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find Keyword "脑电图" 169 results
  • A method of mental disorder recognition based on visibility graph

    The causes of mental disorders are complex, and early recognition and early intervention are recognized as effective way to avoid irreversible brain damage over time. The existing computer-aided recognition methods mostly focus on multimodal data fusion, ignoring the asynchronous acquisition problem of multimodal data. For this reason, this paper proposes a framework of mental disorder recognition based on visibility graph (VG) to solve the problem of asynchronous data acquisition. First, time series electroencephalograms (EEG) data are mapped to spatial visibility graph. Then, an improved auto regressive model is used to accurately calculate the temporal EEG data features, and reasonably select the spatial metric features by analyzing the spatiotemporal mapping relationship. Finally, on the basis of spatiotemporal information complementarity, different contribution coefficients are assigned to each spatiotemporal feature and to explore the maximum potential of feature so as to make decisions. The results of controlled experiments show that the method in this paper can effectively improve the recognition accuracy of mental disorders. Taking Alzheimer's disease and depression as examples, the highest recognition rates are 93.73% and 90.35%, respectively. In summary, the results of this paper provide an effective computer-aided tool for rapid clinical diagnosis of mental disorders.

    Release date:2023-08-23 02:45 Export PDF Favorites Scan
  • An electroencephalogram-based study of resting-state spectrogram and attention in tinnitus patients

    The incidence of tinnitus is very high, which can affect the patient’s attention, emotion and sleep, and even cause serious psychological distress and suicidal tendency. Currently, there is no uniform and objective method for tinnitus detection and therapy, and the mechanism of tinnitus is still unclear. In this study, we first collected the resting state electroencephalogram (EEG) data of tinnitus patients and healthy subjects. Then the power spectrum topology diagrams were compared of in the band of δ (0.5–3 Hz), θ (4–7 Hz), α (8–13 Hz), β (14–30 Hz) and γ (31–50 Hz) to explore the central mechanism of tinnitus. A total of 16 tinnitus patients and 16 healthy subjects were recruited to participate in the experiment. The results of resting state EEG experiments found that the spectrum power value of tinnitus patients was higher than that of healthy subjects in all concerned frequency bands. The t-test results showed that the significant difference areas were mainly concentrated in the right temporal lobe of the θ and α band, and the temporal lobe, parietal lobe and forehead area of the β and γ band. In addition, we designed an attention-related task experiment to further study the relationship between tinnitus and attention. The results showed that the classification accuracy of tinnitus patients was significantly lower than that of healthy subjects, and the highest classification accuracies were 80.21% and 88.75%, respectively. The experimental results indicate that tinnitus may cause the decrease of patients’ attention.

    Release date:2021-08-16 04:59 Export PDF Favorites Scan
  • 利用自动病变检测规划立体定向脑电图:可行性回顾性研究

    本回顾性横断面研究评估了将深度学习的难治性癫痫患儿的结构性磁共振成像(MRI)纳入到规划立体定向脑电图(SEEG)植入的可行性和潜在益处。本研究旨在评估自动病变检测与 SEEG 检测出癫痫发作起始区(SOZ)之间的共定位程度。将神经网络分类器应用于基于皮层 MRI 数据的三个队列:① 对 34 例局灶性皮质发育不良(FCD)患者的神经网络进行学习、训练和交叉验证;② 对 20 名健康儿童对照者进行特异性评估;③ 对 34 例患儿纳入 SEEG 植入计划的可行性进行了评价。SEEG 电极触点的坐标与分类器预测的病变进行核验。临床神经生理学家鉴定癫痫发作起源和易激惹区的 SEEG 电极触点位置。若 SOZ 坐标点和分类器预测的病变之间的距离<10 mm 则被认为是共定位的。影像学诊断病灶的分类敏感度为 74%(25/34)。对照组中未检测到异常(特异性=100%)。在 34 例 SEEG 植入患者中,21 例有局灶性皮层 SOZ,其中 8 例经病理证实为 FCD。分类器正确地检测了这 8 例 FCD 患者中的 7 例(86%)。组织病理学存在异质性的局灶性皮层病变患者中,62% 的患者分类器输出结果与 SOZ 之间存在共定位。3 例患者中,电临床提示为局灶性癫痫,SEEG 上无 SOZ 定位点,但在这些患者中,分类器识别了尚未植入的额外异常点。自动病变检测与 SEEG 之间的共定位存在高度的一致性。 我们已经建立了一个框架,将基于深度学习的 MRI 自动病变检测纳入到 SEEG 植入计划。我们的发现支持了对自动 MRI 分析的前瞻性评估,以规划最佳电极植入轨迹方案。

    Release date:2021-08-30 02:33 Export PDF Favorites Scan
  • Application and evaluation of standardized management in video-electro-encephalogram monitoring

