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find Keyword "Gastric carcinoma Cyclin D1 Cyclin Ep27 proteinImmunohistochemistry" 1 results
  • EXPRESSION AND SIGNIFICANCE OF CYCLIN D1, CYCLINE AND P27 IN GASTRIC CARCINOMAS

    Objective To study the expression and its significance of cyclin D1,cyclin E and p27 protein in gastric carcinoma. Methods The expression of cyclin D1,cyclin E and p27 protein in 60 cases of gastric carcinoma were detected by immunostaining method. Results The positive rates of cyclin D1,cyclin E and p27 protein expression in gastric carcinoma were 41.7%(25/60),38.3%(23/60)and 36.7%(22/60),respectively.The expression of cyclin D1 was significantly correlated with Lauren type of tumor,the expression of cyclin E was significantly correlated with tumor differentiation,infiltration and stage,while the expression of p27 protein was significantly correlated with tumor infiltration,lymph nodes metastasis and stage. Further more, the expression of cyclin E was inversely correlated with the expression of p27. Conclusion Detection of cyclin D1,cyclin E and p27 expression in gastric carcinoma may be helpful in determining tumor progression.

    Release date:2016-08-28 05:30 Export PDF Favorites Scan
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