west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "苗佳" 15 results
  • 容积输液泵在新药Ⅰ期临床试验中的应用及其护理要点

    静脉制剂新药的Ⅰ期临床试验对受试者的给药常常有严格的要求,特别是药物代谢动力学研究,要求同批受试者须在相同的规定时间内匀速输入含相同药物剂量、浓度的等量液体,而容积输液泵的应用为试验顺利实施提供了有力的保障。现就2005年1月以来,开展10项运用容积输液泵给药的Ⅰ期药物代谢动力学研究所取得的经验,重点分析Ⅰ期临床试验中容积输液泵的操作方法和运用过程中的护理工作要点。

    Release date:2016-09-08 09:16 Export PDF Favorites Scan
  • 抗菌药物与细胞色素P450的相关研究

    抗菌药物广泛地应用于临床各个科室,常常与多种药物联合应用而产生药物相互作用。肝微粒体细胞色素P450是药物代谢最重要的酶系之一,药物作用影响其活性是发生药物相互作用的重要分子机制。了解抗菌药物与细胞色素P450的相关关系,有助于明确药物相互作用的分子基础,有助于指导临床合理联合用药,保障临床治疗更加安全有效。现就抗菌药物与细胞色素P450的相关研究作一综述。

    Release date:2016-09-08 09:16 Export PDF Favorites Scan
  • 阿司匹林的临床应用进展

    阿司匹林是临床处方量最大的常用药物,其治疗作用随剂量不同而不同,具有良好的解热、镇痛、抗炎以及血小板聚集抑制作用等。随着对该药研究的深入,近年来又发现了阿司匹林的一些新应用,包括癌症预防、糖尿病防治、缓解白内障等,但这些新应用尚需临床进一步研究才能得以推广。现主要针对阿司匹林的临床应用进展进行综述。

    Release date:2016-09-08 09:16 Export PDF Favorites Scan
  • CYP3A5基因遗传多态性及临床研究进展

    【摘要】细胞色素酶P450 3A(cytochrome P450 3A,CYP3A)是人体代谢许多内源性化合物、外源性底物及其前致癌物的一类重要的肝脏药物氧化代谢酶,占成人肝脏细胞色素总量的30%,代谢超过50%的临床用药物。而CYP3A5是P450 3A家族中活性最强的酶之一,因存在突变多态性,不同的单核苷酸多态(single nucleotide polymorphism, SNP)可导致药物有不同的代谢活性,对不同SNP的分析可以对个性化用药做出指导。不同的SNP可能还与某些疾病的遗传易感性相关,就上述CYP3A5的遗传多态性及临床意义进行综述。

    Release date:2016-09-08 09:51 Export PDF Favorites Scan
  • CYP2C19基因多态性与个体化治疗的研究进展

    CYP2C19作为细胞色素P450重要的酶系之一,参与了多种药物的体内代谢过程。CYP2C19编码基因的突变,可造成CYP2C19酶代谢活性的改变,进而出现不同患者服用以CYP2C19为关键代谢酶的药物后,体内血药浓度差异,甚至产生不同临床反应。通过对CYP2C19基因多态性及与之相关的个体化治疗研究进展的综述,旨在为临床合理用药提供参考资料。

    Release date: Export PDF Favorites Scan
  • Tolerance of Medicinal Charcoal Enteric-coated Tablets in a Phase I Study

    Objective To evaluate the safety and tolerance of medicinal charcoal enteric-coated tablets in healthy volunteers. Methods A total of 44 healthy volunteers were randomly divided into 6 single-dose groups (0.5 g, 2 g, 4 g, 6 g, 8 g and 10 g) and a multiple-dose group (3 g, 3 times a day, for 14 days). The safety profile and tolerance were evaluated by observing symptoms, vital signs, and laboratory tests. Results No serious adverse event was reported for any volunteer. Abdominal distension occurred in 2 volunteers in the 4 g dose group and the 6 g dose group. One volunteer in the 8 g dose group experienced nausea and vomiting. Transient decrease in white blood cell count was observed in one volunteer in the 10 g dose group. Abdominal distension occurred in 2 volunteers of the multiple-dose group. Conclusion  Based on our findings, the maximum tolerated dose of medicinal charcoal enteric-coated tablets in Chinese healthy volunteers is 10 g. The recommended dose for subsequent clinical trials is 3 g, 3 times a day.

