目的总结腔内封堵技术治疗食管癌术后吻合口瘘的应用经验。 方法回顾性分析2006年8月至2011年12月上海中医药大学附属曙光医院应用腔内封堵技术治疗食管癌术后吻合口瘘15例患者的临床资料，其中男12例、女3例，年龄47～73岁。分析其临床效果。 结果窦道造影证实于瘘口附近有窦道形成者，瘘口直径＜0.5 cm者10例一次堵漏成功；瘘口直径大于0.5 cm者1例，堵漏二次后成功。瘘口附近窦道形成不明显者4例，堵漏均失败。 结论腔内封堵技术治疗食管癌术后吻合口瘘有相当的临床效果。瘘口附近有窦道形成是堵瘘成功的关键。
目的 研究质子泵抑制剂在反流性食管炎维持治疗的临床疗效。 方法 将2009年3月-月门诊及住院的121例反流性食管炎并胃镜证实病灶已愈合，且停药1周内症状又复发者，随机分为A、B、C 3组，3组均选用兰索拉唑。A组为兰索拉唑15 mg，1次/d，早餐前服；B组为兰索拉唑15 mg，1次/d，晚餐前服；C组兰索拉唑15 mg，2次/d，餐前服。3组疗程均为4周。疗程结束后进行临床症状疗效评定，并予复查胃镜，评价3组胃镜下总有效率，并观察3组不良反应。 结果 三种方案有效率分别为77.5%、95.0%、92.7%。 结论 晚餐前15 mg 1次/d的兰索拉唑为反流性食管炎较佳维持治疗方案。
目的 探讨嵌顿性食管旁疝的诊断和外科治疗。方法 对我院手术治疗的4例嵌顿性食管旁疝患者的临床资料进行分析。结果 2例急诊剖腹探查确诊，2例经胸部X线平片和CT检查确诊； 4例均行经腹Hill胃背侧固定术，术后均无并发症，无疝复发。结论 胸部X线平片及CT检查是诊断本病的主要手段； 一旦获得诊断或高度怀疑，应及早手术治疗； 经腹Hill胃背侧固定术式简单、可靠、复发率低，适合基层医院医生掌握。
OBJECTIVE: To repair esophageal defects with an artificial prosthesis composed of biodegradable materials and nonbiodegradable materials, which is gradually replaced by host tissue. METHODS: The artificial esophagus was a two-layer tube consisting of a chitosan-collagen sponge and an inner polyurethane stent with a diameter of 20 mm and a length of 50 mm. We used the artificial esophagus to replace 5 cm esophageal defects in group I (five dogs) and in group II (ten dogs), and nutritional support was given after operation. The inner polyurethane stent was removed after 2 weeks in group I and after 4 weeks in group II endoscopically and epithelization of the regenerated esophagus was observed by histologic examination and transmission electron microscope. RESULTS: In group I, the polyurethane stent was removed after 2 weeks, and partial regeneration of esophageal epithelial was observed; and constriction of the regenerated esophagus progressed and the dogs became unable to swallow after 4 weeks. In group II, the polyurethane stent was removed after 4 weeks, highly regenerated esophageal tissue successfully replaced the defect and complete epithelization of the regenerated esophagus was observed. After 12 weeks, complete regeneration of esophageal mucosa structures, including mucosal smooth muscle and mucosal glands and partial regeneration of esophageal muscle tissue were observed. CONCLUSION: Esophageal high-order structures can be regenerated and provided a temporary stent and support by polyurethane stent and an adequate three-dimensional structure for 4 weeks by collagen-chitosan sponge.