Magnetoencephalography (MEG), as a non-invasive brain functional imaging technology, plays an increasingly important role in the diagnosis and treatment of pediatric neurological disorders. In recent years, the emergence of helium-free MEG based on optical pumped magnetometer (OPM) technology (OPM-MEG) has provided a novel tool for pediatric brain research and precise diagnosis and treatment of brain diseases. This article elaborates on the technical principles, clinical application standards, testing protocols, and reporting requirements for pediatric OPM-MEG, aiming to establish a scientific and standardized operational framework to promote its rational application and development in pediatric practice. The content covers key aspects such as core equipment parameters, indications and contraindications, pre-examination preparations, optimized operational workflows, data quality control, and reporting standards, offering comprehensive guidance for conducting pediatric OPM-MEG examinations.