ObjectiveTo summarize the current status of research in the correlation between the liver diseases and oral microbiota, to provide the scientific basis for the prevention and treatment of oral diseases in the patients with liver diseases, and to provide the guidance for further research on the biomarkers for the noninvasive diagnosis of liver diseases.MethodThe related literatures about the studies of correlation between liver diseases and oral microbiota were reviewed by searching the databases such as the PubMed, Web of Science, CNKI, and Wanfang, etc.ResultsAs the second richest microbiota, the oral flora closely interacted with the hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, cirrhosis, liver cancer, etc. Meanwhile, the prognosis of patients underwent liver transplantation was also closely correlated to oral flora.ConclusionsSpecific oral flora in patients with different liver diseases may be a potential non-invasive diagnostic biomarker. At the same time, it is necessary to pay attention to oral health and maintain oral microbiota balance for preventing and treating of liver diseases.
Living donor liver transplantation is one of the main solutions to the organ supply-demand discrepancy at present. However, there was a risk of the recipient developing small-for-size syndrome due to insufficient graft volume, while an excessively large graft volume for donation might lead to postoperative liver failure for the donor. In this context, the dual-graft liver transplantation had emerged, which could minimize the volume of liver resection from the each donor to ensure the donor’s safety and provide the adequate volume of liver for the recipient. Yet, this procedure is less commonly performed in our country. In order to promote the steady implementation of dual-graft liver transplantation in China and serve as an important supplement to the donor pool, the West China Hospital of Sichuan University organized relevant experts and draw on the mature experiences of advanced countries in the field of transplantation jointly formulated the “Expert consensus on dual-graft liver transplantation”. The consensus had been developed around aspects such as donor evaluation and selection, surgical methods, and postoperative complications.