目的:减少雷公藤多苷片引起的严重不良反应发生,保证用药安全。方法:通过检索雷公藤多苷片不良反应相关文献,筛选个案或典型病例报告,分析该类不良反应的临床特征。结果:64例个案病例中,不良反应累及器官或系统以血液系统为主、其次为生殖系统、泌尿系统和肝胆系统,大多较轻微,为一过性,停药后对症治疗可以恢复,但长期或大剂量服用可能导致严重的不良反应。结论:雷公藤多苷片所致不良反应与服药时间相关,可累积多个系统,建议根据病情严格控制服药剂量,并且在服药前和服药期间检查血、尿常规和肝肾功能。
Objective To provide references for production and dissemination of evidence in the fields of medical emergency management, treatment, and prevention of epidemics after May 2008 Wenchuan earthquake by systematically reviewing, analyzing, and comparing quake related papers in medical journals. Methods We systematically searched MEDLINE and CBM (Chinese Biomedical Literature) databases (range: from inception to Sept. 2009). Quake related papers were imported into EndNote software, checked for duplication, and categorized by predefined standards. Descriptive statistical analysis was performed by SPSS 13.0. Results There were relatively fewer quake related articles globally before the occurrence of the Wenchuan earthquake, and the quantity of papers in MEDLINE was four times than that in CBM. In contrast, the quantity of Chinese quake articles increased rapidly after Wenchuan earthquake, peaking in Aug. 2008 at 6.9 times the average during the 50 years before the quake. The quake related papers in CBM appeared in 378 journals covering a diverse range of subject matter. Meanwhile, there was little change in the quantity of quake related articles in MEDLINE database. Conclusions The effort of producing and disseminating Wenchuan earthquake related medical research has been effectively organized and conducted in a scientific and timely manner, producing the largest in number of quake related medical papers in human history. It has provided first-hand guidance for disaster medical relief around the globe. We should strengthen the systematic construction of disaster medicine, and make an effort to summarize and disseminate evidence in the fields of rehabilitation, system reestablishment, and prevention of epidemics.
目的 总结鲑鱼降钙素致不良反应的一般规律和特点。 方法 检索中国期刊全文数据库（CNKI）、万方数据库（WanFang）1994年1月－2012年3月鲑鱼降钙素所致不良反应的个案报道，按患者年龄、性别、给药途径、用药剂量、不良反应发生时间、临床表现症状、有无过敏史、治疗与转归等进行分类统计分析。 结果 15例不良反应包括皮肤系统、心血管系统、消化系统、神经系统和超敏反应，高年龄段和女性发生率较高。 结论 临床上应重视鲑鱼降钙素可致不良反应，坚持合理用药。
Objective To analyze acupuncture resources in the Cochrane Database of Systematic Reviews (CDSR). Methods We identified acupuncture literature from CDSR (2008 year) electronically. W analyzed this literature by research time date, author, study contents, and conCochrane Library usions. Results We initially found 82 articles. Finally, we identified 67 systematic reviews. The number of acupuncture articles has increased all over the world with higher growth rate in China than overseas. The disease spectrum of acupuncture treatment increased widely, focusing on nervous system diseases and pain diseases. Eight articles (25.8%) definitely supported the efficacy of acupuncture. Twenty two articles (71%) considered the efficacy of acupuncture as uncertain owning to insufficient evidence. Just one article expressed that acupuncture treatment was ineffective according to current evidence.
ObjectivesTo evaluate the level and variation of Chinese scholars' scientific research capability in the world by analysing the status of literature published on top-five global biomedicine journals by Chinese scholars in the past 10 years.MethodsLiterature published on NEJM, JAMA, BMJ, Lancet and PLoS Medicine from 2007 to 2016 were searched in PubMed database. Types of diseases were classified by using International Classification of Diseases (version 10) (ICD-10). Quantitatively analysis were used to classify the different authors, institutes, studies designs, quality of publication and variation.ResultsLiterature (56.4%) published on Lancet had the largest quantity among the top-five journals. Infectious and parasitic diseases, circulation system diseases, cancers, endocrine, nutrition and metabolic diseases and neuropsychiatric diseases were the top-five in disease categories list, accounting for 38.4%. In different study design, reviews (non-experimental research) and randomized controlled trials were the first and the second study types, separately.ConclusionsFor productivity of Chinese scholars’ diseases publications on top-five medical journals, the top-five specific diseases are from the top-five disease categories-infectious and parasitic diseases, circulation system diseases, cancer, endocrine, nutrition and metabolic diseases and neuropsychiatric diseases. The main study types are reviews, randomized controlled trials and cross-sectional studies.
