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我国首例胰腺次全切除联合自体胰岛细胞移植治疗慢性胰腺炎临床分析△

目的　总结分析胰腺次全切除联合自体胰岛细胞移植治疗慢性胰腺炎的临床疗效。方法　对1例全胰腺实质弥漫性病变及其他治疗均失败的慢性胰腺炎患者行胰腺次全切除联合自体胰岛细胞移植，并对随访3个月的资料进行总结与分析。结果　患者术后恢复顺利，无出血、无吻合口漏、无严重低血糖等并发症发生，腹痛完全缓解，术后未使用任何镇痛药。随访期间患者空腹血糖及C 肽在正常水平，腹部超声检查未发现异常。结论　胰腺次全切除联合自体胰岛细胞移植是治疗全胰腺实质弥漫性病变及其他治疗均失败的慢性胰腺炎患者的理想方法，既能缓解患者的临床症状，又最大程度地预防了外科性糖尿病的发生，即使术后移植胰岛仅保留部分功能，但对于维持血糖的生理性平衡、减少糖尿病并发症的发生尤其是致命性低血糖的发作是十分重要的。

Molecular Imaging of Islet Transplantation：Tracking and Monitoring

Objective　To summarize and analyze the different modality on molecular imaging of tracking and monitoring for islet transplantation．Methods　The current domestic and foreign reports on molecular imaging of islet transplantation were reviewed．Results　Magnetic resonance imaging has high sensitivity，high spatial resolution，no ionizing radiation，is clinically applicable，and could be used of real-time MR-guided injections，but can’t discriminate between liver and dead cells，difficult to do in patients with liver iron overload．Nuclear molecular imaging only displays liver cells generate signal，is clinically applicable，but disadvantage is genetic manipulation，ionizing radiation，no anatomical information，low spatial resolution．The advantage of in vivo optical imaging is only liver cells generate signal，widely available，no ionizing radiation，and the disadvantage is genetic manipulation，not clinically applicable，low spatial resolution．Conclusions　Islet imaging using magnetic resonance，nuclear molecular imaging，in vivo optical imaging，or multimodal imaging of microencapsulated islets may provide us with a direct means to interrogate islet cell distribution，survival，and function．Multimodal imaging of microencapsulated islets may be best way for tracking and monitoring in the future．

Evolution of Pancreatic Islet Transplantation for Diabetes Mellitus：History，Challenge，and Future

The progress of islet cells co-transplantation with bone marrow mesenchymal stem cells inthe treatment of diabetes

Objective To summarize the feasibility and safety of the islet cells co-transplantation with bone marrow mesenchymal stem cells (BMSCs) in the treatment of diabetes. Methods The latest progress and new achievements of islet cells transplantation and BMSCs transplantation in treatment of diabetes in the world were analyzed and reviewed. Results At present, the pancreas transplantation and the islet cells transplantation were mainly treatments for diabetes, the pancreas transplantation had disadvantages of large trauma and high mortality; the islet cells transplantation was safe, but had disadvantages of strong rejection, and the survival time of islets cells were short which affected the treatment effect of diabetes. The BMSCs co-transplanted with the islet cells could prolong the survival time of islet cells and could alleviate the rejection in body, so the co-transplantation can be more effective in treatment of diabetes. Conclusion The BMSCs co-transplant with the islet cells could reduce the rejection in vivo, reduce the inflammation in vivo, prolong the survival time of islet cells, extend the time of normal glucose, which may become the new treatment method for the diabetes.