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find Keyword "认知功能" 80 results
  • 脑深部电刺激对帕金森病认知功能的影响

    【摘要】帕金森病(Parkinson’s disease, PD)是中老年人常见的神经系统变性疾病。脑深部电刺激(deep brain stimulation, DBS)可以改善中晚期或药物难治性PD患者的运动症状、生活质量,并且丘脑底核脑深部电刺激(subthalamic nucleus deep brain stimulation, STN DBS)还可减少术后多巴胺能药物的治疗剂量,但DBS术后同时可出现认知功能、行为、情绪和精神等方面的变化。目前DBS对认知功能如语言功能、执行功能、记忆力、注意力、视功能和精神运动速度等方面的影响尚无一致的结论,现就DBS对认知功能各方面的影响进行综述。

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  • Correlation between Neuroendocrine and Cognitive Function in Patients with Refractory Depression

    Objective To investigate the characteristics of cognitive function and its correlation to neuroendocrine status in patients with refractory depression. Methods A total of 41 patients diagnosed by ICD-10 as depression onset who have been treated with more than two antidepressants drugs, fulfilled the criteria of refractory depression. Another 40 patients diagnosed by ICD-10 as depression onset but who have not been treated, or have been treated with only one antidepressant drug were selected as controls. Patients in both groups were evaluated by WAIS-RC, STROOP, VF, TRAILS A, B, TOH and M-WCST, and the concentrations of CORT, ACTH, T3, FT3, T4, FT4, TSH were also determined. Results A significant difference was found in VF between the refractory depression group and the control group. This showed that the damage to short-term memory, attention and interference rejection capability was much more serious in the refractory depression group. The ACTH concentration in the refractory depression group was significantly different from that of the control group, which indicated that the damage to the Hypothalamic-pituitary-adrenal axis was more serious in the refractory depression group. In particular in relation to memory and attention defect. Conclusion Changes in the levels of CORT, ACTH, TSH, FT3 and T4 may be correlated to cognitive function damage in patients with refractory depression.

    Release date:2016-09-07 02:16 Export PDF Favorites Scan
  • A Study of Cognitive Functions in People at High Risk for Schizophrenia

    Objective To investigate the cognitive functions in people at high risk for schizophrenia.Methods Two hundred and twenty-two people at high risk for schizophrenia and 331 normal controls were assessed with 14 neuropsychological tests. Results The results of some neuropsychological tests in people at high risk for schizophrenia were worse than those in the normal controls. These tests included information, arithmetic, digital symbol, block design, logical memory, visual memory, Stroop test, verbal fluency, tower of Hanoi, WCST and CPT (Plt;0.01). The time for trail making test A in was longer in the group at high risk for schizophrenia than in the control group (Plt;0.05).Conclusion People at high risk for schizophrenia have general cognitive deficits. Attention and executive function may represent the genetic endophenotype for schizophrenia.

    Release date:2016-09-07 02:18 Export PDF Favorites Scan
  • Evidence-Based Treatment for Type 2 Diabetes Mellitus

    Based on literatures on Meta-analysis and randomized controlled trial, drug use and some geriatrics syndromes such as cognitive impairment and depression, in elderly diabetic patients were reviewed. Insulin plus oral hypoglycemic drugs was more rational therapy for insulin resistance and islet dysfunction in type 2 diabetes mellitus. We should pay more attention to cognitive impairment and depression in elderly type 2 diabetic patients.

    Release date:2016-09-07 02:28 Export PDF Favorites Scan
  • Mismatch Negativity in Patients with Obsessive-Compulsive Disorder

    目的 探讨强迫症患者失匹配负波(MMN)的特征以及强迫症可能存在的认知功能障碍。 方法 2010年9月-2012年3月将符合纳入标准的21例强迫症患者(OCD)进行耶鲁-布朗强迫症状量表(Y-BOCS)评分,使用日本Nihon Kohden脑诱发电位仪,记录21例OCD患者、21例性别相匹配的正常对照组进行Cz导联MMN潜伏期以及波幅的测定,并将数据进行t检验、相关性分析等处理。 结果 强迫症与正常人组间比较存在MMN潜伏期(t=2.834,P=0.007)延长,波幅增高,但较正常对照组比较无统计学意义,MMN潜伏期与病程以及Y-BOCS评分无相关性。 结论 强迫症患者在大脑处理信息的早期阶段存在认知的自动加工功能的损害,与病程长短以及病情的严重程度无明显相关性。MMN是检测认知功能比较敏感的指标。

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  • 全身麻醉药物与手术后认知功能障碍

    全身麻醉药物被认为是造成手术后认知功能障碍的重要因素之一,前期实验大都是推理性和描述性的,样本规模小,不能充分说明两者间的关系。为今后从大脑神经元形态学和神经生物学研究方面获得突破,现从吸入麻醉药、静脉麻醉药各自对认知功能的影响和可能机制,以及不同麻醉药的比较等方面进行综述。

    Release date:2016-09-08 09:12 Export PDF Favorites Scan
  • 蒙特利尔认知评估量表在不同地区应用现状

    轻度认知功能障碍是介于正常老化和痴呆之间的一种临床状态,如何能够早期相对准确并且及时地筛查出这种状态,同时又不需要较高的医疗费用,各种认知功能障碍相关量表越来越受到重视,其中对蒙特利尔认知评估量表研究最多,同时应用最为广泛,不同地区的医疗工作者做了大量的工作,以期其更加适合国内临床工作初步筛查使用。现对国内相关研究进行综述。

    Release date:2016-09-08 09:13 Export PDF Favorites Scan
  • 脑微出血研究进展

    使用磁敏感加权或梯度回波加权对头颅进行MRI扫描所发现的脑微出血灶已经成为了临床上研究的热点。现对脑微出血的检查手段,可能的临床意义,以及其对临床用药方面带来的潜在影响等进行综述。

    Release date:2016-09-08 09:17 Export PDF Favorites Scan
  • 血管型轻度认知功能障碍的影像学研究进展

    【摘要】 血管型轻度认知功能障碍(vascular mild cognitive impairment,V-MCI)是与小血管疾病密切相关的MCI的一种亚型,是一组临床早期出现的处于正常老化与痴呆之间的过渡状态。近年来, 随着影像学技术逐渐成熟并应用于临床研究,国内外很多学者从神经影像学角度对V-MCI患者进行了初步研究,发现其脑结构及功能均存在异常。文章综述了相关的研究进展, 为进一步系统了解该病提供了重要依据。

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
  • 农娱治疗对慢性精神分裂症患者认知功能恢复作用

    目的 探索农娱治疗对慢性精神分裂症患者认知功能恢复的作用。 方法 对1994年4月-2008年12月收治的80例住院慢性精神分裂症患者随机分为干预组和对照组,对照组给予常规治疗,干预组除常规治疗外,实施自行设计的农娱治疗,治疗时间为6个月,使用韦氏记忆测验(WMS)及威斯康星卡片分类测试(WCST)测评。 结果 两组患者在治疗前WMS、WCST各因子分及总评总和分(指各因子总评分相加)比较,无统计学意义(Pgt;0.05);治疗后对照组与干预组间记忆商数、正确应答数和持续错误数比较均有统计学意义(Plt;0.05)。 结论 农娱治疗可改善慢性精神分裂症患者的认知功能,促进其积极参加人际交往、参与社会生活,在精神分裂症全程治疗中起到了积极作用。

    Release date:2016-09-08 09:47 Export PDF Favorites Scan
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