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find Keyword "氧化还原" 2 results
  • 急性百草枯中毒致急性肺损伤发病机制的研究进展

    百草枯中毒所致急性肺损伤是目前临床上百草枯中毒致死的主要因素,近年来对于其损伤机制的研究不断深入,但其具体机制尚不完全明确。现对近年来百草枯中毒肺损伤在炎症反应、氧化损伤、基因异常表达等方面的机制研究进行综述,以期为临床医生对百草枯中毒致肺损伤的治疗提供依据。

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  • Current research on the influence of genetic factors on warfarin maintenance dose

    Warfarin is one of the most frequently prescribed oral anticoagulant. Many researches have shown that the genotypes have been strongly associated with warfarin maintenance doses. Especially, it has been accepted in academia that cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex 1 subunit (VKORC1) could affect the warfarin maintenance doses. There are also many other genotypes that were reported to be related to warfarin doses, but the results have been in controversial so far. The studies found that the dose formula which contained the genetic factors and clinical information could accurately predict the maintenance dose of warfarin, however, its usefulness is suspected due to the inconsistent results of clinical trials. Large-sample and multi-center studies are necessary to verify the specific effects of gene and non-gene factors to warfarin dose; at the same time, testing constructed models or building new models help to improve the explained percentages of individual differences.

    Release date:2018-07-27 02:40 Export PDF Favorites Scan
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