摘要:目的: 分析特非那定所致不良反应的临床特征、相关因素,为临床药物治疗中药品不良反应的防治提供参考依据。 方法 :检索1986～2008年国内文献源特非那定的不良反应资料,并加以分析研究。 结果 :34例不良反应报告中女性明显多于男性;不良反应以心血管系统损害最多(23例,占6766%),其次为皮肤及附件损害(5例,1470%);不良反应预后较好。 结论 :患者的性别、体质、合并用药等因素能影响不良反应的发生,对于引起心律失常不良反应临床应提高警惕,减少不良反应的发生。Abstract: Objective: To analyze the clinical features、correlation factors of ADRs caused by Terfenadine drugs and provide beneficial references for preventing and curing the ADRs. Methods :To collect and analyze the cases of ADRs caused by Terfenadine from medical journals of 19862008 Results :Women were more than men in 34 ADRs;cardiovascular system lesions accounted for 6766%,skin and its appendix lesions accounted for 1470%;ADRs prognosis well. Conclusion :The occurrence of ADRs caused by Terfenadine due to many factors such as sex、age and combination drug,ect. The ADRs caused by second generation antihistamine drugs must be reconstred.
目的 了解国内医院品质管理圈（品管圈）活动的发展现况，为品管圈活动的进一步推广和研究提供依据。 方法 2012年2月－6月采用文献研究法，检索公开发表于国内学术期刊的有关品管圈活动的所有文献，并阅读分析全文。 结果 共收集符合要求的文献125篇，文献主要来源于我国东部地区、类型以回顾性分析为主，主题内容侧重护理质量与药事服务管理。 结论 我国医院品管圈活动发展迅速，涉及面广，但研究方法、研究内容如社区发展等方面仍亟待进一步加强。
Objective To explore the characteristics of articles related to Evidence-based Nursing (EBN) and to identify the problems and difficulties encountered by clinical nurses when they were engaged in evidence-based practice in China.Methods We searched for articles published in 6 nursing journals in China from 2000 to early 2006, and classified, investigated and analyzed the retrieved articles. Results Research on EBN has been changing from explaining theories and methods to applying research results in nursing practice. Among articles on clinical application, 90.9% did not describe the methods and search strategy used; 63.6% did not specify the sources of the evidence applied in practice; 93.9% did not describe the methodological quality of the evidence; only 6.1% used the results of systematic reviews or randomized trials to guide clinical practice; and 72.7% did not use effective evaluation methods to identify the nursing outcomes after applying evidences in clinical practice. Conclusions The quality of EBN related articles needs to improve further. Nurses should learn more about the knowledge and skills associated with EBN so as to improve the quality of nursing practice and of academic articles on EBN
To analyze the adverse drug reactions (ADRs) induced by levetiracetam, providing a scientific basis and reference for clinical safe and rational drug use.Using Chinese search terms such as "levetiracetam", " antiepileptic", "adverse drug reaction", "side effect", and English search terms such as "levetiracetam", "antiepileptic", "adverse reaction", "ADR", "side effect", and "induced", we conducted a literature search in databases including CNKI, Wanfang Data, VIP Biomedical Database, PubMed, and Web of Science from the inception of the databases until March 1, 2025. Relevant information was extracted and statistically analyzed. A total of 39 articles were included, involving 46 patients, of which 24 were male (52.17%) and 22 were female (47.83%). ADRs involved 9 organ/systems, primarily the nervous system (39.13%), muscular system (32.61%), skin (13.04%), and urinary system (10.87%), including symptoms such as irritability, hallucinations, cognitive impairment, rhabdomyolysis, papules, and frequent urination. ADRs induced by levetiracetam affect multiple organ/systems. During clinical use, patient conditions should be regularly monitored, and the dosage should be promptly reduced or discontinued upon the occurrence of adverse reactions to mitigate clinical risks.