ObjectiveTo summarize the research progress on the impact of postoperative adjuvant chemotherapy on frailty, cognitive function, and quality of life in older patients with breast cancer.MethodCollected literatures about the impact of postoperative adjuvant chemotherapy on frailty, cognitive function, and quality of life in older patients with breast cancer to make an review.ResultsElderly breast cancer patients were likely to benefit from postoperative adjuvant chemotherapy without undergoing significant impairment of frailty, cognitive function, and quality of life. However, postoperative adjuvant chemotherapy might cause an aggravation of the frailty in patients who was already with it.ConclusionWe should develop personalized treatment plans for elderly breast cancer patients after multidisciplinary assessment.
ObjectiveTo summarize recent research on the surgical treatment of breast cancer after neoadjuvant chemotherapy (NAC) and to review the impact of NAC on the surgical treatment of breast cancer. MethodRelevant studies on NAC and surgical treatment of breast cancer from both domestic and international sources were reviewed. The literatures were analyzed, summarized, and discussed. ResultsFollowing NAC, the survival outcomes and risk of local recurrence in patients undergoing breast-conserving surgery were similar to those undergoing mastectomy. The using of image-guided minimally invasive biopsy accurately predicted pathological complete remission (pCR) of breast lesions after NAC, potentially allowed some breast cancer patients to undergo only radiation therapy after NAC, thus avoiding breast surgery. For patients with positive axillary lymph nodes, techniques such as dual-tracer, triple-tracer, and targeted axillary lymph node dissection had achieved clinical requirements in terms of detection rate and false-negative rate of sentinel lymph node biopsy, provided a safe alternative to axillary lymph node dissection. ConclusionsNAC is an important component of comprehensive breast cancer treatment. However, there is still controversy regarding the local treatment of the primary breast lesion and axillary lymph nodes after NAC. Currently, individualized treatment based on the specific circumstances of the patient remains the approach in clinical practice, aiming to achieve the optimal control of local recurrence and survival benefits for patients.
Objective To investigate the levels of IL-6 and TNF-α in children with obstructive sleep apnea syndrome (OSAS) and to determine their clinical significance. Methods One hundred children with OSAS in our department from August 2005 to February 2006, and 40 healthy children were enrolled in the study. The serum levels of IL-6 and TNF-α were measured. Results Serum levels of IL-6 and TNF-α were significantly higher in patients with OSAS than those in the control group (Plt;0.05). Both IL-6 and TNF-α were not correlated with AHI. Conclusion It is concluded that OSAS is a chronic inflammatory process. A close correlation was observed between high levels of IL-6 and TNF-α and OSAS. High levels of IL-6 and TNF-α account for the risk factors in the development of cardiovascular diseases in children with OSAS.
【摘要】 目的 探讨老年糖尿病患者合并脑梗死的临床特点及相关危险因素。 方法 回顾分析2008年7月-2009年7月收治的96例老年糖尿病合并脑梗死患者（A组）及116例老年非糖尿病脑梗死（B组）的临床资料，比较两组患者临床症状、体重指数（BMI）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、纤维蛋白原（FIB）水平及头颅CT结果等。 结果 A组与B组相比，BMI，TC、TG、LDL及FIB水平明显增高，而HDL降低，颅内病灶直径多较小，数目较多。 结论 老年糖尿病患者合并高BMI、TC、TG、LDL及低HDL脑梗死的危险性较高，且以多发腔隙性脑梗死多见。【Abstract】 Objective To investigate the clinical features and risk factors of the cerebral infarction in elder diabetic patients. Methods The clinical data of 96 (group A) and 116 (group B) elder patients with and without diabetes mellitus treated in our hospital due to cerebral infarction from July 2008 to July 2009 were retrospectively anlalyzed. The differences in clinical symptoms, body mass index (BMI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), fibrinogen (FIB) and the results of head CT between the two groups were compared. Results The levels of BMI, TC, TG, LDL, and FIB were obviously higher in group A than those in group B; HDL decreased, and the size and number of cerebral infarction was smaller and more in group A. Conclusion The elder diabetic patients with high BMI, TC, TG, and LDL and low HDL have a high risk of cerebral infarction, most commonly lacunar infarction.