    ObjectiveTo explore the application effect of standardized management on video-electroencephalogram (VEEG) monitoring.MethodsIn January 2018, a multidisciplinary standardized management team composed with doctors, technicians, and nurses was established. The standardized management plan for VEEG monitoring from outpatient, pre-hospital appointment, hospitalization and post-discharge follow-up was developed; the special quilt for epilepsy patients was designed and customized, braided for the patient instead of shaving head, standardized the work flow of the staff, standardized the health education of the patients and their families, and standardized the quality control of the implementation process. The standardized managemen effect carried out from January to December 2018 (after standardized managemen) was compared with the management effect from January to December 2017 (before standardized managemen).ResultsAfter standardized management, the average waiting time of patients decreased from (2.08±1.13) hours to (0.53±0.21) hours, and the average hospitalization days decreased from (6.63±2.54) days to (6.14±2.17) days. The pass rate of patient preparation increased from 63.14% to 90.09%. The capture rate of seizure onset increased from 73.37% to 97.08%. The accuracy of the record increased from 33.12% to 94.10%, the doctor’s satisfaction increased from 76.34±29.53 to 97.99±9.27, and the patient’s satisfaction increased from 90.04±18.97 to 99.03±6.51. The difference was statistically significant (P<0.05).ConclusionStandardization management is conducive to ensuring the homogeneity of clinical medical care, reducing the average waiting time and the average hospitalization days, improving the capture rate and accuracy of seizures, ensuring the quality of medical care and improving patient’s satisfaction.

    Release date:2019-06-25 09:50 Export PDF Favorites Scan
  • EEG waveform and spectrum-power analysis under different settings of filter parameter

    Objective To explore the change of EEG waveform recorded by clinical EEG under different filtering parameters. Methods22 abnormal EEG samples of epilepsy patients with abundant abnormal waveforms recorded in Peking University first hospital were selected as the case group (abnormal group), and 30 normal EEG samples of healthy people with matched sex and age were selected as the control group (normal group). Visual examination and power spectrum analysis were then performed to compare the difference of wave forms and spectrum power under different settings of filter parameter between the two groups. ResultsThe results of visual examination show that, lower high-frequency filtering has an effect on the fast wave composition of EEG and may distort and reduce the spike wave. Higher low-frequency filtering has an effect on the overall background and slow wave activity of EEG and may change the amplitude morphology of some slow waves. The results of power spectrum analysis show that, Compare the difference between the EEG normal group and the abnormal group, the main difference under the settings of 0.5~70Hz was on the θ and α3 frequency band, different brain regions were slightly different. In the central region, the difference in the high frequency band (α3, γ1, γ2) decreases or disappears with the decrease of the high frequency filtering. In the rest of the brain, the difference in the δ band appears gradually with the increase of the low frequency filtering. Compare the difference between frontal area and occipital area under different filter set, for the normal group, under the settings of 0.5 ~ 70 Hz, the difference between two regions is mainly on the θ, γ1 and γ2 band. When high frequency filter reduces, the difference between two regions on high frequency band (γ1, γ2) are gradually reduced or disappeared. And when low frequency filter increases, the difference on δ band appears. For the abnormal group, the difference between frontal and occipital region under the settings of 0.5 ~ 70 Hz is mainly on γ1 and γ2 bands. When the high-frequency filter decreases, the difference between two regions on high-frequency bands are gradually decreased or disappeared. All the results can be corrected by FDR. ConclusionThe results show that the filter setting has a significant influence on EEG results. In clinical application, we should strictly set 0.5 ~ 70 Hz bandpass filtering as the standard.

    Release date:2022-04-28 09:14 Export PDF Favorites Scan
  • 关于《癫痫患者的睡眠生理: 癫痫发作对快速眼动睡眠潜伏期和持续时间的影响》一文的解读

    本文对最近发表于Epilepsia杂志的“Sleep physiology in patients with epilepsy: Influence of seizures on rapid eye movement (REM) latency and REM duration”一文进行解读,该研究以接受术前评估的成年药物难治性癫痫患者为研究对象,通过分析频谱图和视频脑电图发现,癫痫本身可以改变潜在的睡眠,对于癫痫发作和长期癫痫发作风险预警具有一定意义,并且首次提出了几个癫痫发作与睡眠的概念如primary sleep period、 perisleep等。通过文章解读,期望为相关专业人员提供癫痫研究新方向。

    Release date:2024-07-03 08:46 Export PDF Favorites Scan
  • Recognition of Low Arousal Level Electroencephalogram in the Vigilance Based on Wavelet Packet Rhythm and Support Vector Machine

