ObjectiveTo explore the prevalence of depression and anxiety of chronic obstructive pulmonary disease complicated coronary artery disease before and after percutaneous intracoronary arterial stenting. MethodsA total of 114 chronic obstructive pulmonary disease complicated coronary artery disease patients were enrolled in this study and were measured with the Hospital Anxiety and Depression Scale before and after percutaneous intracoronary arterial stenting. ResultsA total of 71 patients (62.3%) had depression symptom and 68 patients (59.6%) had anxiety symptom before percutaneous intracoronary arterial stenting. There were 46 patients (40.4%) had significant depression symptom and 40 patients (35.1%) had significant anxiety symptom before percutaneous intracoronary arterial stenting. A total of 85 patients (74.6%) had depression symptom and 83 patients (72.8%) had anxiety symptom after percutaneous intracoronary arterial stenting. There were 60 patients (52.6%) had significant depression symptom and 48 patients (42.1%) had significant anxiety symptom after percutaneous intracoronary arterial stenting. There was significant difference in prevalence rate of depression and anxiety before and after percutaneous intracoronary arterial stenting (P < 0.05). ConclusionsThe patients with chronic obstructive pulmonary disease complicated coronary artery disease show higher prevalence of depression and anxiety. The prevalence of depression and anxiety increases significantly after percutaneous intracoronary arterial stenting.