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find Author "康敢军" 5 results
  • 重组人红细胞生成素在体外循环围术期中的作用

    目的 观察重组人红细胞生成素(rHuEPO)在体外循环围术期对红细胞动员的效应. 方法 选择体外循环心脏直视手术患者80例,随机分为两组,治疗组:40例,从手术前7天至术后7天,皮下注射rHuEPO,每次200~250IU/kg,每周3次,共2周;同时口服铁剂.对照组:40例,不给予rHuEPO处理,其他同治疗组.术前7天、1天、术后1天、7天和14天测定血红蛋白(Hb)、红细胞压积(Hct)、网织红细胞(Ret)值. 结果治疗组用药后7天Ret明显增高,术后14天达峰值,显著高于对照组(P<0.05);Hb和Hct术后7天、14天均明显高于对照组(P<0.05);治疗组术中用血量及术后输血均显著低于对照组(P<0.05).治疗组中出现血压升高、低热等各1例,停药后症状消失. 结论 在体外循环围术期应用rHuEPO,可以促进红细胞动员、释放,减少术中预充血量及术后迟发性贫血的发生.

    Release date:2016-08-30 06:31 Export PDF Favorites Scan
  • 心脏不停跳二尖瓣置换术的心肌保护作用

    目的 通过与常规心脏停搏二尖瓣置换术的对比研究,评价心脏不停跳心瓣膜置换术的心肌保护作用.方法 24例风湿性心脏病行二尖瓣置换术患者随机分为两组,每组12例.实验组:采用心脏不停跳二尖瓣置换术;对照组:采用常规心脏停搏二尖瓣置换术.于麻醉诱导后、升主动脉开放后(或心内主要操作完成)2小时、12小时、24小时、36小时、48小时和72小时分别采中心静脉血,检测血清心肌肌钙蛋白I(cTnI)含量;观察心肌超微结构;记录心律失常情况、术后多巴胺用量、辅助通气时间和ICU恢复时间等临床指标. 结果 升主动脉开放后(或心内主要操作完成)2小时、12小时、24小时和36小时,实验组cTnI均较对照组低(Plt;0.05, 0.01);心肌组织超微结构观察对照组线粒体嵴间隙明显增宽,可见嵴断裂,实验组线粒体肿胀不明显,嵴无断裂.术后临床恢复情况与对照组比较,实验组发生心律失常例数少,多巴胺用量少(P<0.01),辅助通气和ICU恢复时间短(P<0.05). 结论 浅低温心肺转流心脏不停跳心内直视手术可减轻心肌缺血-再灌注损伤,有较好的心肌保护作用.

    Release date:2016-08-30 06:32 Export PDF Favorites Scan
  • Application of single-direction gastric mobilization under 3D-laparoscopy in minimally invasive esophagectomy for the treatment of esophageal cancer

    ObjectiveTo evaluate the safety, feasibility and short-term outcomes of single-direction gastric mobilization under 3D-laparoscopy in minimally invasive esophagectomy for the treatment of esophageal cancer.MethodsFrom February 2018 to December 2019, 118 consecutive patients who underwent minimally invasive McKeown esophagectomy for esophageal squamous cell carcinoma in our hospital were included. There were 94 males and 24 females with an average age of 53.7 (41–77) years. They were divided into two groups based on the methods of gastric mobilization: a traditional dissociation (TD) group (n=55) and a single-direction mobilization (MD) group (n=63). The clinical data of the two groups were compared.ResultsEnbloc resection and a negative resection margin were obtained in all patients. There was no postoperative mortality or incision complication. The rate of postoperative complications was 22.9%. There was no significant difference in the spleen injury, gastric injury, conversion to open surgery, abdominal reoperation as well as cervical anastomotic leakage between the two groups (P>0.05). It took significantly less time in the MD group compared with the TD group (P<0.05). There was an obvious statistical difference in the incidence of gastric mobilization related complications between the MD group (1.6%, 1/63) and TD group (12.7%, 7/55, P<0.05).ConclusionApplication of single-direction gastric mobilization under 3D-laparoscopy in minimally invasive esophagectomy for the treatment of esophageal cancer is safe and easy to perform with a satisfactory short-term outcome.

    Release date:2021-02-22 05:33 Export PDF Favorites Scan
  • Colon Interposition Grafting as An Esophageal Substitute for 108 Patients

    ObjectiveTo summarize the experience of colon interposition for esophageal replacement. MethodThe clinical data of 108 consecutive patients underwent colon interposition for esophageal replacement in our hospital between January 2005 and March 2013 were reviewed for benign and malignant lesions. Their ages ranged from 2 to 71 years (mean age at 34.3 years). There were 81 males and 27 females. ResultThere was no surgical death. Esophago-colic anastomotic insufficiency occurred in 7 patients. One case of graft necrosis was observed. Injury of recurrent laryngeal nerve occurred in 8 patients, incomplete intestinal obstruction in 2 patients, and wound infection of the abdominal wall in 1 patient, and deep venous thrombosis in 1 patient. In-hospital mortality was 15.7% (17/108). The postoperative follow-up was made for 12 months in 97 patients (91.5%) and all of them were alive. The patients' body weight and appetite improved. ConclusionColon interposition is a valuable alternative with a good long-term function.

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  • Changes of serum cTnI level in patients after lung transplantation: A retrospective study in a single center

    Objective To investigate the changes of serum cardiac-specific troponin I (cTnI) level in patients after lung transplantation. Methods Clinical data of patients undergoing lung transplantation in our hospital from December 2016 to December 2022 were retrospectively analyzed. The relationship between postoperative serum cTnI level and clinical characteristics were explored. Results Finally 20 patients were collected, including 15 males and 5 females with an average age of (51.65±12.79) years. The serum cTnI level was significantly increased after lung transplantation. The serum cTnI reached the highest level on the first day after transplantation, and significantly decreased from the third day after transplantation. The serum cTnI levels in patients with obstructive pulmonary disease and bilateral lung transplantation were significantly higher than those in patients with restrictive pulmonary disease and unilateral lung transplantation on the day after surgery and on the first day after transplantation. Conclusion Transient myocardial injury can occur after lung transplantation, which is characterized by an abnormal increase in serum cTnI level.

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