    Poor and monotonous work could easily lead to a decrease of arousal level of the monitoring work personnel. In order to improve the performance of monitoring work, low arousal level needs to be recognized and awakened. We proposed a recognition method of low arousal by the electroencephalogram (EEG) as the object of study to recognize the low arousal level in the vigilance. We used wavelet packet transform to decompose the EEG signal so the EEG rhythms of each component were obtained, and then we calculated the parameters of relative energy and energy ratio of high-low frequency, and constructed the feature vector to monitor low arousal state in the operation. We finally used support vector machine (SVM) to recognize the low arousal state in the simulate operation. The experimental results showed that the method introduced in this article could well distinguish low arousal level from arousal level in the vigilance and it could also get a high recognition rate. Have been compared with other analysis methods, the present method could more effectively recognize low arousal level and provide better technical support for wake-up mechanism of low arousal state.

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  • 立体脑电图颅内电极植入的准确性:系统评价和 Meta 分析

    立体脑电图(SEEG)是一种将电极植入大脑以帮助确定致痫灶的操作。它是在非侵入性检查不能确定致痫灶的情况下,对耐药性局灶性癫痫患者进行明确的癫痫手术之前进行的。这项操作的主要风险是出血,发生率为 1%~2%,可能原因是电极放置不准确,或者计划的植入电极损伤了在术前血管成像中未检测到的血管。推荐的电极植入技术包括:使用立体定向框架、无框架影像导航系统、机器人导航系统和定制的患者固定装置。研究参照系统评价和 Meta 分析推荐报告条目(Preferred reporting items for systematic reviews and Meta-analysis,PRISMA),结构化搜索 PubMed、Embase 和 Cochrane 数据库,纳入的研究涉及:①SEEG 电极植入作为术前工作的一部分;② 针对耐药性局灶性癫痫患者;③ 提供准确数据。数据库检索出 326 篇文章,删除重复和非英语语言的研究后,筛选出 293 篇文章。应用纳入和排除标准后,最终有 15 项研究纳入定性和定量分析。利用随机效应的元分析和技术分层,最终总结出 SEEG 电极植入的准确性。发表有关 SEEG 植入技术的准确性文献有限。目前并没有比较不同 SEEG 植入技术的前瞻性对照临床试验。在已确定的研究之间存在显著的系统异质性,妨碍了各项技术之间有意义的比较。最近引进的机器人导航系统被认为提供了一种更精确的植入方法,但支持证据仅限于 3 级。在将新技术引入进行广泛临床应用之前,有必要通过良好设计、方法合理的研究将新技术与以前的“金标准”进行比较。

    Release date:2018-09-18 10:17 Export PDF Favorites Scan
  • 灰质异位与癫痫发作

    灰质异位在药物难治性癫痫中并非少见,是胚胎发育阶段神经元移行障碍导致的大脑畸形之一,其主要原因有遗传因素(最常见的是 FLNA 基因突变)、肌动蛋白缺乏及母亲在妊娠期接受 X 线或其他外界因素的影响。灰质异位癫痫发作的机制尚不完全了解,据颅内电极尤其是立体定向脑电图(SEEG)研究发现,发作多起源于异位灰质及相关皮质两者,少数起源于异位灰质或大脑皮质。灰质异位的诊断主要依据为在大脑内有与大脑皮质信号一致的结节、团块或与皮质平行的带状异常。对于合并癫痫发作者头皮脑电图意义不大,颅内电极尤其是 SEEG 可以发现发作的起源、异位灰质与大脑皮质的关系,以及异常网络间的联系,所以 SEEG 是必不可少的检测项目。灰质异位合并的癫痫,绝大多数为药物难治性患者,在 SEEG 指导下的外科治疗可以获得非常好的疗效。

    Release date:2018-11-21 02:23 Export PDF Favorites Scan
  • 抗体介导的自身免疫性脑炎患者的癫痫特点

    越来越多的自身免疫性脑炎(Autoimmune encephalitis,AE)患者的资料显示,其临床表现和结局的特异性依赖于患者脑脊液、血清中特定抗原的抗体。这些特异性包括了癫痫相关的临床表现及对抗癫痫药物的反应。虽然学者们对这一类疾病的研究热情不断增加,且发现了新的抗体和相关的临床综合征,但仍有一些问题需要进一步解答。首先,鉴于每一种自身免疫性抗体介导的综合征的严重程度、患者特点、治疗时间不尽相同,治疗需要个体化;其次,缺乏随机对照试验是形成适当的免疫治疗策略的重大障碍。文章就一些已阐明的 AE 患者的癫痫诊断和治疗方面的新进展和挑战作一综述,并阐述在这一新兴领域中合理应用精确药物的原则。

    Release date:2020-07-20 08:13 Export PDF Favorites Scan
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