Objective To assess the effect of naloxone in treating the disease of acute cerebral infarction. Methods Sixty patients of acute cerebral infarction were randomly divided into two groups. One group received routine therapy and the other routine therapy plus naloxone. Neuroprotective effect of naloxone were measured by using NIH stroke scale and Bathel-Index. Adverse effect of the drug was also observed. Results There were 27 patients (90%) improved with clinical manifestations in experiment group, and 20 patients (67%) improved in control group. There is a significant difference between the two groups (Plt;0.05).There is no adverse reactions of naxloxone observed. Conclusion Naloxone might protect the nervous cells and restore the function of the nervous system in patients with acute cerebral infraction.
摘要:目的:探讨纳络酮对急性酒精中毒的临床疗效及经验。方法: 将58例酒精中毒患者随机分为2组:常规治疗组29例,给予利尿剂、胃肠黏膜保护剂及静脉补液对症治疗;纳络酮治疗组29例,除了应用常规治疗方法外,加用纳络酮。结果:纳络酮治疗组患者症状改善,清醒时间明显提前于对照组(Plt;0.01)。结论: 纳络酮治疗急性酒精中毒疗效肯定、使用简单安全,值得临床推广使用。Abstract: Objective: To evaluate the clinical effect of naoxone on acute alcoholism. Methods: Fiftyeight cases of acute alcoholism were randomly divided into two groups: remedial group (29 cases) and the comparison group (29 cases). Both groups were given diuretic, protection of mucous membrane of stomach and fluid infusion. The remedial group was treated with naloxone. Results: Symptoms of the remedial group were obviously improved. Consciousness was regained much earlier than that of the comparison group (Plt;0.01). Conclusion: Naloxone can be used effectively and safely in treating acute alcoholism.