    Release date:2016-09-07 02:09 Export PDF Favorites Scan
  • Key Points of Nursing in Phase Ⅰ Clinical Tolerance Trial of Intravenous Formulation

    目的 总结静脉制剂Ⅰ期临床耐受性试验中的护理要点。方法 2011年10月-12月,采用随机、盲法、安慰剂平行对照试验设计,在健康志愿者中按剂量递增原则,逐组完成8个剂量单次静脉滴注给药耐受性试验。 结果 试验顺利完成。静脉制剂的Ⅰ期耐受性试验中,研究护士在临床试验前需认真学习试验方案,做好试验病房、监护急救设施设备的充分准备,针对可能出现的不良反应制定切实可行的处理预案,试验过程中密切监测,对出现的不良反应做好救治工作。特别针对静脉制剂,须做好受试者的心理疏导,保证静脉穿刺一次成功,减少受试者因情绪紧张、穿刺疼痛等因素干扰对试验药物耐受性的评价。 结论 Ⅰ期临床耐受性试验实施前准备充分,试验过程中为受试者提供良好的试验环境和心理护理,提高静脉穿刺一次成功率,密切监测,可使试验过程顺利,并获得客观、准确的试验结果。

    Release date:2016-09-08 09:16 Export PDF Favorites Scan
  • 餐后高脂血症临床研究进展

    临床常规血脂检查要求采集清晨空腹血,但现实生活中人体绝大部分时间处于餐后状态,仅检测空腹血脂水平不足以反映机体真实的脂代谢全貌。近年来国内外较多研究通过脂肪餐负荷试验,探讨了餐后血脂的变化过程及其与血管内皮病变、心血管疾病及胰岛素抵抗、2 型糖尿病等发生发展的相关性。本文对脂肪餐负荷试验及餐后高脂血症与相关疾病的研究进行了综述。

    Release date:2017-03-27 11:42 Export PDF Favorites Scan
  • A multicenter randomized controlled clinical trial on domestic sparfloxacin orally in the treatment of acute bacterial infections

    Objective To evaluate the clinical efficacy and safety of domestic sparfloxacin in the treatment of acute bacterial infections. Methods A multicenter randomized controlled clinical trial was conducted. 117 patients were treated with domestic sparfloxacin 200-300 mg qd for 5-14 days and 114 patients were treated with domestic lomefloxacin 300 mg bid for 5-14 days. Results The cure rates and the efficacy rates in each group were 84.62%, 74.56% and 94.87%, 92.98%, respectively. The bacterial clearance rates were 94.28% and 92.02%, respectively. Adverse drug reactions rates were 7.69% and 11.40%, most of them were mild. There were no significant differences of above results between the two groups (Pgt;0.05). Conclusions The results suggest that sparfloxacin with wide antibacterial spectrum, satisfactory activity, is an effective and safe antibacterial agent in treatment of mild to moderate acute bacterial infections.

    Release date:2016-08-25 03:16 Export PDF Favorites Scan
  • A multicentre randomized controlled clinical trial on amoxicillin/sulbactam in the treatment of acute bacterial infections

    Objective To evaluate the efficacy and safety of amoxicillin/sulbactam (AMX/SBT) in the treatment of acute bacterial infections. Method A multicentre randomized controlled clinical trial was conducted. Ampicillin/sulbactam (AMP/SBT) was chosen as the control drug. 113 patients were enrolled in the study (58 cases in test group and 55 cases in control group). AMX/SUL and AMP/SUL were administered 4.5-6.0 g and 4.5-12.0 g every day respectively. Both drugs were given intravenously for 7-14 days. Results The cure rates and the efficacy rates of the two groups were 75.86%, 80.0% and 94.83%, 98.18% respectively. The β-lactamase producing rates were 67.35% , 69.57% and the bacterial clearance rates were 93.88%, 95.65%.There were no significant differences of the above results between the two groups (Pgt;0.05). There was no serious adverse drug reaction in AMX/SBT groups. Conclusion This study suggests that AMX/SBT is an effective and safe drug for treating acute bacterial infections.

    Release date:2016-08-25 03:16 Export PDF Favorites Scan
2 pages Previous 1 2 Next

Format

Content