups by random number table method: a group B with bupivacaine hydrochloride (n=118), and a group LB with LB (n=110). Intraoperative intercostal nerve block was performed under endoscopy, and the time of first use of analgesic drugs after surgery, cumulative use of opioids 72 h after surgery, incidence of postoperative nausea and vomiting, length of stay and other indicators were evaluated and recorded. Results Visual analogue scale (VAS) scores at 4 h, 8 h, 12 h, 24 h, 48 h and 72 h in the LB group were significantly lower than those in the group B (P<0.05). The total number of activities within 48 h after surgery in the group B was significantly lower than that in the LB group (P<0.05), and the postoperative hospitalization stay in the LB group was shorter than that in the group B, but the difference was not statistically significant. There was no statistical difference between the two groups in postoperative adverse reactions. Conclusion Intercostal nerve block with LB during single-port thoracoscopic lung surgery can significantly reduce postoperative pain, improve quality of life, and promote recovery of the patients. It is worthy of clinical application.

    Release date:2024-09-20 01:01 Export PDF Favorites Scan
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