【摘要】 目的 评价经皮冠状动脉成形术(percutaneous coronary interventions,PCI)术后,穿刺股动脉应用Perclose ProGlide血管缝合器止血的安全性、可靠性及对常见并发症的防范。 方法 2007年4月-2009年5月,收治217例经股动脉PCI术后患者,根据术后是否使用血管缝合器将患者随机分成血管缝合器组(105例)和对照组(经手法压迫止血112例)。观察记录两组患者下肢制动时间及血管并发症等。 结果 血管缝合器组103例操作成功(98.1%),2例失败;对照组成功112例(100%)。两组成功率比较,差异无统计学意义(Pgt;0.05)。血管缝合器组和对照组患者下肢制动时间分别为(4.1±1.2)和(25.0±3.1)h,两组比较,差异有统计学意义(Plt;0.01)。术后两组并发症发生率比较,差异无统计学意义(Pgt;0.05)。 结论 血管缝合器是一种安全、可靠的止血方法,可明显缩短制动时间,无明显的穿刺部位血管并发症,熟练操作可减少并发症的发生。【Abstract】 Objective To evaluate the safety of Perclose ProGlide Suture-Mediated Closure System applied to femoral artery puncture site after percutaneous coronary interventions (PCI) and to explore the prevention of possible common complications. Methods A total of 217 patients who underwent PCI from April 2007 to May 2009 were randomly divided into Perclose ProGlide group (105 patients, hemostasis by Perclose ProGlide Suture-Mediated Closure System) and control group (112 patients, hemostasis by compression). The Lower-limb braking time and the complications were recorded and analyzed. Results The successful rate was 98.1% (103 patients) in Perclose ProGlide group, and 100% (112 patients) in the control group; the difference between the two groups was not significant (Pgt;0.05). But there was a significant difference (Plt;0.01) in Lower-limb braking time between the two groups[(4.1±1.2) and (25±3.1) hours]. The post-operative complications between the two groups didn’t differ much. Conclusions Perclose ProGlide Suture-Mediated Closure System is a safe,effective and simple method after percutaneous coronary intervention to achieve immediate hemastasis. Skillfully processing may reduce the vascular complications.